检索结果-南通市图书馆

Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

Military Medical Research 2024年第2期11卷 180-205页

作者： Hong Weng Kang-Ping Xiong Wang Wang Kai-Yu Qian Shuai Yuan Gang Wang fang Yu Jun Luo meng‑Xin Lu Zhong‑Hua Yang Tao Liu Xing huang Hang Zheng Xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain ***,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of ***:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of Wuhan *** advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in *** expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting *** elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in *** Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical ***:ASPA was identified as a novel inhibitor of PCa *** expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,mig

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Alternating current heating techniques for lithium-ion batteries in electric vehicles:Recent advances and perspectives

引用

Journal of Energy Chemistry 2024年第9期96卷 679-697页

作者： Xinrong huang Jinhao meng Wei Jiang Wenjie Liu Kailong Liu Yipu Zhang Daniel-Ioan Stroe Remus Teodorescu School of Energy and Electrical Engineering Chang’an UniversityXi’an 710018ShaanxiChina School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina School of Highway Chang’an UniversityXi’an 710018ShaanxiChina School of Automation Northwestern Polytechnical UniversityXi’an 710072ShaanxiChina School of Control Science and Engineering Shandong UniversityJinan 250100ShandongChina Department of Energy Aalborg UniversityAalborg 9220Denmark

The significant decrease in battery performance at low temperatures is one of the critical challenges that electric vehicles(EVs)face,thereby affecting the penetration rate in cold *** current(AC)heating has attracted widespread attention due to its low energy consumption and uniform heating *** paper introduces the recent advances in AC heating from the perspective of practical EV ***,the performance degradation of EVs in low-temperature environments is introduced *** concept of AC heating and its research methods are ***,the effects of various AC heating methods on battery heating performance are *** on existing studies,the main factors that affect AC heating performance are ***,various heating circuits based on EVs are categorized,and their cost,size,complexity,efficiency,reliability,and heating rate are elaborated and *** evolution of AC heaters is presented,and the heaters used in brand vehicles are sorted ***,the perspectives and challenges of AC heating are *** paper can guide the selection of heater implementation methods and the optimization of heating effects for future EV applications.

关键词： Lithium-ion battery Low temperature Alternating current heating Heater Electric vehicle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Designing weakly and strongly solvating polymer electrolytes:Systematically boosting high-voltage lithium metal batteries

引用

SusMat 2024年第4期4卷 50-64页

作者： Tianyi Wang Yimeng Zhang Xueyan huang Peifeng Su Min Xiao Shuanjin Wang Sheng huang Dongmei Han Yuezhong meng The Key Laboratory of Low-carbon Chemistry&Energy Conservation of Guangdong Province State Key Laboratory of Optoelectronic Materials and TechnologiesSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhouChina Department of Chemical Engineering Tsinghua UniversityBeijingChina School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhaiChina Institute of Chemistry Henan Provincial Academy of SciencesZhengzhouChina

Practical high-voltage lithium metal batteries hold promise for high energy density applications,but face stability challenges in electrolytes for both 4 V-class cathodes and lithium *** address this,we delve into the positive impacts of two crucial moieties in electrolyte chemistry:fluorine atom(-F)and cyano group(-CN)on the electrochemical performance of polyether electrolytes and lithium metal ***-bearing polyether electrolytes possess strong solvation,accelerating Li^(+)desolvation with minimal SEI *** polyether electrolytes possess weak solvation,and stabilize the lithium anode via preferential decomposition of F-segment,exhibiting nearly 6000-h stable cycling of lithium symmetric ***,the electron-withdrawing prop-erties of-F and-CN groups significantly bolster the high-voltage tolerance of copolymer electrolyte,extending its operational range up to 5 *** advance-ment enables the development of 4 V-class lithium metal batteries compatible with various cathodes,including 4.45 V LiCoO_(2),4.5 V LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2),and 4.2 V LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2).These findings provide insights into design prin-ciples centered around polymer components for high-performance polymer electrolytes.

