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Further Insights on the <i>Datura innoxia</i>Hyoscyamine 6<i>β</i>-Hydroxylase (DiH6H) Based on Biochemical Characterization and Molecular Modeling

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American Journal of Plant Sciences 2021年第1期12卷 53-70页

作者： Daniel Schlesinger faris salama Rachel Davidovich Rikanati Rotem Sertchook Ofir Tal Mosaab Yahyaa Adi Faigenboim Mwafaq Ibdah Moshe Inbar Efraim Lewinsohn Department of Evolutionary & Environmental Biology University of Haifa Haifa Israel Department of Vegetable Crops Newe Ya’ar Research Center Agricultural Research Organization Ramat Yishay Israel Institute of Plant Sciences Agriculture Research Organization RishonLe Zion Israel Lilienblum 3 Gedera Israel Department of Vegetable Crops The Robert Smith Faculty of Agriculture The Hebrew University of Jerusalem Rehovot Israel

Hyoscyamine, anisodamine and scopolamine are tropane alkaloids present in some Solanaceae species and used in modern medicine. L-Hyoscyamine is hydroxylated to 6β-hydroxyhyoscyamine (anisodamine) and then epoxidated to scopolamine by the dual action of hyoscyamine 6β-hydroxylase (H6H), a 2-oxoglutarate dependent dioxygenase. A natural mutation in the Gly-220 residue to Cys was previously shown to be associated with the loss of function of H6H in Mandragora officinarum, preventing the accumulation of anisodamine and scopolamine in these plants. We show here that a deliberate Gly220Cys mutation in the Datura innoxia DiH6H protein caused a loss of both its enzymatic abilities and rendered it unable to hydroxylate L-hyoscyamine into anisodamine and to epoxidate anisodamine into scopolamine. By using protein modeling based on an available crystal structure of H6H from Datura metel, we show how the Cys220 residue causes a steric interference in the active site cavity impairing the interaction of both substrates, hyoscyamine and anisodamine with the active site of the protein. We also address the enantiomeric preference of DiH6H based on molecular modeling.

关键词： Hyoscyamine 6β Hydroxylase Datura innoxia. Mill. Solanaceae Scopolamine Hyoscyamine

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Surface morphology and cell viability of samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide/polycaprolactone targeting wound dressing

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Journal of Rare Earths 2024年第3期42卷 555-561,I0005页

作者： Muteb H.Alshammari Ahmed Onayzan Alshammari Mohamed Tharwat Elabbasy Rafat Zreiq faris Mohammed Albati M.A.El-Morsy A.A.Menazea Department of Health Informatics College of Public Health and Health InformaticsUniversity of Ha'ilHa'ilSaudi Arabia Department of Surgery College of MedicineUniversity of Ha'ilHa'ilSaudi Arabia Department of Public Health College of Public Health and HealthInformaticsHalUniversityHa'il2440Saudi Arabi Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Applied Science Research Center Applied Science Private UniversityAmman541350Jordan College of Shariah and Law Ha'il UniversityHa'il2440Saudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamittaNew Damietta34517.Egyp Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt

Combinations of metal and lanthanide oxides have been done through casted films for potential medical applications. In this regard, samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide(GO)/polycaprolactone(PCL) based films nano-composites(NCs) were fabricated, pointing their utilization as a biological scaffold for wound dressing purposes. Also, samarium(Ⅲ) oxide and chromium(Ⅲ) oxide have been merged as promising optical constituents due to their unique optical behavior. The structural and compositional examination of the studied NCs was executed by X-ray diffraction(XRD), Raman, and field emission scanning electron microscopy(FESEM). The Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL NC exhibits a surface with a lower roughness degree owing to the presence of GO. Cr_(2)O_(3)shows size reduction upon GO insertion to reach 1.2 μm as the average grain size, whilst Sm_(2)O_(3)records an average grain size of less than 1 μm. As well, the polymeric nano-compositions exhibit variation in contact angle values that hit 29.76°± 3.52°for Sm_(2)O_(3)/PCL, and 48.62°± 1.37°for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL as the second lowest contact angle. The optical behavior contributes to absorption edge relocation along the x-axis from 1.7 eV for pure PCL, to 2.65 eV for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL. Regarding biological responses, the cell exposed to 2.5 μg/m L of Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL shows cell viability of 119.31%, while 5 μg/m L hits 99.6%. Additionally, the resulting cell attachment micrographs show layers of fibroblast tissue, besides the proliferation and growth of cultivated cells. Thus, the Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL scaffold provides 3D proliferation of fibroblast cells endorsing the wound healing process.

