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A candidate identification questionnaire for postmenopausal osteoporosis patients switched from daily or weekly bisphosphonate to once-monthly ibandronate: An open, prospective, multicenter study—BONCURE study

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Health 2013年第7期5卷 30-40页

作者： Yesim Gokce Kutsal Nurten Eskiyurt Jale Irdesel Vesile Sepici Hatice Ugurlu Yesim Kirazli Fusun Ardic Mirko Korsic Tonko Vlak Mane Grlickov Snezana Markovic Temelkova Miroslav Lazarov Nada Pilipovic Vera Popovic Aleksandar Dimic Branka Kovacev Dorina Ruci Argjend Tafaj Elma Kucukalic-Selimovic Dijana Avdic Hajrija Seleskovic Snjezana Pejicic Bulent Butun Gulseren Akyuz Lale Cerrahoglu Omer faruk Sendur Peyman Yalcin Sema Oncel Merih Saridogan Tunay Sarpel Mehmet Tosun Kazim Senel Savas Gursoy Ferhan Canturk Huseyin Demir Blazenka Miskic Dalibor Krpan Franjo Skreb Simeon Grazio Zeljka Crncevic-Orlic Fatih Ozdener Hakan Oncel Clinic for Orthopaedic Surgery Clinical Centre Vodnjansk Skopje Macedonia Clinic of Endocrinology Diabetes and Metabolic Disorders Skopje Macedonia Clinic of Rheumatology Clinical Centre Skopje Macedonia Clinical Center of Vojvodina Novi Sad Serbia Clinical Center Banja Luka Bosnia and Herzegovina Clinical Hospital Centre Split Croatia Department of PMR Cerrahpasa School of Medicine Istanbul University Istanbul Turkey Department of PMR Clinical Hospital Center Rijeka Rijeka Croatia Department of PMR Dr. Josip Bencevic General Hospital Slavonski Brod Croatia Department of PMR Istanbul School of Medicine Istanbul University Istanbul Turkey Department of PMR Polyclinic for Internal Medicine Zagreb Croatia Department of PMR School of Medicine Adnan Menderes University Aydin Turkey Department of PMR School of Medicine Akdeniz University Ankara Turkey Department of PMR School of Medicine Ankara University Ankara Turkey Department of PMR School of Medicine Ataturk University Erzurum Turkey Department of PMR School of Medicine Celal Bayar University Manisa Turkey Department of PMR School of Medicine Cukurova University Adana Turkey Department of PMR School of Medicine Dokuz Eylul University Izmir Turkey Department of PMR School of Medicine Ege University Izmir Turkey Department of PMR School of Medicine Erciyes University Kayseri Turkey Department of PMR School of Medicine Gazi University Ankara Turkey Department of PMR School of Medicine Gaziantep University Gaziantep Turkey Department of PMR School of Medicine Hacettepe University Ankara Turkey Department of PMR School of Medicine Karadeniz Technical University Trabzon Turkey Department of PMR School of Medicine Marmara University Istanbul Turkey Department of PMR School of Medicine Ondokuz Mayis University Samsun Turkey Department of PMR School of Medicine Pamukkale University Denizli Turkey Department of PMR School of Medicine Selcuk University Konya Turkey Department

A candidate identification questionnaire (CIQ) was tested to determine its predictive value for patient-reported satisfaction in patients switched from once-weekly or once-daily treatment with a bisphosphonate to once-monthly dosing. This was a prospective, open-label, multicenter international study in patients with postmenopausal osteoporosis who had been receiving once-daily or once-weekly alendronate or risendronate for at least 3 months. Patients completed a CIQ, then commenced 150 mg monthly ibandronate for 6 months. Patients completed the Osteoporosis Patient Satisfaction Questionnaire (OPSAT-QTM) at baseline for 6 months. Scores were converted to composite satisfaction scores (CSS, scale 0-100). Totally 677 patients completed a CIQ, 645 were enrolled in the treatment phase and comprised the intent-to-treat (ITT) population, and 630 completed the study. In the ITT population, 68.1% patients answered “yes” to one or more CIQ questions. OPSAT-Q scores increased for the convenience, quality of life and overall satisfaction domains (p scores for the side effects domains were significant (p < 0.001) in the CIQ “yes” group, but not for the degree of bother (decrease in mean of 0.1 points, p = 0.50) or duration (no change, p = 0.84) of non-gastrointestinal side effects. Of 638 patients who completed the preference questionnaire, 93.0% of patients preferred the once-monthly dosing schedule and 563 patients (90.7%) found it more convenient. The most common adverse events were dyspepsia (1.9%), nausea (1.1%), and upper abdominal pain (0.9%). Patients are likely to prefer treatment with monthly ibandronate to a weekly or monthly bisphosphonate irrespective of their stated preference before switching treatment.

