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Effect of oral premedication of midazolam, ketamine, and dexmedetomidine on pediatric sedation and ease of parental separation in anesthesia induction for elective surgery: A randomized clinical trial

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Journal of Acute Disease 2022年第4期11卷 133-139页

作者： Aref Zarei Hesameddin Modir Behnam Mahmoodiyeh Alireza Kamali farzad zamani-barsari Student Research Committee Arak University of Medical SciencesArakIran Anesthesiology Department Arak University of Medical SciencesArakIran Department of ENT Surgery Arak University of Medical SciencesArakIran

Objective:To compare effect of midazolam,dexmedetomidine,and ketamine as oral premedication on pediatric sedation and ease of parental separation anxiety in anesthesia induction.Methods:This multicenter,prospective,randomized,double-blind,clinical trial focused on a pediatric population aged 2-7 years(n=153)with the American Society of AnesthesiologistsⅠ-Ⅱwho required elective surgery.The patients were stratified into three intervention groups:midazolam,ketamine,and dexmedetomidine.Hemodynamic parameters(blood pressure,heart rate,and oxygen saturation)every 5 min until induction of anesthesia along with non-hemodynamic factors,comprised of sedation score before the administration and at the time of being separated from the parents,as well as parental separation anxiety scale,acceptance of anesthesia induction,and side effects were recorded and compared.Results:No statistically significant difference in oxygen saturation,heart rate,blood pressure,duration of surgery,time to achieve an Aldrete score of 9-10,or sedation score was noted in the study groups.More patients in the dexmedetomidine and midazolam groups could better ease parental separation anxiety than the ketamine group(P=0.001).Moreover,fewer patients accept anesthesia induction(P=0.001)and more had side effects in the ketamine group(P=0.047).Conclusions:Our findings indicate that compared to the ketamine group,dexmedetomidine and midazolam are better in easing parental separation anxiety and accepting induction of anesthesia with fewer side effects.Dexmedetomidine and midazolam may be considered better choices.However,the final choice hinges on the patient's specific physical condition and the anesthesiologist's preference.Clinical registarion:This study is registered in the Iranian Registry Clinical Trial center with the clinical trial code of IRCT20211007052693N1.

关键词： Dexmedetomidine Ketamine Midazolam Premedication Sedation

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Hippo-YAP/TAZ signaling in breast cancer:Reciprocal regulation of microRNAs and implications in precision medicine

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Genes & Diseases 2024年第2期11卷 760-771页

作者： farzad Sadri Seyede fatemeh Hosseini Zohreh Rezaei Mohammad Fereidouni Student Research Committee Birjand University of Medical SciencesBirjand ***Iran Tabas School of Nursing Birjand University of Medical SciencesBirjand ***Iran Department of Biology University of Sistan and BaluchestanZahedan ***Iran Cellular and Molecular Research Center Birjand University of Medical SciencesBirjand ***Iran

Breast cancer is a molecularly heterogeneous disease and the most common female malignancy.In recent years,therapy approaches have evolved to accommodate molecular diversity,with a focus on more biologically based therapies to minimize negative consequences.To regulate cell fate in human breast cells,the Hippo signaling pathway has been associated with the alpha subtype of estrogen receptors.This pathway regulates tissue size,regeneration,and healing,as well as the survival of tissue-specific stem cells,proliferation,and apoptosis in a variety of organs,allowing for cell differentiation.Hippo signaling is mediated by the kinases MST1,MST2,LATS1,and LATS2,as well as the adaptor proteins SAV1 and MOB.These kinases phosphorylate the downstream effectors of the Hippo pathway,yes-associated protein(YAP),and transcriptional coactivator with PDZ-binding motif(TAZ),suppressing the expression of their downstream target genes.The Hippo signaling pathway kinase cascade plays a significant role in all cancers.Understanding the principles of this kinase cascade would prevent the occurrence of breast cancer.In recent years,small noncoding RNAs,or microRNAs,have been implicated in the development of several malignancies,including breast cancer.The interconnections between miRNAs and Hippo signaling pathway core proteins in the breast,on the other hand,remain poorly understood.In this review,we focused on highlighting the Hippo signaling system,its key parts,its importance in breast cancer,and its regulation by miRNAs and other related pathways.

关键词： Breast cancer Hippo signaling Large tumor suppressor kinase 1 microRNAs PDZ-binding motif Yes-associated protein

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Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor Khosravi farzad Dastaviz Mehdi Sheikh Arabi Ayyoob Khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell line.METHODS:Niosome nanocarriers were produced using two surfactants Span 60 and Tween 80.RPE cell line was treated with both free AUR and niosome-encapsulated.Optimum dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay.Expression of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,respectively.Release study revealed that niosomal AUR had more gradual delivery to the cells.RT-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal AUR.CONCLUSION:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE cells.VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

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Late infection after peri-orbital autologous micro-fat graft:a case presentation and literature review