关键词： Wound healing Wound dressing Polycaprolactone Sm_(2)O_(3) Cr_(2)O_(3) Rare earths

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Physical Layer Security of 6G Vehicular Networks with UAV Systems:First Order Secrecy Metrics,Optimization,and Bounds

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Computers, Materials & Continua 2024年第9期80卷 3685-3711页

作者： Sagar Kavaiya Hiren Mewada Sagarkumar Patel Dharmendra Chauhan faris A.Almalki Hana Mohammed Mujlid Smt.Chandaben Mohanbhai Patel Institute of Computer Applications Charotar University of Science and TechnologyChangaAnand388421India Electrical Engineering Department Prince Mohammad Bin Fahad UniversityP.O.Box 1664Al Khobar31952Kingdom of Saudi Arabia Department of Electronics and Communication Engineering Chandubhai S.Patel Institute of TechnologyCharotar University of Science and TechnologyChangaAnand388421India Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Kingdom of Saudi Arabia

The mobility and connective capabilities of unmanned aerial vehicles(UAVs)are becoming more and more important in defense,commercial,and research ***,their open communication makes UAVs susceptible toundesirablepassive attacks suchas eavesdroppingor ***,the inefficiencyof traditional cryptography-based techniques has led to the addition of Physical Layer Security(PLS).This study focuses on the advanced PLS method for passive eavesdropping in UAV-aided vehicular environments,proposing a solution to complement the conventional cryptography ***,we present a performance analysis of first-order secrecy metrics in 6G-enabled UAV systems,namely hybrid outage probability(HOP)and secrecy outage probability(SOP)over 2×2 Nakagami-m ***,we propose a novel technique for mitigating passive eavesdropping,which considers first-order secrecy metrics as an optimization problem and determines their lower and upper ***,we conduct an analysis of bounded HOP and SOP using the interactive Nakagami-m channel,considering the multiple-input-multiple-output configuration of the UAV *** findings indicate that 2×2 Nakagami-mis a suitable fadingmodel under constant velocity for trustworthy receivers and *** results indicate that UAV mobility has some influence on an eavesdropper’s intrusion during line-of-sight-enabled communication and can play an important role in improving security against passive eavesdroppers.

关键词： Physical layer security 3D positioning 6G communications UAV systems

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Mapping the global research landscape on nonalcoholic fatty liver disease and insulin resistance:A visualization and bibliometric study

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World Journal of Hepatology 2024年第6期16卷 951-965页

作者： Sa'ed H Zyoud Omar E Hegazi Samer O Alalalmeh Muna Shakhshir faris Abushamma Shadi Khilfeh Samah W Al-Jabi Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research Center An-Najah National University HospitalNablus 44839Palestine College of Pharmacy and Health Sciences Ajman UniversityAjman 346United Arab Emirates Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Medicine College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Urology An-Najah National University HospitalNablus 44839Palestine Department of Gastroenterology Hepatology and EndoscopyAn-Najah National University HospitalNablus 44839Palestine

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a liver condition that is prevalent worldwide and associated with significant health risks and economic *** it has been linked to insulin resistance(IR),this study aimed to perform a bibliometric analysis and visually represent the scientific literature on IR and *** To map the research landscape to underscore critical areas of focus,influential studies,and future directions of NAFLD and *** This study conducted a bibliometric analysis of the literature on IR and NAFLD indexed in the SciVerse Scopus database from 1999 to *** search strategy used terms from the literature and medical subject headings,focusing on terms related to IR and *** software was used to visualize research trends,collaborations,and key thematic *** analysis examined publication type,annual research output,contributing countries and institutions,funding agencies,journal impact factors,citation patterns,and highly cited *** This analysis identified 23124 documents on NAFLD,revealing a significant increase in the number of publications between 1999 and *** search retrieved 715 papers on IR and NAFLD,including 573(80.14%)articles and 88(12.31%)*** most productive countries were China(n=134;18.74%),the United States(n=122;17.06%),Italy(n=97;13.57%),and Japan(n=41;5.73%).The leading institutions included the Universitàdegli Studi di Torino,Italy(n=29;4.06%),and the Consiglio Nazionale delle Ricerche,Italy(n=19;2.66%).The top funding agencies were the National Institute of Diabetes and Digestive and Kidney Diseases in the United States(n=48;6.71%),and the National Natural Science Foundation of China(n=37;5.17%).The most active journals in this field were Hepatology(27 publications),the Journal of Hepatology(17 publications),and the Journal of Clinical Endocrinology and Metabolism(13 publications).The main research hotspots were“therapeutic approaches for IR and NAFLD”and“inflamma

