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Miniscope3D:optimized single-shot miniature 3D fluorescence microscopy

Light(Science & Applications) 2020年第1期9卷 367-379页

作者： Kyrollos Yanny Nick Antipa William Liberti Sam Dehaeck Kristina Monakhova fanglin linda liu Konlin Shen Ren Ng Laura Waller UCB/UCSF Joint Graduate Program in Bioengineering University of CaliforniaBerkeleyCA 94720USA Department of Electrical Engineering&Computer Sciences University of CaliforniaBerkeleyCA 94720USA TIPs Department Universite libre de Bruxelles(ULB)1050 BrusselsBelgium

Miniature fluorescence microscopes are a standard tool in systems ***,widefield miniature microscopes capture only 2D information,and modifications that enable 3D capabilities increase the size and weight and have poor resolution outside a narrow depth ***,we achieve the 3D capability by replacing the tube lens of a conventional 2D Miniscope with an optimized multifocal phase mask at the objective’s aperture *** the phase mask at the aperture stop significantly reduces the size of the device,and varying the focal lengths enables a uniform resolution across a wide depth *** phase mask encodes the 3D fluorescence intensity into a single 2D measurement,and the 3D volume is recovered by solving a sparsity-constrained inverse *** provide methods for designing and fabricating the phase mask and an efficient forward model that accounts for the fieldvarying aberrations in miniature *** demonstrate a prototype that is 17mm tall and weighs 2.5 grams,achieving 2.76μm lateral,and 15μm axial resolution across most of the 900×700×390μm^(3) volume at 40 volumes per *** performance is validated experimentally on resolution targets,dynamic biological samples,and mouse brain *** with existing miniature single-shot volume-capture implementations,our system is smaller and lighter and achieves a more than 2×better lateral and axial resolution throughout a 10×larger usable depth *** microscope design provides single-shot 3D imaging for applications where a compact platform matters,such as volumetric neural imaging in freely moving animals and 3D motion studies of dynamic samples in incubators and lab-on-a-chip devices.

关键词： enable resolution narrow

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Variation in the surface heat flux on the north and south slopes of Mount Qomolangma

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Atmospheric and Oceanic Science Letters 2024年第5期17卷 28-33页

作者： Yonghao Jiang Maoshan Li Yuchen liu Ting Wang Pei Xu Yaoming Ma fanglin Sun School of Atmospheric Sciences/Plateau Atmosphere and Environment Key Laboratory of Sichuan Province/Chengdu Plain Urban Meteorology and Environment Observation and Research Station of Sichuan Province Chengdu University of Information TechnologyChengduChina Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchChinese Academy of SciencesCAS Center for Excellence in Tibetan Plateau Earth SciencesBeijingChina Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Chinese Academy of SciencesLanzhouChina

The distinctive conditions present on the north and south slopes of Mount Qomolangma,along with the intricate variations in the underlying surfaces,result in notable variations in the surface energy flux patterns of the two *** this paper,data from TESEBS(Topographical Enhanced Surface Energy Balance System),remote sensing data from eight cloud-free scenarios,and observational data from nine stations are utilized to examine the fluctuations in the surface heat flux on both *** inclusion of MCD43A3 satellite data enhances the surface albedo,contributing to more accurate simulation *** model results are validated using observational *** RMSEs of the net radiation,ground heat,sensible heat,and latent heat flux are 40.73,17.09,33.26,and 30.91 W m^(−2),*** net radiation flux is greater on the south slope and exhibits a rapid decline from summer to *** to the influence of the monsoon,on the north slope,the maximum sensible heat flux occurs in the pre-monsoon period in summer and the maximum latent heat flux occurs during the *** south slope experiences the highest latent heat flux in *** dominant flux on the north slope is sensible heat,while it is latent heat on the south *** seasonal variations in the ground heat flux are more pronounced on the south slope than on the north *** in summer,the ground heat flux on the north slope surpasses that on the south slope.

