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Local anesthesia with ropivacaine for patients undergoing laparoscopic cholecystectomy

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World Journal of Gastroenterology 2009年第19期15卷 2376-2380页

作者： Chun-Nan yeh Hsiang-Lin Lee Chun-Yi Tsai Chih-Chung Lin Tzu-Chieh Chao Ta-Sen yeh Yi-Yin Jan Department of Surgery Chang Gung Memorial HospitalChang Gung University5 Fu-Hsing StreetKwei-ShanTaoyuan 33375TaiwanChina Department of Anesthesiology Chang Gung Memorial HospitalChang Gung University5 Fu-Hsing StreetKwei-ShanTaoyuan 33375TaiwanChina

AIM:To investigate the effect of pain relief after infu-sion of ropivacaine at port sites at the end of ***:From October 2006 to September 2007,72 patients undergoing laparoscopic cholecystectomy(LC) were randomized into two groups of 36 *** group received ropivacaine infusion at the port sites at the end of LC and the other received normal saline.A visual analog scale was used to assess postoperative pain when the patient awakened in the operating room,6 and 24 h after surgery,and before *** amount of analgesics use was also *** demographics,laboratory data,hospital stay,and perioperative complications were compared between the two ***:There was no difference between the two groups preoperatively in terms of demographic and lab-oratory *** surgery,similar operation time,blood loss,and no postoperative morbidity and mortality were observed in the two ***,a significantly lower pain score was observed in the patients undergo-ing LC with local anesthesia infusion at 1 h after LC and at *** analgesic use,the amount of meperidine used 1 h after LC and the total used during admission were lower in patients undergoing LC with local anesthesia *** group also had a shorter hospital ***:Local anesthesia with ropivacaine at the port site in LC patients signif icantly decreased post-operative pain *** explains the lower meperidine use and earlier discharge for these patients.

关键词： Prospective randomized trial Localanesthesia Ropivacaine Normal saline Laparoscopic cholecystectomy

Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma

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World Journal of Gastroenterology 2005年第28期11卷 4357-4362页

作者： Sung-Hsin Kuo Li-Tzong Chen Chi-Long Chen Shin-Lian Doong Kun-Huei yeh Hui-Chen Hsu Ming-Shiang Wu Jaw-Town Lin Hsiu-Po Wang Ann-Lii cheng Departments of Oncology National Taiwan University Hospital Taipei Cancer Research Center and Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan China Division of Cancer Research National Health Research Institutes Taipei Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taipei Taiwan China Department of Pathologyl Taipei MedicalUniversity Taipei Taiwan China Graduate Institute of Microbiology National Taiwan University College of Medicine Taipei Taiwan China Departments of Oncology National Taiwan University Hospital Taipei Cancer Research Center National Taiwan University College of Medicine Taipei Taiwan China Department of Internal Mcclicine National Taiwan University Hospital Taipei Taiwan China Department of Emergency Medicine National Taiwan University Hospital Taipei Taiwan China Department of internal Medicine and Department of Oncology National Taiwan University Hospital Taipei Cancer Research Center National Taiwan University College of MedicineTaipei Division of Cancer Research National Health Research Institutes Taipei Taiwan China

