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Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115

Cellular & Molecular Immunology 2024年第3期21卷 275-291页

作者： Zhi-Dong Zhang Chang-Rui Shi fang-xu li Hu Gan Yanhong Wei Qianhui Zhang Xin Shuai Min Chen Yu-lin lin Tian-Chen Xiong Xiaoqi Chen Bo Zhong Dandan lin Department of Gastrointestinal Surgery Medical Research InstituteFrontier Science Center of Immunology and MetabolismZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan430071China Department of Virology College of Life SciencesWuhan UniversityWuhan430072China TaiKang Center for life and Medical Sciences Wuhan UniversityWuhan430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan430071China Department of Rheumatology and Immunology Zhongnan Hospital of Wuhan UniversityWuhan430071China Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China

STING(also known as MITA)is an adaptor protein that mediates cytoplasmic DNA-triggered signaling,and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe ***,we show that STING-mediated inflammation and autoimmunity are promoted by RNF115 and alleviated by the RNF115 inhibitor disulfiram(DSF).Knockout of RNF115 or treatment with DSF significantly inhibit systemic inflammation and autoimmune lethality and restore immune cell development in Trex1^(–/–)mice and STING^(N153S/WT) bone marrow chimeric *** addition,knockdown or pharmacological inhibition of RNF115 substantially downregulate the expression of IFN-α,IFN-γand proinflammatory cytokines in PBMCs from patients with systemic lupus erythematosus(SLE)who exhibit high concentrations of dsDNA in peripheral ***,knockout or inhibition of RNF115 impair the oligomerization and Golgi localization of STING in various types of cells transfected with cGAMP and in organs and cells from Trex1^(–/–)***,knockout of RNF115 inhibits the activation and Golgi localization of STINGN153S as well as the expression of proinflammatory cytokines in myeloid cells but not in endothelial cells or *** together,these findings highlight the RNF115-mediated cell type-specific regulation of STING and STINGN153S and provide potential targeted intervention strategies for STING-related autoimmune diseases.

关键词： STING/MITA Disulfiram RNF115 SLE Autoimmunity

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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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Science China(life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia xue-Feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao li Chang-Fa Fan Ke Song Yuan-Guo li Run-Ze Ye fang-xu li Dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi Ming-Zhu Zhang liang-Jing li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang Yan-ling Hu Na Jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China life Sciences Institute Guangxi Medical UniversityNanning 530020China College of life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

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Dynamic Location Method for Shallow Ocean Bottom Nodes Using the Levenberg-Marquart Algorithm

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Journal of Ocean University of China 2024年第4期23卷 953-960页

作者： TONG Siyou li Junjie xu Xiugang fang Yunfen WANG Zhongcheng Key Laboratory of Submarine Geosciences and Prospecting Techniques MOEOcean University of ChinaQingdao 266100China Laboratory for Marine Mineral Resources Qingdao Marine Science and Technology CenterQingdao 266237China R&D Center of BGP CNPCZhuozhou 072751China Insitute of Shengli Oilfield SINOPECDongying 257022China

Ocean bottom node(OBN)data acquisition is the main development direction of marine seismic exploration;it is widely promoted,especially in shallow sea ***,the OBN receivers may move several times because they are easily affected by tides,currents,and other factors in the shallow sea environment during long-term *** uncorrected,then the imaging quality of subsequent processing will be *** conventional secondary positioning does not consider the case of multiple movements of the receivers,and the accuracy of secondary positioning is *** first arrival wave of OBN seismic data in shallow ocean mainly comprises refracted *** this study,a nonlinear model is established in accordance with the propagation mechanism of a refracted wave and its relationship with the time interval curve to realize the accurate location of multiple receiver *** addition,the Levenberg-Marquart algorithm is used to reduce the influence of the first arrival pickup error and to automatically detect the receiver movements,identifying the accurate dynamic relocation of the *** simulation and field data show that the proposed method can realize the dynamic location of multiple receiver movements,thereby improving the accuracy of seismic imaging and achieving high practical value.

