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湿地监测背景下的语义虚拟地理环境初探

遥感学报 2024年第5期28卷 1350-1363页

作者：肖昕陈浩徐丙立方朝阳林珲江西师范大学地理与环境学院鄱阳湖湿地与流域研究教育部重点实验室南昌330022 陆军装甲兵学院信息通信系北京100072

作为新一代的地理分析工具,丰富的地理空间大数据为虚拟地理环境的发展带来了前所未有的契机。然而,伴随数据获取的逐渐便捷,虚拟地理环境普遍存在“可视”而“不智”的问题,还远未达到对现实地理环境可计算、可管理、可决策的需求。提... 详细信息

作为新一代的地理分析工具,丰富的地理空间大数据为虚拟地理环境的发展带来了前所未有的契机。然而,伴随数据获取的逐渐便捷,虚拟地理环境普遍存在“可视”而“不智”的问题,还远未达到对现实地理环境可计算、可管理、可决策的需求。提高虚拟地理环境中数据的语义互操作性是解决该问题的关键。本研究首先提出了具有知识驱动、语义协同和结构统一等特点语义虚拟地理环境。然后阐述了语义虚拟地理环境可以利用知识图谱作为现实地理环境的形式表达,通过集成实时的感知数据,以及虚实之间的交互数据信息,形成现实地理环境在虚拟空间的映射。最后本文以湿地监测为例,基于知识图谱构建语义虚拟地理环境,通过湿地监测本体实现多要素、多源异构、多时空尺度的湿地监测数据语义整合,以直观的方式刻画复杂的湿地生态系统。利用关联的监测数据之间构建的丰富语义关系,实现湿地虚拟地理环境的知识化搜索和语义推理,从而为湿地的综合信息化管理决策提供支持。

关键词：遥感虚拟地理环境语义虚拟地理环境知识图谱本体湿地监测

新加坡小学科学教材中跨学科概念的建构与启示

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教学与管理 2024年第17期 73-76页

作者：孙慧芳北京教育学院数学与科学教育学院

通过对新加坡小学科学教材STAR SCIENCE进行分析,发现该教材在跨学科概念方面具有以跨学科概念为中心架构课程内容、将跨学科概念转化为问题驱动学生认知参与、丰富的活动为跨学科概念建构提供直接经验、“图文并茂”的知识结构图将概... 详细信息

通过对新加坡小学科学教材STAR SCIENCE进行分析,发现该教材在跨学科概念方面具有以跨学科概念为中心架构课程内容、将跨学科概念转化为问题驱动学生认知参与、丰富的活动为跨学科概念建构提供直接经验、“图文并茂”的知识结构图将概念联系显性化等特点,并从内容组织、概念传递、栏目设置等方面为我国科学教材的编写提出了建议。

关键词：跨学科概念科学教材新加坡科学课程多样性

Efficacy of graphene nanocomposites for air disinfection in dental clinics: A randomized controlled study

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World Journal of Clinical Cases 2024年第28期12卷 6173-6179页

作者： Ya-Qiong Ju Xiang-Hua Yu Jing Wu Ying-hui Hu Xiang-Yong Han Dan fang Department of Nursing Minhang District Dental ClinicShanghai 201107China Department of Medical Sciences Minhang District Dental ClinicShanghai 201107China Department of Orthopedics Center for Spinal Minimally Invasive ResearchShanghai Jiao Tong UniversityShanghai 201107China

BACKGROUND Aerosols containing disease-causing microorganisms are produced during oral diagnosis and treatment can cause secondary *** To investigate the use of graphene material for air disinfection in dental clinics by leveraging its adsorption and antibacterial *** Patients who received ultrasonic cleaning at our hospital from April 2023 to April *** were randomly assigned to three groups(n=20 each):Graphene nanocomposite material suction group(Group A),ordinary filter suction group(Group B),and no air suction device group(Group C).The air quality and air colony count in the clinic rooms were assessed before,during,and after the ***,bacterial colony counts were obtained from the air outlets of the suction devices and the filter screens in Groups A and *** Before ultrasonic cleaning,no significant differences in air quality PM2.5 and colony counts were observed among the three ***,significant differences in air quality PM2.5 and colony counts were noted among the three groups during ultrasonic cleaning and after ultrasonic ***,the number of colonies on the exhaust port of the suction device and the surface of the filter were significantly lower in Group A than in Group B(P=0.000 and P=0.000,respectively).CONCLUSION Graphene nanocomposites can effectively sterilize the air in dental clinics by exerting their antimicrobial effects and may be used to reduce secondary pollution.

