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Analysis of the necessity of implementing the “dual specialty” training model from the perspective of nursing master students

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Journal of Integrative Nursing 2021年第1期3卷 30-35页

作者： Miao‑Qing ZHUANG hong‑fang CHEN Huan‑Ze LI School of Nursing Shaanxi University of Chinese MedicineXianyangShaanxiChina Department of Nursing Shaanxi Traditional Chinese Medicine HospitalXi’anShaanxiChina

Objective:The objective is to understand the current situation of clinical practice training for nursing master’s degree postgraduates,and discuss the necessity of implementing the“dual specialty”training mode for nursing master’s degree postgraduates in ***:Phenomenological research method was used to conduct semi‑structured in‑depth interviews with 10 nursing master’s degree graduates,and the data were analyzed by Colaizzi 7‑step analysis ***:Four topics were extracted:The objective of clinical practice training for nursing master degree postgraduates was not specific;the cultivation direction is not refined;the ability of clinical practice is weak;the research direction is not consistent with the required ***:Implementing special double training mode can solve nursing professional master degree postgraduate education lacking the ability to service the needs of society,graduate students and the existing problems of specialist nurse training and the cultivation of“heavy science,light clinical practice”status quo and the effective way of guiding graduate students career planning,so the implementation of special“double”training mode is necessary.

关键词： Dual specialty graduate student master’s degree nurse specialist nursing education nursing talents

Sleep disorders in Alzheimer’s disease:the predictive roles and potential mechanisms

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Neural Regeneration Research 2021年第10期16卷 1965-1972页

作者： Huang Kuang Yu-Ge Zhu Zhi-Feng Zhou Mei-Wen Yang Fen-fang hong Shu-Long Yang Department of Physiology College of MedicineNanchang UniversityNanchangJiangxi ProvinceChina Department of Nurse Nanchang University HospitalNanchangJiangxi ProvinceChina Department of Experimental Teaching Center Nanchang UniversityNanchangJiangxi ProvinceChina

Sleep disorders are common in patients with Alzheimer’s disease,and can even occur in patients with amnestic mild cognitive impairment,which appears before Alzheimer’s *** disorders further impair cognitive function and accelerate the accumulation of amyloid-βand tau in patients with Alzheimer’s *** present,sleep disorders are considered as a risk factor for,and may be a predictor of,Alzheimer’s disease *** that sleep disorders are encountered in other types of dementia and psychiatric conditions,sleep-related biomarkers to predict Alzheimer’s disease need to have high specificity and ***,we summarize the major Alzheimer’s disease-specific sleep changes,including abnormal non-rapid eye movement sleep,sleep fragmentation,and sleep-disordered breathing,and describe their ability to predict the onset of Alzheimer’s disease at its earliest *** the mechanisms underlying these sleep changes is also crucial if we are to clarify the role of sleep in Alzheimer’s *** paper therefore explores some potential mechanisms that may contribute to sleep disorders,including dysregulation of the orexinergic,glutamatergic,andγ-aminobutyric acid systems and the circadian rhythm,together with amyloid-β*** review could provide a theoretical basis for the development of drugs to treat Alzheimer’s disease based on sleep disorders in future work.

关键词： Alzheimer’s disease amyloid-βaccumulation circadian rhythm GABAergic system glutamatergic system non-rapid eye movement sleep orexinergic system sleep disorders sleep fragmentation sleep-disordered breathing

Methionine as a methyl donor regulates caste differentiation in the European honey bee(Apis mellifera)

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Insect Science 2021年第3期28卷 746-756页

作者： Wen-Feng Chen Ying Wang Wei-Xing Zhang Zhen-Guo Liu Bao-Hua Xu hong-fang Wang College of Animal Science and Technology Shandong Agricultural UniversityTaianShandong ProvinceChina

Nutrition contributes to honey bee caste differentiation,but the role of individual nutrients is still *** essential amino acid contents,except that of methionine(Met),are greater in royal jelly than worker ***〜3.5 i the Met content in the latter was slightly greater than in the *** is the major raw material used in the synthesis of S-adenosyl-L-methionine,an active methyl donor for DNA methylation,which is an epigenetic driver of caste ***,we tested whether Met regulates caste differentiation in honey bees by determining its effects on the caste development of bees receiving four diets:the basic,basic+0.2%Met,basic+0.2%Met+20 mg/kg 5-azacytidine,and basic+20 mg/kg *** presence of Met decreased the adult bee body length and the numbers of ovarioles,indicating that Met may direct the development of female larvae toward worker *** upregulated expression of SAMS,Dnmtl,and Dnmt3 caused by Met exposure in 4-d-old larvae indicated that the worker-inductive effects of Met may occur through the promotion of DNA *** investigated the co-effects of Met and glucose on bee development,and found that the effects of an increased glucose level on the number of ovarioles and body length did not strengthen the worker-inductive effects caused by *** results contribute to caste development theory and suggest that Met-as a methyl donor一plays a regulatory,but not decisive,role in caste differentiation.