关键词： OBN dynamic location method Levenberg-Marquart algorithm seismic exploration of shallow sea

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In-orbit performance of HE onboard Insight-HXMT in the first 5 years

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Radiation Detection Technology and Methods 2023年第1期7卷 3-14页

作者： xu-fang li Cong-Zhan liu Yi-Fei Zhang Xiao-Bo li Zheng-Wei li xue-Feng Lu Zhi Chang Ming-Yu Ge Juan Zhang Yu-Peng xu fang-Jun Lu li-Ming Song Shuang-Nan Zhang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Science19B Yuquan RoadShijingshan DistrictBeijing 100049China

Purpose The high-energy X-ray telescope(HE),one of the three main payloads of the Insight-HXMT mission,is composed of eighteen NaI(Tl)/CsI(Na)phoswich detectors,where NaI(Tl)serves as the primary detector covering 20–250 keV,and CsI(Na)is used as an active shield detector to suppress the background of NaI(Tl)and also serves as an all-sky gammaray burst monitor covering 0.2–*** this paper,we review the in-orbit performance of HE in the first 5 years since Insight-HXMT was launched on June 15,*** The major performances we concern include the gain and energy resolution of NaI(Tl)and CsI(Na)detectors,the performance of pulse shape discriminator(PSD)and system dead *** this work,we investigate these performances mainly using the data of blank-sky observations and the data when the telescope is in earth *** The overall performance of HE/NaI(Tl)is very stable in the first 5 years,whereas the gain of HE/CsI(Na)shows a continuously increasing trend and should be calibrated *** In general,HE is still in good health and well-calibrated status after five-year’s *** in-orbit performance of HE has no significant deviation from *** is expected to be in operation healthily for another several years of extended mission life.

关键词： Insight-HXMT Hard X-ray telescope Scintillation detector In-orbit

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An improved transfer learning strategy for short-term cross-building energy prediction usingdata incremental

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Building Simulation 2024年第1期17卷 165-183页

作者： Guannan li Yubei Wu Chengchu Yan Xi fang Tao li Jiajia Gao Chengliang xu Zixi Wang School of Urban Construction Wuhan University of Science and TechnologyWuhan 430065China Anhui Province Key Laboratory of Intelligent Building and Building Energy-saving Anhui Jianzhu UniversityHefei 230601China State Key Laboratory of Green Building in Western China Xi'an University of Architecture and TechnologyXi'an 710055China College of Urban Construction Nanjing Tech UniversityNo.200North Zhongshan RoadNanjing 210009China Key Laboratory of Low-grade Energy Utilization Technologies and Systems(Chongqing University) Ministry of Education of ChinaChongqing UniversityChongqing 400044China College of Civil Engineering Hunan UniversityChangsha 410082China Hubei Provincial Engineering Research Center of Urban Regeneration Wuhan University of Science and TechnologyWuhan 430065China

The available modelling data shortage issue makes it difficult to guarantee the performance of data-driven building energy prediction(BEP)models for both the newly built buildings and existing information-poor *** knowledge transfer learning(KTL)and data incremental learning(DIL)can address the data shortage issue of such *** new building scenarios with continuous data accumulation,the performance of BEP models has not been fully investigated considering the data accumulation ***,which can learn dynamic features from accumulated data adapting to the developing trend of new building time-series data and extend BEP model's knowledge,has been rarely *** studies have shown that the performance of KTL models trained with fixed data can be further improved in scenarios with dynamically changing ***,this study proposes an improved transfer learning cross-BEP strategy continuously updated using the coarse data incremental(CDI)*** hybrid KTL-DIL strategy(LSTM-DANN-CDI)uses domain adversarial neural network(DANN)for KLT and long short-term memory(LSTM)as the Baseline BEP *** evaluation is conducted to systematically qualify the effectiveness and applicability of KTL and improved ***-world data from six-type 36 buildings of six types are adopted to evaluate the performance of KTL and KTL-DIL in data-driven BEP tasks considering factors like the model increment time interval,the available target and source building data *** with LSTM,results indicate that KTL(LSTM-DANN)and the proposed KTL-DIL(LSTM-DANN-CDI)can significantly improve the BEP performance for new buildings with limited *** with the pure KTL strategy LSTM-DANN,the improved KTL-DIL strategy LSTM-DANN-CDI has better prediction performance with an average performance improvement ratio of 60%.

