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Management Problems of Trans-Frontier Yellow Fever Cases in Burkina Faso 2010

Advances in Infectious Diseases 2013年第2期3卷 84-88页

作者： Seydou Yaro Aline R. Ouoba Alidou Zango Jérémi Rouamba Aly Drabo Soumeya Ouangraoua fati samandoulougou-kirakoya Jean Macq Annie Robert Jean Bosco Ouedraogo Centre Muraz Bobo-Dioulasso Burkina Faso

This last decade, Burkina Faso has been confronted with yellow fever confirmed cases, mainly from Western part of the country. In 2010, National Reference laboratory of yellow fever received 970 sera of suspected cases from the 65 Health Districts of the country. We found 11 positive results by ELISA test researching specific IgM against yellow fever. An aliquot of these eleven positive sera were sent to Dakar for confirmation by sero neutralization and RT-PCR. Eight have been confirmed by regional laboratory of Pasteur Institute of Dakar and three were classified as doubtful. Confirmed cases were manly notified by Sindou (4/8) and Mangodara (3/8) Health Districts and the last one came from Nongr-masson health District situated in the central part of the country. Three out of the four confirmed cases in Sindou Health District were resident from neighboring village in Ivory Cost. Conformed cases coming from neighboring villages of Ivory Cost were difficult to manage because of the relative lack of coordination between the two health centers responsible in two different countries. The three cases were not notified to Ivory Cost Health authorities and, in addition, they didn’t benefit from the Burkina Faso response plan. The goal of this work is to present results from National Reference yellow fever laboratory in 2010 in Burkina Faso and stressing trans-frontier cases management problems in order to suggest a multinational mechanism of response to fight against this disease more effectively.

关键词： Yellow Fever Surveillance Reference Laboratory Trans-Frontier Burkina Faso

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Neisseria meningitis serogroup X outbreak in Burkina Faso,2009-2010

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Open Journal of Internal Medicine 2012年第2期2卷 41-49页

作者： Seydou Yaro Aly Drabo Soumeya Ouangraoua fati kirakoya-Samadoulougou Judith Mueller Oumar Sanou Haoua Tall Phillip Jaillard Berthe-Marie Njanpop-Lafourcade Jean Macq Annie Robert Jean Bosco Ouedraogo Centre Muraz Bobo-DioulassoBurkina Faso Pole Epidémiologie et Biostatistique Institut de Recherche Experimentale et Clinique(IREC)Faculte de Sante Publique(FSP)Universite Catholique de Louvain(UCL)LouvainBelgique Agence de Médecine Préventive(AMP) ParisFrance Institut de Recherche Sante et Societe(IRSS) Faculte de Sante Publique(FSP)Universite Catholique de Louvain(UCL)LouvainBelgique

Background: Centre MURAZ of Bobo-Dioulasso (Burkina Faso) organized in 2009 and 2010 a system of Cerobro-Spinal Fluid (CSF) collection in eight pilot Districts as an initial step for the future Ministry of Health’s led strategy of individual surveillance in a context of meningococcal conjugate A vaccine introduction. Methods: CSF samples were analyzed with Polymerase Chain Reaction (PCR). This allowed for meningitis etiologies dynamics studies in the pilot Districts. Results: Because of geographical difficulties and lack of means, less than 40% of suspected cases had their CSF analyzed at PCR reference laboratory. In 2009, among confirmed cases at reference laboratory, Sp (Streptococcus pneumonia), NmA (Neisseria meningitis A) and Hib (Hemophilus influenzae b) were responsible respectively for 90%, 6.6% and 4.4% of cases. In 2010, serogroup distribution among confirmed cases was: Sp 62.7%, NmX 32.2% and NmA 5.1%. Sp which was continuously present in Burkina Faso takes more significant proportions, just as serogroup X which until there was sporadically encountered. The attack rates of NmX were tree to twelve times higher than for NmA in the two Districts where NmX has been notified. Conclusion: As a consequence of such results, efforts must be maintained in epidemiologic surveillance field and in reinforcement of laboratory capacities. Fast care should be guaranteed to patients with adequate antibiotics according to country national guideline and chemoprophylaxis measures should be undertaken among contacts of patients to prevent secondary cases. A plea must be made on one hand for pneumococcal vaccine introduction in Burkina Faso and on other hand towards manufacturers for taking into account serogroup X into meningococcal polyvalent vaccine composition. With this polyvalent vaccine including serougruop X, we suggested to conduct periodically mass campaign vaccination of people before the beginning of meningitis epidemiological season.

关键词： Epidemiologic Surveillance Pneumococcal NmX Emergence Meningitis Burkina Faso

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