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Racial disparity in colorectal cancer: Gut microbiome and cancer stem cells

World Journal of Stem Cells 2016年第9期8卷 279-287页

作者： Sachin Goyal Pratima Nangia-Makke Lulu farhana Yingjie Yu Adhip PN Majumdar Department of Internal Medicine John D Dingell VA Medical Center Detroit MI 48201 United States Department of Internal Medicine Wayne State University Detroit MI 48201 United States Karmanos Cancer Institute Wayne State University School of Medicine Detroit MI 48201 United States

Over the past two decades there has been remarkable progress in cancer diagnosis, treatment and screening. The basic mechanisms leading to pathogenesis of various types of cancers are also understood better and some patients, if diagnosed at a particular stage go on to lead a normal pre-diagnosis life. Despite these achievements, racial disparity in some cancers remains a mystery. The higher incidence, aggressiveness and mortality of breast, prostate and colorectal cancers(CRCs) in AfricanAmericans as compared to Caucasian-Americans are now well documented. The polyp-carcinoma sequence in CRC and easy access to colonic epithelia or colonic epithelial cells through colonoscopy/colonic effluent provides the opportunity to study colonic stem cells early in course of natural history of the disease. With the advent of metagenomic sequencing, uncultivable organisms can now be identified in stool and their numbers correlated with the effects on colonic epithelia. It would be expected that these techniques would revolutionize our understanding of the racial disparity in CRC and pave a way for the same in other cancers as well. Unfortunately, this has not happened. Our understanding of the underlying factors responsible in African-Americans for higher incidence and mortality from colorectal carcinoma remains minimal. In this review, we aim to summarize the available data on role of microbiome and cancer stem cells in racial disparity in CRC. This will provide a platform for further research on this topic.

关键词： Colorectal cancer Cancer stem cells Racial disparity Microbiome MiRNA

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Induction of bioactive compound composition from marine microalgae(Lyngbya sp.)by using different stress condition

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Journal of Coastal Life Medicine 2013年第3期 205-209页

作者： Nurul farhana Rosly Rabeah Adawiyah Abdul Razak Palaniselvam Kuppusamy Mashitah M.Yusoff Natanamurugaraj Govindan Mammalian Cell Technology Laboratory Faculty of Industrial Sciences and TechnologyUniversiti Malaysia PahangLebuhraya Tun Razak26300 GambangKuantanPahangMalaysia

Objective:To the effect of salinity stress on the production of microalgae(Lyngbya sp.)and chlorophyll pigments in the growth ***:Stress was investigated by using green algae strains Lyngbya *** response to change bioactive compounds without any modification of cell growth and biomass production *** different stress conditions like 10%-40%were ***:During the stress condition,various biochemical and microbiological assays were *** photochemical composition was evaluated by GC-MS *** studies expressed that 30%higher salinity stress was suitable for high phytochemical production rate including chlorophyll ***:Our study indicates the wide range of salinity stress to enhance the growth on microalgae culture and enhance the production of major secondary metabolites.

关键词： Lyngbya Sp. Salinity stress Secondary metabolites Biomass Chlorophyll

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Efﬁciency and safety of sofosbuvir in Bangladeshi children with chronic hepatitis C virus

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iLIVER 2023年第3期2卷 146-150页

作者： Salahuddin Mahmud Jahida Gulshan MdBelayet Hossain Madhabi Baidya Rafia Rashid farhana Tasneem Ahmed Rashidul Hasan Tanzila farhana Mohammed Reaz Mobarak MdJahangir Alam Syed Shafi Ahmed Department of Pediatric Gastroenterology Hepatology&NutritionBangladesh Shishu Hospital&InstituteDhakaBangladesh Institute of Statistical Research and Training(ISRT) University of DhakaDhakaBangladesh Department of Pediatric Hematology&Oncology Bangladesh Shishu Hospital&InstituteDhakaBangladesh Department of Pediatric Gastroenterology Dr.M R Khan Shishu Hospital&Institute of Child HealthDhakaBangladesh Department of Pediatrics BIHS General HospitalDiabetic Association of BangladeshDhakaBangladesh Department of Epidemiology&Research Bangladesh Shishu Hospital&InstituteDhakaBangladesh Bangladesh Shishu Hospital&Institute DhakaBangladesh