关键词： Apis mellifera body length caste differentiation methionine methyl donor ovarioles

Age and mean platelet volume-based nomogram for predicting the therapeutic efficacy of metoprolol in Chinese pediatric patients with vasovagal syncope

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World Journal of Pediatrics 2024年第9期20卷 957-965页

作者： Xiao-Juan Du Ya-Qian Huang Xue-Ying Li Ying Liao hong-fang Jin Jun-Bao Du Department of Pediatrics Peking University First HospitalNo.1 Xi’anmen StreetWest DistrictBeijing100034China State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityNo.38Xueyuan RoadHaidian DistrictBeijing100191China Department of Statistics Peking University First HospitalBeijing100034China

Background Vasovagal syncope(VVS)is the most common type of orthostatic intolerance in *** investigated whether platelet-related factors related to treatment efficacy in children suffering from VVS treated with *** Metoprolol-treated VVS patients were *** median duration of therapy was three *** were followed and divided into two groups,treament-effective group and treatment-ineffective *** and least absolute shrinkage selection operator regressions were used to examine treatment outcome ***-operating characteristic(ROC)curves,precision-recall(PR)curves,calibration plots,and decision curve analyses were used to evaluate the nomogram *** Among the 72 patients who complete the follow-up,treatment-effective group and treatment-ineffective group included 42(58.3%)and 30(41.7%)cases,*** patients in the treatment-effective group exhibited higher mean platelet volume(MPV)[(11.0±1.0)fl vs.(9.8±1.0)fl,P<0.01]and platelet distribution width[12.7%(12.3%,14.3%)vs.11.3%(10.2%,12.2%),P<0.01]than those in the treatment-ineffective *** sex ratio was significantly different(P=0.046).A fit model comprising age[odds ratio(OR)=0.766,95%confidence interval(CI)=0.594-0.987]and MPV(OR=5.613,95%CI=2.297-13.711)might predict therapeutic *** area under the curve of the ROC and PR curves was computed to be 0.85 and 0.9,*** P value of the Hosmer-Lemeshow test was *** decision curve analysis confirmed that managing children with VVS based on the predictive model led to a net advantage ranging from 0.01 to *** nomogram is convenient for clinical *** A novel nomogram based on age and MPV can predict the therapeutic benefits of metoprolol in children with VVS.

关键词： Metoprolol Nomogram Retrospective study Therapeutic effect Vasovagal syncope

Role of c-Jun NH_(2)-terminal kinase-mediated mitogen-activated protein kinase pathway in response to pesticides in Apis cerana cerana

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Insect Science 2023年第1期30卷 47-64页

作者： Xiao-Jing Niu Li-Jun Wang Hui Meng hong-fang Wang Bao-Hua Xu Chen Wang State Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTaianShandong ProvinceChina College of Animal Science and Technology Shandong Agricultural UniversityTaianShandong ProvinceChina

The mitogen-activated protein kinase(MAPK)cascade pathway plays an important role in regulating stress *** function of the c-Jun NH_(2)-terminal kinase(JNK),a component of the MAPK cascade pathway,in Apis cerana cerana(Acc)remains ***,JNK was isolated and identified from *** analyses revealed there is a typical serine/threonine protein kinase catalytic domain in the AccJNK *** expression profile analysis showed that AccJNK was significantly induced by pesticide *** further explore the functional mechanisms of AccJNK,a yeast 2-hybrid screen was performed,activator protein-1(AP-1)was screened as the interaction partner of AccJNK,and the interaction relationship was further verified by pull-down *** real-time polymerase chain reaction showed the expression pattern of AccAP-I was similar to that of *** a knockdown of AccJNK or AccAP-I by RNA interference,the survival rate of Acc after pesticide treatments ***,the expression levels of antioxidant-related genes and the activities of antioxidant enzymes increased,suggesting that the knockdown of AccJNK or AccAP-I increased the antioxidant capacity of *** study revealed that the JNK-mediated MAPK pathway responds to pesticide stress by altering the antioxidant capacity of Acc.

关键词： Apis cerana cerana MAPK cascade oxidative stress pesticide stress RNA interference

Effect of Tillage System on Distribution of Aggregates and Organic Carbon in a Hydragric Anthrosol

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Pedosphere 2008年第5期18卷 574-581页

作者： GAO Ming LUO You-Jin WANG Zi-fang TANG Xiao-hong WEI Chao-Fu College of Resources and Environment Southwest University Chongqing 400716 （China）.

The effect of different tillage systems on the size distribution of aggregates and organic carbon distribution and storage in different size aggregates in a Hydragric Anthrosol were studied in a long-term experiment in Chongqing,China. The experiment included three tillage treatments:conventional tillage with rotation of rice and winter fallow(CT-r) system,no-till and ridge culture with rotation of rice and rape(RT-rr) system,and conventional tillage with rotation of rice and rape(CT-rr) system. The results showed that the aggregates 0.02-0.25 mm in diameter accounted for the largest portion in each soil layer under all treatments. Compared with the CT-r system,in the 0-10 cm layer,the amount of aggregates > 0.02 mm was larger under the RT-rr system,but smaller under the CT-rr system. In the 0-20 cm layer,the organic carbon content of all fractions of aggregates was the highest under the RT-rr system and lowest under the CT-rr system. The total organic carbon content showed a positive linear relationship with the amount of aggregates with diameter ranging from 0.25 to 2 mm. The storage of organic carbon in all fractions of aggregates under the RT-rr system was higher than that under the CT-r system in the 0-20 cm layer,but in the 0-60 cm soil layer,there was no distinct difference. Under the CT-rr system,the storage of organic carbon in all fractions of aggregates was lower than that under the CT-r system;most of the newly lost organic carbon was from the aggregates 0.002-0.02 and 0.02-0.25 mm in diameter.

