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A hepatocellular carcinoma–bone metastasis-on-a-chip model for studying thymoquinone-loaded anticancer nanoparticles

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Bio-Design and Manufacturing 2020年第3期3卷 189-202页

作者： fatemeh sharifi Ozlem Yesil-Celiktas Aslihan Kazan Sushila Maharjan Saghi Saghazadeh Keikhosrow Firoozbakhsh Bahar Firoozabadi Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMAUSA School of Mechanical Engineering Sharif University of TechnologyTehranIran Department of Bioengineering Faculty of EngineeringEge UniversityBernovaIzmirTurkey

We report the development of a metastasis-on-a-chip platform to model and track hepatocellular carcinoma(HCC)-bone metastasis and to analyze the inhibitory effect of an herb-based compound,thymoquinone(TQ),in hindering the migration of liver cancer cells into the bone *** bioreactor consisted of two chambers,one accommodating encapsulated HepG2 cells and one bone-mimetic niche containing hydroxyapatite(HAp).Above these chambers,amicroporous membrane was placed to resemble the vascular barrier,where medium was circulated over the *** was observed that the liver cancer cells proliferated inside the tumor microtissue and disseminated from the HCC chamber to the circulatory flow and eventually entered the bone *** number of metastatic HepG2 cells to the bone compartment was remarkably higher in the presence of HAp in the *** was then used as ametastasis-controlling agent in both free form and encapsulated nanoparticles,to analyze its suppressing effect on HCC *** indicated that the nanoparticle-encapsulated TQ provided a longer period of inhibitory *** summary,HCC-bone metastasis-on-a-chip platform was demonstrated to model certain key aspects of the cancer metastasis process,hence corroborating the potential of enabling investigations on metastasis-associated biology as well as improved anti-metastatic drug screening.

关键词： Tumor-on-a-chip Organ-on-a-chip Hydroxyapatite Hepatocellular carcinoma Thymoquinone

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Platform Evolution in an Oligo-Miocene Back-arc Basin:An Example from the Central Iran Basin

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 185-206页

作者： Masoud sharifi-YAZDI Amirhossein ENAYATI Jamal SALEHI AGHDAM Mohammad BAHREHVAR Seyed Mustafa REZAEI Department of Geology Faculty of Earth SciencesGeography and AstronomyUniversity of Vienna1090 Vienna.Austria Geology and Geophysics Department Tehran Energy Consultants(TEC Co.)TehranIran School of Geology College of ScienceUniversity of TehranTehranIran Department of Geology Tarbiat Modares UniversityTehranIran

The Qom Formation is the most important hydrocarbon reservoir target in Central *** Qom platform developed in a back-arc basin during the Oligo-Miocene due to the closing of the Tethyan *** formation consists of a variety of carbonate and non-carbonate facies deposited on a platform ranging from supratidal to basin.A combination of tectonic and eustatic events led to some lateral and vertical facies variations in the study *** third-order depositional sequences and related surfaces were identified regarding vertical facies changes in the studied sections of this Oligo-Miocene *** to all results and data,this succession was initially deposited during the Chattian upon a distally steepened ramp of siliciclastic-carbonate composition,including the Bouma ***,from the late Chattian to the Aquitanian,the platform changed into a homoclinal carbonate ramp with a gentle *** respect to tectonic activity,this phase was a calm period during the deposition of the Qom ***,a drowned carbonate platform and a rimmed shelf emerged during the Burdigalian,terminated by the continental deposits of the Upper Red *** all geological characteristics,three main tectono-eustatic evolutionary phases have been recognized in the Qom back-arcbasin.

关键词： carbonate ramp depositional facies submarine fan eustasy basement faults back-arc basin

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Global systematic review and meta-analysis of knowledge, attitudes, and practices towards dengue fever among the general population

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Asian Pacific Journal of Tropical Medicine 2024年第5期17卷 191-207,I0001-I0003页

作者： Abdolreza Sotoodeh Jahromi Mohammad Jokar Arman Abdous Nader sharifi Tahere Abbasi Vahid Rahmanian Zoonoses Research Center Jahrom University of Medical SciencesJahromIran Faculty of Veterinary Medicine Karaj BranchIslamic Azad UniversityKarajIran Department of Public Health Khomein University of Medical SciencesKhomeinIran Research Center for Social Determinants of Health Jahrom University of Medical SciencesJahromIran Department of Public Health Torbat Jam Faculty of Medical SciencesTorbat JamIran

