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Prognostic value of systemic immune- inflammation index in acute/subacute patients with cerebral venous sinus thrombosis

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Stroke & Vascular Neurology 2020年第4期5卷 368-373页

作者： Shen li Kai liu yuan gao Lu zhao Rui Zhang Hui fang yongli Tao Hongbing liu Jiawei zhao Zongping Xia Yuming Xu Bo Song Department of Neurology Zhengzhou University First Affiliated HospitalZhengzhouHenanChina

Objective To evaluate the prognosis values of systemic immune-inflammation index(SII)in non-chronic cerebral venous sinus thrombosis(CVST).Methods patients with CVST,admitted to the First Affiliated Hospital of Zhengzhou University,were retrospectively identified from January 2013 to December *** selected patients in acute/subacute phase from *** outcomes of patients were evaluated with the modified Rankin Scale(mRS)-mRS 3-6 as poor outcomes and mRS 6 as *** overall survival time was defined as the date of onset to the date of death or last follow-up *** analysis was described by the Kaplan-Meier curve and Cox regression *** logistic regression analysis assessed the relationship between SII and poor functional *** area under the Receiver Operating Curve curve(AUC)was estimated to evaluate the ability of SII in *** A total of 270 patients were included and their duration of follow-up was 22 months(6-66 months),of whom 31 patients had poor outcomes and 24 patients *** regression analysis showed that SII(HR=1.304,95%CI:1.101 to 1.703,p=0.001)was a predictor of death in non-chronic *** with higher SII presented lower survival rates(p=0.003).The AUC of SII was 0.792(95%CI:0.695 to 0.888,p=0.040)with a sensitivity of 69.6%and specificity of 80.1%.Subgroups analysis demonstrated that SII was an important predictor of poor outcomes in male(OR=1.303,95%CI:1.102 to 1.501,p=0.011)and pregnancy/puerperium female(OR=1.407,95%CI:1.204 to 1.703,p=0.034).Conclusions SII was a potential predictor in the poor prognosis of patients with acute/subacute CVST,especially in male and pregnancy/puerperium female.

关键词： patients inflammation admitted

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Progressive liver injury and increased mortality risk in COVID-19 patients:A retrospective cohort study in China

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World Journal of Gastroenterology 2021年第9期27卷 835-853页

作者： Shui-Sheng Zhang li dong gao-Ming Wang yuan Tian Xiao-fang Ye Yue zhao Zheng-Yin liu Jia-Yu Zhai Zhi-ling zhao Jun-Hong Wang Hui-Min Zhang Xiao-Long li Chang-Xin Wu Cai-Ting yang li-Juan yang Hai-Xia Du Hui Wang Qing-Gang Ge Dian-Rong Xiu Ning Shen Department of General Surgery Peking University Third HospitalBeijing 100191China Institutes of Biomedical Sciences Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina Department of Radiotherapy Oncology Shandong Provincial Qianfoshan HospitalThe First Hospital Affiliated with Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of Respiratory and Critical Medicine Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Infectious Diseases Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100005China Department of Rheumatology Peking University Third HospitalBeijing 100191China Department of Critical Care Medicine Peking University Third HospitalBeijing 100191China Department of Emergency Medicine Peking University Third HospitalBeijing 100191China Department of Cardiac Surgery Peking University Third HospitalBeijing 100191China Department of Urology Peking University Third HospitalBeijing 100191China Department of Gynecology Peking University Third HospitalBeijing 100191China Department of Rehabilitation Peking University Third HospitalBeijing 100191China Department of Gastroenterology Peking University Third HospitalBeijing 100191China Department of Respiratory and Critical Medicine Peking University Third HospitalBeijing 100191China

BACKGROUND liver injury is common and also can be fatal,particularly in severe or critical patients with coronavirus disease 2019(COVID-19).AIM To conduct an in-depth investigation into the risk factors for liver injury and into the effective measures to prevent subsequent mortality *** A retrospective cohort study was performed on 440 consecutive patients with relatively severe COVID-19 between January 28 and March 9,2020 at Tongji Hospital,Wuhan,*** on clinical features,laboratory parameters,medications,and prognosis were *** COVID-19-associated liver injury more frequently occurred in patients aged≥65 years,female patients,or those with other comorbidities,decreased lymphocyte count,or elevated D-dimer or serum ferritin(Pliver injury(severe patients:Odds ratio[OR]=2.86,95%confidence interval[CI]:1.78-4.59;critical patients:OR=13.44,95%CI:7.21-25.97).The elevated levels of on-admission aspartate aminotransferase and total bilirubin indicated an increased mortality risk(Pliver *** drugs tended to be of assistance to treat the liver injury and improve the prognosis of patients with COVID-19-associated liver *** More intensive monitoring of aspartate aminotransferase or total bilirubin is recommended for COVID-19 patients,especially patients aged≥65 years,female patients,or those with other *** hepatotoxicity of antibiotics and intravenous nutrition should be alert for COVID-19 patients.

