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Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice

Asian Journal of Andrology 2021年第3期23卷 281-287页

作者： fathiah abdullah Mohamed Noor Khan Nor-Ashikin Renu Agarwal Yuhaniza Shafinie Kamsani Mastura Abd Malek Nor Salmah Bakar Aqila-Akmal Mohammad Kamal Mimi-Sophia Sarbandi Nor-Shahida Abdul Rahman Nurul Huda Musa Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia Faculty of Applied Sciences Universiti Teknologi MARAPerak BranchTapah CampusTapah Road 35400PerakMalaysia Faculty of Medicine Universiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam 42300SelangorMalaysia Centre of Foundation Studies Universiti Teknologi MARASelangor BranchDengkil CampusDengkil 43800SelangorMalaysia

Diabetes mellitus(DM)is known to cause reproductive *** men,it has been linked to altered sperm quality and testicular *** stress(OS)plays a pivotal role in the development of DM ***(GSH)is a part of a nonenzymatic antioxidant defense system that protects lipid,protein,and nucleic acids from oxidative ***,the protective effects of exogenous GSH on the male reproductive system have not been comprehensively *** study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac *** at the doses of 15 mg kg^(-1)and 30 mg kg^(-1)was given intraperitoneally to mice weekly for 6 consecutive *** mice were then weighed,euthanized,and had their reproductive organs *** diabetic(D Group)showed significant impairment of sperm quality and testicular histology compared with the nondiabetic(ND Group).Diameters of the seminiferous lumen in diabetic mice treated with 15 mg kg^(-1) GSH(DGSH15)were decreased compared with the D *** motility was also significantly increased in the DGSH15 *** in testicular morphology might be an early indication of the protective roles played by the exogenous GSH in protecting sperm quality from effects of untreated type 1 DM or diabetic *** investigation using different doses and different routes of GSH is necessary to confirm this suggestion.

关键词： diabetes mellitus glutathione mice sperm quality testis histology

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Vitamin E supplementation may negatively affect preimplantation development and mitochondrial ultrastructure of vitrified murine embryos

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Asian pacific Journal of Reproduction 2021年第3期10卷 137-144页

作者： Mimi-Sophia Sarbandi Nor-Ashikin Mohamed Noor Khan Nor-Shahida Abdul Rahman Zolkapli Eshak fathiah abdullah Mastura Abd Malek Aqila-Akmal Mohammad Kamal Maternofetal and Embryo Research Group Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia Faculty of Applied Sciences Universiti Teknologi MARAPerak BranchTapah Campus35400 Tapah RoadPerakMalaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam42300 Kuala SelangorSelangorMalaysia Faculty of Pharmacy Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam42300 Kuala SelangorSelangorMalaysia

Objective:To observe the effects of vitamin E on post-vitrification preimplantation development,gross morphology as well as mitochondrial distribution and ***:Twenty-four female C57BL/6NTac mice,aged 12-16 weeks,were randomly divided into four *** A did not receive any treatment and served as the control *** B was treated with corn oil stripped of tocopherols and served as the vehicle *** C was treated with 60 mg/kg body weight of tocotrienol-rich-fraction with corn oil stripped of *** D was treated with 60 mg/kg body weight of alpha-tocopherol with corn oil stripped of *** treatments were administered orally for 7 consecutive *** superovulation and mating with fertile males,2-cell stage embryos were harvested for *** vitrification development in vitro,gross morphology and ultrastructure were compared between ***:The number of 2 and 8-cell embryo,and blastocysts in the treatment and control groups were not significantly different(P>0.05).Following vitrification,all 2-cell embryos had equal-sized blastomeres and intact zona *** aggregation toward the perinuclear region was seen in all of the treatment *** groups C and D had vacuolated mitochondria,which was reflected in the trend of preimplantation development ***:Vitamin E supplementation of 60 mg/kg body weight does not improve the viability of healthy embryos according to this *** a result,the most effective dose of vitamin E supplementation may be determined by the initial quality of the embryos.

