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基于临界半衰期的连续流反应热安全风险评估方法

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含能材料 2024年第3期32卷 298-311页

作者：盛敏田均均王芳芳李玮晔吴展华华东理工大学反应安全中心上海200237 中国工程物理研究院化工材料研究所四川绵阳621999

为了更好地评估连续流反应热安全风险,研究以通道式反应器为例,通过构建基于热量衡算和物料衡算的反应体系模型,对连续流反应体系的实际传热量和热安全风险进行了研究。针对通道式反应器进口端的绝热温升反应现象,提出了临界半衰期作为... 详细信息

为了更好地评估连续流反应热安全风险,研究以通道式反应器为例,通过构建基于热量衡算和物料衡算的反应体系模型,对连续流反应体系的实际传热量和热安全风险进行了研究。针对通道式反应器进口端的绝热温升反应现象,提出了临界半衰期作为热安全判据的方法,获得了具有热安全高风险的两大反应条件,分别为:当目标反应产热总量大于800 J·g^(-1),且该反应在反应温度下半衰期小于临界半衰期;当分解反应产热总量大于800 J·g^(-1),且目标反应在反应温度下半衰期小于临界半衰期,同时分解反应在100%MTSR(工艺反应能够达到的最高温度)下半衰期也小于临界半衰期。并且通过氯苯硝化反应验证其准确性和实用性,结果显示,通道式反应器在该条件下可发生分解爆炸反应,证实了该评估方法可用于确定连续流反应热安全的高风险条件。

关键词：通道式反应器传热速率绝热温升反应反应安全风险评估方法分解爆炸事故

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卤代苯醌类消毒副产物的毒理学研究进展

环境化学 2024年第7期43卷 2206-2213页

作者：王芳赖玮毅汪海林江汉大学持久性有毒污染物环境与健康危害湖北省重点实验室环境与健康学院武汉430056 中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室北京100085

卤代苯醌(halobenzoquinones,HBQs)是近年来在水体中发现的一类具有潜在毒理学效应且未受管控的新型消毒副产物(disinfection by-products,DBPs).本文综述了HBQs的化学特征与生成机制、环境中的分布情况,并对其引起的细胞毒性、氧化应... 详细信息

卤代苯醌(halobenzoquinones,HBQs)是近年来在水体中发现的一类具有潜在毒理学效应且未受管控的新型消毒副产物(disinfection by-products,DBPs).本文综述了HBQs的化学特征与生成机制、环境中的分布情况,并对其引起的细胞毒性、氧化应激毒性、遗传毒性、生物毒性进行了概述.这些内容旨在为深入探讨HBQs的毒理学机制和全面评估其暴露所可能导致的健康风险及癌症风险提供科学依据.

关键词：卤代苯醌消毒副产物环境暴露毒性评估

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基于LES的射流火焰湍流辐射交互作用研究

北京航空航天大学学报 2024年第8期50卷 2667-2676页

作者：宋绪光金捷张敏琦王方北京航空航天大学能源与动力工程学院北京100191 北京航空航天大学江西研究院南昌330096 北京航空航天大学成都航空动力创新研究院成都611930

在大涡模拟中,研究了亚格子湍流辐射交互作用(SGS-TRI)对Sandia Flame D和Flame 4D(Scaled Sandia flame D)辐射源项的影响。模拟中,采用概率密度函数输运方程(TPDF)湍流燃烧模型模拟湍流燃烧过程,球谐函数(P1近似)法、灰气体加权和模型... 详细信息

在大涡模拟中,研究了亚格子湍流辐射交互作用(SGS-TRI)对Sandia Flame D和Flame 4D(Scaled Sandia flame D)辐射源项的影响。模拟中,采用概率密度函数输运方程(TPDF)湍流燃烧模型模拟湍流燃烧过程,球谐函数(P1近似)法、灰气体加权和模型(WSGGM)模拟辐射换热。采用湍流涡团光学薄脉动近似(OTFA)处理滤波吸收项,分别采用考虑和忽略SGS-TRI的方法求解滤波发射项。结果显示,SGS-TRI仅在辐射源项本身数值较小的区域对时均辐射源项有相对较大的影响(最大为25%);考虑和忽略SGS-TRI计算得到的时均温度以及CO_(2)浓度等径向分布基本重合(相对差别小于3%)。因此,亚格子湍流辐射交互作用对无碳烟湍流射流火焰(Flame D和Flame 4D)的影响较小。

