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Hippo-YAP/TAZ signaling in breast cancer:Reciprocal regulation of microRNAs and implications in precision medicine

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Genes & Diseases 2024年第2期11卷 760-771页

作者： farzad Sadri Seyede fatemeh Hosseini Zohreh Rezaei Mohammad Fereidouni Student Research Committee Birjand University of Medical SciencesBirjand ***Iran Tabas School of Nursing Birjand University of Medical SciencesBirjand ***Iran Department of Biology University of Sistan and BaluchestanZahedan ***Iran Cellular and Molecular Research Center Birjand University of Medical SciencesBirjand ***Iran

Breast cancer is a molecularly heterogeneous disease and the most common female *** recent years,therapy approaches have evolved to accommodate molecular diversity,with a focus on more biologically based therapies to minimize negative *** regulate cell fate in human breast cells,the Hippo signaling pathway has been associated with the alpha subtype of estrogen *** pathway regulates tissue size,regeneration,and healing,as well as the survival of tissue-specific stem cells,proliferation,and apoptosis in a variety of organs,allowing for cell *** signaling is mediated by the kinases MST1,MST2,LATS1,and LATS2,as well as the adaptor proteins SAV1 and *** kinases phosphorylate the downstream effectors of the Hippo pathway,yes-associated protein(YAP),and transcriptional coactivator with PDZ-binding motif(TAZ),suppressing the expression of their downstream target *** Hippo signaling pathway kinase cascade plays a significant role in all *** the principles of this kinase cascade would prevent the occurrence of breast *** recent years,small noncoding RNAs,or microRNAs,have been implicated in the development of several malignancies,including breast *** interconnections between miRNAs and Hippo signaling pathway core proteins in the breast,on the other hand,remain poorly *** this review,we focused on highlighting the Hippo signaling system,its key parts,its importance in breast cancer,and its regulation by miRNAs and other related pathways.

关键词： Breast cancer Hippo signaling Large tumor suppressor kinase 1 microRNAs PDZ-binding motif Yes-associated protein

Cellulose-MXene composites: New platforms with outstanding multifunctional characteristics

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Journal of Bioresources and Bioproducts 2024年第3期9卷 243-245页

作者： farzad Seidi Wensi Jiang Zhaochuan Yu Chao Deng Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials Nanjing Forestry UniversityNanjing 210037China Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The progress of society has caused a quick rise in the requirement for materials with superior *** composite materials demonstrate exceptional performance due to the synergistic effects resulting from the combination of unique properties exhibited by their constituent *** advantageous characteristic enables these materials to leverage the collective strengths of each component,leading to their outstanding *** leveraging the strengths of each individual component,the shortcomings can be overcome and the strong points can be shared effectively.

关键词： composites MXene composite

Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor Khosravi farzad Dastaviz Mehdi Sheikh Arabi Ayyoob Khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell ***:Niosome nanocarriers were produced using two surfactants Span 60 and Tween *** cell line was treated with both free AUR and *** dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,*** study revealed that niosomal AUR had more gradual delivery to the ***-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal ***:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE ***-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

Late infection after peri-orbital autologous micro-fat graft:a case presentation and literature review

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 603-606页

作者： farzad Pakdel Hassan Asadigandomani Melika Arab Bafrani Zohreh Nozarian Zohre Abedinifar Niloofar Pirmarzdashti Behzad Jafari Zaynab Siami Department of Oculofacial Plastic Surgery Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Craniomaxillofacial Research Center Tehran University of Medical SciencesTehran ***Iran Department of Ophthalmology School of MedicineTehran University of Medical SciencesTehran ***Iran Department of Pathology Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Department of Microbiology Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Pediatric Cell and Gene Therapy Research Center Children’s Medical CenterSchool of MedicineTehran University of Medical SciencesTehran ***Iran

Citation:Pakdel F,Asadigandomani H,Arab Bafrani M,Nozarian Z,Abedinifar Z,Pirmarzdashti N,Jafari B,Siami *** infection after peri-orbital autologous micro-fat graft:a case presentation and literature *** J Ophthalmol ... 详细信息

关键词： graft orbital after

Vibration analysis of fluid-conveying multi-scale hybrid nanocomposite shells with respect to agglomeration of nanofillers

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Defence Technology（防务技术） 2021年第1期17卷 212-225页

作者： farzad Ebrahimi Ali Dabbagh Department of Mechanical Engineering Faculty of EngineeringImam Khomeini International UniversityQazvinIran School of Mechanical Engineering College of EngineeringUniversity of TehranTehranIran

The vibration problem of a fluid conveying cylindrical shell consisted of newly developed multi-scale hybrid nanocomposites is solved in the present manuscript within the framework of an analytical *** consistent material is considered to be made from an initial matrix strengthened via both macro-and nano-scale *** influence of nanofillers’agglomeration,generated due to the high surface to volume ratio in nanostructures,is included by implementing Eshelby-Mori-Tanaka homogenization ***,the equivalent material properties of the carbon nanotube reinforced(CNTR)nanocomposite are coupled with those of CFs within the framework of a modified rule of *** the other hand,the influences of viscous flow are covered by extending the Navier-Stokes equation for cylinders.A cylindrical coordinate system is chosen and mixed with the infinitesimal strains of first-order shear deformation theory of shells to obtain the motion equations on the basis of the dynamic form of principle of virtual ***,the achieved governing equations will be solved by Galerkin’s method to reach the natural frequency of the structure for both simply supported and clamped boundary *** a set of illustrations,effects of each parameter on the dimensionless frequency of nanocomposite shells will be shown graphically.