关键词： COVID-19 liver injury Prognosis Risk factors Drugs Alanine aminotransferase

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Sepsis-induced immunosuppression:mechanisms,diagnosis and current treatment options

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Military Medical Research 2023年第2期10卷 242-261页

作者： Di liu Si-yuan Huang Jian-Hui Sun Hua-Cai Zhang Qing-li Cai Chu gao li li Ju Cao fang Xu yong Zhou Cha-Xiang Guan Sheng-Wei Jin Jin Deng Xiang-Ming fang Jian-Xin Jiang ling Zeng Department of Trauma Medical Center Daping HospitalState Key Laboratory of TraumaBurns and Combined InjuryArmy Medical UniversityChongqing 400042China Department of Respiratory Disease Daping HospitalArmy Medical UniversityChongqing 400042China Department of Laboratory Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Critical Care Medicine the First Affiliated Hospital of Chongqing Medical University400016 ChongqingChina Department of Physiology School of Basic Medicine ScienceCentral South UniversityChangsha 410078China Department of Anesthesia and Critical Care the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityZhejiang 325027 WenzhouChina Department of Emergency the Affiliated Hospital of Guizhou Medical UniversityGuizhou Medical University550001 GuiyangChina Department of Anesthesiology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310052China.

Sepsis is a common complication of combat injuries and trauma,and is defined as a life-threatening organ dysfunction caused by a dysregulated host response to *** is also one of the significant causes of death and increased health care costs in modern intensive care *** use of antibiotics,fluid resuscitation,and organ support therapy have limited prognostic impact in patients with *** its pathophysiology remains elusive,immunosuppression is now recognized as one of the major causes of septic ***-induced immunosuppression is resulted from disruption of immune *** is characterized by the release of antiinflammatory cytokines,abnormal death of immune effector cells,hyperproliferation of immune suppressor cells,and expression of immune *** targeting immunosuppression,especially with immune checkpoint inhibitors,preclinical studies have demonstrated the reversal of immunocyte dysfunctions and established host ***,we comprehensively discuss recent findings on the mechanisms,regulation and biomarkers of sepsis-induced immunosuppression and highlight their implications for developing effective strategies to treat patients with septic shock.

关键词： Sepsis Immunosuppression Immune monitoring Immunomodulatory therapy

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Preparation and characterization of MgO hybrid biochar and its mechanism for high efficient recovery of phosphorus from aqueous media

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Biochar 2022年第1期4卷 518-532页

作者： Yueru fang Amjad Ali Yuxi gao Peng zhao Ronghua li Xianxian li Junxi liu yuan Luo Yaru Peng Hailong Wang Hongbin liu Zengqiang Zhang Junting Pan College of Natural Resources and Environment Northwest A&F UniversityYanglingXianyang 712100ShaanxiChina School of Environmental and Municipal Engineering Shaanxi Key Laboratory of Environmental EngineeringXi’an University of Architecture and TechnologyXi’an 710055China Biochar Engineering Technology Research Center of Guangdong Province School of Environmental and Chemical EngineeringFoshan UniversityFoshan 528000GuangdongChina Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081China

Conversion of organic waste into engineered metal-biochar composite is an effective way of enhancing biochar’s efficiency for adsorptive capture of phosphorus(P)from aqueous ***,various strategies have been created for the production of metal-biochar composites;however,the complex preparation steps,high-cost metal salt reagent application,or extreme process equipment requirements involved in those strategies limited the large-scale production of metal-biochar *** this study,a novel biochar composite rich in magnesium oxides(MFBC)was directly produced through co-pyrolysis of magnesite with food waste;the product,MFBC was used to adsorptively capture P from solution and bio-liquid *** results showed that compared to the pristine food waste biochar,MFBC was a uniformly hybrid MgO biochar composite with a P capture capacity of 523.91 mg/*** capture of P by MFBC was fitted using the Langmuir and pseudo-first-order kinetic *** P adsorptive capture was controlled by MgHPO4 formation and electrostatic attraction,which was affected by the coexisting F−and CO_(3)^(2−)*** could recover more than 98%of P from the solution and bio-liquid *** the P-adsorbed MFBC showed very limited reusability but it can be substituted for phosphate fertiliser in agricultural *** study provided an innovative technology for preparing MgO-biochar composite against P recovery from aqueous media,and also highlighted high-value-added approaches for resource utilization of bio-liquid wastewater and food waste.

