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Convalescent plasma therapy in a pregnant COVID-19 patient with a dramatic clinical and imaging response: A case report

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World Journal of Radiology 2020年第7期12卷 137-141页

作者： Ramezan Jafari Nematollah Jonaidi-Jafari fatemeh dehghanpoor Amin Saburi Radiology Department Faculty of Medicine and Chemical Injuries Research CenterBaqiyatallah University of Medical SciencesTehran 18151777Iran Health Research Center and Faculty of Medicine Baqiyatallah University of Medical SciencesTehran 18151777Iran Radiology Department Faculty of MedicineBaqiyatallah University of Medical SciencesTehran 18151777Iran Chemical Injuries Research Center and Faculty of Medicine Baqiyatallah University of Medical SciencesTehran 18151777Iran

BACKGROUND Coronavirus disease 2019(COVID-19)is a novel very contagious infection which was designated a pandemic in all countries of the world in April *** presentation varies from mild to severe infection,but the majority of infected patients have mild *** therapeutic choices have been suggested to treat the infection,but none are fully *** SUMMARY Herein we present a 26-year-old woman with a twin pregnancy at 36 wk and one day gestation with confirmed COVID-19 who responded dramatically to convalescent plasma therapy(CPT)and *** Although this case report shows the efficacy of CPT in addition to usual medications used for COVID-19,there are many questions that need to be answered regarding dosage,para-clinical efficacy,side effects and combination therapy.

关键词： Case report Convalescent plasma therapy Pregnancy COVID-19 Favipiravir Radiologic findings

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“Pulmonary target sign” as a diagnostic feature in chest computed tomography of COVID-19

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World Journal of Radiology 2021年第7期13卷 233-242页

作者： Ramezan Jafari Nematollah Jonaidi-Jafari Houshyar Maghsoudi fatemeh dehghanpoor U Joseph Schoepf Kyle A Ulversoy Amin Saburi Department of Radiology Faculty of MedicineBaqiyatallah University of Medical SciencesTehran 11151877Iran Health Research Center Baqiyatallah University of Medical SciencesTehran 11151877Iran Department of Radiology and Radiological Science Medical University of South CarolinaCharlestonSC 29425United States Faculty of Medicine Augusta University/University of Georgia Medical PartnershipAthensGA 30606United States Chemical Injuries Research Center Systems Biology and Poisonings InstituteBaqiyatallah University of Medical SciencesTehran 11151877Iran

BACKGROUND In chest computed tomography(CT)scan,bilateral peripheral multifocal groundglass opacities,linear opacities,reversed halo sign,and crazy-paving pattern are suggestive for coronavirus disease 2019(COVID-19)in clinically suspicious cases,but they are not specific for the diagnosis,as other viral pneumonias,like influenza and some viral pneumonia may show similar imaging *** To find a specific imaging feature of the disease would be a welcome guide in diagnosis and management of challenging *** Chest CT imaging findings of 650 patients admitted to a university Hospital in Tehran,Iran between January 2020 and July 2020 with confirmed COVID-19 infection by RT-PCR were reviewed by two expert *** addition to common non-specific imaging findings of COVID-19 pneumonia,radiologic characteristics of“pulmonary target sign”(PTS)were *** is defined as a circular appearance of non-involved pulmonary parenchyma,which encompass a central hyperdense dot surrounded by ground-glass or alveolar *** PTS were presented in 32 cases(frequency 4.9%).The location of the lesions in 31 of the 32 cases(96.8%)was peripheral,while 4 of the 31 cases had lesions both peripherally and *** 25 cases,the lesions were located near the pleural surface and considered pleural based and half of the lesions(at least one lesion)were in the lower segments and lobes of the lungs.22 cases had multiple lesions with a>68%*** than 87%of cases had an adjacent bronchovascular ***-glass opacities were detectable adjacent or close to the lesions in 30 cases(93%)and only in 7 cases(21%)was consolidation adjacent to the *** Although it is not frequent in COVID-19,familiarity with this feature may help radiologists and physicians distinguish the disease from other viral and noninfectious pneumonias in challenging cases.

关键词： Chest computed tomography Diagnosis Viral pneumonia COVID-19 Pulmonary target sign Case report

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