关键词： Nonalcoholic fatty liver disease Insulin resistance Bibliometric Visualization

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Driving forces of continuing evolution of rotaviruses

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World Journal of Virology 2024年第2期13卷 58-70页

作者： Mohamad Saifudin Hakim faris Muhammad Gazali Suci Ardini Widyaningsih Mohammad Khalid Parvez Postgraduate School of Molecular Medicine Erasmus MC-University Medical CenterRotterdam 3015GDNetherlands Viral Infection Working Group International Society of Antimicrobial ChemotherapyLondon EC4R 9ANUnited Kingdom Master Program in Biotechnology Postgraduate SchoolUniversitas Gadjah MadaYogyakarta55281Indonesia Master of Medical Sciences in Clinical Investigation Harvard Medical SchoolBostonMA 02115United States Department of Pharmacognosy College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia

Rotaviruses are non-enveloped double-stranded RNA virus that causes acute diarrheal diseases in children(<5 years).More than 90%of the global rotavirus infection in humans was caused by Rotavirus group *** infection has caused more than 200000 deaths annually and predominantly occurs in the low-income *** evolution is indicated by the strain dynamics or the emergence of the unprecedented *** major factors that drive the rotavirus evolution include the genetic shift that is caused by the reassortment mechanism,either in the intra-or the ***,other factors are also known to have an impact on rotavirus *** review discusses the structure and types,epidemiology,and evolution of *** article also reviews other supplemental factors of rotavirus evolution,such as genetic reassortment,mutation rate,glycan specificity,vaccine introduction,the host immune respo-nses,and antiviral drugs.

关键词： Rotavirus Epidemiology Evolution Reassortment Vaccine

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Further Insights on the Datura innoxia Hyoscyamine 6β -Hydroxylase (DiH6H) Based on Biochemical Characterization and Molecular Modeling

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American Journal of Plant Sciences（美国植物学期刊） 2021年第1期

作者： Daniel Schlesinger faris salama Rachel Davidovich Rikanati Rotem Sertchook Ofir Tal Mosaab Yahyaa Adi Faigenboim Mwafaq Ibdah Moshe Inbar Efraim Lewinsohn

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Finite element analysis on the static and fatigue characteristics of composite multi-leaf spring

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第3期13卷 159-164页

作者： Joo-teck Jeffrey KUEH Tarlochan faris Department of Mechanical Engineering Universiti Tenaga Nasional

This paper investigated the static and fatigue behaviors of steel and composite multi-leaf spring using the ANSYS V I 2 software. The dimensions of an existing conventional leaf spring of a light commercial vehicle were used. The same dimensions were used to design composite multi-leaf spring for the two materials, E-glass fiber/epoxy and E-glass fiber/vinyl ester, which are of great interest to the transportation industry. Main consideration was given to the effects of material composition and its fiber orientation on the static and fatigue behaviors of leaf spring. The design constraints were bending stresses, deflection and fatigue life. Compared to the steel leaf spring, the designed composite spring has much lower bending stresses and deflections and higher fatigue life cycles.

关键词： Leaf spring Composites Finite element Stress Deflection Fatigue

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Finite Element Analysis of Porous Titanium Alloy Hip Stem to Evaluate the Biomechanical Performance During Walking and Stair Climbing

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Journal of Bionic Engineering 2019年第6期16卷 1103-1115页

作者： Sami Emad Alkhatib Hassan Mehboob faris Tarlochan School of Mechanical and Chemical Engineering M050The University of Western Australia35 Stirling HighwayCrawleyPerthWA6009Australia Department of Engineering Management College of EngineeringPrince Sultan UniversityRiyadhKingdom of Saudi Arabia Department of Mechanical and Industrial Engineering College of EngineeringQatar UniversityDohaQatar

Despite the success of cementless hip stem,stress shielding still presents a serious problem leading to bone *** incorporating porous cellular structures represent a promising ***,this study validates the finite element models of titanium(Ti)alloy(Ti-6Al-4V)porous stem and effective porous *** effective porous stems with strut thicknesses 0.33 mm-1.25 mm(18%-90%porosity)under different loading conditions were *** results of finite element models revealed that changing the load type and porosity affect stress *** loads yield the maximum stress levels while walking loads result in the lowest stresses in the ***,the point load results in the maximum stress shielding and micromotions(-19% to 18%,40μm to 703μm),as compared to walking(-17.5% to 3%,35μm to 242μm)and climbing loads(-7% to 1.6%,30μm to 221 μm).Finally,effective porous stems of strut thickness 0.87 mm exhibit the lowest stress shielding signals(<5%)under all loading conditions.