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 603-606页

作者： farzad Pakdel Hassan Asadigandomani Melika Arab Bafrani Zohreh Nozarian Zohre Abedinifar Niloofar Pirmarzdashti Behzad Jafari Zaynab Siami Department of Oculofacial Plastic Surgery Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Craniomaxillofacial Research Center Tehran University of Medical SciencesTehran ***Iran Department of Ophthalmology School of MedicineTehran University of Medical SciencesTehran ***Iran Department of Pathology Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Department of Microbiology Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Pediatric Cell and Gene Therapy Research Center Children’s Medical CenterSchool of MedicineTehran University of Medical SciencesTehran ***Iran

Citation:Pakdel F,Asadigandomani H,Arab Bafrani M,Nozarian Z,Abedinifar Z,Pirmarzdashti N,Jafari B,Siami Z.Late infection after peri-orbital autologous micro-fat graft:a case presentation and literature review.Int J O... 详细信息

关键词： graft orbital after

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Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell line.METHODS:UMB-containing niosomes were created,optimized,and characterized.RPE-like cells were treated with free UMB and UMB-containing niosomes.The IC_(50)values of the treatments were determined using an MTT assay.Gene expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA synthesis.Niosomes’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were assessed.Free UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/mL.RESULTS:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free UMB.CONCLUSION:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes expression.However,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual delivery.These findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

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Development of hybrid optimization algorithm for structures furnished with seismic damper devices using the particle swarm optimization method and gravitational search algorithm

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 455-474页

作者： Najad Ayyash farzad Hejazi Civil Engineering University Putra MalaysiaSeri Kembangan 43300Malaysia

Previous studies about optimizing earthquake structural energy dissipation systems indicated that most existing techniques employ merely one or a few parameters as design variables in the optimization process,and thereby are only applicable only to simple,single,or multiple degree-of-freedom structures.The current approaches to optimization procedures take a specific damper with its properties and observe the effect of applying time history data to the building;however,there are many different dampers and isolators that can be used.Furthermore,there is a lack of studies regarding the optimum location for various viscous and wall dampers.The main aim of this study is hybridization of the particle swarm optimization(PSO) and gravitational search algorithm(GSA) to optimize the performance of earthquake energy dissipation systems(i.e.,damper devices) simultaneously with optimizing the characteristics of the structure.Four types of structural dampers device are considered in this study:(ⅰ) variable stiffness bracing(VSB) system,(ⅱ) rubber wall damper(RWD),(ⅲ) nonlinear conical spring bracing(NCSB) device,(iv) and multi-action stiffener(MAS) device.Since many parameters may affect the design of seismic resistant structures,this study proposes a hybrid of PSO and GSA to develop a hybrid,multi-objective optimization method to resolve the aforementioned problems.The characteristics of the above-mentioned damper devices as well as the section size for structural beams and columns are considered as variables for development of the PSO-GSA optimization algorithm to minimize structural seismic response in terms of nodal displacement(in three directions) as well as plastic hinge formation in structural members simultaneously with the weight of the structure.After that,the optimization algorithm is implemented to identify the best position of the damper device in the structural frame to have the maximum effect and minimize the seismic structure response.To examine the performance of the proposed PSO-GSA optimization method,it h

关键词： hybrid optimization algorithm structures earthquake seismic damper devices particle swarm optimization method gravitational search algorithm

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Sensitivity Analysis of Pollutants and Pattern Factor in a Gas Turbine Model Combustor due to Changes in Stabilizing Jets Characteristics

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Journal of Thermal Science 2022年第5期31卷 1622-1641页

作者： BAZDIDI-TEHRANI farzad TEYMOORI Alireza GHIYASI Mehdi School of Mechanical Engineering Iran University of Science and TechnologyTehran16846-13114Iran

In the present paper,a sensitivity analysis of pollutants and pattern factor in a model combustor due to changes in the geometrical characteristics of stabilizing jets has been carried out.The exhaust pollutants including NO_(x),CO and soot have been chosen due to their harmful effect on the environment.The pattern factor has been also considered owing to its impact on turbine blades.The geometrical characteristics comprise diameter,angle and position of stabilizing jets.Eulerian-Lagrangian approach has been employed to model liquid fuel injection and distribution,breakup and evaporation of droplets.For the analysis of reactive-spray flow characteristics,RANS approach,realizable k-εturbulence model,discrete ordinates radiative heat transfer model and steady flamelet combustion model together with the chemical reaction mechanism of diesel fuel(C_(10)H_(22))have been applied.NO_(x) modeling has been performed via post-processing.Sensitivity analysis is such that by making variations in the problem inputs(diameter,angle and position of jets)in an organized manner,the effects on the outputs(NO_(x),CO,soot and pattern factor)are predicted.The number and order of simulations are predicted by design of experiments and full factorial model.Results have been analyzed using analysis of variance.It has been observed that if interactions among the characteristics of jets are considered,it is possible to analyze the exhaust pollutants more accurately.In fact,by using the interactions,it is likely to find a point where all output parameters are improved.Results show that by considering interactions of stabilizing jet characteristics,the maximum values of NO_(x),CO,soot and pattern factor change from 13.927 ppm,11.198%mole fraction,2.877 ppm and 0.043 to 26.233 ppm,14.693%mole fraction,142.357 ppm and 0.060,respectively.Furthermore,the minimum values change from 5.819 ppm,7.568%mole fraction,0.013 ppm and 0.029 to 6.098 ppm,5.987%mole fraction,0.002 ppm and 0.027,respectively.