Objective:To determine the global level of knowledge,attitudes,and practices towards dengue fever among the general ***:To complete this systematic review and meta-analysis,a thorough search for pertinent English-language literature was undertaken during the study's extension until October *** search used Google Scholar,Scopus,PubMed/MEDLINE,Science Direct,Web of Science,EMBASE,Springer,and ProQuest.A quality assessment checklist developed using a modified Newcastle-Ottawa Scale for the cross-sectional study was used to evaluate the risk of bias in the included *** variance and Cochran Q statistics were employed in the STATA software version 14 to assess study *** there was heterogeneity,the Dersimonian and Liard random-effects models were ***:59 Studies totaling 87353 participants were included in this *** investigations included 86278 participants in 55 studies on knowledge,20196 in 33 studies on attitudes,and 74881 in 29 studies on *** pooled estimates for sufficient knowledge,positive attitudes,and dengue fever preventive behaviors among the general population were determined as 40.1%(95%CI 33.8%-46.5%),46.8%(95%CI 35.8%-58.9%),and 38.3%(95%CI 28.4%-48.2%),*** exhibits the highest knowledge level at 63.5%,and Africa shows the lowest at 20.3%.Positive attitudes are most prevalent in the Eastern Mediterranean(54.1%)and Southeast Asia(53.6%),contrasting sharply with the Americas,where attitudes are notably lower at 9.05%.Regarding preventive behaviors,the Americas demonstrate a prevalence of 12.1%,Southeast Asia at 28.1%,Western Pacific at 49.6%,Eastern Mediterranean at 44.8%,and Africa at 47.4%.Conclusions:Regional disparities about the knowledge,attitude and preventive bahaviors are evident with Europe exhibiting the highest knowledge level while Africa has the *** findings emphasize the importance of targeted public health interventions tailored to regional

关键词： Break-bone fever Knowledge Attitudes Practices

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Enhancing Hyper-Spectral Image Classification with Reinforcement Learning and Advanced Multi-Objective Binary Grey Wolf Optimization

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Computers, Materials & Continua 2024年第6期79卷 3469-3493页

作者： Mehrdad Shoeibi Mohammad Mehdi sharifi Nevisi Reza Salehi Diego Martín Zahra Halimi Sahba Baniasadi TheWPI Business School Worcester Polytechnic InstituteWorcesterMassachusetts01609-2280USA Department of Industrial Engineering Iran University of Science and TechnologyNarmakTehran16846-13114Iran ETSI de Telecomunicación Universidad Politécnica de MadridAv.Complutense 30Madrid28040Spain Department of Civil and Environmental Engineering University of MarylandCollege ParkMaryland20742USA Department of Industrial Engineering College of EngineeringUniversity of HoustonHoustonTexas77204USA

Hyperspectral(HS)image classification plays a crucial role in numerous areas including remote sensing(RS),agriculture,and the monitoring of the *** band selection in HS images is crucial for improving the efficiency and accuracy of image *** process involves selecting the most informative spectral bands,which leads to a reduction in data *** on these key bands also enhances the accuracy of classification algorithms,as redundant or irrelevant bands,which can introduce noise and lower model performance,are *** this paper,we propose an approach for HS image classification using deep Q learning(DQL)and a novel multi-objective binary grey wolf optimizer(MOBGWO).We investigate the MOBGWO for optimal band selection to further enhance the accuracy of HS image *** the suggested MOBGWO,a new sigmoid function is introduced as a transfer function to modify the wolves’*** primary objective of this classification is to reduce the number of bands while maximizing classification *** evaluate the effectiveness of our approach,we conducted experiments on publicly available HS image datasets,including Pavia University,Washington Mall,and Indian Pines *** compared the performance of our proposed method with several state-of-the-art deep learning(DL)and machine learning(ML)algorithms,including long short-term memory(LSTM),deep neural network(DNN),recurrent neural network(RNN),support vector machine(SVM),and random forest(RF).Our experimental results demonstrate that the Hybrid MOBGWO-DQL significantly improves classification accuracy compared to traditional optimization and DL ***-DQL shows greater accuracy in classifying most categories in both datasets *** the Indian Pine dataset,the MOBGWO-DQL architecture achieved a kappa coefficient(KC)of 97.68%and an overall accuracy(OA)of 94.32%.This was accompanied by the lowest root mean square error(RMSE)of 0.94,indicating very precise

关键词： Hyperspectral image classification reinforcement learning multi-objective binary grey wolf optimizer band selection

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Secrecy Outage Probability Minimization in Wireless-Powered Communications Using an Improved Biogeography-Based Optimization-Inspired Recurrent Neural Network

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Computers, Materials & Continua 2024年第3期78卷 3971-3991页

