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Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase

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Chinese Journal of Natural Medicines 2024年第6期22卷 486-500页

作者： YANG Yanqiu CHE yue fang Mingxia yao Xiaohu zhou Di WANG Feng CHEN Gang LIANG Dong LI Ning HOU yue Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNorth-eastern UniversityShenyang 110000China National Frontiers science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110000China School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning provinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110000China State Key Laboratory for chemistry and molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541000China

Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative diseases(NDDs).Reynos-in,a natural sesquiterpene lactone(SL),exhibits a broad spectrum of pharmacological effects,suggesting its potential therapeutic ***,the effects and mechanism of reynosin on neuroinflammation remain *** current study explores the effects and mechanisms of reynosin on neuroinflammation using mice and BV-2 microglial cells treated with lipopolysaccharide(LPS).Our findings reveal that reynosin effectively reduces microglial inflammation in vitro,as demonstrated by decreased CD11b expression and lowered interleukin-1 beta(IL-1β)and interleukin-18(IL-18)mRNA and protein ***,in vivo,results showed a re-duction in the number of Iba-1 positive cells and alleviation of morphological alterations,alongside decreased expressions of IL-1βand *** analysis indicates that reynosin inhibits NLRP3 inflammasome activation,evidenced by reduced transcription of NLRP3 and caspase-1,diminished NLRP3 protein expression,inhibited apoptosis-associated speck-like protein containing a CARD(ASC)oli-gomerization,and decreased caspase-1 ***,reynosin curtailed the activation of nicotinamide adenine dinuc-leotide phosphate(NADPH)oxidase,demonstrated by reduced NADP^(+)and NADPH levels,downregulation of gp91^(phox) mRNA,pro-tein expression,suppression of p47^(phox) expression and translocation to the ***,reynosin exhibited a neuroprotective effect against microglial inflammation in vivo and in *** collective findings underscore reynosin’s capacity to mitigate mi-croglial inflammation by inhibiting the NLRP3 inflammasome,thus highlighting its potential as a therapeutic agent for managing neuroinflammation.

关键词： Microglia NLRP3 inflammasome Reactive oxygen species NADPH oxidase Neuron Reynosin

Electrochemical Studies of Glutathione Monolayer Assembled on A Polycrystalline Gold Electrode

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wuhan university Journal of Natural sciences 2002年第1期7卷 102-106页

作者： fang cheng, zhou xing-yao  college of chemistry and molecular sciences, wuhan university, wuhan 430072. Hubei, china wuhan university College of Chemistry and Molecular Sciences Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***)

The glutathione (GSH) monolayer and complex monolayer of GSH-metallic ion on polycrystalline gold electrode were studied by using K3Fe(CN)6 as the redox probe. As for the GSH monolayer, it was found that the metallic ions could open the ion-gate in the monolayer dramatically in the order La3+> Pb2+>>Ba2+>Ca2+ whereas Zn2+ ion closed the ion-gate. The complexes of GSH-metallic ions were capable of self-assembling the different kind of monolayer. All the differences were related to the structural configuration of the anchored GSH molecule, which changed with different metallic ions or pH.

关键词： glutatione monolayer complex voltammetry and ac impedance

Pillar[5]arene based artificial light-harvesting supramolecular polymer for efficient and recyclable photocatalytic applications

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Chinese Chemical Letters 2024年第9期35卷 179-182页

作者： Lei zhou Youjun zhou Lizhen fang Yiqiao Bai Yujia Meng Liang Li Jie Yang Yong yao School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai 201418China School of chemistry and Chemical Engineering Nantong City Key Laboratory of Life-Organic ChemistryNantong UniversityNantong 226019China college of science Nanjing Forestry UniversityNanjing 210037China

Photosynthesis is the process through which living plants utilize photosynthetic pigments,such as chlorophyll,to convert CO_(2)and water into organic compounds and release O_(2)under visible *** this study,we have successfully constructed a fluorescent supramolecular polymer(P5Py_(2)/Zn/Gen)n by employing orthogonal pillar[5]arene-based molecular recognition and metal ion *** the supramolecular polymer,the guest molecule Gen unit acts as a light-harvesting moiety,as the ACQ effect is inhibited by host-guest interactions,while the(Py)_(2)/Zn center serves as a catalytic *** employing this orthogonal self-assembly strategy,we have enhanced the stability of both the donor and acceptor in catalyzing the reduction of p-nitrophenol to ***,this photocatalyst can be reused at least 5 times without significant conversion *** findings provide a pathway for constructing a recyclable artificial LHS that mimics the entire photosynthesis process.

关键词： Pillararenes Light-harvest Supramolecular polymer Photosynthesis Orthogonal self-assembly

Separation of Dopamine and Epinephrine by a Novel Electrophoresis Technique with Nafion Membrane as Separation Column

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wuhan university Journal of Natural sciences 2004年第1期9卷 102-104页

作者： fangcheng WuBing-liang ZhangWu-ming zhouxing-yao collegeofchemistryandmolecularsciences WuhanUniversityWuhan430072HubeiChina

A novel electrophoresis technique, in which a strip of perflurosulfonic-acid (nafion 117) membrane was used to replace the conventional separation column and liquid buffer solution within, was developed and employed to separate the mixture of dopamine and epinephrine under a low separation voltage of 100 V with quadruple pulses amperometry detection. It was showed that the so-called Nafion membrane electrophoresis could be one of very simple and easy method and has the potentiality to be used to separate and analyze some small organic biologic molecules. Key words nafion membrane - electrophoresis - electrochemical detector - dopamine - epinephrine CLC number O 657. 7 Foundation item: Support by the Foundation of Electroanalytical chemistry Open Lab (203231510), Changchum, china.Biography: fang cheng (1971-), male, Lecture, Ph. D, research direction: Electroanalysis.

关键词： nafion membrane electrophoresis electrochemical detector dopamine epinephrine

Bisulfite-mediated base-free decarboxylative carbonylsulfination of alkenes:access to β-keto sultines

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science china chemistry 2024年

作者： Yongxin Zhang Pan zhou Xinyue Ma Xiaoxiao Yang xing fang Yuxi Wang Chao Shu State Key Laboratory of Green Pesticide Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction CCNU-uOttawa Joint Research Centre College of Chemistry Central China Normal University (CCNU) Key Laboratory of Functional molecular Solids Ministry of Education Anhui Normal University

A straightforward three-component decarboxylative cross-coupling of α-keto acids, alkenes and sodium bisulfite is established for the construction of otherwise challenging-to-access β-keto sultine derivatives. This reaction involves the photoinduced carbonylsulfination of alkenes and utilizes sodium bisulfite as both a sulfur dioxide surrogate and buffer agent for deprotonation of α-keto carboxylic acids. Of note, the practical procedure featured broad substrate scope and group tolerance for diverse biologically important molecules under mild and operationally simple conditions, using an organic photocatalyst. Mechanistic studies indicated that the transformation proceeds an apparent two-pronged radical addition/radical-polar crossover/SO2insertion/ionic cyclization relay process, distinct from traditional alkenes bifunctionalization.

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SYNTHESIS AND PROPERTIES OF A NEW AZOBENZENE SIDE-CHAIN POLYMER CONTAINING A TEMPO RADICAL

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Chinese Journal of Polymer science 2002年第4期20卷 285-290页

作者： Yong Zhang Ze-da Xu xing-he Fan Xiao-fang Chen Xin-hua Wan Qi-feng zhou Department of Polymer science and Engineering college of chemistry and molecular Engineering Peking university, Beijing 100871, china Peking Univ Coll Chem & Mol Engn Dept Polymer Sci & Engn Beijing 100871 Peoples R China

To allow anisotropies of optical properties in a magnetic field, nitroxide radical is introduced into the ortho-position of the phenylene ring in the side chain. A new azobenzene side-chain polymer (TEMPO-PAZ) containing TEMPO radical was synthesized. The polymer has a good solubility in organic solvents. The ESR spectrum of the polymer indicated three absorption lines characteristic of TEMPO radical. The optical phase conjugated responses (I-4) of the polymer films were investigated by degenerate four-wave mixing (DFWM). The experimental results showed that optical phase conjugated response of the TEMPO-PAZ could be easily controlled by choosing the appropriate direction of magnetic field presumably due to the nitroxide radical in the TEMPO-PAZ molecular structure. For the polymer investigated here, the nitroxide radical was introduced to increase optical phase conjugated response intensity in a magnetic field, aiming originally at searching for a new photo-active organic magnetic multifunctional materials.

关键词： azobenzene nitroxide radical polymer photo-active organic magnetic materials optical phase conjugated responses

Two-dimensional materials for future information technology: status and prospects

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science china(Information sciences) 2024年第6期67卷 1-147页

作者： Hao QIU Zhihao YU Tiange ZHAO Qi ZHANG Mingsheng XU Peifeng LI Taotao LI Wenzhong BAO Yang CHAI Shula CHEN Yiqi CHEN Hui-Ming cheng Daoxin DAI Zengfeng DI Zhuo DONG Xidong DUAN Yuhan FENG Yu FU Jingshu GUO Pengwen GUO yue HAO Jun HE Xiao HE Jingyi HU Weida HU Zehua HU Xinyue HUANG Ziyang HUANG Ali IMRAN Ziqiang KONG Jia LI Qian LI Weisheng LI Lei LIAO Bilu liu Can liu Chunsen liu Guanyu liu Kaihui liu Liwei liu Sheng liu Yuan liu Donglin LU Likuan MA Feng MIAO Zhenhua NI Jing NING Anlian PAN Tian-ling REN Haowen SHU Litao SUN yue SUN Quanyang TAO Zi-Ao TIAN Dong WANG Hao WANG Haomin WANG Jialong WANG Junyong WANG Wenhui WANG xingjun WANG Yeliang WANG Yuwei WANG Zhenyu WANG yao WE... School of Electronic science and Engineering Nanjing University School of Integrated Circuits Interdisciplinary Research Center for Future Intelligent Chips (Chip-X)Nanjing University School of Integrated Circuit science and Engineering Nanjing University of Posts and Telecommunications State Key Laboratory of Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences School of Physics and Key Lab of Quantum Materials and Devices of the Ministry of Education School of Electronic Science & EngineeringSoutheast University college of Integrated Circuits State Key Laboratory of Silicon and Advanced Semiconductor MaterialsZhejiang University Suzhou Laboratory State Key Laboratory of Integrated Chips and Systems School of MicroelectronicsFudan University Shaoxin Laboratory Department of Applied Physics The Hong Kong Polytechnic University Key Laboratory for Micro-Nano Physics and Technology of Hunan Province College of Materials Science and EngineeringHunan University college of Integrated Circuits Zhejiang University Shenzhen Geim Graphene Center Shenzhen Key Laboratory of Layered Materials for Value-Added ApplicationsTsinghua-Berkeley Shenzhen Institute & Institute of Materials ResearchTsinghua Shenzhen International Graduate SchoolTsinghua University State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZijingang CampusZhejiang University National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences CAS Key Laboratory of Nanophotonic Materials and Devices & Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics (SINANO)Chinese Academy of Sciences college of chemistry and Chemical Engineering Hunan University Key Laboratory of Quantum State Construction and Manipulation (Ministry of Education) Department of PhysicsRenmin University of China School

Over the past 70 years, the semiconductor industry has undergone transformative changes,largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensional(2D) materials like transition metal dichalcogenides(TMDs) and graphene are pivotal in overcoming the limitations of silicon-based technologies, offering innovative approaches in transistor design and functionality, enabling atomic-thin channel transistors and monolithic 3D integration. We review the important progress in the application of 2D materials in future information technology, focusing in particular on microelectronics and optoelectronics. We comprehensively summarize the key advancements across material production, characterization metrology, electronic devices, optoelectronic devices, and heterogeneous integration on silicon. A strategic roadmap and key challenges for the transition of 2D materials from basic research to industrial development are outlined. To facilitate such a transition, key technologies and tools dedicated to 2D materials must be developed to meet industrial standards, and the employment of AI in material growth, characterizations, and circuit design will be essential. It is time for academia to actively engage with industry to drive the next 10 years of 2D material research.

关键词： two-dimensional (2D) materials information technology production technology standardization of characterization microelectronic devices optoelectronic devices multi-functional integration

Synthesis of Poly(styrene-b-isoprene-b-styrene)viaNitroxide-mediated Radical Polymerization by a Novel Alkoxyamine

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Chemical Research in Chinese Universities 2005年第5期21卷 615-618页

作者： GAO Long-cheng PAN Qi-wei FAN xing-he CHEN Xiao-fang WAN Xin-hua zhou Qi-feng college of chemistry and molecular Engineering Peking University Beijing 100871 P. R. China Key Laboratory of Polymer chemistry and Physics of Ministry of Education Bering 100871 P. R. China

Bifunctional alkoxyamine bis-TIPNO derived from 2,2,5-trimethyl-4-phenyl-3-azahexane-3-oxyl （TIPNO） and α, ω-alkyl bromide by atom transfer radical addition（ATRA） was employed as “biradical initiator” for nitroxide-mediated radical polymerization（NMRP） of isoprene and styrene. The kinetics study for the polymerization of styrene at different time showed living features. The poly（styrene-b-isoprene-b-styrene）（SIS） copolymers have two glass transition temperatures, indicating the immiscibility of the corresponding blocks.

关键词： Radical polymerization Block copolymer Nitroxide Isoprene

Crystallographic Understanding of Photoelectric Properties for C_(60) Derivatives Applicable as Electron Transporting Materials in Perovskite Solar Cells

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Chemical Research in Chinese Universities 2022年第1期38卷 75-81页

作者： xing zhou LI Shu-Hui XU Piao-Yang TIAN Han-Rui DENG lin-Long yao Yang-Rong CHEN Bin-Wen XIE fang-fang AN Ming-Wei YUN Da-Qin XIE Su-Yuan ZHENG Lan-Sun State Key Lab for Physical chemistry of Solid Surfaces iChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005P.R.China Pen-Tung Sah Institute of Micro-Nano science and Technology Xiamen UniversityXiamen 361005P.R.China college of Energy Xiamen UniversityXiamen 361005P.R.China

Hundreds of C60 derivatives stand out as electrontransporting materials(ETMs), for example, in perovskite solar cells(PSCs), due to their properties on electron extraction or defect passivation. However, it still lacks of guidelines to update C60-based ETMs with excellent photoelectric properties. In this work, crystallographic data of eight C60-based ETMs, including pristine C60 and the well-known PCBM as well as six newly synthesized fullerenes, are analyzed to establish the connections between derivatized structures and photoelectric properties for the typical carbon cluster of C60. In terms of packing centroid-centroid distance between neighboring carbon cages, the crystallographic data are useful for probing photoelectric properties, such as electrochemical properties, electron mobility and photovoltaic performances, and therefore facilitate to design novel C60-based ETMs for PSCs with high performances.

关键词： Perovskite solar cell(PSC) Electron transporting material(ETM) Fullerene Power conversion efficiency Crystallographic understanding