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High Technology Letters 2007年第2期13卷 221-224页

作者：陈慕雁 Yang Hongsheng shi fangfang Institute of Oceanology Chinese Academy of Sciences Qingdao 266071P.R.China Graduate University Chinese Academy of Sciences Beijing 100049 P.R.China

Mixtures of hemolymph from Chlamys farreri with three different anticoagulant solutions were incu-bated for an hour in vitro, then the ultrastructural alterations of hemocytes were observed, and the aggre-gation rate was analyzed by using transmission electron microscropy and flow cytometry respectively. The results showed that Formula 3 （glucose 20.8 g L^-1; EDTA 20mM; sodium chloride 20 g L^-1; Tris-HCI 0.05M;pH 7.4）was the desirable anticoagulant solution for C. farreri hemocytes. Further phagocytosis assay showed that no obvious negative effect was given to the hemocyte phagocytic activity when using Formula 3 as the anticoagulant solution.

关键词： hemolymph anticoagulant solution TEM flow cytometry Chlamys farreri

Experimental investigation of the detection and location of a target in layered media by using the TR-RTM mixed method

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Science China(Physics,Mechanics & Astronomy) 2019年第3期62卷 75-81页

作者： Xiang Gao Jian Li Jun Ma JunHong Li fangfang shi Wen Wang ChengHao Wang Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences School of Electronic and Electrical Engineering Wuhan Textile University State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

Targets in layered media can be detected and located using a time reversal(TR)-reversed-time migration(RTM) mixed *** this study, this single emission-multiple receiving method is tested experimentally by using two types of layered media and three types of targets. The signal reflected at the interface and the signal scattered by the target are measured by each receiver to obtain the travel time for several transmitter-receiver pairs. Thereafter, the amplitude ratio between the two measured signals is compared with the theoretical amplitude. The RTM process involves the convolution of the forward acoustic beam from the source with the backward acoustic beam from the receiver which adds an appropriate delay determined on the measured travel time data. By using this approach, the acoustic field distribution can be obtained, and the position of the target can be ***, the measured positions of the target are compared with the actual position to validate the accuracy of this technique.

关键词： time reversal reversed-time migration ultrasonic detection layered media

An Analysis of Reading Materials in New Senior English for China Based on Cultivation of Cultural Awareness —A Case Study of Compulsory Book 3

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Open Journal of Applied Sciences 2023年第1期13卷 51-59页

作者： fangfang shi School of Foreign Languages Shaoxing University Shaoxing China

China is in the era of rapid development of information technology and the era of close cultural communication between countries, which requires English teaching to cultivate students’ cultural awareness, develop their intercultural communicative competence. Based on Byram’s checklist, this paper analyzes the cultural contents in reading materials of New Senior English for China (NSEFC) Compulsory Book 3. The research indicates that the textbook is rich in cultural content and the selected reading materials are authentic. However, there are two shortcomings: the uneven distribution of themes as well as cultural contents and the lack of cultural content comparison in the textbook. According to the findings, this paper provides some suggestions for textbook editors and English teachers, aiming at realizing the improvement and a better use of the textbook, so as to cultivate students’ cultural awareness.

关键词： English Textbooks Reading Materials Cultural Contents Cultural Awareness

Optical sensor array for the discrimination of liquors

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Journal of Future Foods 2024年第1期4卷 48-60页

作者： Yang Yu fangfang shi Yi Zhang Fei Li Jinsong Han State Key Laboratory of Natural Medicines National R&D Center for Chinese Herbal Medicine ProcessingDepartment of Food Quality and SafetyCollege of EngineeringChina Pharmaceutical UniversityNanjing 210009China

The discrimination of liquors plays a vital role in our daily life as a large amount of cheap alcoholic beverages and low-quality counterfeits greatly damage the health of ***-based optical sensors have been developed as a fast and effective tool to discriminate multi-analytes or complex mixtures with similar structures,such as acids,esters,aldehydes and *** the past decades,optical sensor arrays have demonstrated remarkable capabilities in fast and accurate detection of diverse types,qualities,and authentic *** identification strategy mainly focuses on the specific/non-specific interactions of flavor compounds in liquors with sensor *** cross-reactive optical signal readouts from the combination of sensor elements with liquors and multiple machine learning algorithms are essential to ensure the discriminatory capability of sensing *** this review,we discuss the advantages and recent advances in pattern recognition of liquors in terms of the design of various types of sensing materials and the construction strategies of sensor arrays.

