Neisseria meningitis serogroup X outbreak in Burkina Faso,2009-2010

作     者：Seydou Yaro Aly Drabo Soumeya Ouangraoua Fati Kirakoya-Samadoulougou Judith Mueller Oumar Sanou Haoua Tall Phillip Jaillard Berthe-Marie Njanpop-Lafourcade Jean Macq Annie Robert Jean Bosco Ouedraogo 

作者机构：Centre MurazBobo-DioulassoBurkina Faso Pole Epidémiologie et BiostatistiqueInstitut de Recherche Experimentale et Clinique(IREC)Faculte de Sante Publique(FSP)Universite Catholique de Louvain(UCL)LouvainBelgique Agence de Médecine Préventive(AMP)ParisFrance Institut de Recherche Sante et Societe(IRSS)Faculte de Sante Publique(FSP)Universite Catholique de Louvain(UCL)LouvainBelgique 

出 版 物：《Open Journal of Internal Medicine》 (内科学期刊（英文）)

年 卷 期：2012年第2卷第2期

页      面：41-49页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the Fonds de Solidarite Prioritaire(FSP)of the Ministry for Foreign Affairs of France(MAE)for the financial support to this program 

主　　题：Epidemiologic Surveillance Pneumococcal NmX Emergence Meningitis Burkina Faso 

摘      要：Background: Centre MURAZ of Bobo-Dioulasso (Burkina Faso) organized in 2009 and 2010 a system of Cerobro-Spinal Fluid (CSF) collection in eight pilot Districts as an initial step for the future Ministry of Health’s led strategy of individual surveillance in a context of meningococcal conjugate A vaccine introduction. Methods: CSF samples were analyzed with Polymerase Chain Reaction (PCR). This allowed for meningitis etiologies dynamics studies in the pilot Districts. Results: Because of geographical difficulties and lack of means, less than 40% of suspected cases had their CSF analyzed at PCR reference laboratory. In 2009, among confirmed cases at reference laboratory, Sp (Streptococcus pneumonia), NmA (Neisseria meningitis A) and Hib (Hemophilus influenzae b) were responsible respectively for 90%, 6.6% and 4.4% of cases. In 2010, serogroup distribution among confirmed cases was: Sp 62.7%, NmX 32.2% and NmA 5.1%. Sp which was continuously present in Burkina Faso takes more significant proportions, just as serogroup X which until there was sporadically encountered. The attack rates of NmX were tree to twelve times higher than for NmA in the two Districts where NmX has been notified. Conclusion: As a consequence of such results, efforts must be maintained in epidemiologic surveillance field and in reinforcement of laboratory capacities. Fast care should be guaranteed to patients with adequate antibiotics according to country national guideline and chemoprophylaxis measures should be undertaken among contacts of patients to prevent secondary cases. A plea must be made on one hand for pneumococcal vaccine introduction in Burkina Faso and on other hand towards manufacturers for taking into account serogroup X into meningococcal polyvalent vaccine composition. With this polyvalent vaccine including serougruop X, we suggested to conduct periodically mass campaign vaccination of people before the beginning of meningitis epidemiological season.