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Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients

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World Journal of Gastrointestinal Oncology 2012年第5期4卷 103-108页

作者： Taher Abu Hejleh Barry R deYoung Eric Engelman Jeremy M deutsch Bridget Zimmerman Thorvardur R Halfdanarson daniel J Berg Kalpaj R Parekh William R Lynch Mark d Iannettoni Sudershan Bhatia Gerald Clamon division of Hematology Oncology and Marrow TransplantationDepartment of Internal MedicineUniversity of Iowa Hospitals and Clinics200 Hawkins DriveC32 GHIowa CityIA 52242-1081United States department of Pathology University of Iowa Hospitals and Clinics200 Hawkins Drive5238C RCPIowa CityIA 52242-1081United States department of Biostatistics College of Public HealthUniversity of Iowa200 Hawkins DriveN377 CPHBIowa CityIA 52242-1081United States department of Cardiothoracic Surgery University of Iowa Hospitals and Clinics200 Hawkins DriveSE514 GHIowa CityIA 52242-1081United States department of Radiation Oncology University of Iowa Hospitals and Clinics200 Hawkins Drive1624 PFPIowa CityIA 52242-1081United States

AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following ***:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and *** analyzed consisted of demographic and clinical *** brain metastasis tissue was assayed for HER-2 overexpression utilizing the FdA approved dAKO Hercept Test.RESULTS:One hundred and forty two patients were *** age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant *** complete and partial responses were achieved in 17(19%) and 71(81%) *** relapsed in 43/142(30%) *** brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following *** studies will be required to validate this observation.

关键词： Esophageal neoplasm Esophageal cancer HER-2 Genes,erbB-2 Brain Neoplasms Brain metastasis

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电熔法生产氧化锆副产物硅灰性质与颗粒特性

中国粉体技术 2018年第6期24卷 25-29页

作者：孙思佳丁浩史亚超中国地质大学(北京)材料科学与工程学院北京100083

为优化电熔法生产氧化锆过程副产物硅灰(dR-gh)加工技术、提高其利用价值,采用粒度分布测试、扫描电子显微镜(SEM)和透射电子显微镜(TEM)观察,并结合化学元素、X射线衍射(XRd)分析、dR-gh水悬浮液搅拌手段,对dR-gh的化学成分、物相组成... 详细信息

为优化电熔法生产氧化锆过程副产物硅灰(dR-gh)加工技术、提高其利用价值,采用粒度分布测试、扫描电子显微镜(SEM)和透射电子显微镜(TEM)观察,并结合化学元素、X射线衍射(XRd)分析、dR-gh水悬浮液搅拌手段,对dR-gh的化学成分、物相组成、颗粒特性进行研究。结果表明,dR-gh主要由无定形SiO_2实心体微球和少量ZrO_2粒子组成,SiO_2微球原级粒径为0.5～3μm,彼此间先聚集形成结合力强的二次颗粒,再由二次颗粒凝聚成结合力较弱的SiO_2团聚体。对dR-gh水悬浮液搅拌可使SiO_2团聚体解聚至二次颗粒尺度,其粒度d_(90)由18.551μm降至5.379μm,d_(50)由2.582μm降至1.88μm。

关键词：硅灰无定形SiO2 颗粒解聚

由显微注射了金属巯基组氨酸三甲内盐—生长激素融合基因的受精卵发育而戍的小鼠生长显著

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遗传工程 1984年第3期 20-26页

作者： R.d.Palmiter R.L.Brinster R.E.Hammer M.E.Trumbauer M.G.Rosenfeld N.C.Birnberg 戴宗汉

将大鼠生长激素结构基因与小鼠金属巯基组氨酸三甲内盐—Ⅰ基因启动子相融合,用此dNA片段显微注射入小鼠受精卵的原核中。由这些受精卵发育成的21只小鼠中,有7只具有融合基因,其中有6只比它们的同胎小鼠长得要显著地大。这些基因转移小... 详细信息

将大鼠生长激素结构基因与小鼠金属巯基组氨酸三甲内盐—Ⅰ基因启动子相融合,用此dNA片段显微注射入小鼠受精卵的原核中。由这些受精卵发育成的21只小鼠中,有7只具有融合基因,其中有6只比它们的同胎小鼠长得要显著地大。这些基因转移小鼠中,有几只在其肝脏中有很高水平的融合mRNA,在其血清中则有很高水平的生长激素。这个工作对于研究生长激素的生物学效应;作为一个加速动物生长的途径;作为巨大发育的模型;作为矫正遗传疾病的工具以及作为生产有价值的基因产物的方法,都具有潜在的意义。

关键词：小鼠生长肝脏 gh 生长激素 mRNA 显微注射动物受精卵大鼠组氨酸内盐两性离子巯基

选择性头部降温在新生儿脑病后全身轻度低温中应用的多中心随机试验

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 1-1页

作者： Gluckman P.d. Wyatt J.S. Azzopardi d. A. J. Gunn 郭俊 department of Physiology Fac. of Medicine and Health Science Private Bag 92019 AucklandNew Zealand Dr.