关键词： Graphene Nanocomposites Oral clinic Air disinfection Secondary contamination

Analysis of status and influencing factors of mental health in patients with systemic lupus erythematosus

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World Journal of Psychiatry 2024年第6期14卷 829-837页

作者： Xuan Zhang Zhe Wang Gui-Ling Lin fang-Zhi Wei Yan-Ping Zhuang Wen-Lu Xu Qi Zhang hui-Tao Wu Zi-Man He Xi-Yu Yin Ying Liu Long Mi Ai-Min Gong School of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571101Hainan ProvinceChina Department of Rheumatology and Immunology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina Department of Radiology The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 570100Hainan ProvinceChina

BACKGROUND Systemic lupus erythematosus(SLE)is a heterogeneous autoimmune disorder with varied clinical courses and prognoses,not only did the patients suffer from physical impairment,but also various physical and psychiatric *** evidence have suggested that mental disorders in SLE patients,can lead to various adverse *** To explored the features and influencing factors of mental health in patients with SLE and clarifying the correlations between mental health and personality characteristics and perceived social *** results would provide a basis for psychological intervention in patients with *** The clinical data of 168 patients with SLE admitted at the First Affiliated Hospital of Hainan Medical University between June 2020 and June 2022 were *** assessment and correlation analysis were conducted using the Symptom Checklist-90(SCL-90)and Perceived Social Support Scale,and the collected data were compared with the national norms in *** relevant factors influencing mental health were identified by statistical analysis.A general information questionnaire,the Revised Life Orientation Test,and Short-Form 36-Item Health Survey were employed to assess optimism level and quality of life(QoL),*** Patients with SLE obtained higher scores for the somatization,depression,anxiety,and phobic anxiety subscales than national norms(P<0.05).A correlation was identified between total social support and total SCL-90 score or each subscale(P<0.05).The factors significantly affecting patients’mental health were hormone dosage and disease activity index(DAI)(P<0.05).The average optimism score of patients with SLE was 14.36±4.42,and 30 cases were in the middle and lower levels.A positive correlation was found between optimism level and QoL *** Patients with SLE develop psychological disorders at varying degrees,which are significantly influenced by hormone dosage and ***’menta

关键词： Systemic lupus erythematosus Mental health Quality of life Influencing factors

Adaptive ultra-hypofractionated whole-pelvic radiotherapy in high-risk and very high-risk prostate cancer on 1.5-Tesla MR-Linac:Estimated delivered dose and early toxicity results

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Chronic Diseases and Translational Medicine 2024年第1期10卷 51-61页

作者： Linrui Gao Ran Wei Shirui Qin Yuan Tian Wenlong Xia Yongwen Song Shulian Wang hui fang Yu tang Hao Jing Yueping Liu Yuan tang Shunan Qi Bo Chen Yexiong Li Nianzeng Xing Ningning Lu Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina GCP Center/Clinical Research Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Urology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background: Magnetic resonance(MR)-guided ultra-hypofractionated radiotherapy with whole-pelvic irradiation(UHF-WPRT)is a novel approach to radiotherapy for patients with high-risk(HR)and very high-risk(VHR)prostate cancer(PCa).However,the inherent complexity of adaptive UHF-WPRT might inevitably result in longer on-couch *** aimed to estimate the delivered dose,study the feasibility and safety of adaptive UHF-WPRT on a 1.5-Tesla ***: Ten patients with clinical stage T3a-4N0-1M0-1c PCa,who consecutively received UHF-WPRT,were enrolled *** contours of the target and organ-at-risks on the position verification-MR(PV-MR),beam-on 3D-MR(Bn-MR),and post-MR(after radiotherapy delivery)were derived from the pre-MR data by deformable image *** physician then manually adjusted them,and dose recalculation was performed *** Prism 9(GraphPad Prism Software Inc.)was utilized for conducting statistical ***: In total,we collected 188 MR scans(50 pre-MR,50 PV-MR,44 Bn-MR,and 44 post-MR scans).With median 59 min,the mean prostate clinical target volume(CTV)-V_(100%)was 98.59%±2.74%,and the mean pelvic CTVp-V_(100%)relative percentages of all scans was 99.60%±1.18%.The median V29 Gy change in the rectal wall was−2%(−18%to 20%).With a median follow-up of 9 months,no patient had acute Common Terminology Criteria for Adverse Events(CTCAE)grade 2 or more severe genitourinary(GU)or gastrointestinal(GI)toxicities(0%).Conclusion: UHF-RT to the prostate and the whole pelvis with concomitant boost to positive nodes using an Adapt-To-Shape(ATS)workflow was technically feasible for patients with HR and VHR PCa,presenting only mild GU and GI *** estimated target dose during the beam-on phase was clinically acceptable based on the 3D-MR-based dosimetry *** trial registration Chinese Clinical Trial Registry ChiCTR2000033382.

关键词： dosimetry hypofractionation magnetic resonance imaging prostate cancer radiation dose radiotherapy

多维真值视角下主观化的实现机制研究——以“有2+vp”的复现为例

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外语学刊 2024年第4期 8-15页

作者：陈伟方华辉浙江工商大学人文与传播学院、文化产业创新发展研究院杭州310018 杭州市交通职业高级中学杭州310064

“有+vp”形式在现代汉语中的使用日渐频繁,其中尤以“有2+vp”频率的提升引人关注。与以往研究不同的是,本文不仅从历时层面来看“有2+vp”的演化过程,更是从多维真值视角来考察“有2+vp”的主观化进程。经研究发现,“有2+vp”形式在... 详细信息

