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基于监督学习的HSK阅读文本自动分级模型研究

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河北科技大学学报 2024年第2期45卷 150-158页

作者：任梦王方伟河北师范大学文学院河北石家庄050024 河北师范大学计算机与网络空间安全学院河北石家庄050024

针对HSK(汉语水平考试)各类阅读材料难度判定与等级对应中缺乏有效参照标准和分析工具的问题,以历年HSK真题阅读文本为研究对象,提取文本可读性特征,采用支持向量机、随机森林、极端梯度增强等9种监督学习算法,建立可将自选文本自动归... 详细信息

针对HSK(汉语水平考试)各类阅读材料难度判定与等级对应中缺乏有效参照标准和分析工具的问题,以历年HSK真题阅读文本为研究对象,提取文本可读性特征,采用支持向量机、随机森林、极端梯度增强等9种监督学习算法,建立可将自选文本自动归类于相应HSK等级的模型,采用准确率、AUC等多项指标评价各模型的分级效果,并选择最佳模型制成在线工具。结果表明,监督学习在HSK阅读材料文本分析及分级方面具有较高性能,9种模型中极端梯度增强的分级效果最好,准确率为0.913,AUC为0.994。建立的分级模型和在线工具能够以较高的准确率对HSK自选文本进行分级,帮助用户有针对性地遴选文本,提高学习效率。

关键词：自然语言处理监督学习 HSK阅读文本可读性特征分级模型

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基于多裁剪的恶意软件检测和分类模型

华中科技大学学报（自然科学版） 2024年第3期52卷 121-126页

作者：王方伟史锡朋李青茹王长广河北师范大学计算机与网络空间安全学院河北石家庄050024 河北师范大学河北省网络与信息安全重点实验室河北石家庄050024

针对恶意软件检测和分类中存在局部关键特征丢失、样本不足、样本不平衡和分类准确率低等问题,提出了一种基于多裁剪策略的恶意软件检测与分类模型MadcuG.模型首先将恶意软件字节文件用字节数组的形式放至内存缓冲区中生成彩色图像;然... 详细信息

针对恶意软件检测和分类中存在局部关键特征丢失、样本不足、样本不平衡和分类准确率低等问题,提出了一种基于多裁剪策略的恶意软件检测与分类模型MadcuG.模型首先将恶意软件字节文件用字节数组的形式放至内存缓冲区中生成彩色图像;然后用多裁剪策略将彩色图像生成恶意软件局部图像,以增加对局部关键特征的关注,解决样本不平衡和局部关键特征丢失问题;最后,用深度卷积生成对抗网络构造了打分判别器和分类判别器,目标损失函数为打分判别器和生成器的对抗损失及分类判别器的分类损失,以增加训练中参数的利用率和模型的泛化能力.实验结果表明:MadcuG模型在BIG2015和Malimg数据集上分别获得了99.88%和99.2%的分类准确率,优于已有模型.

关键词：系统安全深度卷积生成对抗网络多裁剪策略恶意软件分类样本不平衡

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论中国式现代化赓续发展中华文明的精神内涵与价值意蕴

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西安交通大学学报（社会科学版） 2024年第1期44卷 13-22页

作者：陆卫明王方伟于晶晶西安交通大学马克思主义学院陕西西安710049

以“第二个结合”为视角,深入阐释中国式现代化的文明根基及其对中华文明的赓续发展,对新时代全面推进中国式现代化、建设中华民族现代文明具有十分重要的理论与时代意义。中国式现代化建设之所以能实现与中华文明的深度融合,其根源在... 详细信息

以“第二个结合”为视角,深入阐释中国式现代化的文明根基及其对中华文明的赓续发展,对新时代全面推进中国式现代化、建设中华民族现代文明具有十分重要的理论与时代意义。中国式现代化建设之所以能实现与中华文明的深度融合,其根源在于马克思主义对现代化与文明发展交互关系的科学论述、中国共产党对中华民族现代文明建设与文化创新的高度自觉、新时代筑牢中国特色社会主义道路文明根基的时代需要。中国式现代化建设传承发展中华文明的深刻内涵在于其逻辑起点、总体布局及在国际关系上的价值追求,既充分体现了科学社会主义的价值观主张,又内在蕴含、赓续发展了丰厚的中华文明基因。深入研究中国式现代化建设中传承发展中华文明的重大价值,有利于赋予中国式现代化以深厚的文明根基、打破“现代化=西方化”的文明神话、建设中国共产党领导的中华民族现代文明。

