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World Journal of Gastroenterology 2009年第3期15卷 366-368页

作者： Jian-Yu Hao Dong-fang Wu yue-Zeng wang Ying-Xin Gao Hai-Po Lang Wei-Zhen Zhou Department of Digestion Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China

AIM:To examine the prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis and ***:Patients scheduled for ERCP were randomly divided into study group and placebo *** in study group and placebo group were treated with 5 mg glyceryl trinitrate and 100 mg vitamin C,respectively,5 min before endoscopic ***:A total of 74 patients were enrolled in the final ***-ERCP pancreatitis occurred in 3 patients(7.9%) of the study group and 9 patients(25%) in the placebo group(P = 0.012).Hyperamylasemia occurred in 8 patients of the study group(21.1%) and 13 patients(36.1%) of the placebo group(P = 0.037).CONCLUSION:Glyceryl trinitrate before ERCP can effectively prevent post-ERCP and hyperamylasemia.

关键词： Glyceryl trinitrate Cholangiopancreatography Endoscopic retrograde Pancreatitis

Gallium enrichment in skarn iron deposits， Eastern China: Insights from the hydrothermal magnetite

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Journal of Earth Science 2024年

作者： Xian Liang fang-yue wang Long Zhang Tao-Fa Zhou Yu Fan Ju-Quan Zhang Jun-Wu Zhang Ore Deposit and Exploration Center， School of Resources and Environmental Engineering， Hefei University of Technology Anhui Province Engineering Research Center for Mineral Resources and Mine Environments Anhui Provincial Key Laboratory for Deep Exploration， Evaluation and Utilization of Strategic Mineral Resources (Hefei University of Technology) College of Earth Sciences， Hebei GEO University Institute of Earth Sciences， China University of Geosciences(Beijing)

Skarn deposits have provided large quantities of Fe， Cu， W， Sn， and other critical elements such as Ga， Co， In， Te， and Se. Previous studies on critical elements in skarn deposits have focused on the mechanism of Co， Te， and In enrichment， while the occurrence and enrichment mechanism of Ga remain unclear. In this study， we compared Ga contents in magnetite from five skarn iron deposits (including Zhuchong， Anqing， Baijian， Zhongguan， and Beiminghe) in eastern China， with a focus on the Ga enrichment at the Zhuchong deposit. Magnetite from the Zhuchong deposit has the highest Ga contents ranging from 6.4 to 134 ppm (mean = 69.4 ppm)， which is much higher than the Anqing (37.3 ppm)， Beiminghe (41.1 ppm)， and Zhongguan (19.9 ppm). Magnetite at the Zhuchong deposit can be categorized into three types based on its texture and occurrence: dense massive magnetite within magnetite ore layer (MagI: average Ga = 85.1 ppm)， disseminated magnetite in skarn layer (MagII: 23.7 ppm)， and veinlet magnetite in altered diorite (MagIII: 19.7 ppm). The positive correlation between the Ga contents in whole-rock magmatic samples and the Ga contents in magnetite from skarn deposits suggests that higher Ga contents in the magmatic rocks contribute to the formation of Ga-rich magnetite within these deposits. Due to widely developed diopside and garnet in skarn deposits， the Ga in these hydrothermal minerals is also an important factor for Ga in magnetite. Ga content in MagI decreases with the depth， following the same trend of Ti， Mn， and V， suggesting the control of temperature on the enrichment of Ga in magnetite. This study indicates that Ga in the Zhuchong deposit has the potential to be recycled during the exploitation of magnetite.

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Lifetime Measurements of Thin Carbon Stripping Foils

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IMP & HIRFL Annual Report 2004年 199-200页

作者： Li Zhankui, Zhao Yongtao, Zhang Hongbin, Xu Hushan, wang yue, fang Yan and wang Yuyu

Carbon stripping foil with long lifetime is very important in the proton or heavy ion accelerators with high intensity beam. At CSRm ring in Lanzhou, thin carbon foil with 1μg/cm2 or even less is also possibly used as an internal target. The carbons foils were made by carbon arc-discharge vapor-deposition technique. The carbon is deposited onto a surface covered with a thin layer of release agent of betaine, and is subsequently floated off in distilled water and mounted by introducing the holder made of aluminum alloy under the floating foil, allowing them to come into contact and then gently removing them together from the water.

