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Materials Sciences and Applications 2024年第9期15卷 336-349页

作者： farzana rashid Suraya Sabrin Soshi Md. Abdul Gafur Department of Medicine Hallym University Chuncheon-si South Korea Department of MPE AUST Dhaka Bangladesh PP&PDC Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh

With the modern advancement of treatment approaches in medical science, the application of biomaterials in tissue engineering provides a remarkable opportunity to overcome graft rejection as well as proper wound healing. In this study, novel hybrid films have been synthesized by incorporation of polyvinyl alcohol (PVA), gelatin, and gelatin with glycerin along with different concentrations of pre-prepared hydroxyapatite (HAP) by solution casting method at room temperature in a biosafety cabinet. Glutaraldehyde has been added as a crosslinker in this whole procedure. Fourier-transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD) have been conducted to observe and compare the structural and chemical stability of the synthesized hybrid film properties. The FTIR results and X-Ray Diffraction analyses confirmed the chemical interactions between HAP, PVA, gelatin, and glycerin have occurred. The crystallinity of HAP also remains in all the prepared hybrid film samples that are observed in XRD. It is expected that these newly synthesized hybrid films could be a better opportunity for various sectors of tissue engineering such as skin, bone, tendon, and cartilage. These synthesized hybrid films can be suitable for wound healing covering. These studies could be a new scope for long-term drug delivery directly on wound sites in diabetic gangrene foot or burn patients as well as cartilage or joint replacement therapy.

关键词： XRD FTIR HAP PVA Gelatin

Development and Characterization of Hybrid Film Made of Hydroxyapatite, Poly Vinyl Alcohol and Gelatin for Biomedical Application

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Materials Sciences and Applications 2024年第9期15卷 320-335页

In the recent research field of bone tissue engineering, polymeric materials play an implacable role in mimes the natural behavior of hard and soft tissues. In some medical conditions such as diabetics, osteoarthritis, burns, or joint replacement conditions, this polymeric materials implication enhances the internal mechanical activities which result in the early recovery of disease by facilitating the wound healing process. In this study, hybrid films have been synthesized based on polyvinyl alcohol (PVA), gelatin, and gelatin with glycerin incorporated with different concentrations of pre-prepared hydroxyapatite (HAP) by solution casting method at room temperature in biosafety cabinet. Glutaraldehyde has been added as a crosslinker in this whole procedure. The mechanical property, swelling, and porosity percentage have been conducted to characterize the structural stability of the synthesized hybrid films. Porosity and swelling of samples are also represented by proper biocompatibility (>90% porosity and swelling in DDW and PBF vary between 287%~72%). Tensile strength (TS), E modulus (Young’s modulus), Elongation at maximum, and Elongation at break are observed to perceive the mechanical properties of hybrid film samples, which are compatible with mechanical properties of different tissue such as trabecular bone, articular cartilage, tendon, nerve and skin tissue. Though, biocompatibility tests both in vivo and in vitro are essential for clinical application in the future. However, the experiment carried out till now explains the true possibility of newly synthesized hybrid films for long-term drug delivery directly on wound sites for wound healing and burn dressing patients in head-neck surgery reconstruction, diabetic gangrene foot, as well as cartilage or joint replacement therapy.

关键词： HAP PVA Gelatin Swelling Test Tensile Strength

Role of the JNK signal transduction pathway in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第2期14卷 200-202页

作者： Praveen K Roy farzana rashid Jack Bragg Jamal A Ibdah Division of Gastroenterology and Hepatology University of Missouri School of Medicine Columbia Missouri United States

The c-Jun NH2-terminal Kinase (JNK) pathway representsone sub-group of the mitogen-activated protein (MAP)kinases which plays an important role in variousinflammatory diseases states, including inflammatorybowel disease (IBD). Significant progress towardsunderstanding the function of the JNK signaling pathwayhas been achieved during the past few years. Blockadeof the JNK pathway with JNK inhibitors in animal modelsof IBD lead to resolution of intestinal *** data suggest specific JNK inhibitors hold promiseas novel therapies in IBD.

