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Development of a Risk Model for Abdominal Wound Dehiscence

Surgical Science 2016年第10期7卷 466-474页

作者： Mujahid Ahmad Mir farzana manzoor Balvinder Singh Imtiyaz Ahmad Sofi Abu Zaved Rameez Sheikh Imran Farooq Department of General Surgery Government Medical College Srinagar India

Objectives: To identify independent risk factors for abdominal wound dehiscence and develop a risk model to recognize high risk patients. Methods: The samples studied were patients who underwent midline laparotomy in the department of surgery, SMHS Hospital Srinagar from March 2009 to April 2015. For each case of abdominal wound dehiscence, three controls were selected from a group of patients who had undergone open abdominal surgery as close as possible in time. Preoperative, perioperative, and postoperative variables and in-hospital mortality were studied for all patients. Cases were compared with controls using the chi-square test or the Mann-Whitney U-test for categorical or continuous data, respectively. Subsequently, multivariate stepwise logistic regression with backwards elimination test used to identify main independent risk factors of abdominal wound dehiscence. The resulting regression coefficients for the major risk factors were used as weights for these variables to calculate a risk score for abdominal wound dehiscence. Results: 140 cases of abdominal wound dehiscence were reported and compared with 420 selected controls. All variables that were significant in univariate analyses were entered in a multivariate stepwise logistic regression to determine which variables were significant independent risk factors. Major independent risk factors were male gender, chronic pulmonary disease, corticosteroid use, smoking, obesity, anemia, jaundice, ascites, and sepsis, type of surgery, postoperative coughing, and wound infection. Based on these findings, a risk model was developed. Conclusions: The model can give an estimate of the risk of abdominal wound dehiscence for individual patients. High-risk patients may be planned preventive wound closing with reinforcements as mesh.

关键词： Abdominal Wound Dehiscence Risk Factors Risk Model Abdominal Complications

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Clinicopathological Profile of Breast Cancer Patients at a Tertiary Care Hospital in Kashmir Valley

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Surgical Science 2017年第3期8卷 162-168页

作者： Mujahid Ahmad Mir farzana manzoor Balvinder Singh Wasim Raja Shaukat Jeelani Waheed Ahmad Zargar Faraidon Faiq Ahmad Aung Zar Ko Imteyaz Ahmad Sofi Department of General Surgery Government Medical College Srinagar India

Introduction: Breast cancer is the commonest malignancy in women worldwide. There are considerable variations in risk factors and presentation of the disease region wise. The present study aimed to describe clinical and pathological profile of breast cancer patients attending tertiary care hospital. Method: All consenting patients attending to surgical out-patient department (OPD) with complaints pertaining to breast disease were enrolled from 16th June 2015 to 15th June 2016. The patients were followed and demographic, clinical and pathologic information was recorded and analysed. Results: Total Of 180 patients with breast disease were enrolled. 34/100 were diagnosed of malignancy and formed the cases of the present study. Age of the patients ranged from 22 to 60 years with mean age of 42.06 ± 10.7 years. All the patients presented as breast lump variably associated with pain or discharge. Infiltrating Ductal Carcinoma Not Otherwise Specified (IDC NOS) was common histologic diagnosis (76.47%). Conclusion: Breast carcinoma presents with painless lump and patients are usually diagnosed in our setup at locally advanced stage. Implementation of the simple and effective screening programs for early detection is urgent need in our population.

关键词： Breast Cancer Histopathology Infiltrating Ductal Carcinoma Lump Risk Factors Stage

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Facile synthesis of graphene anchored rare earth doped mixed metal ferrite nanorods:A potential candidate for azo dye mineralization

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Journal of Rare Earths 2024年第5期42卷 907-916,I0004页

作者： Tehmina Kousar Muhammad Aadil Sonia Zulfiqar Sobhy MIbrahim Sidra Mubeen Warda Hassan Kashuf Shafiq farzana Mahmood Institute of Chemical Sciences Bahauddin Zakariya UniversityMultan60800Pakistan Department of Chemistry Rahim Yar Khan CampusThe Islarnia University of BahawalpurRahim Yar Khan64200Pakistan Department of Chemistry Faculty of ScienceUniversity of Ostrava30.Dubna 22Ostrava70103Czech Republic Department of Chemical and Biological Engineering Iowa State UniversitySweeney Hall618 Bissell RoadAmeslowa50011United States Department of Biochemistry College of ScienceKing Saud UniversityPO.Box 2455Riyadh11451Saudi Arabi Department of Chemistry The Women University Multan66000Pakistan