关键词： Sensor array Chemical tongue Chemical nose Liquors Fluorescent Colorimetric Pattern recognition Machine learning algorithm

Research on the propagation of guided waves in multi-layered plates

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Chinese Journal of Acoustics 2017年第4期36卷 400-414页

作者： ZHANG Chao YAN Shouguo ZHANG Bixing shi fangfang State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of Sciences University of Chinese Academy of Sciences

The dispersion characteristics and excitation mechanisms of the guided waves in multilayered plates are studied in this paper. Firstly, the dispersion equation is obtained by the propagator matrix method. Then, the bisection technique is employed to find all the roots of the dispersion equation. The dispersion characteristics of the guided waves are investigated and analyzed. For the multilayered plates in which the S-wave velocity increases or decreases from top to bottom, it is found that the velocity limits in high frequency of the first and high modes are equal to the Rayleigh wave and S-wave velocities of the low-velocity layer, respectively. It is also found that the velocity limits in the high frequency of all modes are equal to the S-wave velocity of the low-velocity layer for the plate with a low-velocity middle layer. The normal displacement spectrum of all the modes excited by the normal force source with a definite width on the surface of the plate is also investigated. It is proved that the dominant mode is the first mode when the S-wave velocity increases from top to bottom layer and the dominant mode is different in different frequency range for the plate with a low-velocity middle layer.

关键词： guided layered Rayleigh excited excitation normalized limits Figure Dispersion attractive

Antibody targeted microbubbles release oxygen and doxorubicin to inhibit cancer stem cells derived multiple myeloma by ultrasound exposure

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Antibody targeted microbubbles release oxygen and doxorubici...

Acoustic field analysis of detection and location of targets in layered media by time reversal-reverse time migration mixed method

第十二届全国免疫学学术大会

作者： shi fangfang Department of Pathogenic Biology and Immunology School of MedicineSoutheast University Department of Oncology Zhongda Hospital School of MedicineSoutheast University

In despite of much progress made over the past decade in individualized treatment of multiple myeloma(MM),it remains mostly *** this study,we developed the doxorubicin(DOX)/oxygen loaded microbubbles(MBs)conjugated wi... 详细信息

关键词： Multiple myeloma cancer stem cells microbubble doxorubicin oxygen ATP-binding cassette sub-fami

来源： cnki会议评论

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Chinese Journal of Acoustics 2017年第4期36卷 385-399页

作者： GAO Xiang LI Jian shi fangfang MA Jun WANG Wen WANG Chenghao Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences

Using the time reversal（TR）-reverse time migration（RTM） mixed method, the numerical analysis towards the acoustic field for detection and location of targets in layered media is performed. First the approaches and steps of the numerical analysis and simulation for acoustic field are proposed, then, the acoustic field distribution of single target and multiple targets are further computed by using the approaches of single emission-multiple receiving and multiple emission-multiple receiving. The numerical simulation results indicate that target detection and location can be well realized. By comparison, good results are obtained from the both two approaches, but large time-consuming is observed in way of multiple emission-multiple receiving, and so would be unacceptable. Additionally, the improved way is also proposed for multiple target detection.

关键词： migration layered reversal consuming contour receiving steps disturbance realized convolution

High-performance SOD mimetic enzyme Au@Ce for arresting cell cycle and proliferation of acute myeloid leukemia

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Bioactive Materials 2022年第4期7卷 117-130页

作者： Yuxiang Sun Xin Liu Lei Wang Li Xu Kunliang Liu Lei Xu fangfang shi Yu Zhang Ning Gu Fei Xiong State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science and Medical Engineering&Collaborative Innovation Center of Suzhou Nano-Science and TechnologySoutheast UniversityNanjing210096PR China Department of Gastroenterology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjingPR China Jiangsu Key Laboratory of Molecular Medicine Medical School of Nanjing UniversityNanjing210093PR China Department of Research and Development Jinan Guoke Medical Technology Development Co.Ltd.Address:No.1Gangxing 3rd RoadHigh-tech Industrial Development ZoneJinan CityShandong Province250013PR China Department of Oncology Zhongda HospitalSoutheast UniversityNanjing 210009China