关键词： building energy prediction(BEP) cross-building data incremental learning(DIL) domain adversarial neural network(DANN) knowledge transfer learning(KTL)

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First Record of Cyclocarya from the Early Oligocene Qaidam Basin,North Tibet:Implications for the Paleogeography and Paleoecology

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Journal of Earth Science 2024年第1期35卷 201-211页

作者： Yafei Hou Bowen Song Xiangchuan li fang Han xu Zhang Kexin Zhang Institute of Geological Survey China University of GeosciencesWuhan 430074China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan 430074China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430074China College of Earth Sciences and Resources&Key Laboratory of Western Mineral Resources and Geological Engineering of the Ministry of Education Chang'an UniversityXi'an 710054China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China School of Earth Sciences East China University of TechnologyNanchang 330013China

As the largest intermontane basin in the northeastern Tibetan Plateau(TP),the Qaidam Basin provides unique insight into paleoclimatic change and its relationship with global change and uplift on the *** this study,based on morphological comparison,fossil fruit of Cyclocarya from the Early Oligocene Shangganchaigou Formation in the Qaidam Basin is assigned as Cyclocarya *** discovery of Cyclocarya *** demonstrates the occurrence of Cyclocarya in the Oligocene sediment in Qaidam *** is the first record of Cyclocarya fossil of Early Oligocene Age in China and indicates that Cyclocarya has existed on the northeastern TP since at least the Early *** living analogues of the current fossil now lives in sub-tropical China,where the East Asian Monsoon is *** the new fossils and previously reported fossil remains of plants and fishes,it can be inferred that the Early Oligocene Qaidam Basin was primarily influenced by westerly circulation and had a relatively warm and humid climate,which was in sharp contrast to the present-day climate in Qaidam Basin.

关键词： biostratigraphy climate change winged-fruit fossil Qaidam Basin Early Oligocene paleoclimate paleogeography

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Organic Matter Accumulation in the Upper Permian Dalong Formation from the Lower Yangtze Region,South China

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 150-167页

作者： fang Chaogang ZHANG Chengcheng MENG Guixi xu Jinlong xu Naicen li Hualing liU Mu liU Bo Institute of International Rivers and Eco-Security Yunnan UniversityKunming 650500China Nanjing Center China Geological SurveyNanjing 210016China Exploration Research Institute Anhui Provincial Bureau of Coal GeologyHefei 230088China China United Coalbed Methane Corporation Ltd. Beijing 100015China Geological Survey of Anhui Province Hefei 230001China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

The Late Permian was marked by a series of important geological events and widespread organic-rich black shale depositions,acting as important unconventional hydrocarbon source ***,the mechanism of organic matter(OM)enrichment throughout this period is still *** on geochemical data,the marine redox conditions,paleogeographic and hydrographic environment,primary productivity,volcanism,and terrigenous input during the Late Permian in the Lower Yangtze region have been studied from the Putaoling section,Chaohu,to provide new insights into OM *** Phases are distinguished based on the TOC and environmental *** Phase I,anoxic conditions driven by water restriction enhanced OM *** Phase II,euxinic and cycling hydrological environments were the two most substantial controlling factors for the massive OM *** Phase III,intensified terrestrial input potentially diluted the OM in sediment and the presence of oxygen in bottom water weakened the preservation *** IV was characterized by a relatively higher abundance of mercury(Hg)and TOC(peak at 16.98 wt%),indicating that enhanced volcanism potentially stimulated higher productivity and a euxinic *** Phase V,extremely lean OM was preserved as a result of terrestrial dilutions and decreasing primary *** I,II and IV are characterized as the most prominent OM-rich zones due to the effective interactions of the controlling factors,namely paleogeographic,hydrographic environment,volcanism,and redox conditions.

关键词： geochemistry redox condition primary productivity OM accumulation Lopingian/Changhsingian Lower Yangtze region

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Numerical investigation on thermomechanical behavior of alumina–calcium hexaluminate refractories for purging plug

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Journal of Iron and Steel Research(International) 2024年第2期31卷 389-400页

作者： li-ping Pan Ya-wei li fang-guan Tan Yi-chen Chen Yang-fan xu Zhu He Bao-kuan li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina National-Provincial Joint Engineering Research Center of High Temperature Materials and lining Technology Wuhan University of Science and TechnologyWuhan430081HubeiChina