Bandgap tuning using rare earth metals as dopants in ferrite-based photocatalytic materials has received a lot of interest because the Fermi 4f energy of these metals generates a sub-energy state in the bandgap generated by the overlapping of Fe-3d and O-2p ***,dysprosium-doped cobalt-nickel mixed ferrite(D-CNFO)and its graphene-reinforced composite(D-CNFO@G)were prepared and an ideal photocatalyst material for azo dye mineralization was proposed.A cost-effective combination of wetchemical and ultrasonication methods was used to prepare the doped and composite *** characterization methodologies were used to scrutinize the optical,compositional,structural,morphological,and photocatalytic characteristics of as-prepared *** X-ray diffraction analysis identified the spinel phase's(cubic)structure,while the electronic spectroscopy examination confirmed the prepared samples'rod-like *** UV/visible absorbance spectrum shows the higher light harvesting behavior of the D-CNFO@G in the visible *** mineralization performance of the DCNFO and D-CNFO@G composites was analyzed using Congo-red(an anionic dye),a well-known azo *** D-CNFO@G sample removes Congo-red dye at a rate almost 2.4%faster than the D-CNFO *** experiment involving trapping free radicals indicates that hydroxyl radical play s a crucial role in dye *** the D-CNFO@G catalyst is magnetic and can be isolated easily from the photocatalytic system,it shows an awkward cycle activity of more than 96%after five mineralization *** asprepared D-CNFO@G composite is proved as an excellent option for azo dye mineralization because of the combined impacts of rare earth doping,graphene reinforcement and nanotechnology.

关键词： azo-dye Composite Graphene Dy-doped Nanotechnology Rare earths

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Assessment of plastic degradation by indigenous bacteria from waste disposal sites

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Emerging Contaminants 2024年第3期10卷 111-123页

作者： farzana Javid Ghadir Ali Abdul Rehman Rehan Naeem Imran Ali Iffat Naz Department of Microbiology and Biotechnology Faculty of Life SciencesAbasyn University Peshawar CampusPeshawar25000Khyber PakhtunkhwaPakistan Department of Life Sciences School of ScienceUniversity of Management and Technology(UMT)Lahore54700Pakistan Department of Microbiology Kohat University of Science and Technology(KUST)Kohat26000Khyber PakhtunkhwaPakistan Department of Biotechnology and Genetic Engineering Kohat University of Science and Technology(KUST)Kohat26000Khyber PakhtunkhwaPakistan Department of Botany Kohat University of Science and Technology(KUST)Kohat26000Khyber PakhtunkhwaPakistan Department of Biology Deanship of Educational ServicesQassim UniversityBuraydah51452Kingdom of Saudi Arabia

The present study focuses on the isolation of bacterial pathogens from waste disposal sites,and examination of their efficiencies for degrading various *** bacterial isolates such as ***,Corynebacterium spp.,Micrococcus spp.,Azotobacter spp.,Pseudomonas spp.,Staphylococcus spp.,and Bacillus *** *** *** the highest percentage reduction in black plastic weight(47.46%),while Corynebacterium spp.,and *** achieved a maximum reduction of 45.76 and 46.42%for pink plastic *** *** Micrococcus *** notable reductions of 46.43%and 56.60%in white and Canteen Stores Department(CSD)biodegradable plastics,*** density(OD)measurements revealed that bacterial isolates achieved maximum OD values with CSD plastics,emphasizing their proficiency in plastic *** Transform Infrared Spectroscopy(FTIR)confirmed the degradation process,with a decrease in the peak value from 2916 to 2914 cm^(-1) for pink plastic,signifying alkane,and alkene *** new peaks at 1398,1371,and 1361 cm^(-1) in the FTIR spectrum of CSD plastic indicated presence of *** Electron Microscopic(SEM)micrographs illustrated bacterial colonization,cracks,and spots on plastic surfaces,while Xray Diffraction(XRD)spectra showed peaks at 4.083,3.705,3.020,and 1.909,suggesting plastic *** conclusion,soil of waste disposal site harbored diverse microbial species,and have highlighted their effectiveness in mitigating environmental pollution by degrading hazardous plastic waste.

