Development and Characterization of Hybrid Film Made of Hydroxyapatite, Poly Vinyl Alcohol and Gelatin for Biomedical Application
Development and Characterization of Hybrid Film Made of Hydroxyapatite, Poly Vinyl Alcohol and Gelatin for Biomedical Application作者机构：Department of Medicine Hallym University Chuncheon-si South Korea Department of MPE AUST Dhaka Bangladesh PP&PDC Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh
出 版 物：《Materials Sciences and Applications》 (材料科学与应用期刊（英文）)
年 卷 期：2024年第15卷第9期
页 面：320-335页
学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）]
主 题：HAP PVA Gelatin Swelling Test Tensile Strength
摘 要：In the recent research field of bone tissue engineering, polymeric materials play an implacable role in mimes the natural behavior of hard and soft tissues. In some medical conditions such as diabetics, osteoarthritis, burns, or joint replacement conditions, this polymeric materials implication enhances the internal mechanical activities which result in the early recovery of disease by facilitating the wound healing process. In this study, hybrid films have been synthesized based on polyvinyl alcohol (PVA), gelatin, and gelatin with glycerin incorporated with different concentrations of pre-prepared hydroxyapatite (HAP) by solution casting method at room temperature in biosafety cabinet. Glutaraldehyde has been added as a crosslinker in this whole procedure. The mechanical property, swelling, and porosity percentage have been conducted to characterize the structural stability of the synthesized hybrid films. Porosity and swelling of samples are also represented by proper biocompatibility (90% porosity and swelling in DDW and PBF vary between 287%~72%). Tensile strength (TS), E modulus (Young’s modulus), Elongation at maximum, and Elongation at break are observed to perceive the mechanical properties of hybrid film samples, which are compatible with mechanical properties of different tissue such as trabecular bone, articular cartilage, tendon, nerve and skin tissue. Though, biocompatibility tests both in vivo and in vitro are essential for clinical application in the future. However, the experiment carried out till now explains the true possibility of newly synthesized hybrid films for long-term drug delivery directly on wound sites for wound healing and burn dressing patients in head-neck surgery reconstruction, diabetic gangrene foot, as well as cartilage or joint replacement therapy.
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