关键词： cyano-bearing copolymer electrolyte fluorinated copolymer electrolyte high-voltage lithium metal battery in situ polymerization solvation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Conversion-type anode chemistry with interfacial compatibility toward Ah-level near-neutral high-voltage zinc ion batteries

引用

National Science Review 2024年第7期11卷 226-238页

作者： Shan Guo Liping Qin Jia Wu Zhexuan Liu Yuhao huang Yiman Xie Guozhao fang Shuquan Liang School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan ProvinceCentral South University College of Biological and Chemical Engineering Guangxi University of Science and Technology Information and Network Center Central South University

High-voltage aqueous zinc ion batteries（AZIBs） with a high-safety near-neutral electrolyte is of great significance for practical sustainable application; however, they suffer from anode and electrode/electrolyte interfacial incompatibility. Herein, a conversion-type anode chemistry with a low anodic potential, which is guided by the Gibbs free energy change of conversion reaction, was designed for high-voltage near-neutral AZIBs. A reversible conversion reaction between ZnC2O4·2H2O particles and three-dimensional Zn metal networks well-matched in CH3COOLi-based electrolyte was revealed. This mechanism can be universally validated in the battery systems with sodium or iodine ions. More importantly, a cathodic crowded micellar electrolyte with a water confinement effect was proposed in which lies the core for the stability and reversibility of the cathode under an operating platform voltage beyond 2.0 V, obtaining a capacity retention of 95% after 100 cycles. Remarkably, the scientific and technological challenges from the coin cell to Ah-scale battery, sluggish kinetics of the solid-solid electrode reaction, capacity excitation under high loading of active material, and preparation complexities associated with large-area quasi-solid electrolytes,were explored, successfully achieving an 88% capacity retention under high loading of more than 20 mg cm-2and particularly a practical 1.1 Ah-level pouch cell. This work provides a path for designing low-cost, eco-friendly and high-voltage aqueous batteries.

关键词： zinc compound anode conversion reaction voltage regulation interfacial design pouch cell

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Photoelectrocatalytic hydrogen evolution and synchronous degradation of organic pollutants by pg-C_(3)N_(4)/β-FeOOH S-scheme heterojunction

引用

Science China(Technological Sciences) 2024年第4期67卷 1238-1252页

作者： LI XiBao HAN Tao ZHOU YingTang XIE Yu LUO YiDan huang JunTong CHEN Zhi DENG fang School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang 330063China National-Local Joint Engineering Research Center of Heavy Metal Pollutants Control and Resource Utilization Nanchang Hangkong UniversityNanchang 330063China Zhejiang Key Laboratory of Petrochemical Environmental Pollution Control National Engineering Research Center for Marine AquacultureMarine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316022China

Crafting photoelectrocatalytic materials with robust oxidation-reduction properties for simultaneous hydrogen evolution and pollutant degradation poses a formidable *** this study,a pg-C_(3)N_(4)/β-FeOOH S-scheme heterostructure with a special energy band structure was developed by anchoring porous pg-C_(3)N_(4)on needle shapedβ-*** as a hole extraction layer,needle-leaf-likeβ-FeOOH can facilitate efficient hole migration and enhance charge ***,the optimized 0.2-pg-C_(3)N_(4)/β-FeOOH could degrade 78%of ofloxacin(OFLO)in 90 *** organic pollutants could absorb a large number of holes,which prompted a greater proportion of photogenerated electrons to actively participate in the hydrogen evolution reaction at the ***,the hydrogen production of 0.2-pg-C_(3)N_(4)/β-FeOOH reached 1452.88μmol cm^(-2)h^(-1),exhibiting a notable increase of 61.81-165.12μmol cm^(-2)h^(-1)compared with that in the absence of *** and theoretical calculation results underscore that this investigation is grounded in a distinctive electron and hole dual channel transfer *** findings offer novel insights for the future development of S-scheme heterojunction photoelectrocatalytic materials capable of concurrently degrading pollutants and promoting hydrogen evolution.