关键词： Plastic degradation Bacterial isolates Waste disposal sites Fourier transform infrared spectroscopy Scanning electron microscopy X-ray diffraction Environmental pollution

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Studies of XRD and FTIR on Synthesized Novel Hybrid Thin Film Made of Hydroxyapatite, Poly Vinyl Alcohol and Gelatin for Biomedical Application

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Materials Sciences and Applications 2024年第9期15卷 336-349页

作者： farzana Rashid Suraya Sabrin Soshi Md. Abdul Gafur Department of Medicine Hallym University Chuncheon-si South Korea Department of MPE AUST Dhaka Bangladesh PP&PDC Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh

With the modern advancement of treatment approaches in medical science, the application of biomaterials in tissue engineering provides a remarkable opportunity to overcome graft rejection as well as proper wound healing. In this study, novel hybrid films have been synthesized by incorporation of polyvinyl alcohol (PVA), gelatin, and gelatin with glycerin along with different concentrations of pre-prepared hydroxyapatite (HAP) by solution casting method at room temperature in a biosafety cabinet. Glutaraldehyde has been added as a crosslinker in this whole procedure. Fourier-transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD) have been conducted to observe and compare the structural and chemical stability of the synthesized hybrid film properties. The FTIR results and X-Ray Diffraction analyses confirmed the chemical interactions between HAP, PVA, gelatin, and glycerin have occurred. The crystallinity of HAP also remains in all the prepared hybrid film samples that are observed in XRD. It is expected that these newly synthesized hybrid films could be a better opportunity for various sectors of tissue engineering such as skin, bone, tendon, and cartilage. These synthesized hybrid films can be suitable for wound healing covering. These studies could be a new scope for long-term drug delivery directly on wound sites in diabetic gangrene foot or burn patients as well as cartilage or joint replacement therapy.

关键词： XRD FTIR HAP PVA Gelatin

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Development and Characterization of Hybrid Film Made of Hydroxyapatite, Poly Vinyl Alcohol and Gelatin for Biomedical Application

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Materials Sciences and Applications 2024年第9期15卷 320-335页

In the recent research field of bone tissue engineering, polymeric materials play an implacable role in mimes the natural behavior of hard and soft tissues. In some medical conditions such as diabetics, osteoarthritis, burns, or joint replacement conditions, this polymeric materials implication enhances the internal mechanical activities which result in the early recovery of disease by facilitating the wound healing process. In this study, hybrid films have been synthesized based on polyvinyl alcohol (PVA), gelatin, and gelatin with glycerin incorporated with different concentrations of pre-prepared hydroxyapatite (HAP) by solution casting method at room temperature in biosafety cabinet. Glutaraldehyde has been added as a crosslinker in this whole procedure. The mechanical property, swelling, and porosity percentage have been conducted to characterize the structural stability of the synthesized hybrid films. Porosity and swelling of samples are also represented by proper biocompatibility (>90% porosity and swelling in DDW and PBF vary between 287%~72%). Tensile strength (TS), E modulus (Young’s modulus), Elongation at maximum, and Elongation at break are observed to perceive the mechanical properties of hybrid film samples, which are compatible with mechanical properties of different tissue such as trabecular bone, articular cartilage, tendon, nerve and skin tissue. Though, biocompatibility tests both in vivo and in vitro are essential for clinical application in the future. However, the experiment carried out till now explains the true possibility of newly synthesized hybrid films for long-term drug delivery directly on wound sites for wound healing and burn dressing patients in head-neck surgery reconstruction, diabetic gangrene foot, as well as cartilage or joint replacement therapy.

关键词： HAP PVA Gelatin Swelling Test Tensile Strength

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Klippel Trenaunay Syndrome with Angiokeratoma Circumscriptum Naeviforme and Bilateral Congenital Anorchia: A Rare Association

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Open Journal of Pediatrics 2024年第1期14卷 43-49页

作者： Mujammel Haque Kalyan Benjamin Gomes Sajib Kumar Talukdhar Mustafizur Rahman farzana Sharmin Manik Kumar Talukder Department of Paediatrics Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

Klippel-Trenaunay syndrome (KTS) is not a common congenital vascular abnormality. A trio of capillary malformation, venous varicosities, and bony or soft-tissue hypertrophy define this syndrome. Significant morbidities associated with this illness include bleeding, deep vein thrombosis, and embolic consequences. Angiokeratoma circumscriptum naeviforme (ACN) is indeed a congenital variant of angiokeratoma that appears as a hyperkeratotic plaque on the lower extremity. Bilateral congenital anorchia (BCA) is the total lack of testicular tissue in a male with a normal phenotype and karyotype. KTS has been linked to ACN. Here we presented an 8-year-old male child who came with a swollen left thigh and the right side of his face with overlying blackish nodules on his left thigh and scrotum. The patient was diagnosed as KTS with angiokeratoma circumscriptum naeviforme and bilateral congenital anorchia based on his history, imaging studies and the typical clinical features of the disease.

关键词： Klippel-Trenaunay Syndrome Angiokeratoma Circumscriptum Neviforme Bilateral Congenital Anorchia

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Post Thyroidectomy Assessment of Intact Parathyroid Hormone for Early Prediction of Hypocalcaemia

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第2期13卷 71-84页

作者： Md. Masum Billah Ripon Kumar Sarkar Md. Yousuf Ali Saad Zaman Md. Nazmul Hasan Md. Shehab Uddin Md. Mosleh Uddin Kazi Shameemus Salam farzana Binte Abedin Leera Department of Otolaryngology-Head & Neck Surgery Universal Medical College Hospital Dhaka Bangladesh Department of Otolaryngology-Head & Neck Surgery National Institute of Ear Nose and Throat Dhaka Bangladesh Shaheed Ahsan Ullah Master General Hospital Gazipur Bangladesh Department of Otolaryngology-Head & Neck Surgery Cumilla Medical College Cumilla Bangladesh Department of ENT Oncology National Institute of Cancer Research & Hospital Dhaka Bangladesh Department of ENT Outdoor Rajshahi Medical College Hospital Rajshahi Bangladesh Department of Otolaryngology-Head & Neck Surgery Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Department of Biochemistry Delta Medical College Hospital Dhaka Bangladesh

Background: As the half-life of intact parathyroid hormone (iPTH) is very low, it reflects parathyroid insufficiency within minutes to hours after total thyroidectomy. Therefore, iPTH level assessment in the postoperative period can be used to predict the development of hypocalcaemia. The optimal time point to measure serum iPTH is important for the accurate prediction of hypocalcaemia. Aim: This paper aims to evaluate the ability of iPTH as an early predictive marker of hypocalcaemia and determine which time iPTH is more able to predict postoperative hypocalcaemia. Method: This prospective observational study was conducted in the Department of Otolaryngology-Head & Neck Surgery, BSMMU, Dhaka, from July 2020 to December 2021, with 67 patients who underwent total thyroidectomy. iPTH levels were measured on the day before the operation and at 1 hour, 4 hours, and 24 hours after the operation. *** levels were measured on the day before the operation and 1st postoperative day. All the data were compiled and sorted properly and were analyzed statistically. Results: Postoperative hypocalcaemia developed in 18 cases, with an incidence of 26.9%. Pearson correlation showed a significant correlation between postoperative iPTH at 1 hr, 4 h, and 24 hr with 1st postoperative calcium value. The Receiver operating characteristic (ROC) curve was processed for the postoperative iPTH at 1 hr, 4 h, and 24 hr. The sensitivity, specificity, cut-off value, and mean AUC found 93.9%, 94.4%, ≤14.0, 0.988;95.9%, 94.4%, ≤09.5, 0.993 and 91.8%, 94.4%, ≤11.0, 0.993 respectively. Conclusion: iPTH can be used as an early predictor of post-thy-roidectomy hypocalcaemia. 4 hr iPTH showed more sensitivity and specificity for a cut-off value near the laboratory reference range.

