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Correlation analysis of serum thyroglobulin,thyroid-stimulating hormone levels,and thyroid-cancer risk in thyroid nodule surgery

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世界临床病例杂志 2023年第27期11卷 6407-6414页

作者： Jin-Hao Shuai Zhao-fang leng Peng Wang Yi-Chi Ji Department of Thyroid and Breast Surgery Meishan City People's HospitalMeishan 620000Sichuan ProvinceChina

BACKGROUND Thyroglobulin(Tg)is one of the markers of thyroid cancer,and its concentration may be elevated in patients with malignant thyroid ***-stimulating hormone(TSH)is secreted by the pituitary gland,which has a significant impact on thyroid gland *** high or low TSH levels may be associated with an increased risk of thyroid ***,in-depth studies on the association of serum Tg and TSH levels with thyroid cancer risk in patients with thyroid nodules are *** can help determine whether Tg and TSH levels can predict the degree of malignancy of thyroid nodules,which can in turn guide doctors in making accurate diagnoses and treatment ***,such studies can provide more accurate diagnostic methods for thyroid nodules and help patients become aware of the presence of thyroid cancer as early as possible,thereby improving the success rate of treatment and *** To investigate the association of serum Tg and TSH levels with the risk of thyroid cancer in patients undergoing thyroid nodule *** The clinical data and laboratory examination results of 130 patients who underwent thyroid nodule surgery were retrospectively ***,their preoperative serum Tg and TSH levels were *** examination conducted during follow-up revealed the presence of thyroid *** analysis were used to analyze the association of Tg and TSH levels with the risk of thyroid *** Of the 130 patients,60 were diagnosed with thyroid *** analysis revealed a significant positive correlation between serum Tg levels and the risk of thyroid cancer(P0.05).CONCLUSION In patients who underwent thyroid nodule surgery,serum Tg levels exhibited a significant co

关键词： Thyroid nodule surgery Serum thyroglobulin Serum thyroid-stimulating hormone Thyroid cancer Risk correlation Prediction of thyroid nodules

Characterization of blueberry exosome-like nanoparticles and miRNAs with potential cross-kingdom human gene targets

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Food Science and Human Wellness 2024年第2期13卷 869-878页

作者： Yangfan leng Liubin Yang Siyi Pan Leilei Zhan fang Yuan College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Fruit&Vegetable Processing&Quality Control Huazhong Agricultural UniversityWuhan 430070China Wuhan GeneCreate Biological Engineering Co. Ltd.Wuhan 430070China

Edible plant derived exosome-like nanoparticles(ELNs)have been shown to have multiple nutraceutical ***,the diversity of plant materials makes the plant derived ELN study *** efforts are still needed to explore the feasible isolation methods of edible plant derived ELNs and the possible roles of food-derived ELNs in improving human *** this study,a size exclusion chromatography based method was compared with the traditional ultracentrifugation method to isolate blueberry derived ELNs(B-ELNs),and the miRNA profile of B-ELNs was analyzed by high-throughput sequencing.A total of 36 miRNAs were found to be enriched in B-ELNs compared with berry tissue,and their potential cross-kingdom human gene targets were further *** showed that size exclusion chromatography was effective for B-ELN *** most abundant miRNAs in B-ELNs mainly belonged to the miR166 family and miR396 *** gene prediction indicated that B-ELNs could potentially regulate pathways related to the human digestive system,immune system and infectious diseases.