SOD-like activity of CeO_(2) nanoparticles(Ce NPs)is driven by Ce^(3+)/Ce^(4+),high oxidative stress can oxidize Ce^(3+) to reduce the ratio of Ce^(3+)/Ce^(4+),inactivating the SOD activity of Ce ***,we found Au@Ce NPs,assembled by Au NPs and Ce NPs,exhibited high-performance of SOD mimetic enzyme activity even upon the oxidation of H_(2)O_(2).Ce NPs supported by nano-Au can acquire the electrons from Au NPs through the enhanced localized surface plasmon resonance(LSPR),maintaining the stability of Ce^(3+)/Ce^(4+) and SOD-like ***,Au@Ce NPs retained the peroxidase function and catalase *** a result,Au@Ce NPs effectively scavenged O_(2·-) and the derived ROS in AML cells,which are the important signaling source that drives AML cell proliferation and accelerates cell cycle *** HL-60 cells were treated by Au@Ce NPs,the removal of endogenous ROS signal significantly arrested cell cycle at G1 phase and suppressed the cell proliferation by blocking the mitogen-activated protein kinases(MAPKs)signaling and the Akt/Cyclin D1 cell cycle ***,this treatment strategy showed therapeutic effect for subcutaneous transplantation of AML model as well as a satisfactory result in diminishing the leukocyte infiltration of liver and spleen ***,assembled Au@Ce NPs show the high-performance SOD-like activity,promising the potential in treating AML and regulating abnormal ROS in other diseases safely and efficiently.

关键词： Superoxide dismutase Au nanoparticles CeO_(2)nanoparticles Reactive oxygen species Acute myeloid leukemia

Experimental study on effect of recombinant human growth hormone combined with chemotherapy on stomach neoplasms implanted in nude mice

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The Chinese-German Journal of Clinical Oncology 2007年第1期6卷 27-31页

作者： fangfang shi Suyi Li Cancer Center Zhongda Hospital Southeast University Nanjing 210009 China

Objective: To investigate the effect of different doses of recombined growth hormone (rhGH) on stomach neo- plasms implanted in nude mice, and its efficacy in combining with chemotherapy (flurouracil, 5-FU). Methods: Human stom- ach neoplasms model was established in nude mice. The nude mice were divided into control group, moderate-dose of rhGH group, low-dose rhGH group, 5-FU group, moderate-dose rhGH/5-FU group, and low-dose rhGH/5-FU group. The results of each group were observed after ten days. Results: After therapy, the body mass of rhGH groups was significantly increased compared with control group (P0.05). The average tumor mass and volume of rhGH groups were not significantly increased compared with control group (P>0.05), but they were significantly reduced in 5-FU group and rhGH/5-FU groups (P0.05). After treatment, the percentages of S, G0/G1 and G2/M phases and proliferation index (PI) were not significantly changed in rhGH groups compared with control group (P>0.05), and the same with rhGH/5-FU groups compared with 5-FU group (P>0.05). The difference caused by dose of rhGH was not significant. Conclusion: rhGH enhances body mass, does not stimulate tumor growth, and has no adverse effects on tumor bearing nude mice. Combined with flurouracil, rhGH does not influence the efficacy of chemotherapy, and has no effect on tumor cell cycle kinetics.

关键词： stomach neoplasms/drug therapy mice nude recombined human growth hormone

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饮食性别文化：一项符号人类学视角的分析

广西民族研究 2017年第5期 73-78页

作者：石访访四川大学符号学-传媒学研究所四川大学文学与新闻学院成都610065

任何一个社会构成的最基本分类是男性和女性,而保障和维持社会最基础的物质媒介则是食物,性别与饮食及其衍生出的各种社会关系成为探究和分析社会文化的一个不可或缺的层面。从符号人类学的视角出发,对饮食及其性别意义作出文化上的"深... 详细信息

任何一个社会构成的最基本分类是男性和女性,而保障和维持社会最基础的物质媒介则是食物,性别与饮食及其衍生出的各种社会关系成为探究和分析社会文化的一个不可或缺的层面。从符号人类学的视角出发,对饮食及其性别意义作出文化上的"深描",通过分析人类常态与非常态下的饮食活动的性别差异,对其背后的深层逻辑做出析解,即:在人类最为日常的饮食活动,及其内含的性别差异的背后是意识形态与文化的规约。

关键词：性别饮食符号文化