Alumina–spinel refractories used in slit-type purging plugs are susceptible to cross-sectional damage,resulting in a serious mismatch between their service life and that of ***–calcium hexaluminate refractories have gradually become the new trend in purging plug materials with the development of refining *** thermomechanical damage of slit-type purging plugs with alumina–calcium hexaluminate refractory was investigated by the thermo-solid coupling *** with the polynomial fitting and design of experiments methods,the influence of thermophysical parameters on temperature and thermal stress of alumina–calcium hexaluminate refractories for purging plugs was systematically *** results show that the maximum thermal stress of the purging plugs appears during the stages of steel transporting and stirring,and the vulnerable parts are located above Y=0.323 *** thermal conductivity and the coefficient of thermal expansion of the material are the most sensitive parameters to the temperature and thermal stress inside the structure,*** addition of more calcium hexaluminate can relieve the stress concentration and large deformation around the ***,when the content of calcium hexaluminate is 47 wt.%and in the form of aggregate-binder,the temperature and thermal stress distribution inside the refractory are optimal,which can effectively improve the service life of the slit-type purging plug.

关键词： Purging plug Thermomechanical damage Refractory Design of experiments method Stress

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Comprehensive understanding of glioblastoma molecular phenotypes:classification,characteristics,and transition

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Cancer Biology & Medicine 2024年第5期21卷 363-381页

作者： Can xu Pengyu Hou Xiang li Menglin Xiao Ziqi Zhang Ziru li Jianglong xu Guoming liu Yanli Tan Chuan fang School of Clinical Medicine Hebei UniversityDepartment of NeurosurgeryAffiliated Hospital of Hebei UniversityBaoding 07100China Hebei Key Laboratory of Precise Diagnosis and Treatment of Glioma Baoding 071000China School of Basic Medical Sciences Hebei UniversityBaoding 07100China Department of Pathology Affiliated Hospital of Hebei UniversityBaoding 07100China

Among central nervous system-associated malignancies,glioblastoma(GBM)is the most common and has the highest mortality *** high heterogeneity of GBM cell types and the complex tumor microenvironment frequently lead to tumor recurrence and sudden relapse in patients treated with *** precision medicine,research on GBM treatment is increasingly focusing on molecular subtyping to precisely characterize the cellular and molecular heterogeneity,as well as the refractory nature of GBM toward *** understanding of the different molecular expression patterns of GBM subtypes is *** have recently proposed tetra fractional or tripartite methods for detecting GBM molecular *** various molecular subtypes of GBM show significant differences in gene expression patterns and biological *** subtypes also exhibit high plasticity in their regulatory pathways,oncogene expression,tumor microenvironment alterations,and differential responses to standard ***,we summarize the current molecular typing scheme of GBM and the major molecular/genetic characteristics of each ***,we review the mesenchymal transition mechanisms of GBM under various regulators.

关键词： Glioblastoma molecular phenotype classification characteristic mesenchymal transition

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Matrix metalloproteinase 2 contributes to adult eclosion and immune response in the small hive beetle,Aethina tumida

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Insect Science 2024年第3期31卷 733-747页

作者： lixian Wu Yajing xu liangbin li Dainan Cao fang liu Hongxia Zhao Guangdong Key Laboratssory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouChina

During the pupal-adult eclosion process of holometabolous insects,the old cuticle is shed and replaced by a completely different new cuticle that requires tanning and expansion,along with extensive extracellular matrix(ECM)*** vertebrates,matrix metalloproteinases(MMPs),a class of zinc-dependent endopeptidases,play key roles in regulating the ECM that surrounds ***,little is known about these extracellular proteinases available in *** small hive beetle(SHB),Aethina tumida,is a widespread invasive parasite of honey *** this study,6 MMP homologs were identified in the SHB *** interference experiments showed that all 6 AtMmps are not required for the larval-pupal transition,only AtMmp2 was essential for pupal-adult eclosion in *** of AtMmp2 resulted in eclosion defects and wing expansion failure,as well as mortality within 3 d of adult *** analysis revealed that knockdown of AtMmp2 significantly increased expression of the Toll and Imd pathways,chitin metabolism,and cross-linking(such as the pro-phenoloxidase activating cascade pathway and the tyrosine-mediated cuticle sclerotization and pigmentation pathway).These data revealed evolutionarily conserved functions of Mmp2 in controlling adult eclosion and wing expansion,also provided a preliminary exploration of the novel function of regulating Toll and Imd pathways,as well as new insights into how MMPs regulate insect development and defense barriers.

关键词： Aethina tumida adult eclosion immune response matrix metalloproteinase RNAinterference

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