关键词： photoelectrocatalysis hydrogen evolution degradation synchronous S-scheme heterojunction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hybrid ionic/electronic interphase enabling uniform nucleation and fast diffusion kinetics for stable lithium metal anode

引用

Chinese Chemical Letters 2024年第2期35卷 626-633页

作者： Lun Li Pengxia Ji meng huang Zixin Zhang Hong Wang Francis Verpoort Jinlong Yang Daping He State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China

Lithium(Li)dendrite issue,which is usually caused by inhomogeneous Li nucleation and fragile solid electrolyte interphase(SEI),impedes the further development of high-energy Li metal ***,the integrated construction of a high-stable SEI layer that can regulate uniform nucleation and facilitate fast Li-ion diffusion kinetics for Li metal anode still falls ***,we designed an artificial SEI with hybrid ionic/electronic interphase to regulate Li deposition by in-situ constructing metal Co clusters embedded in LiF *** generated Co and LiF both enable fast Li-ion diffusion kinetics,meanwhile,the lithiophilic properties of Co clusters can serve as Li-ion nucleation sites,thereby contributing to uniform Li nucleation and non-dendritic *** a result,a dendrite-free Li deposition with a low overpotential(16.1 mV)is achieved,which enables an extended lifespan over 750 h under strict *** full cells with high-mass-loading LiFePO_(4)(11.5 mg/cm^(2))as cathodes exhibit a remarkable rate capacity of 84.1 mAh/g at 5 C and an improved cycling performance with a capacity retention of 96.4%after undergoing 180 cycles.

关键词： Lithium metal anode Hybrid ionic/electronic interphase Solid electrolyte interphase Fast diffusion kinetics Dendritic growth of lithium

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effectiveness and safety of tenofovir amibufenamide in chronic hepatitis B patients

引用

World Journal of Gastroenterology 2024年第26期30卷 3261-3263页

作者： Li-Yang meng Chao-Ting Yang Jian-Feng Bao Jin-Song huang The Fourth Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Hepatology Hangzhou Xixi HospitalZhejiang University School of MedicineHangzhou 310023Zhejiang ProvinceChina

This letter to the editor relates to the study entitled“Tenofovir amibufenamide vs tenofovir alafenamide for treating chronic hepatitis B:A real-world study”,which was recently published by Peng et *** B virus infection represents a significant health burden worldwide and can lead to cirrhosis and even liver *** antiviral drugs currently used to treat patients with chronic hepatitis B infection still have many side effects,so it is crucial to identify safe and effective drugs to inhibit viral replication.

关键词： Tenofovir amibufenamide Chronic hepatitis B Non-alcoholic fatty liver disease Alanine transaminase normalization Virological response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progression from ductal carcinoma in situ to invasive breast cancer:molecular features and clinical significance

引用

Signal Transduction and Targeted Therapy 2024年第5期9卷 1841-1868页

作者： Jing Wang Baizhou Li meng Luo Jia huang Kun Zhang Shu Zheng Suzhan Zhang Jiaojiao Zhou The Key Laboratory of Cancer Prevention and Intervention China National Ministry of Educationthe Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Breast Surgery and Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Clinical Research Center for Cancer HangzhouChina Department of Pathology the Fourth Affiliated HospitalZhejiang University School of MedicineYiwuChina Department of Plastic Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityHangzhouChina

Ductal carcinoma in situ(DCIS)represents pre-invasive breast *** untreated cases,25-60%DCIS progress to invasive ductal carcinoma(IDC).The challenge lies in distinguishing between non-progressive and progressive DCIS,often resulting in over-or under-treatment in many *** increasing screen-detected DCIS in these years,the nature of DCIS has aroused worldwide attention.A deeper understanding of the biological nature of DCIS and the molecular journey of the DCIS-IDC transition is crucial for more effective clinical ***,we reviewed the key signaling pathways in breast cancer that may contribute to DCIS initiation and *** also explored the molecular features of DCIS and IDC,shedding light on the progression of DCIS through both inherent changes within tumor cells and alterations in the tumor *** addition,valuable research tools utilized in studying DCIS including preclinical models and newer advanced technologies such as single-cell sequencing,spatial transcriptomics and artificial intelligence,have been systematically ***,we thoroughly discussed the clinical advancements in DCIS and IDC,including prognostic biomarkers and clinical managements,with the aim of facilitating more personalized treatment strategies in the *** on DCIS has already yielded significant insights into breast carcinogenesis and will continue to pave the way for practical clinical applications.