Background and aims:Currently,treatment with oral direct-acting antivirals is recommended for all hepatitis C virus(HCV)-infected pediatric *** aim of this study was to evaluate the efficacy and safety of sofosbuvir and ribavirin combination ther apy for children and adolescents in Bangladesh who are living with chronic HCV in ***:An experimental study was performed from January 2021 to December *** polymerase chain reaction(PCR)-positive thalassemic children,who were 6–18 years of age,were enrolled by consecutive non-probability *** features were recorded,and investigations were *** patients were initially treated with sofosbuvir(200 mg for 6-to 11-year-olds and 400 mg for 12-to 18-year-olds)and ribavirin(10–15 mg/kg/day)and were assessed clinically on a four-weekly basis,along with liver-function *** total duration of therapy was 24 *** PCR was done at the end of treatment and 12 weeks after the completion of treatment to see the sustained virological ***:There were 26 cases in total,with a mean age of 9.26?2.82 years;14 were males(53.8%),and 12 females(46.2%).Twenty-five(96.15%)patients achieved a sustained virological response,and the end-of-treatment PCR was *** patient(3.85%)was a nonresponder even after 24 weeks of *** medication was well received,with only four patients(15.3%)reporting headaches that were reported ***:The combination of sofosbuvir and ribavirin is effective in treating chronic HCV infection and is not accompanied by any major negative side effects.

关键词： Hepatitis C virus Direct-acting antivirals Sofosbuvir Ribavirin

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The Efficacy of Ferumoxytol in Peritoneal Dialysis Patients: A Short Scientific Report

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Open Journal of Nephrology 2014年第2期4卷 100-102页

作者： Sayed Husain Hani Judeh Manaf Alroumoh farhana Yousaf Prince Mohan Ahla Husain Chaim Charytan Bruce Spinowitz Cape Fear Valley Hospital NC Fayetteville USA Columbia Medical University New York USA New York Hospital Queens New York USA South Texas Regional Medical Center San Antonio USA St. Luks/Roosevelet Hospital New York USA

One of the major elements contributing to anemia in Chronic Kidney Disease (CKD) patients is iron deficiency. Iron supplementation in oral form is often not tolerated and ineffectively absorbed. Intravenous (IV) infusion is time consuming and is inconvenient in Peritoneal Dialysis (PD) patients self-treating at home. A new preparation of iron, ferumoxytol, is a carbohydrate-coated, paramagnetic iron oxide nanoparticle, which can be administered as a bolus intravenous injection, allowing the PD patient to more easily comply with current IV iron dosing regimens. Few studies have been done to evaluate the efficacy of ferumoxytol in PD population. We retrospectively reviewed the medical records of peritoneal dialysis patients who received at least one dose of ferumoxytol between January 2010 and August 2010 and observed that 17 patients showed an improvement in hemoglobin (Hb) to 1 gm/dl within a month of treatment along with a decrease in epoetin dosage in subsequent weeks.

关键词： Anemia Ferumoxytol Peritoneal Dialysis

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激素抑制P38 MAPK依赖性支气管收缩的实验研究

激素抑制P38 MAPK依赖性支气管收缩的实验研究

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中华医学会呼吸病学年会——2011（第十二次全国呼吸病...

作者：李锋张旻 Triantaphyllopoulos Kostas Hussain farhana Bhavsar Pankaj K Chung Kian Fan 周新上海交通大学附属第一人民医院呼吸科 Experimental Studies Section of Airway DiseaseNational Heart and Lung InstituteImperial CollegeLondonUK200080

目的研究p38 MAPK是否参与臭氧暴露后小鼠气道气道平滑肌收缩性增高以及激素是否通过调节p38 MAPK而抑制增高的气道收缩反应。因为MKP-1是MAPK通路(包括p38MAPK)的生理性抑制剂,我们应用MKF-1小鼠。方法野生型小鼠和MKP-1小鼠分为对照...

目的研究p38 MAPK是否参与臭氧暴露后小鼠气道气道平滑肌收缩性增高以及激素是否通过调节p38 MAPK而抑制增高的气道收缩反应。因为MKP-1是MAPK通路(包括p38MAPK)的生理性抑制剂,我们应用MKF-1小鼠。方法野生型小鼠和MKP-1小鼠分为对照组和臭氧吸入组,分别暴露于空气或臭氧(3ppm;3小时)

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Screening of Methyl Red Degrading Bacteria Isolated from Textile Effluents of Savar Area, Dhaka, Bangladesh

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Advances in Bioscience and Biotechnology 2020年第7期11卷 301-318页

作者： Ishteak Ahmed farhana Haque Mirza A. T. M. Tanvir Rahman Md. Anowar Khasru Parvez Taslin Jahan Mou Department of Microbiology Jahangirnagar University Savar Bangladesh Department of Environmental Sciences Jahangirnagar University Savar Bangladesh