“有+vp”形式在现代汉语中的使用日渐频繁,其中尤以“有2+vp”频率的提升引人关注。与以往研究不同的是,本文不仅从历时层面来看“有2+vp”的演化过程,更是从多维真值视角来考察“有2+vp”的主观化进程。经研究发现,“有2+vp”形式在现代汉语中复现以后,依次应用于话语的答句、问句以及陈述句之中,并分别产生焦点标记、倾向表述和存在强调的主观性含义。其主观化的实现机制包括系统缺位、构造类推、形式冗余、真值转移4个环节,在此过程中缺位的表达真值与类推产生的形式重新组合,完成语义从描述维度向表达维度的发展,其本质为形式与意义的再平衡。

关键词： “有2+vp” 多维语义学主观化描述表达

“十四五”时期药品安全监管相关政策分析与比较

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中国新药杂志 2024年第7期33卷 644-650页

作者：唐湘燕曹永芳何辉国家药品监督管理局药品审评中心北京100061

人民健康是民族昌盛和国家强盛的重要标志。为保障人民健康、促进医药产业走高质量发展道路,我国先后发布了“十四五”时期的规划、纲要,针对国家药品安全、医药工业、中医药发展、市场监管等方面提出一系列重要政策和措施。本文围绕《... 详细信息

人民健康是民族昌盛和国家强盛的重要标志。为保障人民健康、促进医药产业走高质量发展道路,我国先后发布了“十四五”时期的规划、纲要,针对国家药品安全、医药工业、中医药发展、市场监管等方面提出一系列重要政策和措施。本文围绕《“十四五”国家药品安全及促进高质量发展规划》,系统梳理相关国家部委针对“十四五”所发布有关药品安全监管的相关内容,并对其进行分析和比较,以期更好地理解国家层面对药品安全监管政策的整体规划和制定脉络。

关键词：药品安全 “十四五”规划高质量发展监管现代化

Network pharmacology investigation of the mechanism underlying the therapeutic action of Shikang granules in retinal ischemia-reperfusion injuries

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Integrative Medicine Discovery 2024年第17期8卷 1-8页

作者： Xiao-Xuan Wang Cong-Ying Wang Chi Zhang fang-Yuan Zheng Long-hui Han Ming-Lian Zhang Hebei Eye Hospital Hebei Provincial Key Laboratory of OphthalmologyHebei Provincial Clinical Research Center for Eye DiseasesXingtai 054000China

Background:Retinal ischemia/reperfusion(I/R)injury often results in vision loss,and effective clinical management options are currently *** granules(SKG)are traditional Chinese medicine-based preparations commonly used in clinical practice for treating optic ***:Despite decades of clinical use,the precise mechanism of action(MoA)of SKG remains ***,we employ a network pharmacological approach to elucidate its MoA by identifying active ingredients and relevant targets using the Traditional Chinese Medicine System Pharmacology Database and Analytical *** associated with retinal I/R injury were sourced from GeneCards,Online Mendelian Inheritance in Man,and *** software facilitated the identification of intersecting targets,which were then subjected to gene ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway *** validate the protective effect and explore the MoA of SKG in retinal I/R injuries,we conducted experiments using rat ***:Our animal experiments demonstrated that SKG mitigated apoptosis following retinal I/R injury by upregulating the expression of the anti-apoptotic protein Bcl-2 and downregulating the expression of BAX,Caspase-9,Caspase-3,PARP,and cytochrome ***,SKG was found to increase the expression of PI3K and ***:SKG may exert its protective effects by inhibiting apoptosis through modulation of pro-apoptotic and anti-apoptotic protein expression,as well as activation of the PI3K/AKT pathway.

关键词： retinal ischemia-reperfusion injury Shikang granules apoptosis PI3K/AKT pathway

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房价上涨对城镇居民初婚推迟的影响

劳动经济研究 2024年第3期12卷 64-86页

作者：许敏波曾梦房慧北京师范大学经济与工商管理学院

近20年来,中国年轻群体的初婚年龄不断推迟,与房价攀升趋势相吻合,二者之间的关系值得探究。本文利用2010年以来的全国人口普查和1%人口抽样调查数据及城市统计信息,实证检验了城市房价上涨对城镇居民未婚比例和初婚年龄的影响。基于性... 详细信息

近20年来,中国年轻群体的初婚年龄不断推迟,与房价攀升趋势相吻合,二者之间的关系值得探究。本文利用2010年以来的全国人口普查和1%人口抽样调查数据及城市统计信息,实证检验了城市房价上涨对城镇居民未婚比例和初婚年龄的影响。基于性别-年龄群组的分析结果发现,房价上涨显著提高了16~49岁适婚年龄人口的未婚比例,房价上涨1%导致城镇居民的未婚比例提高约0.11个百分点。进一步利用2010年和2020年两次全国人口普查数据构建的个人回顾性事件史数据进行生存分析,结果表明房价上涨导致年轻群体维持未婚状态的几率增加,房价上涨1%导致适婚人口的结婚几率在2000-2010年间和2010-2020年间分别降低0.09个和0.13个百分点,影响程度不断增大。分年龄段来看,房价上涨主要使得30岁以下年轻群体推迟了初婚时间。

关键词：房价上涨初婚年龄婚姻市场