关键词： aggregates Hydragric Anthrosol organic carbon tillage system

Cross-section measurement of(n,2n) reactions for Nd isotopes induced by 14 MeV neutrons

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Nuclear Science and Techniques 2019年第1期30卷 67-72页

作者： Qiang Wang Bing-Jun Chen Qian Zhang Si-Min Cai Chang-Lin Lan Kai-hong fang School of Nuclear Science and Technology Lanzhou University Engineering Research Center for Neutron Application Technology Ministry of Education Lanzhou University

Cross-sections of the(n,2n) reactions for neodymium(Nd) isotopes induced by 14 MeV neutrons were measured in this work by using the activation and relative methods. The measured cross-sections of the ^(150)Nd(n,2n)^(149)Nd,^(148)Nd(n,2n)^(147)Nd, and ^(142)Nd(n,2 n)^(141)Nd reactions were 1854 ± 81, 1789 ± 119, and 1559 ± 98 mb, respectively, at a neutron energy of 14.2 ± 0.2 MeV,and 1485 ± 74, 1726 ± 85, and 1670 ± 119 mb, respectively, at 14.9 ± 0.2 MeV. The results were compared with the experimental values from the reported literature, with the evaluated data from the ENDF/B-VII.1, CENDL-3.1, and JENDL-4.0 libraries, and with the curves calculated by the Talys-1.8 code.

关键词： Cross-section Neodymium (n,2n)reaction Activation method 14 MeV neutron

Preparation　and　Evaluation　of　Polyethylene　Glycol　Acrylate　Coated　Capillary　Zone　Elcctrophoresis　Column

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Chinese Chemical Letters 1996年第12期7卷 1109-1112页

作者： Xiao hong fang Ai Jin HUANG and Yi Liang SUN(Department of Chemistry, Peking University, Beijing 100871) Department of Chemistiy Peking University Beijing 100871

Polyethylene glycol acrylate was covalently bound onto the capillary surface and crosslinked by azobisisobutyronitrile(AIBN ). The coating is stable oiler pH 2-9. has a good coating reproducibility and can be used for... 详细信息

关键词： Evaluation Polyethylene and Glycol Acrylate Capillary

Phenotypic and genotypic characterization of inflammatory bowel disease in children under six years of age in China

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World Journal of Gastroenterology 2018年第9期24卷 1035-1045页

作者： You-hong fang You-You Luo Jin-Dan Yu Jin-Gan Lou Jie Chen Department of Gastroenterology Children's Hospital Zhejiang University School of Medicine

AIM To analyze clinical differences between monogenic and nonmonogenic very-early-onset inflammatory bowel disease(VEO-IBD) and to characterize monogenic IBD phenotypically and genotypically via genetic testing. METHODS A retrospective analysis of children aged 0 to 6 years diagnosed with VEO-IBD in a tertiary hospital in southern China from 2005 to 2017 was performed. Clinical data for VEO-IBD patients were collected, and genetic characteristics were analyzed using whole exome sequencing or target gene panel sequencing. RESULTS A total of 54 VEO-IBD patients were included in this study. A diagnosis of Crohn's disease(CD) or CDlike intestinal manifestations accounted for 72.2% of the VEO-IBD cases. Nine patients(16.7%) were identified by genetic testing as having monogenic IBD. The median age of diagnosis in the monogenic group was younger than that of the nonmonogenic IBD group, at 18 mo(interquartile range(IQR): 4 to 78) and 43.5 mo(IQR: 3 to 173), respectively; the P-value was 0.021. The incidence of perianal disease in the monogenic group was higher than that in the nonmonogenic group(P = 0.001). However, there were no significant differences between weight-forage and height-for-age Z-scores between the two groups, and similar laboratory results were obtained for the two groups. Five patients were found to have IL10 receptor mutation, two patients had chronic granulomatous disease, one patient had common variable immunodeficiency disease, and one patient had X-linked inhibitor of apoptosis protein deficiency. CONCLUSION A high proportion of monogenic IBD was observed in the VEO-IBD group, especially with disease onset before the age of 6 mo. Monogenic IBD and nonmonogenic IBD exhibited similar clinical features. Furthermore, next-generation sequencing played an important role in the diagnosis of monogenic IBD, and IL10 receptor mutation was predominant in this cohort.

关键词： Monogenic very-early-onset inflammatory bowel disease primary immunodeficiency diseases IL10 IL10R