关键词： Biochar Bio-liquid wastewater Fertiliser Magnesite Phosphorus recovery

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Evolutionary stages and disk properties of young stellar objects in the Perseus cloud

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Research in Astronomy and Astrophysics 2015年第8期15卷 1294-1324页

作者： Hong-Xin Zhang Yu gao Min fang Hai-Bo yuan ying-He zhao Rui-Xiang Chang Xue-Jian Jiang Xiao-Wei liu A-li Luo Hong-Jun Ma Zheng-Yi Shao Xiao-Long Wang National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Kavli Institute for Astronomy and Astrophysics Peking University Chinese Academy of Sciences South America Center for Astronomy Camino EI Observatorio #1515Las CondesSantiagoChile Instituto de Astrofísica Facultad de FísicaPontificia Universidad Católica de ChileAv.Vicuna Mackenna 48607820436 MaculSantiagoChile Purple Mountain Observatory Chinese Academy of Sciences Key Laboratory of Radio Astronomy Chinese Academy of Sciences Departamento de Física Teórica Universidad Autónoma de Madrid 28049 CantoblancoMadridSpain Infrared Processing and Analysis Center California Institute of TechnologyMS 100-22PasadenaCA 91125USA Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of Sciences

We investigated the evolutionary stages and disk properties of 211 young stellar objects（YSOs） across the Perseus cloud by modeling their broadband optical to mid-infrared（IR） spectral energy distribution（SED）. Our optical gri photometry data were obtained from the recently finished Purple Mountain Observatory Xuyi Schmidt Telescope Photometric Survey of the Galactic Anti-center（XSTPS-GAC）.About 81% of our sample fall into the Stage II phase which is characterized by having optically thick disks, while 14% into the Stage I phase characterized by having significant infalling envelopes, and the remaining 5% into the Stage Ⅲ phase characterized by having optically thin disks. The median stellar age and mass of the Perseus YSOs are 3.1 Myr and 0.3 M⊙ respectively. By exploring the relationships among the turnoff wave bands λturnoff（longward of which significant IR excesses above the stellar photosphere are observed）, the excess spectral index αexcess as determined for λ 〉 λturnoff, and the disk inner radius Rin（determined from SED modeling） for YSOs at different evolutionary stages, we found that the median and standard deviation of αexcess for YSOs with optically thick disks tend to increase withλturnoff, especially at λturnoff ≥5.8 μm, whereas the median fractional dust luminosities Ldust/L★ tend to decrease with increasing λturnoff. This points to an inside-out process of disk clearing for small dust grains. Moreover, a positive correlation between αexcess and Rin was found at α〉excess ～ 0 and R〉in～ 10 × the dust sublimation radius Rsub, irrespective of λturnoff, Ldust/L★ and disk flaring. This suggests that the outer disk flaring either does not evolve synchronously with the inside-out disk clearing of small dust grains or has little appreciable influence on the spectral slopes at λ〈～ 24 μm. About 23% of our YSO disks are classified as transitional disks, which haveλturnoff ≥ 5.8 μm and Ldust/L★ 〉 10-3. The transitional disks and full disks occupy distinctly differe

关键词： stars: formation—stars: low-mass—stars: pre-main sequence—individual: Perseus Cloud—circumstellar matter—protoplanetary

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The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation

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Nuclear Science and Techniques 2023年第1期34卷 51-85页

作者： Nan‑Shun Huang Zi‑Peng liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua li Tao liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang yang‑yang Lei Ya Zhu yong‑Zhou He Qi‑Bing yuan Fei gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan yuan Zhuan Xue‑fang Huang Peng‑Cheng dong Zhong‑liang li Shang‑Yu Si lian Xue Si Chen yong‑fang liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang zhao Zhangjiang Laboratory Shanghai 201210China School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China European XFEL Schenefeld 22869Germany ShanghaiTech University Shanghai 201210China

The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic *** general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific *** the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly *** this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE.