作者： Mohammad Mehdi sharifi Nevisi Elnaz Bashir Diego Martín Seyedkian Rezvanjou Farzaneh Shoushtari Ehsan Ghafourian Department of Industrial Engineering Iran University of Science and TechnologyNarmakTehran16846-13114Iran Department of Computer Science Iowa State UniversityAmesIowaIA50011USA ETSI de Telecomunicación Universidad Politécnica de MadridMadrid28040Spain Department of Engineering California State University East BayHaywardCalifornia94542USA Department of Industrial Engineering Bu-Ali Sina UniversityHamedan65178-38695Iran

This paper focuses on wireless-powered communication systems,which are increasingly relevant in the Internet of Things(IoT)due to their ability to extend the operational lifetime of devices with limited *** main contribution of the paper is a novel approach to minimize the secrecy outage probability(SOP)in these *** SOP is crucial for maintaining the confidentiality and integrity of data,especially in situations where the transmission of sensitive data is *** proposed method harnesses the power of an improved biogeography-based optimization(IBBO)to effectively train a recurrent neural network(RNN).The proposed IBBO introduces an innovative migration *** core advantage of IBBO lies in its adeptness at maintaining equilibrium between exploration and *** is accomplished by integrating tactics such as advancing towards a random habitat,adopting the crossover operator from genetic algorithms(GA),and utilizing the global best(Gbest)operator from particle swarm optimization(PSO)into the IBBO *** IBBO demonstrates its efficacy by enabling the RNN to optimize the system parameters,resulting in significant outage probability *** comprehensive simulations,we showcase the superiority of the IBBO-RNN over existing approaches,highlighting its capability to achieve remarkable gains in SOP *** paper compares nine methods for predicting outage probability in wireless-powered *** IBBO-RNN achieved the highest accuracy rate of 98.92%,showing a significant performance *** contrast,the standard RNN recorded lower accuracy rates of 91.27%.The IBBO-RNN maintains lower SOP values across the entire signal-to-noise ratio(SNR)spectrum tested,suggesting that the method is highly effective at optimizing system parameters for improved secrecy even at lower SNRs.

关键词： Wireless-powered communications secrecy outage probability improved biogeography-based optimization recurrent neural network

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Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Eman Al-Balushi Amina Al Marzouqi Shima Tavoosi Amir Hossein Baghsheikhi Arash Sadri Leyla sharifi Aliabadi Mohammad-Mahdi Salarabedi Syed Azizur Rahman Nabeel Al-Yateem Alireza Mosavi Jarrahi Aram Halimi Mohammad Ahmadvand Wael M Abdel-Rahman College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Department of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Medical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third most frequent and the second most fatal *** search for more effective drugs to treat this disease is ongoing.A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein family,have long been implicated in various *** have been numerous studies on the role of USPs in CRC;however,a comprehensive view of this role is *** To provide a systematic review of the studies investigating the roles and functions of USPs in *** We systematically queried the MEDLINE(via PubMed),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes implicated in CRC:Regulation of the cell cycle,apoptosis,cancer stemness,epithelial–mesenchymal transition,metastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biomarkers in *** dysregulation of USPs in CRC contributes to drug resistance through multiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcoming resistance to current treatment regimens in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein family Drug target discovery Biomarker discovery

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Airborne GNSS-Receiver Threat Detection in No-Fading Environments

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Journal of Beijing Institute of Technology 2022年第6期31卷 613-620页

作者： Omid sharifi-Tehrani Department of Electrical and Communication Engineering Imam Hussein Comprehensive UniversityTehranIran.

Jamming and spoofing detection of global navigation satellite systems(GNSS)is of great *** and military aerial platforms use GNSS as main navigation systems and these systems are main target of threat *** this paper a simple method based on different empirical probability density functions of successive received signal powers and goodness of fit tech-nique is proposed for airborne platforms such as unmanned aerial vehicle(UAV),in no fading *** two different paths between UAV-satellite and UAV-threat,experience different empirical probability density functions which can be used to distinguish between authentic and threat *** results including detection and false alarm probabilities show good perfor-mance of proposed method as well as low computational burden.