关键词：湍流辐射交互作用亚格子大涡模拟概率密度函数输运方程模型辐射传热

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等离子体光纤光栅超痕量汞离子传感器

光学学报 2024年第9期44卷 258-266页

作者：王芳廉岚淇卢梦迪张扬太原理工大学电子信息与光学工程学院山西太原030600 大连理工大学物理学院辽宁大连116024

为实现特异性、超痕量、原位的重金属汞离子检测,提出一种基于适配体和磁性纳米粒子增强倾斜光纤布拉格光栅-表面等离激元共振(TFBG-SPR)汞离子传感器。首先,在倾斜光纤布拉格光栅包层区域溅射厚度合适的金膜以激发表面等离激元共振,在... 详细信息

为实现特异性、超痕量、原位的重金属汞离子检测,提出一种基于适配体和磁性纳米粒子增强倾斜光纤布拉格光栅-表面等离激元共振(TFBG-SPR)汞离子传感器。首先,在倾斜光纤布拉格光栅包层区域溅射厚度合适的金膜以激发表面等离激元共振,在探针末端镀金从而形成反射式传感结构。然后,采用具有胸腺嘧啶(T)碱基失配的适配体修饰TFBG-SPR栅区,进行特异性汞离子识别。最后,选择链霉亲和素包被的磁性纳米粒子作为信号放大标签,以提高离子检测性能。汞离子与T碱基作用激活适配体序列,连接磁性纳米粒子,传感器表面折射率发生变化,TFBG-SPR包层模式的振幅产生响应。结果表明:采用差分幅度解调,传感器对汞离子的检测极限为0.5 pmol/L,检测范围为1 pmol/L~10μmol/L,所提传感器具备良好的特异性以及再生性,同时通过测量临床样品的回收率,可以证实其在即时、快速检测领域中的应用前景。

关键词：传感器光纤传感器光纤布拉格光栅表面等离激元痕量离子检测

Exploring the molecular mechanism of Suoquan pill in the treatment of diabetic kidney disease based on network pharmacology,molecular docking,in vitro experiment

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Traditional Medicine Research 2024年第11期9卷 27-37页

作者： Zi-Jie Yan Yu Kang Shu-Man Liu fang-Yu wang Man Xiao Yi-Qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China Graduate School Heilongjiang Academy of Traditional Chinese MedicineHarbin 150001China Department of Pharmacology College of PharmacyHainan Medical UniversityHaikou 571199China Key Laboratory of Biochemistry and Molecular Biology Hainan Medical UniversityHaikou 571199China.

Background:Diabetic kidney disease(DKD)is a microvascular complication of diabetes mellitus and is the main cause of end-stage renal *** pills(SQP)has a variety of pharmacological activities and multiple therapeutic effects,and it is used clinically as a basic formula for the treatment of ***:Public databases were used to identify SQP compounds and the potential targets of SQP and DKD.A drug-component-therapeutic target network was ***-protein interaction network analysis,Gene Ontology functional analysis,and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were used to analyse the potential molecular mechanisms of SQP based on common targets of drugs and *** docking simulations were conducted to confirm the binding abity of the core compounds to key *** efficacy and predicted molecular mechanisms of SQP were validated using cell counting kit-8 assay,flow cytometry,and western blotting with HK-2 cells as a ***:Network pharmacology analysis showed that 26 compounds and 207 potential targets of SQP were involved in the treatment of DKD;boldine,denudatin B,pinocembrin,kaempferoid,and quercetin were considered core compounds,and epidermal growth factor receptor(EGFR)and proto-oncogene,non-receptor tyrosine kinase(SRC)were considered key *** Ontology enrichment analysis indicated that protein phosphorylation and negative regulation of apoptotic processes are important biological processes in the treatment of DKD by *** docking confirmed the excellent binding abilities of boldine,denudatin B,kaempferide,and quercetin to EGFR and *** results of in vitro experiments showed that treatment with an ethanolic extract of SQP significantly protected HK-2 cells from high glucose-induced cell *** addition,the SQP ethanol extract inhibited the phosphorylation of EGFR and SRC,suppressed the apoptosis rate,and regulated apoptosis-related proteins in HK-2 cells under hig