关键词： X-ray free-electron laser Free electron laser oscillator Fully coherent X-ray

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Investigation on step overcharge to self-heating behavior and mechanism analysis of lithium ion batteries

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Journal of Energy Chemistry 2023年第4期79卷 301-311页

作者： Fengling Yun Shiyang liu Min gao Xuanxuan Bi Weijia zhao Zenghua Chang Minjuan yuan Jingjing li Xueling Shen Xiaopeng Qi ling Tang Yi Cui Yanyan fang lihao Guo Shangqian zhao Xiangjun Zhang Shigang Lu China Automotive Battery Research Institute Co. Ltd.Beijing 101407China China Electric Power Research Institute Beijing 100192China China GRINM Group Corporation limited(GRINM Group) Beijing 100088China GRINM(Guangdong)Advanced Materials Technology Research Institute Foshan 528000GuangdongChina General Research Institute for Nonferrous Metals Beijing 100088China Institute of Materials Genome Engineering Shanghai UniversityShanghai 200444China

To obtain intrinsic overcharge boundary and investigate overcharge mechanism,here we propose an innovative method,the step overcharge test,to reduce the thermal crossover and distinguish the overcharge thermal behavior,including 5%state of charge(SOC)with small current overcharge and resting until the temperature equilibrium under adiabatic *** intrinsic thermal response and the self-excitation behaviour are analysed through temperature and voltage changes during the step overcharge *** results show that the deintercalated state of the cathode is highly correlated to self-heating parasitic *** reaching the upper limit of Negative/Positive(N/P)ratio,the temperature changes little,the heat generation is significantly induced by the reversible heat(endothermic)and ohmic heat,which could balance each *** that the lithium metal is gradually deposited on the surface of the anode and reacts with electrolyte upon overcharge,inducing selfheating side ***,this spontaneous thermal reaction could be“self-extinguished”.When the lithium in cathode is completely deintercalated,the boundary point of overcharge is about 4.7 V(~148%SOC,>40℃),and from this point,the self-heating behaviour could be continuously triggered until thermal runaway(TR)without additional *** whole static and spontaneous process lasts for 115 h and the side reaction heat is beyond 320,000 *** continuous self-excitation behavior inside the battery is attributed to the interaction between the highly oxidized cathode and the solvent,which leads to the dissolution of metal *** dissolved metal ions destroy the SEI(solid electrolyte interphase)film on the surface of the deposited li of anode,which induces the thermal reaction between lithium metal and the *** interaction between cathode,the deposited li of anode,and solvent promotes the temperature of the battery to rise *** the temperature of the battery reaches more

关键词： lithium ion battery Step overcharge Self-heating Boundary Heat generation Amount of lithium

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Research of in-service sipping test device

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Nuclear Science and Techniques 1998年第2期9卷 113-114页

作者： Deng Jun-Xian zhao Xi-Juan Ye Xiao-li zhao Hong Zhang Han Zhang En-Hai gao Yan-Gang liu ying-lin Song Ruo li yong-yuan liu Ai-Jun zhao Ping-Jun (Beijing Institute of Nuclear Engineering, Beijing 100840 )Xu Yu-Ming (China National Nuclear Corpora Beijing Institute of Nuclear Engineering Beijing 100840 China China National Nuclear Corporation Beijing 100822 China

Sipping test device is used to identify the tightness of the irradiated fuel assembly during refuelling campaign. The gas is selected as the medium and the xenon-133 as the indicating nuclide. The device consists of the gas system, the γ-activity detection and measurement system, the power supply and signal system, the mechanical components and *** device has satisfactory functions, e.g. easy operation, indication in instrumentation, chart record and acoustic alarm, which can meet the operation demand of the nuclear reactor.

关键词：核裂变产物细微探测器件细微技术

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Major strategies for improving the performance of perovskite solar cells