关键词： detection global navigation satellite systems(GNSS) jamming spoofing unmanned aerial vehicle

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A review of fluid displacement mechanisms in surfactant-based chemical enhanced oil recovery processes:Analyses of key influencing factors

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Petroleum Science 2022年第3期19卷 1211-1235页

作者： Ahmed Bashir Amin sharifi Haddad Roozbeh Rafati School of Engineering Kings CollegeUniversity of AberdeenAB243UEUK

Surfactant-based oil recovery processes are employed to lower the interfacial tension in immiscible displacement processes,change the wettability of rock to a more water-wet system and emulsify the oil to displace it in subsurface porous ***,these phenomena can reduce the capillary pressure and enhance spontaneous *** key factors affecting such immiscible displacement process are temperature,salinity and p H of the fluids,surfactant concentration and ***,before any surfactant flooding process is applied,extensive studies of fluid-fluid and rock-fluid interactions are *** use of other chemicals along with surfactants in chemical enhanced oil recovery(c EOR)processes have been widely considered to exploit the synergy of individual chemicals and complement the weakness arises from each of them during immiscible displacement of fluids in porous ***,such combinations of chemicals lead to alkaline-surfactant(AS),surfactantpolymer(SP),alkaline-surfactant-polymer(ASP),and nanoparticle-surfactant(NS)flooding processes,among *** this review study,we categorised the role and displacement mechanisms of surfactants and discussed the key factors to be considered for analysing the fluid displacement in porous media.

关键词： Alkaline surfactant(AS)flooding Alkaline-surfactant-polymer(ASP)flooding Enhanced oil recovery(EOR) Interfacial tension(IFT) Nanoparticle-surfactant(NS)flooding Surfactant adsorption Surfactant-polymer(SP)flooding Wettability alteration

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Street network patterns for mitigating urban heat islands in arid climates

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International Journal of Digital Earth 2023年第1期16卷 3145-3161页

作者： Kimia Chenary Ali Soltani Ayyoob sharifi Department of Architecture and Urban Planning Bojnourd UniversityBojnourdIran Injury Studies FHMRIBedford ParkAustralia UniSA Business University of South AustraliaAdelaideAustralia Department of Urban Planning Shiraz UniversityShirazIran The IDEC Institute and Network for Education and Research on Peace and Sustainability(NERPS) Hiroshima UniversityHigashihiroshimaJapan

This study explores the impact of street pattern measurements on urban heat islands(UHI)in the arid climate of Mashhad,*** Landsat-8 top-of-the-atmosphere(TOA)brightness images from 2013 to 2021,average values of normalized difference vegetation index(NDvI)and land surface temperature(LST)were *** pattern measurements,including closeness-centrality,straightness,and street orientation,were employed to analyse the patterns in each *** results indicated that districts with higher straightness and lower closeness-centrality exhibit,cooler surface *** correlations were observed between LST and NDVl,straightness,and local *** research highlighted the importance of considering street network measurements in long-term urban planning and design to mitigate the UHI effect in arid regions.A moderate grid street pattern with a reasonable distribution of green spaces throughout the region is suggested to reduce surface temperatures *** pattern indexes,such as straightness and local closeness-centrality,are identified as significant factors in urban design to mitigate *** findings have implications for urban planners,who can use this information to create street network patterns with lower UHI effects by reducing local closeness-centrality and increasing straightness.

关键词： Urban heat island Urban form Street network pattern Green space distribution

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Evaluation of protective effect of IL-22 and IL-12 on cutaneous leishmaniasis in BALB/c mice

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Asian Pacific Journal of Tropical Medicine 2014年第12期7卷 940-945页

作者： Hajar Ziaei Hezarjaribi fatemeh Ghaffarifar Abdolhossein Dalimi Zohreh sharifi Department of Parasitology and Mycology Faculty of MedicineMazandaran University of Medical SciencesSariIran Parasitology and Entomology Department Faculty of Medical SciencesTarbiat Modares UniversityP.O.Box:14115-331Tehran I.R.Iran Blood Transfusion Research Center High Institute for Research and Education in Transfusion MedicineTehranIran

Objective:To investigate the protective effect of IL-22 and IL-12 on cutaneous leishmaniasisin BALB/c ***:The protective effect of IL-22 and IL-I2 on cutaneous leishmanias in BALB/c mice was evaluated by measurement of ***-γ.total IgG,IgG1 and IgG2 a after challenge with Leishamania *** evaluations were performed by measurement of lesion diameter,and survival rate of the ***:In week 27 post infection,the mortality rates for control groups were 100%.While the survival rates for the ***-12 + *** IL-22(5 ng/g) groups were 100%.The size of lesions decreased in the presence IL-22(5 ng/g) of mice weight,which was statistically significant in comparison with other groups(P<0.05).Mean of total IgG,IgG1 and IgG2 a for IL-22(5 ng/g) group was more than other *** IL-22 group(5 ng/g).INF—γ production was significantly higher than other groups and IL-4 was significantly lower than other ***:The results obtained indicate the effectiveness of IL-22 and its effect on IL-12 in protection of cutaneous leishmaniasis.

关键词： Leishmania major IL-22 IL-12 Protection Mice

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