Background: Cerebral hypothermia can improve outcome of experimental perinatal hypoxia-ischaemia. We did a multicentre randomised controlled trial to find ou t if delayed head cooling can improve neurodevelopmental outcome in babies with neonatal ***: 234 term infants with moderate to severe neonat al encephalopathy and abnormal amplitude integrated electroencephalography (aEEG ) were randomly assigned to either head cooling for 72 h, within 6 h of birth, w ith rectal temperature maintained at 34-35°C (n=116), or conventional care (n= 118). Primary outcome was death or severe disability at 18 months. Analysis was by intention to treat. We examined in two predefined subgroup analyses the effec t of hypothermia in babies with the most severe aEEG changes before randomisatio n -ie, severe loss of background amplitude, and seizures-and those with less s evere changes. Findings: In 16 babies, follow-up data were not available. Thus in 218 infants (93%), 73/110 (66%) allocated conventional care and 59/108 (55 %) assigned head cooling died or had severe disability at 18 months (odds ratio 0.61; 95%CI 0.34-1.09, p=0.1). After adjustment for the severity of aEEG chan ges with a logistic regression model, the odds ratio for hypothermia treatment w as 0.57 (0.32-1.01, p=0.05). No difference was noted in the frequency of clinic ally important complications. Predefined subgroup analysis suggested that head c ooling had no effect in infants with the most severe aEEG changes (n=46, 1.8; 0. 49-6.4, p=0.51), but was beneficial in infants with less severe aEEG changes (n =172, 0.42; 0.22-0.80, p=0.009). Interpretation: These data suggest that althou gh induced head cooling is not protective in a mixed population of infants with neonatal encephalopathy, it could safely improve survival without severe neurode velopmental disability in infants with less severe aEEG changes.

关键词：脑病温中随机试验失能随机对照试验随机化延迟性围生期预后指标低温治疗

妊娠相关的中心性浆液性脉络膜视网膜病变的光学相干眼底扫描结果

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 39-39页

作者： Rezai K.A. Eliott d. 秦雪娇 Kresge Eye Institute Wayne State Univ. Schoo l of Medicine 4717 St. Antoine Detroit MI 48201 United States

Purpose: To report the presence and disappearance of subretinal fibrinous exud ate in pregnancy-induced central serous chorioretinopathy studied with optical coherence tomography (OCT). Methods: Case report. A 32-year-old woman was refe rred for ophthalmoscopic evaluation in her 32nd week of pregnancy, complaining o f reduced vision in her right eye. Results: The funduscopic examination revealed a serous detachment of the macula with subretinal exudative deposits in the rig ht eye and a peripapillary serous detachment in the left eye. OCT sections throu gh the right macula demonstrated serous elevation of the retina and the presence of highly reflective material in the subretinal space. Two weeks after delivery , OCT showed resolution of subretinal fluid and the disappearance of submacular exudate in the right eye. Conclusion: during pregnancy and immediately after del ivery, OCT may provide information reflecting the relationship between the retin a, subretinal space, and retinal pigment epithelium without any known adverse ef fects to the infant. In a patient with pregnancy-associated central serous chor ioretinopathy, a highly reflective material, presumably fibrin, was detected spa nning the subretinal space that was subsequently shown to disappear. This inform ation may help us better understand the pathological retinal changes that may oc cur during pregnancy.

关键词：视网膜下间隙视网膜病浆液性脱离视网膜色素上皮右眼视力眼底镜检查黄斑部视网膜下液乳头周围

2岁以下的Prader-Willi综合征患儿的生长激素水平和机体组分

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 40-40页

作者： Eiholzer U. L' Allemand d Schlumpf M 贺莉 Found. Growth Puberty Adolescence Moehrlistrasse 69 CH-8006 Zurich Switzerland

目的:通过使用氘稀释法以及调查早期使用生长激素(gh)治疗在增加肌肉含量(LM)和防止均匀性肥胖方面的疗效,来评价Prader-Willi综合征(PWS)患儿的机体组分。试验设计:由11例<2岁的PWS患儿组成gh组,对他们进行为期30个月的gh治疗,6例只给... 详细信息