关键词： traditional Chinese medicine diabetic kidney disease Suoquan pill network analysis molecular docking

Assessment of rural sustainable development and analysis and prediction of obstacles and coupled coordinated development:A case study of Zaozhuang City

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Chinese Journal of Population,Resources and Environment 2024年第3期22卷 312-325页

作者： Xuesong Zhan Huize Zhang Yufei Zhao Yu He Dazheng Li fang wang Yufen Zhang Chaofeng Shao College of Environmental Science and Engineering Nankai UniversityTianjin 300350China Chinese Society for Sustainable Development Beijing 100036China

In China,the Innovation Demonstration Zone for the National Sustainable Development Agenda is a key initiative for executing the United Nations(UN)2030 Agenda for Sustainable *** Zone also plays critical roles in addressing the developmental bottlenecks that China faces and sharing Chinese insights into global sustainable development *** July 15,2022,the State Council endorsed the Zone’s establishment in Zaozhuang City,Shandong Province,where it focuses on innovation-led sustainable development in rural *** into the levels,impediments,interdependencies,and evolutionary trends of rural sustainable development is ***,this research aimed to assist in comprehensively assessing developmental challenges and facilitating the harmonious advancement of social,economic,and environmental aspects in rural *** pursuit of the three fundamental dimensions of the UN’s Sustainable Development Goals(SDGs),namely development’s drivers,quality,and equity,this study was grounded in China’s national Rural Revitalization Strategy and the demands of sustainable development *** also aligns with the UN 2030 Agenda for Sustainable Development and the associated SDG *** on four key areas,namely production elements,natural elements,social elements,and rural governance,this study developed an evaluation index system for assessing the level of rural sustainable *** employed a range of analytical models,including the game theory-based combination empowerment method,barrier degree model,coupling degree model,coupling coordination degree model,and gray prediction GM(1,1)model,to analyze the status and evolving trends of rural sustainable development in Zaozhuang City from 2015 to *** key findings were as follows:①Relative to the baseline year 2015,the sustainable development level in Zaozhuang’s rural areas has shifted toward an improved state overall.②The primary barrier to achieving rural sustainable develop

关键词： Rural sustainable development Sustainable Development Goals(SDGs) Barrier intensity Coupling coordination degree Forecast analysis

“三生-三链-三创”创新创业教育融入人才培养方案的研究

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生物工程学报 2024年第3期40卷 931-942页

作者：宋晓菲金鑫王方王亚军浙江工业大学生物工程学院浙江杭州310014

目前生物工程专业人才培养中存在创新创业教育理念落后、创新创业教育方法单一、创新创业实践平台薄弱等困境,需要引入新的培养模式加以破解。浙江工业大学生物工程学院“三生-三链-三创”培养模式的探索与实践,对照新工科建设的人才培... 详细信息

目前生物工程专业人才培养中存在创新创业教育理念落后、创新创业教育方法单一、创新创业实践平台薄弱等困境,需要引入新的培养模式加以破解。浙江工业大学生物工程学院“三生-三链-三创”培养模式的探索与实践,对照新工科建设的人才培养目标,通过42年持续探索与实践,优化“生物·生命·生活”三生融合教育理念,丰富“知识链·科研链·产业链”三链联动教育方法,搭建“创意·创新·创业”三创科技实践平台,打造拔尖生物工程科技创新创业人才培养新平台、新范式,为生物工程专业人才培养模式改革提供了有益借鉴及启示。

关键词：生物工程专业培养模式改革创新创业教育

从“专守防卫”到提升“反击能力”:日本安保战略的质变与影响

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东北亚论坛 2024年第4期33卷 3-16,127页

作者：吕耀东王方中国社会科学院大学国际政治经济学院北京100007 中国社会科学院日本研究所北京100007 华北科技学院外国语学院廊坊065201

日本政府曾长期奉行“专守防卫”的安保政策,但随着日本对外关系的变化及其国家战略目标的调整,日本政府从防卫范围、防卫对象、防卫力量等方面逐步将“专守防卫”调整为积极主动的防御政策,直至在推进落实“反击能力”的过程中将自卫... 详细信息