关键词： JNK pathway Inflammatory bowel disease Inflammation

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Hepc20在毕赤酵母中的胞内表达及鉴定

北京化工大学学报（自然科学版） 2010年第2期37卷 104-108页

作者： farzana rashid 袁其朋孙新晓李飞北京化工大学生命科学与技术学院北京100029

构建了Hepc 20的毕赤酵母表达载体,在毕赤酵母中能成功表达有活性的Hepc 20。优化了菌株的培养诱导条件,结果表明BMMY培养基是Hepc 20表达和重组菌株生长的最佳培养基,甲醇诱导终体积分数0.5%,在此条件下Hepc 20在重组菌株中的表达量约... 详细信息

构建了Hepc 20的毕赤酵母表达载体,在毕赤酵母中能成功表达有活性的Hepc 20。优化了菌株的培养诱导条件,结果表明BMMY培养基是Hepc 20表达和重组菌株生长的最佳培养基,甲醇诱导终体积分数0.5%,在此条件下Hepc 20在重组菌株中的表达量约为3.6 mg/L。Western blot检测显示的22000处的条带为重组Hepc 20条带;ELISA验证表明重组Hepc 20可以跟抗体特异结合,琼脂扩散法抗菌实验表明重组Hepc 20对金黄色葡萄球菌和枯草芽孢杆菌表现出抗菌活性。

关键词：抗菌肽 Hepc 20 铁毕赤酵母

人类抗菌肽hepcidin在毕赤酵母中的分泌表达和纯化

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生物技术通报 2009年第9期25卷 121-124页

作者： farzana rashid Ijaz Ali 袁其朋孙新晓李文进李飞北京化工大学生命科学与技术学院北京100029

报道了一种低分子量的人类抗菌肽hepcidin基因的克隆、表达以及纯化。试验证明在毕赤酵母中能成功分泌有活性的hepcidin,hepcidin在重组菌株中的表达量约为3 mg/L,Western blot显示2.2 kD的重组hepcidin条带,重组hepcidin通过凝胶过滤... 详细信息

报道了一种低分子量的人类抗菌肽hepcidin基因的克隆、表达以及纯化。试验证明在毕赤酵母中能成功分泌有活性的hepcidin,hepcidin在重组菌株中的表达量约为3 mg/L,Western blot显示2.2 kD的重组hepcidin条带,重组hepcidin通过凝胶过滤及反向高效液相色谱纯化,质谱验证,重组蛋白对金黄色葡萄球菌和枯草芽孢杆菌表现出抗菌活性。

关键词：抗菌肽 Hepcidin 20 铁毕赤酵母分泌表达

Scalable nonlinear equalization in high-bit-rate optical transmission systems

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Photonics Research 2013年第3期1卷 130-135页

作者： Rameez Asif Humayun Shahid farzana Arshad rashid Saleem Telecommunication Engineering Department(TED) University of Engineering and Technology(UET)Taxila 47050Pakistan

In this paper,we report on the performance comparison of all-optical signal processing methodologies to compensate fiber transmission impairments,namely chromatic dispersion and nonlinear distortion caused by the Kerr effect,in a coherent 112 Gbit∕s dual-polarization 64 bit quadrature amplitude modulation system over 800 km standard single-mode *** numerically compare optical backward propagation(OBP)with optical phase conjugation(OPC)techniques,***-link spectral inversion,predispersed spectral inversion,and OPC with nonlinearity *** also evaluate a self-phase-modulation-based optical limiter with an appropriate prechirping to compensate for the intensity fluctuations as a hybrid approach with *** results depict improvement in system performance by a factor of∼4 dB of signal input power by all-optical signal processing methods,which is comparative with ideal digital backward propagation where the high complexity is the intrinsic impediment in the real-time implementation of the technique with coherent receivers.

关键词： optical polarization nonlinear