Methionine as a methyl donor regulates caste differentiation in the European honey bee(Apis mellifera)
作者机构：College of Animal Science and TechnologyShandong Agricultural UniversityTaianShandong ProvinceChina
出 版 物：《Insect Science》 (昆虫科学（英文版）)
年 卷 期：2021年第28卷第3期
页 面：746-756页
核心收录：
学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 09[农学] 0904[农学-植物保护] 0901[农学-作物学] 0713[理学-生态学]
基 金：Funds of Shandong Province"Double Tops"Program(2016-2020) Shandong Province Agricultural Fine Varieties Breeding Projects(2017LZN006) the earmarked fund for the China Agriculture Research System(No.CARS-44)
主 题：Apis mellifera body length caste differentiation methionine methyl donor ovarioles
摘 要：Nutrition contributes to honey bee caste differentiation,but the role of individual nutrients is still *** essential amino acid contents,except that of methionine(Met),are greater in royal jelly than worker ***〜3.5 i the Met content in the latter was slightly greater than in the *** is the major raw material used in the synthesis of S-adenosyl-L-methionine,an active methyl donor for DNA methylation,which is an epigenetic driver of caste ***,we tested whether Met regulates caste differentiation in honey bees by determining its effects on the caste development of bees receiving four diets:the basic,basic+0.2%Met,basic+0.2%Met+20 mg/kg 5-azacytidine,and basic+20 mg/kg *** presence of Met decreased the adult bee body length and the numbers of ovarioles,indicating that Met may direct the development of female larvae toward worker *** upregulated expression of SAMS,Dnmtl,and Dnmt3 caused by Met exposure in 4-d-old larvae indicated that the worker-inductive effects of Met may occur through the promotion of DNA *** investigated the co-effects of Met and glucose on bee development,and found that the effects of an increased glucose level on the number of ovarioles and body length did not strengthen the worker-inductive effects caused by *** results contribute to caste development theory and suggest that Met-as a methyl donor一plays a regulatory,but not decisive,role in caste differentiation.
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