关键词： Edible plant derived exosomes-like nanoparticles Size exclusion chromatography miRNA Target gene prediction Blueberry

基于三维激光扫描技术的金矿采空区调查对比分析研究

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山东国土资源 2024年第9期40卷 74-78页

作者：孙萌鑫冷芳邢晓平寻鹏毕进超姜兆君山东省地质矿产勘查开发局第六地质大队(山东省第六地质矿产勘查院) 山东威海264209 山东省数据开放创新应用实验室山东威海264209 山东大学文化传播学院山东威海264209

本文采用三维激光扫描技术,分别使用手持ZEB-HORIZON型便携三维激光扫描仪和站式天宝TX8三维激光扫描仪2种设备进行井下采空区测量,结合GeoSLAM Hub、RealWorks、Geomagic Studio等相关软件,进行了点云的去噪、抽稀、三维建模等一系列处... 详细信息

本文采用三维激光扫描技术,分别使用手持ZEB-HORIZON型便携三维激光扫描仪和站式天宝TX8三维激光扫描仪2种设备进行井下采空区测量,结合GeoSLAM Hub、RealWorks、Geomagic Studio等相关软件,进行了点云的去噪、抽稀、三维建模等一系列处理,快速有效地计算出采空区的体积、金属量等相关信息。通过手持ZEB-HORIZON型便携三维激光扫描仪和天宝TX8站式三维激光扫描仪数据对比和精度评定,发现手持ZEB-HORIZON型便携三维激光扫描仪更适合远距离、复杂环境的井下测量,经过多站测量后的数据采集更加高效,测量精度更加准确,能够为国土、公安等相关部门提供有力的数据支撑。

关键词：三维激光扫描采空区三维建模金属量精度评定

Sequentially releasing self-healing hydrogel fabricated with TGFβ3-microspheres and bFGF to facilitate rat alveolar bone defect repair

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Asian Journal of Pharmaceutical Sciences 2022年第3期17卷 425-434页

作者： Fenglin Yu Dezhi Geng Zhanpeng Kuang Shiyi Huang Yating Cheng Yini Chen fang leng Yu Bei Yueping Zhao Qingxia Tang Yadong Huang Qi Xiang Department of Cell Biology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Bioengineering Medicine Jinan UniversityGuangzhou 510632China Biopharmaceutical R&D Center of Jinan University Guangzhou 510632China Department of Stomatology Jinan University Medical CollegeGuangzhou 510632China

Resorption and loss of alveolar bone leads to oral dysfunction and loss of natural or implant teeth. Biomimetic delivery of growth factors based on stem cell recruitment and osteogenic differentiation, as the key steps in natural alveolar bone regenerative process, has been an area of intense research in recent years. A mesoporous self-healing hydrogel(DFH) with basic fibroblast growth factor(bFGF) entrapment and transforming growth factor β3(TGFβ3)-loaded chitosan microspheres(CMs) was developed. The formulation was optimized by multiple tests of self-healing, in-bottle inversion, SEM, rheological, swelling rate and in vitro degradation. In vitro tubule formation assays, cell migration assays, and osteogenic differentiation assays confirmed the ability of DFH to promote blood vessels, recruit stem cells, and promote osteogenic differentiation. The optimum DFH formula is 0.05 ml 4ArmPEG-DF(20%) added to 1 ml CsGlu(2%) containing bFGF(80 ng) and TGFβ3-microspheres(5 mg). The results of in vitro release studied by Elisa kit, indicated an 95% release of b FGF in7 d and long-term sustained release of TGFβ3. For alveolar defects rat models, the expression levels of CD29 and CD45, the bone volume fraction, trabecular number, and trabecular thickness of new bone monitored by Micro-CT in DFH treatment groups were significantly higher than others(*P < 0.05, vs Model). HE and Masson staining show the same *** conclusion, DFH is a design of bionic alveolar remodelling microenvironment, that is in early time microvessels formed by b FGF provide nutritious to recruited endogenous stem cells, then TGFβ3 slowly released speed up the process of new bones formation to common facilitate rat alveolar defect repair. The DFH with higher regenerative efficiency dovetails nicely with great demand due to the requirement of complicated biological processes.