关键词： Mount Qomolangma TESEBS model Remote sensing retrieval Surface heat fluxes

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Insight into the nitrogen-vacancy center formation in type-Ib diamond by irradiation and annealing approach

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Materials Futures 2024年第4期3卷 181-191页

作者： Taiqiao liu fanglin Lyu Tian Shao Diwei Zou Wei Shen Yuzheng Guo Yuan Zhong Chaoyang Chen Liangchen Yi Zhaofu Zhang Andy H Shen The Institute of Technological Sciences Wuhan UniversityWuhan 430072People’s Republic of China Gemmological Institute China University of GeosciencesWuhan 430074People’s Republic of China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072People’s Republic of China Zhongnan Diamond Company Nanyang 473264People’s Republic of China Hubei Key Laboratory of Electronic Manufacturing and Packaging Integration Wuhan UniversityWuhan 430072People’s Republic of China

Comprehending the microscopic formation of nitrogen vacancy(NV)centers in nitrogen-doped diamonds is crucial for enhancing the controllable preparation of NV centers and quantum *** followed by annealing simulations for a type-Ib diamond with a 900 ppm concentration of isolated nitrogen is conducted along different orientations and at different annealing *** these simulations,molecular dynamics(MD)with smoothly connected potential functions are *** simulations revealed the dynamic formation process of the NV center,which was subsequently verified by first-principles calculations and *** results indicate that vacancies undergo one or multiple migrations by exchanging sites with neighboring *** are three mechanisms for the formation of NV centers:direct irradiation-induced NV formation,irradiation with further annealing to form NV and vacancy migration(VM)during the annealing ***,the results show that both VM and NV center formations are affected by *** study clarifies the formation of NV centers across multiple scales and provides a solid foundation for the targeted preparation of NV centers.

关键词： diamond NV center irradiation annealing molecular dynamics

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The roles and mechanisms of SREBP1 in cancer development and drug response

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Genes & Diseases 2024年第4期11卷 258-269页

作者： Ying He Shasha Qi Lu Chen Jinyu Zhu linda Liang Xudong Chen Hao Zhang Lvjia Zhuo Shujuan Zhao Shuiping liu Tian Xie School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhouZhejiang 311121China Laboratory of Cancer Genomics Division of Cellular and Molecular ResearchNational Cancer Centre SingaporeSingapore 169610Singapore

Cancer occurrence and development are closely related to increased lipid produc-tion and glucose *** are the basic component of the cell membrane and play a significant role in cancer cell processes such as cell-to-cell recognition,signal transduction,and energy supply,which are vital for cancer cell rapid proliferation,invasion,and *** regulatory element-binding transcription factor 1(SREBP1)is a key transcription factor regulating the expression of genes related to cholesterol biosynthesis,lipid homeostasis,and fatty acid *** addition,SREBP1 and its upstream or downstream target genes are implicated in various metabolic diseases,particularly ***,no review of sREBP1 in cancer biology has yet been ***,we summarized the roles and mechanisms of SREBP1 biological processes in cancer cells,including SREBP1 modification,lipid metabolism and reprogramming,glucose and mitochondrial metabolism,immunity,and tumor microenvi-ronment,epithelial-mesenchymal transition,cell cycle,apoptosis,and ***-ally,we discussed the potential role of SREBP1 in cancer prognosis,drug response such as drug sensitivity to chemotherapy and radiotherapy,and the potential drugs targeting SREBP1 and its corresponding pathway,elucidating the potential clinical application based on SREBP1 and its corresponding signal pathway.

关键词： Cancer Drug Lipid metabolism reprogramming Resistance SREBP1

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Cellular metabolism: A key player in cancer ferroptosis

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Cancer Communications 2024年第2期44卷 185-204页

作者： Xianjie Jiang Qiu Peng Mingjing Peng linda Oyang Honghan Wang Qiang liu Xuemeng Xu Nayiyuan Wu Shiming Tan Wenjuan Yang Yaqian Han Jinguan Lin Longzheng Xia Yanyan Tang Xia Luo Jie Dai Yujuan Zhou Qianjin Liao Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Public Service Platform of Tumor Organoids Technology ChangshaHunanP.R.China Department of Head and Neck Surgery Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Hengyang Medical School University of South ChinaHengyangHunanP.R.China

Cellular metabolism is the fundamental process by which cells maintain growth and *** produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular *** metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell *** is a recently discovered form of iron-dependent programmed cell *** inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor ***,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well ***,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this ***,we provided a detailed overview of agents used to induce cancer *** explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell *** combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.