日本政府曾长期奉行“专守防卫”的安保政策,但随着日本对外关系的变化及其国家战略目标的调整,日本政府从防卫范围、防卫对象、防卫力量等方面逐步将“专守防卫”调整为积极主动的防御政策,直至在推进落实“反击能力”的过程中将自卫防御型的“专守防卫”政策最终转向为自主进攻型的防卫战略,彻底推翻“专守防卫”。这样的战略转向不仅在于体系结构层次,还在于国家层次,即突破基于“和平宪法”的“专守防卫”原则,改变“战后体制”,谋求政治及军事大国化。日本对华错误认知将加剧中日两国间的紧张关系,进而危及亚太地区乃至世界的和平与安全。

关键词：日本安全保障战略专守防卫反击能力安保三文件中日关系

Risk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis:a nationwide retrospective study in China

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World Journal of Pediatrics 2024年第5期20卷 506-516页

作者： Li-Wen Tan Jun-Li Wan Chun-Hua Zhu Hong Xu Zheng-Kun Xia Li-Zhi Chen Xiao-Chuan Wu fang wang Xiao-Rong Liu Cheng-Guang Zhao Xiao-Zhong Li Jian-Hua Mao Xiao-Wen wang Wen-Yan Huang Yu-Hong Li Jian-Jiang Zhang Shi-Pin Feng Jun Yang Jiao-Jiao Liu Chun-Lin Gao Li-Ping Rong Lan-Jun Shuai Ke Xu He-Jia Zhang Qiu Li Ai-Hua Zhang Mo wang Department of Nephrology Children’s Hospital of Chongqing Medical UniversityZhongshan 2nd Rd.136Chongqing400014China Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Pediatrics Children’s Hospital of Chongqing Medical UniversityChongqingChina Department of Nephrology Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing210008China Department of Nephrology Children’s Hospital of Fudan UniversityNational Paediatric Medical Center of ChinaShanghaiChina Department of Pediatrics Jinling HospitalNanjing Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalThe First School of Clinical MedicineSouthern Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalMedical School of Nanjing UniversityNanjingChina Department of Pediatric Nephrology and Rheumatology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina Department of Pediatrics The Second Xiangya Hospital of Central South UniversityChangshaChina Department of Pediatrics Peking University First HospitalBeijingChina Department of Nephrology Beijing Children’s HospitalCapital Medical UniversityBeijing100045China National Center for Children’s Health BeijingChina Department of Pediatrics Shengjing Hospital of China Medical UniversityShenyangChina Department of Nephrology and Immunology Children’s Hospital of Soochow UniversitySuzhouChina Department of Nephrology Children HospitalZhejiang University School of MedicineHangzhouChina Department of Nephrology Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanChina Department of Nephrology and Rheumatology Shanghai Children’s HospitalSchool

Background Pediatric antineutrophil cytoplasmic antibody-associated vasculitis(AAV)is a life-threatening systemic vasculitis featured by liability to renal ***,there are few studies on the risk factors and predictive models for renal outcomes of AAV in *** Data from 179 AAV children in multiple centers between January 2012 and March 2020 were collected *** risk factors and predictive model of end-stage renal disease(ESRD)in AAV were *** Renal involvement was the most typical manifestation(95.5%),and the crescent was the predominant pathological lesion(84.9%).The estimated glomerular filtration rate(eGFR)was evaluated in 114 patients,of whom 59.6%developed ESRD,and the median time to ESRD was 3.20 *** eGFR[P=0.006,odds ratio(OR)=0.955,95%confidence interval(CI)=0.924–0.987]and the percentages of global glomerulosclerosis(pGGS;P=0.018,OR=1.060,95%CI=1.010–1.112)were independent risk factors for ESRD of renal *** on the pGGS and eGFR at renal biopsy,we developed three risk grades of ESRD and one predictive *** Kaplan‒Meier curve indicated that renal outcomes were significantly different in different risk grades(P<0.001).Compared with serum creatinine at baseline,the predictive model had higher accuracy(0.86 versus 0.58,P<0.001)and a lower coefficient of variation(0.07 versus 0.92)in external *** Renal involvement is the most common manifestation of pediatric AAV in China,of which more than half deteriorates into *** predictive model based on eGFR at renal biopsy and the pGGS may be stable and accurate in speculating the risk of ESRD in AAV children.

关键词： Antineutrophil cytoplasmic antibody End-stage renal disease Glomerulonephritis Pediatric nephrology Vasculitis