关键词： Self-healing hydrogel TGFβ3 microspheres bFGF Sequential release Alveolar defects

Effects of penehyclidine hydrochloride in small intestinal damage caused by limb ischemia-reperfusion

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World Journal of Gastroenterology 2011年第2期17卷 254-259页

作者： Yan Zhang Yu-fang leng Xing Xue Yue Zhang Tao Wang Yu-Qing Kang Department of Anesthesiology First HospitalLanzhou University Lanzhou 730000 Gansu Province China

AIM:To investigate the protective effect of penehyclidine hydrochloride post-conditioning in the damage to the barrier function of the small intestinal mucosa caused by limb ischemia-reperfusion(LIR) injury. METHODS:Male Wistar rats were randomly divided into three groups(36 rats each) :the sham-operation group(group S) ,lower limb ischemia-reperfusion group(group LIR) ,and penehyclidine hydrochloride postconditioning group(group PHC) .Each group was divided into subgroups(n=6 in each group) according to ischemic-reperfusion time,*** 0 h(T1) ,1 h(T2) ,3 h(T3) ,6 h(T4) ,12 h(T5) ,and 24 h(T6) .Bilateral hind-limb ischemia was induced by rubber band application proximal to the level of the greater trochanter for 3 *** group PHC,0.15 mg/kg of penehyclidine hydrochloride was injected into the tail vein immediately after 3 h of bilateral hind-limb *** designated rats were sacrificed at different time-points of reperfusion;diamine oxidase(DAO) ,superoxide dismutase(SOD) activity,myeloperoxidase(MPO) of small intestinal tissue,plasma endotoxin,DAO,tumor necrosis factor-α(TNF-α) ,and interleukin(IL) -10 in serum were detected in the rats. RESULTS:The pathological changes in the small intestine were observed under light *** levels of MPO,endotoxin,serum DAO,and IL-10 at T1-T6,and TNF-αlevel at T1-T4 increased in groups LIR and PHC(P<0.05) compared with those in group S,but tissue DAO and SOD activity at T1-T6 decreased(P<0.05) .In group PHC,the tissue DAO and SOD activity at T2-T6,and IL-10 at T2-T5 increased to higher levels than those in group LIR(P<0.05) ;however,the levels of MPO,endotoxin,and DAO in the blood at T2-T6,and TNF-αat T2 and T4 decreased(P<0.05) . CONCLUSION:Penehyclidine hydrochloride post-conditioning may reduce the permeability of the small intestines after *** protection mechanisms may be related to inhibiting oxygen free radicals and inflammatory cytokines for organ damage.

关键词： Penehyelidine hydrochloride Post-conditioning Limb ischemia-reperfusion injury Small intestine Protection

Oxidative stress and hypoxia-induced factor 1α expression in gastric ischemia

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World Journal of Gastroenterology 2011年第14期17卷 1915-1922页

作者： Tao Wang Yu-fang leng Yan Zhang Xing Xue Yu-Qing Kang Yue Zhang Department of Anesthesiology The First Hospital of Lanzhou University Lanzhou 73000 Gansu Province China

AIM:To investigate the relation of reactive oxygen species (ROS) to hypoxia induced factor 1α (HIF-1α) in gastric ischemia. METHODS:The animal model of gastric ischemia reperfusion was established by placing an elastic rubber band on the proximal part of the bilateral lower limb for ligature for 3 h and reperfusion for 0,1,3,6,12 or 24 h. Ischemic post-conditioning,three cycles of 30-s reperfusion and 30-s femoral aortic reocclusion were conducted before reperfusion. Histological and immunohistochemical methods were used to assess the gastric oxidative damage and the expression of HIF1-α in gastric ischemia. The malondialdehyde (MDA) content and superoxide dismutase (SOD),xanthine oxidase (XOD) and myeloperoxidase (MPO) activities were determined by colorimetric assays. RESULTS:Ischemic post-conditioning can reduce post-ischemic oxidative stress and the expression of HIF-1α of gastric tissue resulting from limb ischemia reperfusion injury. MDA,SOD,XOD and MPO were regarded as indexes for mucosal injuries from ROS,and ROS was found to affect the expression of HIF-1α under gastric ischemic conditions. CONCLUSION:ROS affects HIF-1α expression under gastric ischemic conditions induced by limb ischemia reperfusion injury. Therefore,ROS can regulate HIF-1α expression in gastric ischemia.