关键词： Bisphosphonate Compliance Ibandronate Postmenopausal Osteoporosis

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医疗器械环氧乙烷灭菌及低温灭菌研究进展

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中国医学装备 2023年第3期20卷 192-198页

作者：张家振法如克·艾合买提舍莉萍秦歌马小华李革杨奕姚旭东柳庆坤新疆维吾尔自治区药品审评查验中心新疆乌鲁木齐800054 国家药品监督管理局医疗器械技术审评中心北京100081 安徽省药品审评查验中心安徽合肥230051 山东省食品药品审评查验中心山东济南250014

环氧乙烷(EO)灭菌因其所具备的优点在医疗器械行业广泛使用,综述我国采用EO灭菌的常见医疗器械产品以及国内EO灭菌相关的标准体系,通过梳理EO灭菌工艺流程及分析影响灭菌过程的相关因素(EO浓度、温度、相对湿度等),明确EO灭菌工艺优化... 详细信息

环氧乙烷(EO)灭菌因其所具备的优点在医疗器械行业广泛使用,综述我国采用EO灭菌的常见医疗器械产品以及国内EO灭菌相关的标准体系,通过梳理EO灭菌工艺流程及分析影响灭菌过程的相关因素(EO浓度、温度、相对湿度等),明确EO灭菌工艺优化和性能研究的必要性。介绍EO灭菌存在的环保和健康危害问题,提出国内外对EO灭菌提出的创新挑战及变革情况,阐述EO灭菌及低温灭菌技术未来发展方向。

关键词：环氧乙烷(EO)灭菌医疗器械 EO残留低温灭菌技术进展

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The Faces of Fungi database:fungal names linked with morphology,phylogeny and human impacts

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Fungal Diversity 2015年第5期74卷 3-18页

作者： Subashini C.Jayasiri Kevin D.Hyde Hiran A.Ariyawansa Jayarama Bhat Bart Buyck Lei Cai Yu-Cheng Dai Kamel A.Abd-Elsalam Damien Ertz Iman Hidayat Rajesh Jeewon E.B.Gareth Jones Ali H.Bahkali Samantha C.Karunarathna Jian-Kui Liu J.Jennifer Luangsa-ard H.Thorsten Lumbsch Sajeewa S.N.Maharachchikumbura Eric H.C.McKenzie Jean-Marc Moncalvo Masoomeh Ghobad-Nejhad Henrik Nilsson Ka-Lai Pang Olinto L.Pereira Alan J.L.Phillips Olivier Raspé Adam W.Rollins Andrea I.Romero Javier Etayo faruk Selçuk Steven L.Stephenson Satinee Suetrong Joanne E.Taylor Clement K.M.Tsui Alfredo Vizzini Mohamed A.Abdel-Wahab Ting-Chi Wen Saranyaphat Boonmee Dong Qin Dai Dinushani A.Daranagama Asha J.Dissanayake Anusha H.Ekanayaka S.C.Fryar Sinang Hongsanan Ruvishika S.Jayawardena Wen-Jing Li Rekhani H.Perera R.Phookamsak Nimali Ide Silva Kasun M.T.hambugala Qing Tian Nalin N.Wijayawardene Rui-Lin Zhao Qi Zhao Ji-Chuan Kang Itthayakorn Promputtha Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agro forestry Centre East and Central Asia Office 132 Lanhei RoadKunming 650201China Botany and Microbiology Department College of ScienceKing Saud UniversityRiyadh 1145Saudi Arabia Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha403108 GoaIndia Department of Botany Goa UniversityGoa 403206India Muséum National d’Histoire Naturelle Département Systématique et EvolutionCP 39ISYEBUMR 7205 CNRS MNHN UPMC EPHE12 Rue BuffonF-75005 ParisFrance State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesWest Beicheng RdBeijingChina Institute of Microbiology Beijing Forestry UniversityPO Box 61Beijing 100083China Plant Pathology Research Institute Agricultural Research Center(ARC)12619 GizaEgypt Botanic Garden Meise Department Bryophytes-Thallophytes(BT)Nieuwelaan 38B-1860 MeiseBelgium Fédération Wallonie-Bruxelles Direction Générale de l’Enseignement non obligatoire et de la Recherche scientifiqueRue A.Lavallée 11080 BruxellesBelgium Microbiology Division Research Center for BiologyIndonesian Institute of Sciences(LIPI)Jl.Raya Jakarta-Bogor KM 46Cibinong 16911West JavaIndonesia Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Microbe Interaction Laboratory(BMIT) BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoe Khlong LuangPathum Thani 12120Thailand Science&Education The Field Museum1400 S.Lake Shore DriveChicagoIL 60605USA Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand Department of Natural History Royal Ontario Museumand Department of Ecology and Evolutionary BiologyUniversity of Toronto100 Queen’s ParkTorontoON M5S2C6Canada Department of Biotechnology Iranian Research Organiza

Taxonomic names are key links between various databases that store information on different *** global fungal nomenclural and taxonomic databases(notably Index Fungorum,Species Fungorum and MycoBank)can be sourced to find taxonomic details about fungi,while DNA sequence data can be sourced from NCBI,EBI and UNITE *** the sequence data may be linked to a name,the quality of the metadata is variable and generally there is no corresponding link to images,descriptions or herbarium *** is generally no way to establish the accuracy of the names in these genomic databases,other than whether the submission is from a reputable *** tackle this problem,a new database(FacesofFungi),accessible at ***(FoF)has been *** fungal database allows deposition of taxonomic data,phenotypic details and other useful data,which will enhance our current taxonomic understanding and ultimately enable mycologists to gain better and updated insights into the current fungal classification *** addition,the database will also allow access to comprehensive metadata including descriptions of voucher and type *** database is user-friendly,providing links and easy access between taxonomic ranks,with the classification system based primarily on molecular data(from the literature and via updated web-based phylogenetic trees),and to a lesser extent on morphological data when molecular data are *** FoF species are not only linked to the closest phylogenetic representatives,but also relevant data is provided,wherever available,on various applied aspects,such as ecological,industrial,quarantine and chemical *** data include the three main fungal groups(Ascomycota,Basidiomycota,Basal fungi)and fungus-like *** FoF webpage is an output funded by the Mushroom Research Foundation which is an NGO with seven directors with mycological *** webpage has 76 curators,and with the help of these s

关键词： Classification Database Faces of Fungi Fungi Phylogeny Taxonomy

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