Physicochemical properties and metal contents of five dye-based textile effluents collected in summer and winter season, 2016 from Savar, Dhaka, Bangladesh were within the recommended acceptable limit. The average value of all physicochemical parameters was found high in summer season except turbidity. A total of 94 heavy metal resistant bacteria (46 gram positive & 48 gram negative) were isolated from textile effluent samples and among them 17 isolates were multi metal resistant. Highest tolerance level of the isolates was shown at 10 mM concentration against Pb. All the heavy metal resistant bacterial isolates were presumably grouped into 14 genera according to morphological and biochemical assay. Three isolates designated WFB3c (65.41%), WFB4g (62%) and SFB5c (60.07%) were found to potentially degrade dye as well as tolerate heavy metals. Three potential dye decolorizer isolates were screened out and most potential one (WFB3c) was identified as P

关键词： Textile Effluent Metal Resistant Dye Decolorizer Proteus mirabilis

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宏观流动性失衡逆转新探——基于马尔可夫机制转换模型

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太原理工大学学报（社会科学版） 2013年第1期31卷 31-35页

作者：石春霞 farhana Ferdousi 王秋红武汉大学中国中部发展研究院湖北武汉430072 武汉大学经济与管理学院湖北武汉430072 复旦大学金融研究院上海200433

由于我国宏观流动性过剩或者短缺的状态并不是相互独立的,而是与前一期或者前几期的状态具有相关性,因此构建马尔可夫机制转换模型可对我国流动性的变化做出进一步的分析解释。从模型拟合结果来看,我国宏观流动性表现为以下特点:流动性... 详细信息

由于我国宏观流动性过剩或者短缺的状态并不是相互独立的,而是与前一期或者前几期的状态具有相关性,因此构建马尔可夫机制转换模型可对我国流动性的变化做出进一步的分析解释。从模型拟合结果来看,我国宏观流动性表现为以下特点:流动性序列"过剩"与"短缺"相互转换;机制取值平滑概率趋于"不足"时期伴随着序列较大的波动;流动性的不同状态所持续的时间存在非对称性。文章旨在为宏观流动性的逆转提供决策依据,使宏观流动性预测更具科学性。

关键词：宏观流动性逆转马尔可夫机制

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Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans

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World Journal of Gastrointestinal Pathophysiology 2018年第2期9卷 47-58页

作者： Lulu farhana Fadi Antaki Farhan Murshed Hamidah Mahmud Stephanie L Judd Pratima Nangia-Makker Edi Levi Yingjie Yu Adhip PN Majumdar Department of Internal Medicine John D Dingell Veterans Affairs Medical Center Department of Internal Medicine Wayne State University School of Medicine Division of Gastroenterology John D Dingell VA Medical Center Department of Medicine Karmanos Cancer Institute Department of Pathology Service John D Dingell VA Medical Center

AIM To determine whether and to what extent the gut microbiome is involved in regulating racial disparity in colorectal cancer(CRC). METHODS All patients were recruited and experiments were performed in accordance with the relevant guidelines and regulations by the Institutional Review Boards (IRB), committees of the John D. Dingell VAMC and Wayne State University guidelines. African American (AA) and Caucasian American (CA) patients were scheduled for an outpatient screening for colonoscopy, and no active malignancy volunteer patients were doubly consented, initially by the gastroenterologist and later by the study coordinator, for participation in the study. The gut microbial communities in colonic effluents from AAs and CAs were examined using 16 sRNA profiling, and bacterial identifications were validated by performing SYBR-based Real Time PCR. For metagenomic analysis to characterize the microbial communities, multiple software/tools were used, including Metastats and R statistical *** It is generally accepted that the incidence and mortality of CRC is higher in AAs than in CAs. However, the reason for this disparity is not well understood. We hypothesize that the gut microbiome plays a role in regulating this disparity. Indeed, we found significant differences in species richness and diversity between AAs and CAs. Bacteroidetes was more abundant in AAs than in CAs. In particular, the pro-inflammatory bacteria Fusobacterium nucleatum and Enterobacter species were significantly higher in AAs, whereas probiotic Akkermansia muciniphila and Bifidobacterium were higher in CAs. The polyphyletic Clostridia class showed a divergent pattern, with Clostridium XI elevated in AAs, and Clostridium IV, known for its beneficial function, higher in CAs. Lastly, the AA group had decreased microbial diversity overall in comparison to the CA group. In summary, there were significant differences in pro-inflammatory bacteria and microbial diversity between AA and CA, w