iEnergy

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iEnergy 2023年第3期2卷 172-199页

作者： lixiu Zhang Hang li Kai Zhang Wenzhe li Chuantian Zuo George Omololu Odunmbaku Jingde Chen Cong Chen Luozheng Zhang Ru li Yuping gao Baomin Xu Jiangzhao Chen yongsheng liu yang Wang Yanlin Song Jianxin Tang Feng gao Qing zhao yong Peng Mingzhen liu Lei Tao Yuelong li Zhimin fang Ming Cheng Kuan Sun Dewei zhao Yixin zhao Shihe yang Chenyi Yi liming Ding Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190China State Key Laboratory of Power System Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China College of Materials Science and Engineering&Engineering Research Center of Alternative Energy Materials&Devices Sichuan UniversityChengdu 610065China School of Energy&Power Engineer-ing Chongqing UniversityChongqing 400044China Institute for Energy Research Jiangsu UniversityZhenjiang 212013China Institute of New Energy Technology Department of Electronic EngineeringCollege of Information Science and TechnologyJinan UniversityGuangzhou 510631China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China College of Optoelectronic Engineering Chongqing UniversityChongqing 400044China College of Chemistry Nankai UniversityTianjin 300071China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China State Key Lab for Mesoscopic Physics and Frontiers Science Center for Nano-optoelec-tronics School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Photoelectronic Thin Film Devices and Technology Nankai UniversityTianjin 300350China School of Materials Science and Engineering Shaanxi Normal UniversityXi’an 710119China

Metal halide perovskite solar cell(PSC)has successfully distinguished itself in optoelectronic field by virtue of the sharp rise in power conversion efficiency over the past *** remarkable efficiency breakthrough at such a fast speed can be mainly attributed to the comprehensive study on film deposition techniques,especially the effective management of surface and interfacial defects in recent ***,we summarized the current trends in performance enhancement for PSCs,with a focus on the generally applicable strategies in high-performance works,involving deposition methods,compositional engineering,additive engineering,crystallization manipulation,charge transport material selection,interfacial passivation,optical coupling effect and constructing tandem solar *** directions and perspectives are also provided.

关键词： Perovskite solar cells efficiency improvement strategies milestones

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Scientific Advances and Weather Services of the China Meteorological Administration’s National Forecasting Systems during the Beijing 2022 Winter Olympics

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Advances in Atmospheric Sciences 2024年第5期41卷 767-776页

作者： Guo DENG Xueshun SHEN Jun DU Jiandong GONG Hua TONG liantang DENG Zhifang XU Jing CHEN Jian SUN yong WANG Jiangkai HU Jianjie WANG Mingxuan CHEN Huiling yuan Yutao ZHANG Hongqi li yuanzhe WANG li gao li SHENG Da li li li Hao WANG ying zhao yinglin li Zhili liU Wenhua GUO China Meteorological Administration Earth System Modeling and Prediction Centre Beijing 100081China State Key Laboratory of Severe Weather China Meteorological AdministrationBeijing 100081China Key Laboratory of Earth System Modeling and Prediction China Meteorological AdministrationBeijing 100081China National Meteorological Center China Meteorological AdministrationBeijing 100081China Environmental Modeling Center/NCEP/NWS/NOAA College ParkMD 20740USA Nanjing University of Information Science and Technology Nanjing 210044China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China School of Atmospheric Sciences and Key Laboratory of Mesoscale Severe Weather/Ministry of Education Nanjing UniversityNanjing 210023China Tsinghua University Beijing 100084China

Since the Beijing 2022 Winter Olympics was the first Winter Olympics in history held in continental winter monsoon climate conditions across complex terrain areas,there is a deficiency of relevant research,operational techniques,and *** made providing meteorological services for this event particularly *** China Meteorological Administration(CMA)Earth System Modeling and Prediction Centre,achieved breakthroughs in research on short-and medium-term deterministic and ensemble numerical *** key technologies crucial for precise winter weather services during the Winter Olympics were developed.A comprehensive framework,known as the Operational System for High-Precision Weather Forecasting for the Winter Olympics,was *** of these advancements represent the highest level of capabilities currently available in *** meteorological service provided to the Beijing 2022 Games also exceeded previous Winter Olympic Games in both variety and *** included achievements such as the“100-meter level,minute level”downscaled spatiotemporal resolution and forecasts spanning 1 to 15 *** 30 new technologies and over 60 kinds of products that align with the requirements of the Winter Olympics Organizing Committee were developed,and many of these techniques have since been integrated into the CMA’s operational national forecasting *** accomplishments were facilitated by a dedicated weather forecasting and research initiative,in conjunction with the preexisting real-time operational forecasting systems of the *** program represents one of the five subprograms of the WMO’s high-impact weather forecasting demonstration project(SMART2022),and continues to play an important role in their Regional Association(RA)II Research Development Project(Hangzhou RDP).Therefore,the research accomplishments and meteorological service experiences from this program will be carried forward into forthcoming highimpact weather

关键词： Beijing Winter Olympic Games CMA national forecasting system data assimilation ensemble forecast bias correction and downscaling machine learning-based fusion methods

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