关键词： cancer therapy cellular metabolism ferroptosis inducer ferroptosis

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基于异步时钟序列的分布式认知跳频算法

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计算机应用研究 2024年第1期41卷 231-236页

作者：刘杰龚广伟辜方林李伦辉国防科技大学电子科学学院长沙410000 中国人民解放军31201部队广州510000

为了解决传统跳频算法对动态、复杂电磁干扰环境适应能力不足的难题,以及克服现有跳频算法在分布式通信环境下对公共控制信道和统一时钟源的依赖,提出了一种基于异步时钟序列的分布式认知跳频算法。该算法通过建立认知跳频通信系统模型... 详细信息

为了解决传统跳频算法对动态、复杂电磁干扰环境适应能力不足的难题,以及克服现有跳频算法在分布式通信环境下对公共控制信道和统一时钟源的依赖,提出了一种基于异步时钟序列的分布式认知跳频算法。该算法通过建立认知跳频通信系统模型,分析其通信过程中面临的关键问题,设计了一种应用于分布式跳频通信环境的异步时钟结构序列。基于该序列的分布式认知跳频算法不依赖于任何公共控制信道和统一时钟源,能够在复杂电磁干扰环境下达到高效抗干扰通信的效果。验证实验结果表明,针对典型的窄带、宽带噪声干扰、部分频段干扰以及随机干扰,所提算法的抗干扰性能均显著优于传统的跳频通信算法以及现有的公用控制信道认知跳频算法。

关键词：认知跳频抗干扰分布式异步时钟序列

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公积金支持保障性租赁住房建设:一个创新理论框架

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经济与管理 2024年第4期38卷 77-83页

作者：邱琳妲刘璐西南财经大学经济学院四川成都611130

我国住房市场供需矛盾日益凸显,住房公积金制度应当发挥有效作用,助力实现我国人民住有所居,推动共同富裕。通过构建理论分析模型,测算不同时间期限内的公积金参与保障性租赁住房建设的最优建设规模及其资金需求量。运用四川省四个试点... 详细信息

我国住房市场供需矛盾日益凸显,住房公积金制度应当发挥有效作用,助力实现我国人民住有所居,推动共同富裕。通过构建理论分析模型,测算不同时间期限内的公积金参与保障性租赁住房建设的最优建设规模及其资金需求量。运用四川省四个试点城市的数据,初步完成对模型的实用化校准。各公积金中心可结合自身数据,依据模型测算出适合本中心的最优值以指导实务,保障资金有效利用的同时提供足够的保障性租赁住房。模型和研究结论可助力我国住房公积金更有效率地支持保障性租赁住房建设,缓解住房市场矛盾,更好地满足人们的居住需求。

关键词：住房公积金保障性租赁住房最优建设规模

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千层纸素A调控胆碱能抗炎通路抑制结核分枝杆菌致巨噬细胞焦亡

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中华微生物学和免疫学杂志 2024年第5期44卷 423-430页

作者：张贺敏沈晶晶刘芳琳吴鉴超刘亚奇姜昕上海中医药大学中西医结合学院免疫学与病原生物学教研室上海201203

目的探讨千层纸素A(oroxylin A,OrA)对结核分枝杆菌感染诱导的巨噬细胞焦亡的作用及分子机制。方法构建结核分枝杆菌感染J774A.1细胞体外模型;MTT法检测OrA对J774A.1细胞活力的影响;乳酸脱氢酶(lactate dehydrogenase,LDH)检测试剂盒检... 详细信息

目的探讨千层纸素A(oroxylin A,OrA)对结核分枝杆菌感染诱导的巨噬细胞焦亡的作用及分子机制。方法构建结核分枝杆菌感染J774A.1细胞体外模型;MTT法检测OrA对J774A.1细胞活力的影响;乳酸脱氢酶(lactate dehydrogenase,LDH)检测试剂盒检测细胞LDH释放水平;Western blot检测细胞焦亡相关蛋白NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermal protein domain associated protein 3,NLRP3)、GSDMD-N、caspase1-p20、凋亡相关斑点样蛋白(apoptosis-associated speck-like protein containing a CARD,ASC)、α7烟碱乙酰胆碱受体(α7 nicotinic acetylcholine receptor,α7nAChR)蛋白质表达水平及NF-κB p65的磷酸化。ELISA检测各组细胞IL-1β表达水平;免疫荧光检测α7nAChR蛋白及定位。结果MTT结果表明OrA在80μmol/L浓度范围内对J774A.1细胞无细胞毒性;OrA抑制J774A.1细胞LDH的释放,降低细胞焦亡相关蛋白NLRP3、GSDMD-N、caspase1-p20的蛋白质表达水平以及ASC寡聚化,促进α7nAChR蛋白表达,并抑制NF-κB p65磷酸化和IL-1β的释放;加入α7nAChR激动剂PNU282987可降低GSDMD-N并抑制NF-κB p65磷酸化。结论OrA可能通过调控胆碱能抗炎通路抑制结核分枝杆菌感染诱导的巨噬细胞焦亡。