关键词： Oxidative stress Reactive oxygen species HIF-1α expression Gastric ischemia Limb ischemia reperfusion

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船体行驶过程中的压力监测方法

舰船科学技术 2022年第20期44卷 46-49页

作者：冷芳大连海洋大学辽宁大连116300

本文对船舶航行过程进行分析,着重研究船舶在航行过程中的流场理论,并对船舶受到的阻力进行分析,同时给出船舶摩擦阻力和傅汝德数之间的关系;基于计算流体力学对船舶航行过程中的受力情况进行仿真分析,探讨波浪流速对船舶航行过程的影响... 详细信息

本文对船舶航行过程进行分析,着重研究船舶在航行过程中的流场理论,并对船舶受到的阻力进行分析,同时给出船舶摩擦阻力和傅汝德数之间的关系;基于计算流体力学对船舶航行过程中的受力情况进行仿真分析,探讨波浪流速对船舶航行过程的影响,同时对波浪抨击下的船体受力情况进行分析。最后,构建出船舶压力监测系统。本文对船体行驶过程中压力监测方法的研究,有助于推动船舶结构安全技术的发展。

关键词：船体行驶过程压力检测

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东亚地区碳循环研究新进展

生物化学与生物物理进展 2011年第11期38卷 1015-1019页

作者：冷方伟中国科学院生物物理研究所北京100101

近百年来,温室效应的日益加剧,引发了全球温暖化、海平面上升等一系列重大环境问题,碳循环研究因此而受到全球范围的普遍关注和重视.东亚地区因其独特的气候特征,多样化的物种和生态系统,以及活跃的人类活动而成为世界碳循环研究中不可... 详细信息

近百年来,温室效应的日益加剧,引发了全球温暖化、海平面上升等一系列重大环境问题,碳循环研究因此而受到全球范围的普遍关注和重视.东亚地区因其独特的气候特征,多样化的物种和生态系统,以及活跃的人类活动而成为世界碳循环研究中不可或缺的一部分.在中、日、韩三国联合启动东亚碳循环前沿研究计划(A3 Foresight Program)三周年之际,《中国科学生命科学》(Science China Life Sciences)2010年第7期发表了东亚地区碳循环研究专题,包括14篇述评和研究论文,从区域碳储量及其变化特征,不同地带森林生态系统的碳源汇变化,草地和农田生态系统的碳储量和碳循环研究中的新方法等多个方面系统展示了东亚地区碳循环研究的最新进展.

关键词：碳循环东亚地区碳储量生态系统

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NLRP10蛋白的结构和自组装

生物化学与生物物理进展 2015年第12期42卷 1112-1118页

作者：冷方伟谢灿王大成中国科学院生物物理研究所生物大分子国家重点实验室北京100101 中国科学院大学北京100049 北京大学生命科学学院北京100871

NLRP10是NOD样受体(NOD-like receptor,NLR)蛋白家族的特殊成员,它具有N端热蛋白结构域(pyrin-like domain,PYD)和中间的核苷酸结合寡聚结构域(nucleotide-binding and oligomerization domain,NOD),却不具有亮氨酸富集重复结构域(leucine-rich repeat domain,LRR),这表明NLRP10可能并不直接参与病原微生物的识别,而是行使免疫调节的功能.研究表明,NLRP10能促进NOD1介导的免疫反应,也能抑制NLRP3炎症小体的激活.在参与免疫调控时,NLRP10以聚集体的形式与接头蛋白ASC结合,继而招募相应免疫信号通路中的其他成员.NLRP10蛋白在结构方面的研究很有限,目前仅有PYD结构域的相关报道.本文在尝试纯化全长人源NLRP10时,同时得到了PYD结构域缺失的稳定蛋白片段,电镜结果表明存在条形和环形两种形态的聚集体.通过序列分析和定点突变,我们找到了潜在的蛋白质降解位点,从而解决了纯化过程中蛋白质降解的问题,为后期的高分辨结构测定奠定了基础.

关键词： NLRP10 PYD 自组装免疫调控