AIM： A high percentage of early-stage high-grade gastric mucosa-associated lymphoid tissue （MALT） lymphomas remain Helicobacter pylori （ H pylori）-dependent. However,unlike their low-grade counterparts, high-grade gastric MALT lymphomas may progress rapidly if unresponsive to H pylori eradication. It is mandatory to identify markers that may predict the H pylori-dependent status of these tumors. Proliferation of MALT lymphoma cells depends on cognate help and cell-to-cell contact of H pylori- spedfic intratumoral T-cells. To examine whether the expression of co-stimulatory marker CD86 （B7.2） and the infiltration of CD56 （＋） natural killer （NK） cells can be useful markers to predict Hpylori-dependent status of high-grade gastric MALT iymphoma.METHODS： Lymphoma biopsies from 26 patients who had participated in a prospective study of Hpylori-eradication for stage IE high-grade gastric MALT lymphomas were evaluated. Tumors that resolved to Wotherspoon grade Ⅱ or less alter H pylori eradication were dassified as H pylori-dependent; others were dassified as H *** infiltration of NK cells and the expression of CD86 in pre-treatment paraffin-embedded lymphoma tissues were determined by immunohistochemistry. RESULTS： There were 16 H pylori-dependent and 10 H pylori-independent cases. CD86 expression was detected in 11 （68.8%） of 16 H pylori-dependent cases but in none of 10 H pylori-independent cases （P = 0.001）.H pylori-dependent high-grade gastric MALT lymphomas contained significantly higher numbers of CD56 （＋） NK cells than H pylori-independent cases （2.8±1.4% vs 1.1±0.8%, P = 0.003）. CD86 positive MALT lymphomas also showed significantly increased infiltration of CD56 （＋） NK cells compared to CD86-negative cases （2.9±1.1% vs 1.4±1.3%; P= 0.005）.CONCLUSION： These results suggest that the expression of co-stimulatory marker CD86 and the increased infiltration of NK cells are associated with Hpylori-dependent state of early-stage high-grade gastric M

关键词： MALT lymphoma Hpylori CD86 CD56

Effects of the number of neoadjuvant therapy cycles on clinical outcomes, safety, and survival in patients with metastatic colorectal cancer undergoing metastasectomy

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Oncology Research 2022年第2期30卷 65-76页

作者： YUNG-SUNG yeh HSIANG-LIN TSAI YEN-cheng CHEN WEI-CHIH SU PO-JUNG CHEN TSUNG-KUN CHANG CHING-CHUN LI CHING-WEN HUANG JAW-YUAN WANG Division of Trauma and Surgical Critical Care Department of SurgeryKaohsiungMedical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Emergency Medicine Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Injury Prevention and Control College of Public HealthTaipei Medical UniversityTaipeiTaiwanChina Division of Colorectal Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Surgery Faculty of MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Clinical Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Surgery Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Center for Cancer Research Kaohsiung Medical UniversityKaohsiungTaiwanChina Pingtung Hospital Ministry of Health and WelfarePingtungTaiwanChina

The controversial outcomes in patients with metastatic colorectal cancer(mCRC)highlight the need for developing effective systemic neoadjuvant treatment strategies to improve clinical *** optimal treatment cycles in patients with mCRC for metastasectomy remain undeﬁ*** retrospective study compared the efﬁcacy,safety,and survival of cycles of neoadjuvant chemotherapy/targeted therapy for such ***-four patients with mCRC who received neoadjuvant chemotherapy/targeted therapy following metastasectomy were enrolled between January 2018 and April ***-eight patients received 6 cycles of chemotherapy/targeted therapy,whereas 36 patients received≥7 cycles(median,13;range,7–20).Clinical outcomes,including response,progression-free survival(PFS),overall survival(OS),and adverse events,were compared between these two *** the 64 patients,47(73.4%)were included in the response group,and 17(26.6%)were included in the nonresponse *** analysis revealed chemotherapy/targeted therapy cycle and pretreatment serum carcinoembryonic antigen(CEA)level as independent predictors of the response as well as overall survival and chemotherapy/targeted therapy cycle as an independent predictor of progression(all p0.05).The median OS and PFS were 48 months(95%CI,40.855–55.145)and 28 months(95%CI,18.952–37.48)in the≥7-cycle group and 24 months(95%CI,22.038–25.962)and 13 months(95%CI,11.674–14.326)in the 6-cycle group,respectively(both p<0.001).The oncological outcomes in the≥7-cycle group were signiﬁcantly better than those in the 6-cycle group,without signiﬁcant increases in adverse ***,prospective randomized trials are mand

关键词： Metastatic colorectal cancer Neoadjuvant chemotherapy/targeted therapy Treatment cycles Metastasectomy

The Impact of different warming devices on bacteria contamination in surgical field

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畜牧与兽医 2012年第S2期44卷 54-55页

作者： Ying-Ting Tsai Kuan-Sheng yeh Lih-Seng yeh Institute of Veterinary Clinical Sciences School of Veterinary Medicine National Taiwan University Department of Veterinary Medicine School of Veterinary Medicine National Taiwan University