关键词： Mitochondria Preimplantation Embryo Vitrification Vitamin E Alpha-tocopherol Tocotrienol-richfraction,Transmission electron microscopy

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Anti-inflammatory and anti-cancer potential of pterostilbene:A review

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Asian Pacific Journal of Tropical Biomedicine 2023年第12期13卷 497-506页

作者： Omchit Surien Siti fathiah Masre Dayang Fredalina Basri Ahmad Rohi Ghazali Centre for Toxicology and Health Risk Studies(CORE) Faculty of Health SciencesUniversiti Kebangsaan Malaysia50300Kuala LumpurMalaysia Centre of Diagnostic Therapeutic&Investigative Studies(CODTIS)Faculty of Health SciencesUniversiti Kebangsaan Malaysia50300Kuala LumpurMalaysia

Pterostilbene is a natural compound that can be found in various food plants such as blueberries,grapes,and *** has also been reported to be extracted from Pterocarpus indicus,a tree species native to India and Southeast *** exhibits various pharmacological activities such as antioxidants,anti-proliferation,anti-microbial,and anti-inflammatory activities with favorable pharmacokinetic properties,such as high oral bioavailability and longer *** anti-inflammatory effect of pterostilbene has been reported to contribute to its therapeutic effects in many chronic inflammatory ***,pterostilbene has anti-cancer activity on various types of cancers due to its ability to induce cell cycle arrest and ***,in this review,we discuss the anti-inflammatory and anti-cancer activities of pterostilbene in preclinical studies.

关键词： Pterostilbene Anti-cancer NF-κB Anti-inflammation Natural product Pterocarpus indicus

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Levels of CMV-reactive antibodies correlate with the induction of CD28^null T cells and systemic inflammation in chronic obstructive pulmonary disease （COPD）

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Cellular & Molecular Immunology 2016年第4期13卷 551-553页

作者： Dino BA Tan fathiah S Amran Teck-Hui Teo Patricia Price Yuben P Moodley Centre for Asthma Allergy and Respiratory Research School of Medicine& Pharmacology University of Western Australia Nedlands WA Australia Stem Cell Unit Lung Institute of WA University of Western Australia Nedlands WA Australia School of Pathology and Laboratory Medicine University of Western Australia Nedlands WA Australia School of Biomedical Science Curtin University Bentley WA Australia Department of Respiratory and Sleep Medicine Royal Perth Hospital Perth WA Australia

Chronic obstructive pulmonary disease （COPD） is characterized by chronic irreversible inflammation and progressive decline in lung function. While smoking and other environmental agents （e.g., air pollutants） are common causes of COPD, the major challenges in managing this condition are the persistent inflammation and functional deterioration which are not reversed by removal of precipitating agents （e.g., smoking cessation） or treatment with anti-inflammatory agents.

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试论先知时期“迁徙”的影响 ——从发展人文思想，丰富阿拉伯文化，加强文化间交流的角度

试论先知时期“迁徙”的影响 ——从发展人文思想，丰富阿拉伯文...

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作者： BARGAWI，fathiah，ABDULRAHMAN，O 上海外国语大学

学位级别：硕士

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Numerical Solutions of the Regularized Long-Wave (RLW) Equation Using New Modification of Laplace-Decomposition Method

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Advances in Pure Mathematics 2013年第1期3卷 159-163页

作者： Nawal A. Al-Zaid Huda O. Bakodah fathiah A. Hendi Department of Mathematics Science Faculty for Girls King Abdulaziz University Jeddah KSA

In this paper the new modification of Laplace Adomian decomposition method (ADM) to obtain numerical solution of the regularized long-wave (RLW) equation is presented. The performance of the method is illustrated by s... 详细信息

关键词： Adomian Decomposition Method Regularized Long-Wave (RLW) Laplace Transform

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