Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis:Comprehensive study

作     者：Fares E.M Ali Islam M.Ibrahim Osama M Ghogar Esraa K.Abd-alhameed Hanan S.Althagafy Emad H.M.Hassanein 

作者机构：Pharmacology and ToxicologyFaculty of PharmacyAl-Azhar UniversityAssiut BranchAssiut 71524Egypt Faculty of PharmacyAl-Azhar UniversityAssiut BranchAssiut 71524Egypt Pharmacology and ToxicologyFaculty of PharmacyBeni-Suef UniversityBeni-Suef 12345Egypt Department of BiochemistryFaculty of ScienceUniversity of JeddahJeddah 12345Saudi Arabia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2023年第29卷第6期

页      面：1026-1053页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Ulcerative colitis NLR family pyrin domain containing 3 inflammasome Therapeutic strategies Phytochemicals Probiotics 

摘      要：One of the significant health issues in the world is the prevalence of ulcerative colitis(UC).UC is a chronic disorder that mainly affects the colon,beginning with the rectum,and can progress from asymptomatic mild inflammation to extensive inflammation of the entire *** the underlying molecular mechanisms of UC pathogenesis emphasizes the need for innovative therapeutic approaches based on identifying molecular ***,in response to cellular injury,the NLR family pyrin domain containing 3(NLRP3)inflammasome is a crucial part of the inflammation and immunological reaction by promoting caspase-1 activation and the release of interleukin-1β.This review discusses the mechanisms of NLRP3 inflammasome activation by various signals and its regulation and impact on UC.