目的:通过使用氘稀释法以及调查早期使用生长激素(gh)治疗在增加肌肉含量(LM)和防止均匀性肥胖方面的疗效,来评价Prader-Willi综合征(PWS)患儿的机体组分。试验设计:由11例gh组,对他们进行为期30个月的gh治疗,6例只给予辅酶Q10治疗1年的婴幼儿组成Q10组。由95名健康儿童的资料计算得出身高校正后的LM含量(LMH1)

关键词：稀释法资料计算均匀性试验设计 therap 正常体重 obesity 脂肪组织 institution deviation

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难变形gh049合金热轧棒材新工艺的研制

上海钢研 2006年第3期 25-27,32页

作者：王世普谢伟康金波宝山钢铁股份有限公司特殊钢分公司特殊钢技术中心上海200940

本文研究了gh4049合金电渣锭高温均匀化后采用恒温韧性轧制新工艺,减少了轧制火次,改善了表面质量,有效地提高了生产效率和成材率。

关键词： gh4049 高温均匀化恒温韧性轧制工艺

5-HT_(1A)受体显像剂^(99)Tc^mO(MP MEP)(BMPdEEdA)的研究

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中华核医学杂志 2003年第2期23卷 110-113页

作者：刘飞李洪玉梁积新刘英妹贺佑丰罗志福王荣福何晓坤张春丽付占立北京师范大学化学系 100875 中国原子能科学研究院同位素研究所北京102413 北京大学第一医院核医学科

目的　探讨研制99Tcm [N (2 (4 (2 甲氧基苯 ) 1 哌嗪 1 乙基 ) N (2 吡啶 ) 环己烷酰胺 ) ](WAY10 0 6 35 )类似物中枢神经系统 5 羟色胺 1A(5 HT1A)受体显像剂。方法　将化学合成的单齿配体 1 (2 甲氧基苯基 ) 4 (2 巯... 详细信息

目的　探讨研制99Tcm [N (2 (4 (2 甲氧基苯 ) 1 哌嗪 1 乙基 ) N (2 吡啶 ) 环己烷酰胺 ) ](WAY10 0 6 35 )类似物中枢神经系统 5 羟色胺 1A(5 HT1A)受体显像剂。方法　将化学合成的单齿配体 1 (2 甲氧基苯基 ) 4 (2 巯基乙基 )哌嗪 (MPMEP)和三齿配基N ,N 二 (2 巯基乙基 ) N′,N′ 二乙基乙二胺 (BMPdEEdA)与99Tcm 葡庚糖酸钠 (gh)经三齿配体与单齿配体混合标记方法 (“3+1”)混合配体交换 ,制得99TcmO(MPMEP) (BMPdEEdA)。同时 ,以大鼠脑海马膜组织匀浆为 5 HT1A 受体来源 ,与 5 HT1A受体的特异激动剂3H 2 (二 n 丙胺基 ) 8 羟基四氢化萘 (8 OH dPAT)进行体外竞争结合实验 ,测定99Tcm 标记物的类似物ReO(MPMEP) (BMPdEEdA)对受体蛋白与特异拮抗 (激动 )剂竞争结合达到一半 (5 0 % )时的浓度 (IC50 值 )。结果　制备的99TcmO(MPMEP) (BMPdEEdA)经高压液相层析 (HPLC)纯化并测定其放化纯度 >95 %。大鼠脑海马摄取在注射后 30、6 0、12 0、180min时 %Id g分别为 0 .0 77、0 .0 6 8、0 .0 84和 0 .0 6 7,放射性摄取最高部位为丘脑 ,注射后 12 0min时 %Id g为 0 .15 4 ,各时相海马与小脑的摄取比值分别为 0 .84 7、0 .880、0 .92 1和 1.2 4 4。ReO(MPMEP) (BMPdEEdA)的IC50为 98.

关键词： 5-HTlA 受体显像剂 ^99Tc^mO(MPMEP) 5-羟色胺化学合成

冠状动脉钙化积分可以预测未来的心功能吗?MRI表现为亚临床动脉粥样硬化伴左心室收缩和舒张功能障碍的一组中老年队列研究

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国际医学放射学杂志 2010年第6期 571-571页

作者： P.M.Colletti L.d.dustin N.d.Wong J.E.Shriki M.Kawakubo S.P.Azen 何珍 department of Radiology Keck School of Medicine University of Southern California1200 N State StLAC+USC Medical Center GH 3566Los AngelesCA 90033

目的评估亚临床动脉粥样硬化的冠状动脉钙化积分(CAC)与预测无症状中老年人左心室收缩和舒张功能未来的相关性。材料与方法南加利福尼亚大学和加利福尼亚

关键词：冠状动脉钙化积分 MRI 左心室心室收缩亚临床动脉粥样硬化舒张功能