Anesthesia may cause the development of *** altering the physiologic mechanisms of thermoregulation,such as redistribution of blood flow,reducing metabolic rate,and vasodilatation,heat generation is decreased and heat loss is *** related hypothermia is potentially associated with complications including coagulopathy,myocardial ischemia,surgical wound infection,*** by numerous studies,convection warmers are though to be the most effective active warming device and are widely accepted in veterinary medicine for maintaining normother-

关键词： warming contamination redistribution numerous potentially maintaining convection possibility wound excluded

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Association of overtime work and obesity with needle stick and sharp injuries in medical practice

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World Journal of Clinical Cases 2021年第35期9卷 10937-10947页

作者： Yong-Hsin Chen Chih-Jung yeh Gwo-Ping Jong Department of Occupational Safety and Health Chung Shan Medical University HospitalTaichung 40201Taiwan Department of Public Health Chung Shan Medical UniversityTaichung 40201Taiwan Department of Internal Medicine Chung Shan Medical University Hospital and Chung Shan Medical UniversityTaichung 40201Taiwan

BACKGROUND Needle stick and sharps injuries(NSIs)may cause infections among medical *** and overtime work among medical personnel increase the incidence of work *** To investigate whether overtime work and obesity increase the risk of *** This cross-sectional study used the data of 847 hospital personnel,including 104 doctors,613 nurses,67 medical laboratory scientists,54 specialist technicians,and nine surgical *** them,29 participants notified the hospital of having at least one NSI in *** data collected included age,overtime work,body mass index,medical specialty such as doctor or nurse,and professional grade such as attending physician or ***χ2 and Fisher’s exact tests were used to compare categorical *** logistic regression analysis and the Sobel test were used to assess the risk of *** Overtime work,body weight,and medical specialty were significantly associated with NSIs(P<0.05).After adjustment for risk factors,heavy overtime work was an independent risk factor for NSIs,and healthy body weight and nursing specialty were independent protective factors against *** adjustment for risk factors,medical personnel with healthy body weight has half as many NSIs as those with unhealthy body weight;the proportion of NSIs in doctors with healthy body weight was 0.2 times that in doctors with unhealthy body weight;the proportion of injuries among residents was 17.3 times higher than that among attending physicians;the proportion of injuries among junior nurses was 3.9 times higher than that among experienced nurses;the proportion of injuries among nurses with heavy overtime work was 6.6 times higher than that among nurses with mild overtime work;and the proportion of injuries among residents was 19.5 times higher than that among junior *** overtime work mediated the association of medical specialty with *** In addition to promoting the use of safety needles and pr

关键词： Medical staff Needle stick and sharps injuries Overtime work Healthy body weight Obesity

Microstructures and properties of cancellous bone of avascular necrosis of femoral heads

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Acta Mechanica Sinica 2010年第1期26卷 13-19页

作者： Xuefeng Yao Peng Wang Ruchun Dai Hsien Yang yeh Dai Department of Engineering Mechanics AML Tsinghua University 100084 Beijing China Institute of Metabolism and Endocrinology The Second Xiang-Ya Hospital Central South University410011 Changsha China Department of Mechanical and Aerospace Engineering California State University Long Beach CA 90840-8305 USA

The aim of this study is to investigate microscopic structure and characterize cancellous bone of avascular necrosis of the femoral head （ANFH）. The rabbit model of the ANFH is established. The histopathologic features are studied successfully. The differences between the steroidinjection group （S.G.） and the controlled group （C.G.） are examined, including the weight of rabbits, the hematological examination and the three-dimensional stnactures. It is found that the plasma levels of cholesterol （CHO）, high-density lipoprotein （HDL） and low-density lipoprotein （LDL） in S.G. are lower than those in C.G. when the triglyceride （TG） increased in the S.G.; but the bone mineral content （BMC） and the structural model index （SMI） of the organ and tissue decreased significantly in S.G. Three-dimensional structures of the femoral head are obtained using micro-computed tomography （CT） scanning and the mechanical model is established to analyze the influences of these structural changes on the mechanical properties of the cancellous bone.

