Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases
Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases作者机构：Department of PathologyUniversity of Washington School of MedicineSeattleWA 98195United States Department of MedicineUniversity of Washington School of MedicineSeattleWA 98195United States Department of Pharmaceutical SciencesWashington State University Health SciencesSpokaneWA 99210United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2019年第25卷第30期
页 面：4074-4091页
核心收录：
学科分类：10[医学]
主 题：Hepatocyte nuclear factor 4-alpha Liver cirrhosis Hepatocellular carcinoma Viral hepatitis Gastrointestinal tract Colorectal carcinoma Transcription factor
摘 要：Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver *** of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular ***,the precise role of HNF4αin the etiology of these human pathogenesis is not well *** information is known about the role of HNF4αisoforms in liver and gastrointestinal disease *** is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and *** this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal *** further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches.
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