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Lifetime Measurements of Thin Carbon Stripping Foils

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2004年第1期 178-179页

作者： Li Zhankui, Zhao Yongtao, Zhang Hongbin, Xu Hushan, wang yue, fang Yan and wang Yuyu

关键词：寿命测量剥离气相沉积技术碳重离子加速器使用寿命束流强度 CSRm

siRNA沉默EZH2基因对人宫颈癌细胞侵袭转移的影响

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西安交通大学学报（医学版） 2017年第5期38卷 684-687页

作者：冀静黄康榕黄慧芳王月玲方静西安交通大学第一附属医院妇产科陕西西安710061

目的探讨靶向沉默EZH2基因对宫颈癌细胞侵袭转移的影响及其分子机制。方法采用化学合成siRNA瞬时转染人宫颈癌C33A细胞,沉默EZH2基因的表达。通过细胞划痕实验、Transwell小室侵袭实验、软琼脂克隆形成实验,观察沉默EZH2对宫颈癌细胞迁... 详细信息

目的探讨靶向沉默EZH2基因对宫颈癌细胞侵袭转移的影响及其分子机制。方法采用化学合成siRNA瞬时转染人宫颈癌C33A细胞,沉默EZH2基因的表达。通过细胞划痕实验、Transwell小室侵袭实验、软琼脂克隆形成实验,观察沉默EZH2对宫颈癌细胞迁移、侵袭及体外成瘤能力的影响,Western blot法检测MMP2的表达变化。结果 EZH2siRNA转染C33A细胞后,细胞划痕及Transwell小室侵袭实验结果均显示宫颈癌细胞的迁移、侵袭能力明显减低,差异具有统计学意义;软琼脂克隆形成实验表明,EZH2沉默后克隆形成数目明显减少,差异具有统计学意义;Western blot结果显示MMP2表达水平下调。结论沉默EZH2基因表达能显著抑制宫颈癌C33A细胞的侵袭转移能力,其作用机制可能通过下调MMP2来实现。

关键词： EZH2基因宫颈癌 siRNA 侵袭转移

Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen Duan Lei Liu Shilong fang Weiwei wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

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间充质干细胞来源的外泌体的制备方法及应用

解剖学杂志 2016年第5期39卷 622-626页

作者：严冰浩张燕方硕王越刘厚奇第二军医大学转化医学院上海200433 第二军医大学长海医院整形外科上海200433 第二军医大学组织学与胚胎学教研室上海200433

间充质干细胞是一类多能干细胞，来源于发育早期的中胚层和外胚层，可以在骨髓、脂肪、滑膜、骨骼、肌肉和脐带等多种组织中分离，经诱导后可分化为脂肪、骨、软骨、肌肉、肌腱、韧带、神经、肝、心肌和内皮等多种组织细胞。

关键词：间充质干细胞干细胞来源制备方法外泌体应用组织细胞多能干细胞外胚层

Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia yue Ma Mingtong Gao Shuai Hou Shanshan Xu Yanqiang wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

主动电磁轴承系统变参数非线性PID控制研究

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风机技术 2020年第4期62卷 55-60页

作者：刘路王跃方大连理工大学工程力学系辽宁重大装备制造协同创新中心

主动电磁轴承(AMB)具有低能耗、无磨损、无污染的优点,已广泛用于支撑高速鼓风机等旋转机械。传统的AMB大多采用线性PID控制器,在应用上存在一定的局限性。本文提出了一种改善电磁轴承性能的变参数非线性PID控制方法,在Matlab/Simulink... 详细信息

主动电磁轴承(AMB)具有低能耗、无磨损、无污染的优点,已广泛用于支撑高速鼓风机等旋转机械。传统的AMB大多采用线性PID控制器,在应用上存在一定的局限性。本文提出了一种改善电磁轴承性能的变参数非线性PID控制方法,在Matlab/Simulink平台上搭建了控制系统动态模型,并利用遗传算法寻找非线性增益函数中待定参数的最优组合。通过算例比较了线性PID和非线性PID两种控制方案,表明本文提出的非线性控制方案具有更好的控制效果。

关键词：电磁轴承非线性PID 遗传算法仿真

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie wang Congrui Liu Chao fang Qiuxia Peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway