Prognostic value of systemic immune- inflammation index in acute/subacute patients with cerebral venous sinus thrombosis

作     者：Shen Li Kai Liu Yuan Gao Lu Zhao Rui Zhang Hui Fang Yongli Tao Hongbing Liu Jiawei Zhao Zongping Xia Yuming Xu Bo Song 

作者机构：Department of NeurologyZhengzhou University First Affiliated HospitalZhengzhouHenanChina 

出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)

年 卷 期：2020年第5卷第4期

页      面：368-373页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Science and Technology Department of the Henan Province grant number(No.152102310058) the National Natural Science Foundation of China grant number(Nos.81530037) 

主　　题：patients inflammation admitted 

摘      要：Objective To evaluate the prognosis values of systemic immune-inflammation index(SII)in non-chronic cerebral venous sinus thrombosis(CVST).Methods patients with CVST,admitted to the First Affiliated Hospital of Zhengzhou University,were retrospectively identified from January 2013 to December *** selected patients in acute/subacute phase from *** outcomes of patients were evaluated with the modified Rankin Scale(mRS)-mRS 3-6 as poor outcomes and mRS 6 as *** overall survival time was defined as the date of onset to the date of death or last follow-up *** analysis was described by the Kaplan-Meier curve and Cox regression *** logistic regression analysis assessed the relationship between SII and poor functional *** area under the Receiver Operating Curve curve(AUC)was estimated to evaluate the ability of SII in *** A total of 270 patients were included and their duration of follow-up was 22 months(6-66 months),of whom 31 patients had poor outcomes and 24 patients *** regression analysis showed that SII(HR=1.304,95%CI:1.101 to 1.703,p=0.001)was a predictor of death in non-chronic *** with higher SII presented lower survival rates(p=0.003).The AUC of SII was 0.792(95%CI:0.695 to 0.888,p=0.040)with a sensitivity of 69.6%and specificity of 80.1%.Subgroups analysis demonstrated that SII was an important predictor of poor outcomes in male(OR=1.303,95%CI:1.102 to 1.501,p=0.011)and pregnancy/puerperium female(OR=1.407,95%CI:1.204 to 1.703,p=0.034).Conclusions SII was a potential predictor in the poor prognosis of patients with acute/subacute CVST,especially in male and pregnancy/puerperium female.