Evaluation of protective effect of IL-22 and IL-12 on cutaneous leishmaniasis in BALB/c mice

作     者：Hajar Ziaei Hezarjaribi Fatemeh Ghaffarifar Abdolhossein Dalimi Zohreh Sharifi 

作者机构：Department of Parasitology and MycologyFaculty of MedicineMazandaran University of Medical SciencesSariIran Parasitology and Entomology DepartmentFaculty of Medical SciencesTarbiat Modares UniversityP.O.Box:14115-331Tehran I.R.Iran Blood Transfusion Research CenterHigh Institute for Research and Education in Transfusion MedicineTehranIran 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2014年第7卷第12期

页      面：940-945页

核心收录：

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

基　　金：supported by Tarbiat Modares University 

主　　题：Leishmania major IL-22 IL-12 Protection Mice 

摘      要：Objective:To investigate the protective effect of IL-22 and IL-12 on cutaneous leishmaniasisin BALB/c ***:The protective effect of IL-22 and IL-I2 on cutaneous leishmanias in BALB/c mice was evaluated by measurement of ***-γ.total IgG,IgG1 and IgG2 a after challenge with Leishamania *** evaluations were performed by measurement of lesion diameter,and survival rate of the ***:In week 27 post infection,the mortality rates for control groups were 100%.While the survival rates for the ***-12 + *** IL-22(5 ng/g) groups were 100%.The size of lesions decreased in the presence IL-22(5 ng/g) of mice weight,which was statistically significant in comparison with other groups(P0.05).Mean of total IgG,IgG1 and IgG2 a for IL-22(5 ng/g) group was more than other *** IL-22 group(5 ng/g).INF—γ production was significantly higher than other groups and IL-4 was significantly lower than other ***:The results obtained indicate the effectiveness of IL-22 and its effect on IL-12 in protection of cutaneous leishmaniasis.