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Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2:Prospective therapeutic challenges

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World Journal of Gastroenterology 2021年第15期27卷 1531-1552页

作者： fares e.m ali Zuhair m mohammedsaleh mahmoud m ali Osama m Ghogar Department of Pharmacology and Toxicology Faculty of PharmacyAl-Azhar UniversityAssiut BranchAssiut 71524Egypt Department of medical Laboratory Technology Faculty of Applied Medical SciencesUniversity of TabukTabuk 71491Saudi ArabiaDepartment of Medical Laboratory TechnologyFaculty of Applied Medical SciencesUniversity of TabukTabuk 71491Saudi Arabia Pre-graduated students Faculty of PharmacyAl-Azhar UniversityAssiut BranchAssiut 71524Egypt

Coronavirus disease 2019(COVID-19)is a devastating worldwide pandemic infection caused by a severe acute respiratory syndrome namely coronavirus 2(SARS-CoV-2)that is associated with a high spreading and mortality *** the date this review was written,SARS-CoV-2 infected about 96 million people and killed about 2 million *** arguments disclosed the high mortality of COVID-19 due to acute respiratory distress syndrome or change in the amount of angiotensin-converting enzyme 2(ACe2)receptor expression or cytokine storm strength *** a similar pattern,hepatic impairment patients co-infected with SARS-CoV-2 exhibited overexpression of ACe2 receptors and cytokine storm overwhe.ming,which worsens the hepatic impairment and increases the.mortality *** this review,the impact of SARS-CoV-2 on hepatic impairment conditions we ***,we focused on the recent studies that indicated cytokine storm as well as ACe2 as the.main factors for high COVID-19 spreading and mortality while hinting at the potential therapeutic strategies.

关键词： COVID-19 Hepatic impairment SARS-CoV-2 Cytokine storm Immunomodulators receptors

COVID-19 and hepatic injury: cellular and molecular mechanisms in diverse liver cells

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World Journal of Gastroenterology 2023年第3期29卷 425-449页

作者： fares e.m ali mostafa K Abd el-Aziz mahmoud m ali Osama m Ghogar Adel G Bakr Department of Pharmacology and Toxicology Faculty of PharmacyAl-Azhar UniversityAssiut 71524Egypt Department of Pharmacology Al-Azhar UniversityAssiut 71524Egypt Department of Biochemistry Faculty of Pharmacy Badr University in AssiutEgypt

The coronavirus disease 2019(COVID-19)represents a global health and economic *** injuries have been approved to be associated with severe acute respiratory syndrome coronavirus(SARS-CoV-2)*** viral tropism pattern of SARS-CoV-2 can induce hepatic injuries either by itself or by worsening the conditions of patients with hepatic ***,other factors have been reported to play a crucial role in the pathological forms of hepatic injuries induced by SARS-CoV-2,including cytokine storm,hypoxia,endothelial cells,and even some treatments for *** the other hand,several groups of people could be at risk of hepatic COVID-19 complications,such as pregnant women and *** present review outlines and discusses the interplay between SARS-CoV-2 infection and hepatic injury,hepatic illness comorbidity,and risk ***,it is focused on the vaccination process and the role of developed vac-cines in preventing hepatic injuries due to SARS-CoV-2 infection.

关键词： COVID-19 Hepatic injury Viral tropism COVID-19 comorbidity Vaccination

Abundant exact Traveling Wave Solutions of Generalized Bretherton equation via Improved (G′/G)-expansion method

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Communications in Theoretical Physics 2012年第2期57卷 173-178页

作者： m.ali Akbar Norhashidah Hj.mohd.ali e.m.e.Zayed School of mathematical Sciences Universiti Sains MalaysiaMalaysia mathematics Department Faculty of ScienceZagazig UniversityZagazigEgypt

In this article, we construct abundant exact traveling wave solutions involving free parameters to the generalized Bretherton equation via the improved (G′/G)-expansion method. The traveling wave solutions are presented in te.ms of the trigonometric, the hyperbolic, and rational functions. When the parameters take special values, the solitary waves are derived from the traveling waves.