关键词： clinical breast alterations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrating multi-omics data of childhood asthma using a deep association model

引用

Fundamental Research 2024年第4期4卷 738-751页

作者： Kai Wei fang Qian Yixue Lia Tao Zeng Tao huang Bio-Med Big Data Center CAS Key Laboratory of Computational BiologyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Guoke Ningbo Life Science and Health Industry Research Institute Ningbo 315000China Guangzhou National Laboratory Guangzhou 510000China GMU-GIBH Joint School of Life Sciences The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and DiseasesGuangzhou LaboratoryGuangzhou Medical UniversityGuangzhou 510000China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Childhood asthma is one of the most common respiratory diseases with rising mortality and *** multi-omics data is providing a new chance to explore collaborative biomarkers and corresponding diagnostic models of childhood *** capture the nonlinear association of multi-omics data and improve interpretability of diagnostic model,we proposed a novel deep association model(DAM)and corresponding efficient analysis ***,the Deep Subspace Reconstruction was used to fuse the omics data and diagnostic information,thereby correcting the distribution of the original omics data and reducing the influence of unnecessary data ***,the Joint Deep Semi-Negative Matrix Factorization was applied to identify different latent sample patterns and extract biomarkers from different omics data ***,our newly proposed Deep Orthogonal Canonical Correlation Analysis can rank features in the collaborative module,which are able to construct the diagnostic model considering nonlinear correlation between different omics data *** DAM,we deeply analyzed the transcriptome and methylation data of childhood *** effectiveness of DAM is verified from the perspectives of algorithm performance and biological significance on the independent test dataset,by ablation experiment and comparison with many baseline methods from clinical and biological *** DAM-induced diagnostic model can achieve a prediction AUC of o.912,which is higher than that of many other alternative ***,relevant pathways and biomarkers of childhood asthma are also recognized to be collectively altered on the gene expression and methylation *** an interpretable machine learning approach,DAM simultaneously considers the non-linear associations among samples and those among biological features,which should help explore interpretative biomarker candidates and efficient diagnostic models from multi-omics data analysis for human complexdiseases.

关键词： Deepsub space reconstruction Deepnon-negative matrix factorization Deepcanonical correlationanalysis Multi-omics Interpretable machine learning Childhood asthma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A dual adaptive unscented Kalman filter algorithm for SINS-based integrated navigation system

引用

Journal of Systems Engineering and Electronics 2024年第3期35卷 732-740页

作者： LYU Xu meng Ziyang LI Chunyu CAI Zhenyu huang Yi LI Xiaoyong YU Xingkai Department of Precision Instrument Tsinghua UniversityBeijing 100084China College of Mechanical and Power Engineering Three Gorges UniversityYichang 443002China Unit 91001 of the PLA Beijing 100161China School of Control and Computer Engineering North China Electric Power UniversityBeijing 100096China

In this study, the problem of measuring noise pollution distribution by the intertial-based integrated navigation system is effectively suppressed. Based on nonlinear inertial navigation error modeling, a nested dual Kalman filter framework structure is developed. It consists of unscented Kalman filter (UKF)master filter and Kalman filter slave filter. This method uses nonlinear UKF for integrated navigation state estimation. At the same time, the exact noise measurement covariance is estimated by the Kalman filter dependency filter. The algorithm based on dual adaptive UKF (Dual-AUKF) has high accuracy and robustness, especially in the case of measurement information interference. Finally, vehicle-mounted and ship-mounted integrated navigation tests are conducted. Compared with traditional UKF and the Sage-Husa adaptive UKF (SH-AUKF), this method has comparable filtering accuracy and better filtering stability. The effectiveness of the proposed algorithm is verified.

关键词： Kalman filter dual-adaptive integrated navigation unscented Kalman filter(UKF) robust

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：