关键词： model jet-stabilized combustor liquid fuel injection sensitivity analysis design of experiments pollutants pattern factor

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聚乙烯基胺包裹Fe_3O_4@SiO_2磁性微球用于Knoevenagel缩合（英文）

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催化学报 2014年第1期35卷 21-27页

作者： farzad zamani Elham Izadi Department of Chemistry Shahreza Branch Islamic Azad University Laboratory of Applied Chemistry Central Laboratory Complex Isfahan Science and Technology Town Isfahan University of Technology

Polyvinyl amine coated Fe3O4@SiO2 composite microspheres with a core‐shell structure were prepared and employed as a magnetic catalyst for Knoevenagel condensation under mild conditions. The catalyst can be readily recovered using a magnet and reused several times without loss in activity or selectivity. The performance of the magnetic base catalyst was compared with that of polyvinyl amine functionalized mesoporous SBA‐15, which showed that the magnetic nanoparticles gave improved reaction rate and yield.

关键词： Fe3O4 聚乙烯胺磁性微球 Knoevenagel缩合缩合反应二氧化硅包覆磁性催化剂

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Evaluating Simultaneous Impact of Slag and Tire Rubber Powder on Mechanical Characteristics and Durability of Concrete

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Journal of Renewable Materials 2022年第8期10卷 2155-2177页

作者： Mostafa Amiri farzad Hatami Emadaldin Mohammadi Golafshani Department of Civil Engineering Science and Research BranchIslamic Azad UniversityTehranIran Structural and Earthquake Research Center(SERC) Amirkabir University of Technology(Tehran Polytechnic)TehranIran Department of Civil Engineering Monash UniversityMelbourneAustralia

In this experimental study,the impact of Portland cement replacement by ground granulated blast furnace slag(GGBFS)and micronized rubber powder(MRP)on the compressive,flexural,tensile strengths,and rapid chloride migration test(RCMT)of concrete were assessed.In this study,samples with different binder content and water to binder ratios,including the MRP with the substitution levels of 0%,2.5%and 5%,and the GGBFS with the substitution ratios of 0%,20%and 40%by weight of Portland cement were made.According to the results,in the samples containing slag and rubber powder in the early ages,on average,a 12.2%decrease in the mechanical characteristics of concrete was observed,nonetheless with raising the age of the samples,the impact of slag on reducing the porosity of concrete lowered the negative impact of rubber powder.Regarding durability characteristics,the RCMT results of the samples were enhanced by using rubber powder because of its insulation impact.Moreover,adding slag into the MRP-included mixtures results in a 23%reduction in the migration rate of the chloride ion averagely.At last,four mathematical statements were derived for the mechanical and durability of concrete containing the MRP and GGBFS utilizing the genetic programming method.

关键词： Micronized rubber powder ground granulated blast furnace slag waste materials mechanical properties durability

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Latent Heat Prediction of Nano Enhanced Phase Change Material by ANN Method

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Energy Engineering 2022年第3期119卷 847-861页

作者： farzad Jaliliantabar Rizalman Mamat Sudhakar Kumarasamy College of Engineering Department of Mechanical EngineeringUniversiti Malaysia PahangKuantan26300Malaysia Automotive Engineering Centre Universiti Malaysia PahangPekan26600Malaysia School of Mechanical Engineering Ningxia UniversityNingxia750000China Faculty of Mechanical and Automotive Engineering Technology Universiti Malaysia PahangPekan26600Malaysia Energy Center Maulana Azad National Institute of TechnologyBhopal462003India

Thermal characteristics of phase change material(PCM)are important in design and utilization of thermal energy storage or other applications.PCMs have great latent heat but suffer from low thermal conductivity.Then,in recent years,nano particles have been added to PCM to improve their thermophysical properties such as thermal conductivity.Effect of this nano particles on thermophysical properties of PCM has been a question and many experimental and numerical studies have been done to investigate them.Artificial intelligence-based approach can be a good candidate to predict thermophysical properties of nano enhance PCM(NEPCM).Then,in this study an artificial neural network(ANN)has been developed to predict the latent heat of the NEPCM.A comprehensive literature search was conducted to acquire thermal characteristics data from various NEPCM to train and test this artificial neural network model.Twenty different types of Nano particle and paraffin based PCMs were used in ANN development.The most important properties which are used as the input for the developed ANN model are NP size,density of NP,latent heat of PCM,density of PCM,concentration and latent heat of NEPCM in the range of 1-60 nm,100-8960 kg/m^(3),89.69-311 kJ/kg,760 to 1520 kg/m^(3),0.02-20 wt%and 60.72-338.6 kJ/kg,respectively.The output variable was latent heat of NEPCM.The result indicates that the ANN model can be applied to predict the latent heat of nano enhanced PCM satisfactory.The correlation coefficient of the created model was 0.97.This result shows ability of ANN to predict the latent heat of NEPCM.

关键词： NEPCM ANN latent heat prediction

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