关键词： improved (G'/G)-expansion method travelling wave solutions the Bretherton equation nonlinearevolution equations

Generalized and Improved(G′/G)-expansion method Combined with Jacobi elliptic equation

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Communications in Theoretical Physics 2014年第6期61卷 669-676页

作者： m.ali Akbar Norhashidah Hj.mohd.ali e.m.e.Zayed School of mathematical Sciences Universiti Sains Malaysia Department of Applied mathematics University of Rajshahi mathematics Department Faculty of Science Zagazig University

In this article, we propose an alternative approach of the generalized and improved （G＇/G）-expansion method and build some new exact traveling wave solutions of three nonlinear evolution equations, namely the Boiti- Leon-Pempinelle equation, the Pochhammer-Chree equations and the Painleve integrable Burgers equation with free parameters. When the free parameters receive particular values, solitary wave solutions are constructed from the traveling waves. We use the Jacob/elliptic equation as an auxiliary equation in place of the second order linear equation. It is established that the proposed algorithm offers a further influential mathematical tool for constructing exact solutions of nonlinear evolution equations.

关键词： Boiti-Leon-Pempinelle equation Painleve integrable burgers equation Pochhammer-Chree equa-tion (GI/G)-expansion method traveling wave solutions

Phase analysis of AlFe2B2 by synchrotron X-ray diffraction,magnetic and m?ssbauer studies

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Progress in Natural Science.materials International 2017年第2期27卷 251-256页

作者： Tahir ali m.N.Khan e.Ahmed Asad ali Physics Division Pakistan Institute of Nuclear Science and technology Department of Physics Abdul Wali Khan University PINSAT Preston University

The structural and magnetic properties of essentially phase pure AlFe2B2prepared by arc melting were compared with a sample containing impurities. Analysis was carried out by means of synchrotron X-ray diffraction, magnetic measurements and m?ssbauer spectroscopy. The analysis of synchrotron X-ray diffraction data confirmed the orthorhombic structure of space group Cmmm for AlFe2B2with Al13Fe4as main impurity phase. The.magnetic measurements revealed an unsaturated ferromagnetic state in AlFe2B2with a transition temperature（Tc） of 286 K. Isothe.mal magnetization measurment at 5 K gave a saturation magnetization of 0.7 μB per Fe atom while Arrott plots establish the second order nature of ferromagnetic transition. The the.mal evolution of m?ssbauer spectra confirmed the ferromagnetic nature of this material revealing an hyperfine field of 73 kOe and an isomer shift of 0.46 mm/s at 100 K. The.m?ssbauer spectra of a phase pure sample was compared with the one containing impurity phases. It is suggested that the low temperature paramagnetic contribution in m?ssbauer spectra of phase pure.material may have its origin in some intrinsic phenomena arising from defects or inhomogeneities in crystal structure.

关键词： AlFe2B2 Synchrotron X-ray diffraction Ferromagnetism mossbauer effect spectroscopy

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari marta Cozzi elena Casarotto Paola Pramaggiore Laura Cornaggia Guglie.mo Patelli ali mohamed margherita Piccolella mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the.model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

Pressure-Driven Gas Flows in micro Channels with a Slip Boundary:A Numerical Investigation

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Fluid Dynamics & materials Processing 2020年第2期16卷 147-159页

作者： A.Aissa m.e.A.Slimani F.mebarek-Oudina R.fares A.Zaim L.Kolsi m.Sahnoun m.e.Ganaoui Laboratoire de Physique Quantique de la matière et modélisation mathématique(LPQ3m) University of MascaraMascaraAlgeria Department of energetic and Fluid mechanics University of Science and Technology Houari BoumedieneAlgiers16111Algeria Depatment of Physics Faculty of SciencesUniversity of 20 août 1955-SkikdaSkikdaAlgeria mechanical engineering Department College of EngineeringHaïl UniversityHaïl2240Saudi Arabia Laboratory of metrology and energy Systems University of MonastirMonastir5000Tunisia Le.mAB IUT LongwyUniversitéde LorraineCosnes et Romain54400France

