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QT Dispersion and QTc Interval in Patients with Adult Sickle Cell Disease: Electrocardiographic (EKG) and Echocardiographic Evaluation

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International Journal of Clinical Medicine 2014年第10期5卷 550-557页

作者： Taysir S. Garadah Adla B. Hassan Mohamed Al Alwai Ahmed A. Jaradat fathia qurishi Abdulla Alajmi Colleges of Medicine and Medical Sciences Arabian Gulf University Manama Kingdom of Bahrain Salmaniya Medical Complex Ministry of Health Manama Kingdom of Bahrain Salmaniya Medical Complex Ministry of Health Manama Kingdom of Bahrain Colleges of Medicine and Medical Sciences Arabian Gulf University Manama Kingdom of Bahrain

Background: QT dispersion (QTd) varies according to heterogeneity of recovery time in the myocardium, and the impact of iron overload on the QTd in adult patients with Sickle Cell Disease (SCD) is not clear. Aim: This cross-sectional study was designed to evaluate corrected QTc interval and QTd on 12 leads ECG in patients with SCD, and assess the LV systolic and diastolic function using Pulsed Doppler Echocardiogram. Method: All patients were evaluated clinically with pulse Doppler echocardiography. Twelve leads ECG were taken to measure QTd and QTc. Blood samples withdrawn to assess the blood level of ferritin and hemoglobin. Pearson correlation coefficient was used to measure the linear relationship between serum ferritin and QTd. Results: The study included patients with SCD (n = 70, age 15.7 ± 8.9 years), compared with age-matched healthy control group (n = 70, age 15.9 ± 8.9 years). In patients with SCD compared with healthy control group the QTc (msec) 416 ± 23.21 ms vs. 401 ± 24.12 (p = 0.75), and the QTd were slightly longer in SCD compared with the control of 43 ± 22.1 vs. 38 ± 20.16 msec, (p = 0.071) with no significant difference. M mode echo showed that SCD patients compared with control had higher LVMI gm/M2 of 105 ± 10.3 vs. 83 ± 7.1, P = 0.001, larger LV end diastolic dimension (cm) of 5.5 ± 0.32 vs. 4.72 ± 0.35, p = 0.03, RV diameter (cm) of 2.8 ± 0.42 vs. 2.4 ± 0.31, (p = 0.041) and RV wall thickness (mm) of 0.31 ± 0.06 vs. 0.28 ± 0.03, (p = 0.024). Pulsed Doppler showed high LV transmitral E wave velocity of 85.23 ± 1.92 vs. 62.43 ± 1.67 m/s (p = 0.001), A wave (msec) 46.26 ± 4.7 vs. 56.24 ± 3.2 m/s, p = 0.032, with E/A ratio of 1.86 ± 0.01 vs. 1.10 ± 0.03, (p = 0.024) and DT of E wave (msec) of 156.43 ± 23.5 vs. 189.87 ± 19.5, (p = 0.031). Left ventricle ejection fraction percentage was similar between both groups, but SCD had significantly higher right ventricle tricuspid annular plane systolic excursion TAPSE (cm) of 1.23 ± 0.21 vs. 1.11 ± 0.23

关键词： Sickle Cell Anemia Tissue Doppler QT Dispersion Bahrain

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Structural, Thermal and Optical Studies of Oxypeucedanin Hydrate Monoacetate Micro-Crystals from <i>Prangos pabularia</i>

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American Journal of Analytical Chemistry 2012年第3期3卷 204-209页

作者： Javid Ahmad Banday Feroz Ahmad Mir Saleem Farooq Mushtaq Ahmad qurishi Surinder Koul Tej Kishen Razdan Bio-Organic Division Indian Institute of Integrative Medicine (CSIR) Jammu J&K-India Department of Chemistry University of Jammu Jammu J&K-India Department of Chemistry University of Kashmir Srinagar J&K-India Department of Material Science and Condense Matter Physics S.N. Bose National Centre for Basic Sciences Kolkata India

Oxypeucedanin hydrate monoacetate (Mol. Formula = C18H18O7) micro-crystals were obtained by acetylation of oxy-peucedanin hydrate, a furanocoumarin, isolated from the roots of Prangos pabularia. The composition related structural, thermal and optical properties were investigated. All the crystals were found to have triclinic structure. From thermal studies of these crystals, stability, melting point and other relevant informations were obtained. Their blue emission, less absorption in entire visible range and band gap predicts these crystals as good candidate for modern optoelectronic devices.

关键词： Prangos pabularia Oxypeucedanin Hydrate Monoaceate Furanocoumarin Triclinic Non-Linear Optical

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