关键词： Human gut Microbiome Colorectal cancer Fusobacterium nucleatum African Americans 16S RNA profiling Metagenomics

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Identification of Aflatoxigenic Fungi and Detection of Their Aflatoxin in Red Chilli (<i>Capsicum annuum</i>) Samples Using Direct Cultural Method and HPLC

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Advances in Microbiology 2018年第1期8卷 42-53页

作者： Md. Nur Hossain Asma Talukder farhana Afroze Md. Matiur Rahim Shamima Begum Md. Zahurul Haque Monzur Morshed Ahmed Industrial Microbiology Laboratory Institute of Food Science and Technology (IFST) Bangladesh Council of Scientific and Industrial Research (BCSIR) Dhanmondi Dhaka Bangladesh Department of Genetics and Biotechnology Noakhali Science and Technology University Noakhali Bangladesh Department of Microbiology Jagganath University Dhaka Bangladesh Food Toxicology Research Laboratory Institute of Food Science and Technology (IFST) Bangladesh Council of Scientific and Industrial Research (BCSIR) Dhanmondi Dhaka Bangladesh

Aflatoxins are the potential lethal toxin produced by Aspergillus sp. important health hazard throughout the world. In this study, 26 Aspergillus sp. have been isolated from 50 samples of red chilli collected throughout the country. These 26 isolates were grown primarily on agar media to identify the aflatoxin producing species. It is possible to distinguish A. flavus strains from other Aspergillus sp. developing orange colour on the reverse of the plates. The Coconut Cream Agar (CCA) is used to detect aflatoxin producer strains having blue fluorescence when exposed to a UV-light. Several other media were used for morphological characteristics of Aspergillus sp. Out of 26 isolates, four isolates were confirmed as Aspergillus sp. These isolates were subjected to cross contamination with freshly ground, sterile maize and after 15 days of incubation the contaminated maize were analyzed by HPLC and found aflatoxin in each of the sample containing 186 ppb (max.). This study was conducted to assay the ability to produce aflatoxins by the Aspergillus spp. isolated from red chilli (Capsicum annuum L. Solanaceae) available throughout the country. The results found in the experiment are much more behind the acceptable limit according to some international standard. As red chilli is a widely used spice in Bangladesh, the proper controlling measures may be taken for controlling the surveillance of aflatoxinic fungi like as use of bio-pesticides, proper drying method and storage conditions.

关键词： Aflatoxin Aspergillus Detection HPLC Red Chilli

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Determinants of Health Care Seeking Behaviors in Puerperal Sepsis in Rural Sindh, Pakistan: A Qualitative Study

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Open Journal of Preventive Medicine 2020年第9期10卷 255-266页

作者： Shabina Ariff Fatima Mir farhana Tabassum Farrukh Raza Atif Habib Ali Turab Amnesty LeFevre Linda A. Bartlett Sajid Bashir Soofi Zulfiqar A. Bhutta Department of Paediatric and Child Health Aga Khan University Karachi Pakistan Center of Excellence in Women & Child Health Aga Khan University Karachi Pakistan Department of International Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA

Background: Puerperal sepsis (PS) is one of the major causes of maternal death, contributing to 26,000 deaths per year in developing countries. Early recognition and treatment are essential to managing PS, but numerous social, cultural and technical barriers prevent or delay access to care and necessary medical attention. Through this qualitative study, we identified barriers to care seeking for puerperal sepsis among recently delivered women in Matiari, Pakistan. Methods: We conducted 20 in-depth interviews among recently delivered women with and without sepsis and their family members in September 2012. Key informant interviews were conducted with 14 healthcare providers and traditional birth attendants. The themes used for content analysis were knowledge of danger signs, factors affecting care seeking and local treatment practices for postpartum sepsis. Results: A total of 34 interviews were conducted. Recently delivered women, their family members and traditional birth attendants were unaware of the word PS or the local translated term for PS. However, they were familiar with most of the individual symptoms associated with PS. Healthcare providers were aware of the condition and the associated symptoms. The healthcare providers’ understanding of the seriousness of PS was directly proportional their age and clinical experience. The most common barriers to care seeking was the division of labor within the household, obtaining permission from the primary decision maker, access to transportation, lack of financial resources and support from family members. Conclusion: To improve maternal care seeking behaviors for PS, interventions focusing on increasing knowledge of PS, addressing gender inequality, implementing an affordable community transport service and enhancing TBA’s knowledge and skills to manage PS need to be implemented.

关键词： Puerperal Sepsis Qualitative Care Seeking Barrier Maternal Health

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