关键词： Avascular necrosis of the femoral head Cancellous bone Microstructure Mechanical properties

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Intense blue-emitting Ca_2PO_4Cl:Eu^(2+) phosphor for near-ultraviolet converting white light-emitting diodes

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Journal of Rare Earths 2010年第S1期28卷 250-253页

作者： Yi-Chen Chiu Chun-Kuei Chang Yao-Tsung yeh Shyue-Ming Jang Material and Chemical Research Laboratories Industrial Technology Research Institute Phosphors Research Laboratory and Department of Applied Chemistry National Chiao Tung University

A blue phosphor Ca2PO4Cl:Eu2+(CAP:Eu2+) was synthesized by solid state *** Ca2PO4Cl:Eu2+ exhibited high quantum efficiency and excellent thermal *** luminescent intensity of Ca2PO4Cl:Eu2+ was found to be 128% under excitation at 380 nm,149% under 400 nm,and 247% under 420 nm as high as that of BaMgAl10O17:Eu2+.The optimal doping concentration was observed to 11 mol.% of CAP:Eu2+.The energy transfer between Eu2+ ions in CAP were occurred via electric multipolar interaction,and the critical transfer distance was estimated to be 1.26 nm.A mixture of blue-emitting Ca2PO4Cl:Eu2+,green-emitting(Ba,Sr)2SiO4:Eu2+ and red-emitting CaAlSiN3:Eu2+ phosphors were selected in conjunction with 400 nm chip to fabricate white LED *** average color-rendering index Ra and correlated color temperature(Tc) of the white LEDs were found to be 93.4 and 4590 K,*** results indicated that it was a promising candidate as a blue-emitting phosphor for the near-UV white light-emitting diodes.

关键词： Ca2PO4Cl:Eu2+ phosphors luminscense rare earths

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The experimental study for the allocation of ground-sills downstream of check dams

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International Journal of Sediment Research 2008年第1期23卷 28-43页

作者： Bing-Shyan LIN Chao-Hsien yeh Hui-Pang LIEN Candidate Department of Civil and Hydraulic Engineering Institute and Construction and Disaster Prevention Research Center Feng-Chia University Department of Water Resources Engineering Feng-Chia University

The main purpose of this study is to understand the stabilizing effect of ground-sills on the riverbed through a series of flume model experiments. From results, although check dams have the ability to control upstream sediment transport, the mass energy produced by the free fall of the overtopping discharge still causes strong local scour downstream of the structure, and this scour leads to the instability of the check dam. Therefore, this study conducted model experiments on various types of serial ground-sills to determine the appropriate spacing to best protect the downstream bed. Based on the observations and analysis of channel geomorphology and sedimentation, this study concluded the following results: 1) Serial ground-sills reduces the sediment transport ability perfectly, especially under a mild channel gradient equipped with 2-4 times the average channel width interval. But for steep slopes, it is suggested that the proper spacing should be shortened to 1-2 times the average channel width. 2) Ground-sills can effectively protect the streambed from scouring under a suitable equipped condition and the concepts of guiding scour and riverbed inertia were used in the analysis of optimal ground-sill spacing.

关键词： Serial ground-sills Sedimentation Strong scour area Riverbed inertia Guiding scour

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases

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World Journal of Gastroenterology 2019年第30期25卷 4074-4091页

作者： Matthew M yeh Dustin E Bosch Sayed S Daoud Department of Pathology University of Washington School of MedicineSeattleWA 98195United States Department of Medicine University of Washington School of MedicineSeattleWA 98195United States Department of Pharmaceutical Sciences Washington State University Health SciencesSpokaneWA 99210United States

Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver *** of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular ***,the precise role of HNF4αin the etiology of these human pathogenesis is not well *** information is known about the role of HNF4αisoforms in liver and gastrointestinal disease *** is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and *** this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal *** further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches.

关键词： Hepatocyte nuclear factor 4-alpha Liver cirrhosis Hepatocellular carcinoma Viral hepatitis Gastrointestinal tract Colorectal carcinoma Transcription factor