关键词：中国式现代化中华文明中华民族现代文明 “第二个结合”

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The cGAS-STING pathway:a therapeutic target in chromosomally unstable cancers

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Signal Transduction and Targeted Therapy 2023年第2期8卷 338-340页

作者： Haiyan Yan Weiguo Lu fangwei wang Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City University310015HangzhouChina Women’s Hospital Zhejiang University School of Medicine310006HangzhouChina Cancer Center Zhejiang University310058HangzhouChina The MOE Key Laboratory of Biosystems Homeostasis&Protection and Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology Life Sciences InstituteZhejiang University310058HangzhouChina

In a recent study published in Nature,Hong et *** that the cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)innate immune pathway is critically required for the IL-6-dependent survival of chromosomally unstable cancer cells,1 implying that chronic inflammation can be therapeutically targeted to kill cancers displaying chromosomal instability(CIN).

关键词： unstable chromosomal therapeutic

Tuning anionic redox activity to boost high-performance sodium-storage in low-cost Na_(0.67)Fe_(0.5)Mn_(0.5)O_(2) cathode

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Journal of Energy Chemistry 2022年第10期31卷 214-222,I0005页

作者： Jianyue Jiao Kang Wu Na Li Enyue Zhao Wen Yin Zhongbo Hu fangwei wang Jinkui Zhao Xiaoling Xiao College of Materials Science and Opto-electronic Technology Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808GuangdongChina Spallation Neutron Source Science Center Dongguan 523803GuangdongChina Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Na-based layered iron-manganese oxide Na_(0.67)Fe_(0.5)Mn_(0.5)O_(2) containing only low-cost elements is a promising cathode for Na-ion batteries used in large-scale energy storage ***,the poor cycle stability restricts its practical *** capacity decay of Na_(0.67)Fe_(0.6)Mn_(0.5)O_(2) mainly originates from the irreversible anionic redox reaction charge compensation due to the high-level hybridization between oxygen and ***,we rationally design a surface Ti doping strategy to tune the anionic redox reaction activity of Na_(0.67)Fe_(0.5)Mn_(0.5)O_(2) and improve its Na-storage *** doped Ti ions not only enlarge the Na migration spacing layer but also improve the structure stability thanks to the strong Ti-O *** importantly,the d0-shell electronic structure of Ti^(4+) can suppress the charge transfer from the oxidized anions to cations,thus reducing the anionic redox reaction activity and enhancing the reversibility of charge *** modified Na_(0.67)Fe_(0.5)Mn_(0.5)O_(2) cathode shows a reversible capacity of 198 mA h g^(-1) and an increased capacity retention from 15% to 73% after about1 month of ***,a superior Na-ion diffusion kinetics and rate capability are also *** work advances the commercialization process of Na-based layered iron-manganese oxide cathodes;on the other hand,the proposed modification strategy paves the way for the design of high-performance electrode materials relying on anionic redox reactions.

关键词： Na-ion battery P2-Na_(0.67)Fe_(0.5)Mn_(0.5)O_(2) Anionic redox reaction Surface Ti doping

Tailoring interphase structure to enable high-rate, durable sodium-ion battery cathode

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Journal of Energy Chemistry 2022年第5期31卷 564-571页

作者： Na Li Shaofei wang Enyue Zhao Wen Yin Zhigang Zhang Kang Wu Juping Xu Yoshihiro Kuroiwa Zhongbo Hu fangwei wang Jinkui Zhao Xiaoling Xiao College of Materials Science and Opto-electronic Technology Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803GuangdongChina Songshan Lake Materials Laboratory Dongguan 523808GuangdongChina Department of Physical Science Hiroshima UniversityHigashihiroshimaHiroshima 739-8526Japan Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Na-based layered transition metal oxides with O_(3)-type structure have been considered to be promising cathodes for Na-ion batteries. However, the intrinsically limited Na-ion conductivity induced by the Otype Na-coordinate environment compromises their rate and cycle capability, hindering their practical application. Here, we report an interphase-structure tailoring strategy that improves the electrochemical properties of O_(3)-type layered cathodes achieved through surface coating and doping ***, a Zr-doped interphase structure is designed in the model compound NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2) using the ionic conductor Na_(3)Zr_(2)Si_(2)PO_(12) as the surface coating material and Zr-dopant provider. We discover that the modified NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)cathode shows a stable Na-storage structure as well as an enhanced rate/cycle capability. Combined with theoretical calculations, it is suggested that the superior electrochemical performances originate from the Zr-doped interphase structure, which has an enlarged Na layer spacing that forms favorable Na-ion diffusion channels. This work highlights a general material interface optimization method which opens a new perspective for fabricating high-performance electrodes for Na-ion batteries and beyond.

