The cGAS-STING pathway:a therapeutic target in chromosomally unstable cancers

作     者：Haiyan Yan Weiguo Lu Fangwei Wang Haiyan Yan;Weiguo Lu;Fangwei Wang

作者机构：Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang ProvinceSchool of MedicineHangzhou City University310015HangzhouChina Women’s HospitalZhejiang University School of Medicine310006HangzhouChina Cancer CenterZhejiang University310058HangzhouChina The MOE Key Laboratory of Biosystems Homeostasis&Protection and Zhejiang Provincial Key Laboratory of Cancer Molecular Cell BiologyLife Sciences InstituteZhejiang University310058HangzhouChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第2期

页      面：338-340页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by grants from the National Key Research and Development Program of China(2022YFA1105200,2022YFA1303100) the National Natural Science Foundation of China(32025011,32270772,31771499,and 32061160470) Natural Science Foundation of Zhejiang Province(LZ19C070001,LY17C070003).We also thank Dr.Qinfu Chen for the help to draft the artwork 

主　　题：unstable chromosomal therapeutic 

摘      要：In a recent study published in Nature,Hong et *** that the cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)innate immune pathway is critically required for the IL-6-dependent survival of chromosomally unstable cancer cells,1 implying that chronic inflammation can be therapeutically targeted to kill cancers displaying chromosomal instability(CIN).