关键词： Vibration Agglomeration effect Multi-scale hybrid nanocomposites Galerkin’s solution Viscous fluid flow

Development of hybrid optimization algorithm for structures furnished with seismic damper devices using the particle swarm optimization method and gravitational search algorithm

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 455-474页

作者： Najad Ayyash farzad Hejazi Civil Engineering University Putra MalaysiaSeri Kembangan 43300Malaysia

Previous studies about optimizing earthquake structural energy dissipation systems indicated that most existing techniques employ merely one or a few parameters as design variables in the optimization process,and thereby are only applicable only to simple,single,or multiple degree-of-freedom *** current approaches to optimization procedures take a specific damper with its properties and observe the effect of applying time history data to the building;however,there are many different dampers and isolators that can be ***,there is a lack of studies regarding the optimum location for various viscous and wall *** main aim of this study is hybridization of the particle swarm optimization(PSO) and gravitational search algorithm(GSA) to optimize the performance of earthquake energy dissipation systems(i.e.,damper devices) simultaneously with optimizing the characteristics of the *** types of structural dampers device are considered in this study:(ⅰ) variable stiffness bracing(VSB) system,(ⅱ) rubber wall damper(RWD),(ⅲ) nonlinear conical spring bracing(NCSB) device,(iv) and multi-action stiffener(MAS) *** many parameters may affect the design of seismic resistant structures,this study proposes a hybrid of PSO and GSA to develop a hybrid,multi-objective optimization method to resolve the aforementioned *** characteristics of the above-mentioned damper devices as well as the section size for structural beams and columns are considered as variables for development of the PSO-GSA optimization algorithm to minimize structural seismic response in terms of nodal displacement(in three directions) as well as plastic hinge formation in structural members simultaneously with the weight of the *** that,the optimization algorithm is implemented to identify the best position of the damper device in the structural frame to have the maximum effect and minimize the seismic structure *** examine the performance

关键词： hybrid optimization algorithm structures earthquake seismic damper devices particle swarm optimization method gravitational search algorithm

Synthesis of a PEG-PNIPAm Thermosensitive Dendritic Copolymer and Investigation of Its Self-association

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Chinese Journal of Polymer Science 2015年第1期33卷 192-202页

作者： farzad Seidi Parvin Heshmati Department of Chemistry Sanandaj Branch Islamic Azad University University of Kurdistan Department of Chemistry

A Novel thermosensitive dendritic copolymer based on polyethylene glycol（PEG） and poly（Nisopropylacrylamide）（PNIPAm） with a cloud point（CP） around 36 ？C was successfully synthesized by preparation of a dendritic polyol and followed by atom transfer radical polymerization（ATRP） of N-isopropylacrylamide. The dendritic copolymer was characterized using gel-permeation chromatography（GPC）, FTIR and 1H-NMR spectroscopy. The selfassociation behavior of the copolymer in aqueous medium was investigated by dynamic light scattering（DLS） and transmission electron microscopy（TEM）. These investigations confirmed that the dendritic copolymer showed different association behaviors at various temperatures.

关键词： Thermosensitive Dendritic Atom transfer radical polymerization Poly(N-isopropylacrylamide) Polyethylene glycol.

Wave propagation analysis of rotating thermoelastically-actuated nanobeams based on nonlocal strain gradient theory

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Acta Mechanica Solida Sinica 2017年第6期30卷 647-657页

作者： farzad Ebrahimi Parisa Haghi Department of Mechanical Engineering Faculty of Engineering Imam Khomeini International University Qazvin Iran

This paper is concerned with the wave propagation behavior of rotating functionally graded（FG）temperature-dependent nanoscale beams subjected to thermal loading based on nonlocal strain gradient stress ***,linear and nonlinear temperature distributions across the thickness are ***-elastic properties of FG beam change gradually according to the Mori–Tanaka distribution model in the spatial *** nanobeam is modeled via a higher-order shear deformable refined beam theory which has a trigonometric shear stress *** governing equations are derived by Hamilton’s principle as a function of axial force due to centrifugal stiffening and *** solution of these equations is provided employing a Galerkin-based approach which has the potential to capture various boundary *** applying an analytical solution and solving an eigenvalue problem,the dispersion relations of rotating FG nanobeam are *** results illustrate that various parameters including temperature change,angular velocity,nonlocality parameter,wave number and gradient index have significant effects on the wave dispersion characteristics of the nanobeam under *** outcome of this study can provide beneficial information for the next-generation research and the exact design of nano-machines including nanoscale molecular bearings,nanogears,etc.

关键词： Wave propagation FGMS Nonlocal strain gradient theory Rotating nanobeam Refined beam theory