关键词： Total Thyroidectomy Hypocalcaemia Serum Intact Parathyroid Hormone Early Predictor of Hypocalcaemia

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Comparison of Propofol and Fentanyl for Preventing Emergence Agitation Following Sevoflurane Anesthesia in Pediatric Patients: A Single-Center Study in Bangladesh

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Pharmacology & Pharmacy 2024年第6期15卷 223-235页

作者： Md. Saiful Islam Khan Md. Abir Tazim Chowdhury farzana Fardousi Munama Magdum Md. Ahaduzzaman Taneem Mohammad Shamima Akter Suriya Akter Md. Saiful Islam Azad Md. Mozaffer Hossain M. Abdur Rahman Department of Cardiothoracic Anesthesia Evercare Hospital Dhaka Bangladesh Department of Cardiothoracic and Vascular Surgery Evercare Hospital Dhaka Bangladesh Department of Pathology National Institute of Cancer Research & Hospital Dhaka Bangladesh Department of Preventive and Social Medicine National Institute of Preventive and Social Medicine Dhaka Bangladesh Department of Anesthesia Sheikh Sayera Khatun Medical College Gopalgonj Bangladesh Department of Anesthesia Dhaka Medical College Dhaka Bangladesh Department of Anesthesia Combined Military Hospital Dhaka Bangladesh Department of Cardiac Anesthesia National Institute of Cardiovascular Disease Dhaka Bangladesh Department of Anesthesia Bangladesh Medical College Dhaka Bangladesh

Background: Emergence agitation (EA) is a common phenomenon observed in pediatric patients following general anesthesia. This study aimed to assess the efficacy of propofol and fentanyl in preventing EA and to compare their associated complications or side effects. Methods: This prospective randomized observational comparative study was conducted at Dhaka Medical College Hospital from July 2013 to June 2014. The study aimed to evaluate the effects of propofol and fentanyl on EA in children aged 18 to 72 months undergoing circumcision, herniotomy, and polypectomy operations. Ninety children were included in the study, with 45 in each group. Patients with psychological or neurological disorders were excluded. Various parameters including age, sex, weight, American Society of Anesthesiologists (ASA) class, duration of anesthesia, Saturation of Peripheral Oxygen (SPO2), heart rate (HR), respiratory rate (RR), Pediatric Anesthesia Emergence Delirium (PAED) score, duration of post-anesthesia care unit (PACU) stay, incidence of laryngospasm, nausea, vomiting, and rescue drug requirement were compared between the two groups. Results: Age, sex, weight, ASA class, and duration of anesthesia were comparable between the two groups. Perioperative SpO2 and HR were similar in both groups. However, the PAED score was significantly higher in the fentanyl group during all follow-ups except at 30 minutes postoperatively. The mean duration of PACU stay was significantly longer in the fentanyl group. Although the incidence of laryngospasm was higher in the fentanyl group, it was not statistically significant. Conversely, nausea or vomiting was significantly higher in the fentanyl group. The requirement for rescue drugs was significantly higher in the fentanyl group compared to the propofol group. Conclusion: Both propofol and fentanyl were effective in preventing emergence agitation in pediatric patients undergoing various surgical procedures under sevoflurane anesthesia. However, propo

关键词： Emergence Agitation (EA) General Anesthesia Propofol Fentanyl Pediatric Patients Pediatric Anesthesia Emergence Delirium (PAED) Score Bangladesh

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Point scoring system to rank traffic calming projects

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Journal of Traffic and Transportation Engineering(English Edition) 2016年第4期3卷 324-335页

作者： farzana Rahman Hisashi Kubota Department of Civil Engineering University of Asia Pacific Graduate School of Science and Engineering Department of Civil & Environmental EngineeringSaitama University

The installation of calming measures on a road network is systematically planned way in general to reduce driving speeds, but also reduces the volume of through traffic on local and residential streets. When the demands of traffic calming exceed city resources, there is a need to prioritize or rank them. Asian countries, like lapan, Korea, Bangladesh and etc., do not have a ptioritization system to apply in such cases. The objective of this research is to develop a point ranking system to prioritize traffic calming projects. Firstly paired comparison method was employed to obtain residents＇ opinions about the streets severity and needs of traffic calming treatment. A binary logistic regression model was developed to identify the factors of selecting streets for traffic calming. This model also explored the weight of variables during developing the point ranking system. The weights used in the point ranking system include vehicle speed, pedestrian generation, sidewalk condition and hourly vehicle volume per width （m） of street. Results suggest that the severity of street largely depends on the absence of sidewalks, which has a weight of 45%, and high hourly vehicle volume of traffic per width （m） of street, which has a weight of 38%. These outcomes are significant to develop the state of traffic safety in Japan and other Asian countries.

关键词： Traffic calmingPrioritizePaired comparison methodPreferenceSafety

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