In this paper,flow of slightly rarefied compressible nitrogen in microchannels has been investigated numerically for low values of Reynolds and mach *** 2D governing equations were solved using Finite element method with first-order slip boundary conditions(Comsol multiphysics software).A validation was performed by comparing with similar configuration from the *** was found that our model can accurately predict the pressure driven flow in *** interesting findings are reported about the Relative pressure,longitudinal velocity,mach number,effect of gas rarefaction and flow rate.

关键词： Pressure driven slip flow microchannels gas flow rarefactioneffect

Fractional-Order model for multi-Drug Antimicrobial Resistance

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Computer modeling in engineering & Sciences 2020年第8期124卷 665-682页

作者： m.F.elettreby ali S.Alqahtani e.Ahmed mathematics Department Faculty of ScienceKing Khalid UniversityAbha9004Saudi Arabia mathematics Department Faculty of ScienceMansoura UniversityMansoura35516Egypt

Drug resistance is one of the.most serious phenomena in financial,economic and medical *** present paper proposes and investigates a simple.mathematical fractional-order model for the phenomenon of multi-drug antimicrobial *** model describes the dynamics of the susceptible and three kinds of infected *** first class of the infected society responds to the first antimicrobial drug but resists to the second *** second infected individuals react to the second antimicrobial drug but resist to the first *** third class shows resistance to both of the two *** formulate the.model and associate it with some of its *** stability conditions of the.multi-drug antimicrobial resistance equilibrium states are *** illustrate the analytical results by some numerical simulations.

关键词： Susceptible infectious drug resistance stability predictor-corrector method

Geology and mineral Chemistry of Uranium-and Thorium-bearing minerals in Rare.metal(NYF)Pe.matites of Um Solimate,South eastern Desert,egypt

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Acta Geologica Sinica(english edition) 2021年第5期95卷 1568-1582页

作者： mohamed A.ali Ahmed e.ABDeL GAWAD mohamed m.GHONe.m Nuclear materials Authority 530 El-MaadiCairoEgypt

The garnet muscovite granitic pe.matite of Um Solimate,in southern egypt,represents a promising asset for strategic and economic metals,especially Bi-Ni-Ag-Nb-Ta as well as U and *** ore bodies occur as large.masses,pockets and/or veins of very coarse-grained pe.matites,which consist mainly of K-feldspar,quartz and albite with subordinate.muscovite,garnet,and *** data revealed that e U-and e Th-contents of the pe.matites reach up to 39 ppm and 82 ppm,*** studied pe.matites are enriched in primary U and Th minerals(uraninite,coffinite,thorianite and uranothorite)as well as Hf-rich zircon and monazite,which give rise to anomalous radioactive ***-tantalium-bearing minerals(***,microlite and uranopyrochlore),xenotime,barite,galena,fluorite,and apatite are ubiquitous,and,consequently,the studied pe.matites belong tothe Niobium-Yttrium-Fluorine-type(NYF)*** noble.metal mineralization includes argentite(Ag_(2)S),native Ni and Bi as well as bismite and *** addition,beryl and tourmaline are observed in pe.matites near the contact with metasediments and ultramafic *** observed compositional variations of Ta/(Ta+Nb)and mn/(mn+Fe)ratios in columbite(0.08-0.45 and 0.11-0.57,respectively)and Hf contents in zircon(3.54-6.46 wt%)may reflectan extreme degree of magmatic fractionation leading to formation of the pe.matite orebody.

关键词： radioactivity rare.metal mineralization pe.matites U/Th-bearing minerals Um Solimate egypt