关键词： Na-ion battery NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)cathode Interphase structure Zr doping Surface interface modification

Role of pyroptosis in inflammation and cancer

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Cellular & Molecular Immunology 2022年第9期19卷 971-992页

作者： Xiang Wei Feng Xie Xiaoxue Zhou Yuchen Wu Haiyan Yan Ting Liu Jun Huang fangwei wang Fangfang Zhou Long Zhang International Biomed-X Research Center Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang310058PR China Institutes of Biology and Medical Science Soochow UniversitySuzhou215123PR China MOE Key Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhouZhejiang310058PR China Department of Clinical Medicine The First School of MedicineWenzhou Medical UniversityWenzhouZhejiang325035PR China School of Medicine Zhejiang University City CollegeHangzhouZhejiang310015PR China Department of Cell Biology and Department of General Surgery of Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou310058ZhejiangPR China Zhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province Department of GeriatricsZhejiang HospitalHangzhouZhejiang310030PR China Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology Life Sciences InstituteZhejiang UniversityHangzhouZhejiang310058PR China

Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures,resulting in the release of cellular contents that can activate strong inflammatory and immune ***,an innate immune response,can be triggered by the activation of inflammasomes by various influencing *** of these inflammasomes can induce the maturation of caspase-1 or caspase-4/5/11,both of which cleave gasdermin D to release its N-terminal domain,which can bind membrane lipids and perforate the cell ***,we review the latest advancements in research on the mechanisms of pyroptosis,newly discovered influencing factors,antitumoral properties,and applications in various ***,this review also provides updates on potential targeted therapies for inflammation and cancers,methods for clinical prevention,and finally challenges and future directions in the field.

关键词： Pyroptosis inflammasome influencing factors pyroptosis-associated diseases antitumor targeted therapy

Micro-spot-welding of copper sheets with an IR vortex beam

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Chinese Optics Letters 2022年第4期20卷 44-48页

作者：王晨阳王锋秦应雄王方伟袁孝 School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical Engineering Jiangsu UniversityZhenjiang 212013China Lingyun Photoelectronic System Co.Ltd.Wuhan 430205China School of Optoelectronic Science and Engineering Soochow UniversitySuzhou 215006China

Copper welding with an infrared(IR)Gaussian laser beam usually shows obvious instability,spatters,and worse surface morphology due to the Gaussian distribution,temperature-dependent IR absorption,and high thermal conductivity in *** this paper,the IR quasi-continuous-wave Gaussian beam was converted into a vortex ring beam with a phase-plate and then applied to the micro-spot-welding of copper *** welding with the vortex beam demonstrated a significantly improved welding performance,smoother surface morphology,and higher welding ***,no spatters appeared in the welding process.

关键词： Gaussian beam vortex beam micro-spot-welding copper sheets IR fiber laser

High-capacity lithium-rich cathode oxides with multivalent cationic and anionic redox reactions for lithium ion batteries

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Science China Chemistry 2017年第12期60卷 1483-1493页

作者： Enyue Zhao Xiqian Yu fangwei wang Hong Li Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China

Lithium-rich cathode oxides with capability to realize multivalent cationic and anionic redox reactions have attracted much attention as promising candidate electrode materials for high energy density lithium ion batteries because of their ultrahigh specific capacity. However, redox reaction mechanisms, especially for the anionic redox reaction of these materials, are still not very clear. Meanwhile, several pivotal challenges associated with the redox reactions mechanisms, such as structural instability and limited cycle life, hinder the practical applications of these high-capacity lithium-rich cathode oxides. Herein, we review the lithium-rich oxides with various crystal structures. The multivalent cationic/anionic redox reaction mechanisms of several representative high capacity lithium-rich cathode oxides are discussed, attempting to understand the origins of the high lithium storage capacities of these materials. In addition, we provide perspectives for the further development of these lithium-rich cathode oxides based on multivalent cationic and anionic redox reactions, focusing on addressing the fundamental problems and promoting their practical applications.

关键词： lithium ion batteries high capacity lithium-rich cathode oxides multivalent cationic redox reaction anionic redox reaction