关键词： porous cellular microstructures porous hip stems physiological loads finite element analysis stress shielding

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Assuring enhanced privacy violation detection model for social networks

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International Journal of Intelligent Computing and Cybernetics 2022年第1期15卷 75-91页

作者： Ali Altalbe faris Kateb Faculty of Computing and Information Technology King Abdulaziz UniversityJeddahSaudi Arabia

Purpose-Virtually unlimited amounts of data collection by cybersecurity systems put people at risk of having their privacy *** networks like Facebook on the Internet provide an overplus of knowledge concerning their *** users relish exchanging data online,only some data are meant to be interpreted by those who see value in *** is now essential for online social network(OSN)to regulate the privacy of their users on the *** paper aims to propose an efficient privacy violation detection model(EPVDM)for ***/methodology/approach-In recent months,the prominent position of both industry and academia has been dominated by privateness,its breaches and strategies to dodge privacy *** around the world have become aware of the effects of violating privacy and its effect on them and other *** privacy violations are detected,they must be reported to those affected and it’s supposed to be mandatory to make them to take the next *** there are different approaches to detecting breaches of privacy,most strategies do not have a functioning tool that can show the values of its subject *** EPVDM for Facebook,based on a deep neural network,is proposed in this research ***-The main aim of EPVDM is to identify and avoid potential privacy breaches on Facebook in the *** analyses in comparison with major intrusion detection system(IDS)to detect privacy violation show that the proposed methodology is robust,precise and *** chances of breaches or possibilities of privacy violations can be identified very ***/value-All the resultant is compared with well popular methodologies like adaboost(AB),decision tree(DT),linear regression(LR),random forest(RF)and support vector machine(SVM).It’s been identified from the analysis that the proposed model outperformed the existing techniques in terms of accuracy(94%),precision(99.1%),recall(92.43%),f-score(95.

关键词： Privacy violation Detection IDS Social network Accuracy Recall Precision F-score

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Synchronization and wave propagation in neuronal network under field coupling

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Science China(Technological Sciences) 2019年第3期62卷 448-457页

作者： LV Mi MA Jun YAO YuanGen ALZAHRANI faris Department of Physics Lanzhou University of Technology College of Electrical and Information Engineering Lanzhou University of Technology Department of Physics College of Science Huazhong Agricultural University NAAM-Research Group Department of Mathematics King Abdulaziz University

Electric and chemical synapse play important role in connecting neurons and thus signal propagation can be realized between neurons. External electric stimulus can change the excitability of neuron and then the electrical activities can be modulated completely. Continuous fluctuation of ion concentration in cell can induce complex time-varying electromagnetic field during the exchange of charged ions across the membrane of neuron. Polarization and magnetization in the media(and neuron), which exposed to electromagnetic radiation, can modulate the dynamical response and mode transition in electrical activities of neurons. In this paper, magnetic flux is used to describe the effect of electromagnetic field, and the three-variable HindmarshRose neuron model is updated to propose a four-variable neuron model that the effect of electromagnetic induction and radiation can be explained. Based on the physical law of electromagnetic induction, exchange of charged ions and flow of ion currents will change the distribution of electromagnetic filed in cell, and each neuron will be exposed to the superimposed field triggered by other neurons. Therefore, signal exchange could occur even synapse coupling between neurons is removed in the case of field coupling. A chain network is proposed to investigate the signal exchange between neurons under field coupling when synapse coupling is not available. It is found that field coupling between neurons can change the collective behaviors in electrical activities. A statistical factor of synchronization and spatial patterns are calculated, these results confirmed that field coupling is effective for signal communication between neurons. In the end, open problems are suggested for readers' extensive guidance in this field.

关键词： neuron memristor magnetic flux synchronization pattern formation

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