关键词：细胞焦亡千层纸素A 结核分枝杆菌宿主导向疗法 α7烟碱乙酰胆碱受体

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一种基于随机森林的OFDM系统自适应算法

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信号处理 2024年第6期40卷 1007-1018页

作者：王波刘潇然熊俊辜方林张晓瀛国防科技大学电子科学学院湖南长沙410073

针对动态变化的信道环境,自适应正交频分复用(Orthogonal Frequency Division Multiplexing,OFDM)系统可以对子载波间隔和循环前缀长度进行调整,以最大化系统的吞吐量。为了能够快速准确地找到OFDM系统在不同信道环境中的最优子载波间... 详细信息

针对动态变化的信道环境,自适应正交频分复用(Orthogonal Frequency Division Multiplexing,OFDM)系统可以对子载波间隔和循环前缀长度进行调整,以最大化系统的吞吐量。为了能够快速准确地找到OFDM系统在不同信道环境中的最优子载波间隔和循环前缀长度取值,本文提出了基于随机森林的OFDM系统自适应算法。随机森林算法基于集成的思想,能够有效处理高维度数据,并且具有高效率、高准确率和强泛化能力等优势,可以在复杂的数据场景下进行有效的分类。通过提取通信过程中信噪比、用户移动速度、最大多普勒频率和均方根时延扩展等信道特征与OFDM系统的子载波间隔和循环前缀长度组成训练样本,利用随机森林算法创建了OFDM系统参数多分类模型。所提模型可以根据输入的信道特征,实现OFDM系统子载波间隔和循环前缀长度的自适应分配。同时,针对训练样本主要集中在少数几个系统参数类别的情况,利用合成少数类过采样技术对较少样本数的类别进行扩充,满足了随机森林算法对训练样本类别平衡化的需求,进一步提高了算法的分类准确率。相比传统的自适应算法,所提算法具有更高的分类准确率和模型泛化能力。分析和仿真结果表明,与子载波间隔和循环前缀长度固定的OFDM系统相比,本文所提出的自适应算法能够准确选择出最优的系统参数,可以有效地减轻信道中符号间干扰和子载波间干扰的影响,从而在整个信噪比范围上提供最大的平均频谱效率。基于随机森林的OFDM系统自适应算法能够动态地分配子载波间隔和循环前缀长度,增强OFDM系统的通信质量和抗干扰能力,实现在不同信道环境下的可靠传输。

关键词：正交频分复用合成少数类过采样技术随机森林自适应算法

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基于网络药理学和分子对接技术探讨参芪扶正注射液治疗慢性阻塞性肺疾病的潜在药理学机制

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Journal of Chinese Pharmaceutical Sciences 2024年第4期33卷 339-351页

作者：刘芳琳张春娟沈秋跃周昔程赵越富冯峰刘芳海盐县人民医院药剂科浙江海盐314300 海盐县人民医院呼吸与危重症医学科浙江海盐314300 陆军军医大学西南医院药学部重庆400038

参芪扶正注射液(SFI)是一种由黄芪(黄芪,HQ)和党参(党参,DS)组成的传统中药注射液,我们通过网络药理学和分子对接分析研究了SFI治疗慢性阻塞性肺病(COPD)的潜在机制和分子靶点。首先,我们在多个数据库中检索和筛选了SFI的潜在生物活性... 详细信息

参芪扶正注射液(SFI)是一种由黄芪(黄芪,HQ)和党参(党参,DS)组成的传统中药注射液,我们通过网络药理学和分子对接分析研究了SFI治疗慢性阻塞性肺病(COPD)的潜在机制和分子靶点。首先,我们在多个数据库中检索和筛选了SFI的潜在生物活性化合物和相应的COPD相关靶基因。随后,使用Cytoscape 3.9.1和STRING分析并构建了蛋白质-蛋白质相互作用(PPI)网络,以获得关键靶基因。随后,为了确定与SFI相关的潜在信号通路,研究人员进行了GO和KEGG富集研究,并进行了分子对接分析以验证结果。通过网络药理学分析,共获得65种活性成分(DS35种,HQ 30种)和233个关键靶点。其中,前五大生物活性成分(槲皮素、芹菜素、大豆异黄酮、山柰酚和木犀草素)和前五大靶点(TP53、AKT1、EP300、MAPK1和JUN)在分子对接分析中表现出良好的亲和力和稳定的结合力,结合能≤–5.0kcal/mol。这些研究结果表明,SFI可通过多种化合物和多种途径对慢性阻塞性肺病发挥治疗作用。此外,本研究还为SFI作为慢性阻塞性肺疾病的辅助治疗药物进一步应用于临床提供了药理学依据和参考。

关键词：参芪扶正注射液 COPD 网络药理学分子对接

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