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Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu fangxia Xu Chengcheng Zhou Kaimei Lu bin fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

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Effect of Al and Zn additives on grain size of Mg-3Ni-2MnO_(2) alloy

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Transactions of Nonferrous Metals Society of China 2009年第S02期19卷 355-358页

作者： fang Wa SUN Hong-fei fang Wen-bin WANG bin School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

The effect of Al and Zn additives on the grain size of Mg-3Ni-2MnO_(2) alloy was *** nanostructured Mg-3Ni-2MnO_(2) and Mg-3Ni-2MnO_(2)-3Al-Zn were made by ball milling process under hydrogen *** XRD results and TEM analysis reveal that Al and Zn additives almost have no effect on the grain size of Mg-3Ni-2MnO_(2) *** present study provides us a feasibility of producing nano-structured magnesium alloys,based on hydrogenation,disproportionation,desorption and recombination(HDDR),by adding beneficial elements to hydrogen storage materials.

关键词： nanocrystalline magnesium alloy hydrogenation-disproportionation-desorption-recombination(HDDR) ball milling

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Farmers’risk preference and fertilizer use

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Journal of Integrative Agriculture 2021年第7期20卷 1987-1995页

作者： QIAO fang-bin HUANG Ji-kun China Economics and Management Academy Central University of Finance and EconomicsBeijing 100081P.R.China School of Advanced Agricultural Sciences Peking UniversityBeijing 100089P.R.China School of Economics and Management Jiangxi Agricultural UniversityNanchang 330045P.R.China

This study examines the role of farmers’risk attitudes toward fertilizer use in cotton production in *** previous studies,this paper theoretically shows that the relationship between farmers’risk aversion and fertilizer use is not always *** survey data were collected to test this relationship using the Cobb–Douglas production *** suggest that when the elasticity of fertilizer use and the probability of achieving the desired effects from fertilizer use are high,risk-averse farmers apply more fertilizer than risk-taking ***,when the elasticity of fertilizer use and the probability of achieving the desired effects are low,risk-taking farmers apply more fertilizer than risk-neutral or risk-averse farmers.

关键词： risk preferences fertilizer use farmers environment China

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Effect of ultrasonic vibration on finished quality in ultrasonic vibration assisted micromilling of Inconel718

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Chinese Journal of Aeronautics 2021年第6期34卷 209-219页

作者： bin fang Zhonghang YUAN Depeng LI Liying GAO School of Mechanical and Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China

Inconel718 was machined with the traditional micromilling(TMM)and ultrasonic vibration assisted micromilling(UVAMM)with the different technology parameters,whose surface quality and burrs formation were *** results show that TMM often forms pits,bumps and gullies in the size effect *** effectively improves the surface quality compared with *** surface defects are significantly reduced with the increase of feed per tooth(fz).When fz exceeds 4 lm,the effect of ultrasonic vibration on the surface quality is no longer *** minimum burr size on the down milling side and the up milling side are 50.23 lm and 36.57 lm,*** feasibility of vibration cutting in improving surface quality and suppressing burr size was *** effectively suppresses the formation of built-up edge,which can significantly improve the micromilling *** cutting force is obtained through simulation and *** are agreement in the change *** finite element simulation can be used to predict the cutting *** with TMM,feeding force(Fx),radial force(Fy)and axial force(Fz)of UVAMM decrease by 7.6%,11.5%and 1.3%,respectively.

关键词： Burr Cutting force Simulation Surface quality Ultrasonic vibration assisted micromilling

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Optimization of micellar electrokinetic capillary chromatography method using central composite design for the analysis of components in Yangwei granule

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第3期12卷 193-200页

作者： Shu-fang WANG Hai-yan fang Hai-bin QU Pharmaceutical Informatics Institute Zhejiang University Hangzhou 310058 China

Central composite design(CCD),together with multiple linear regression,was successfully used to optimize the electrophoretic buffer system of micellar electrokinetic capillary chromatography(MEKC) for the determination of albiflorin,paeoniflorin,liquiritin,and glycyrrhizic acid in the traditional Chinese medicine(TCM) prescription,Yangwei *** of sodium deoxycholate(SDC) and borate,and proportions of ammonia,acetonitrile,and methanol were *** total resolutions of peaks between the analytes and their adjacent peaks in real samples were integrated into the evaluation index of separation *** optimum electrophoretic buffer contained 80 mmol/L SDC,20 mmol/L borate,5%(v/v) methanol,0.5%(v/v) ammonia,and 5%(v/v) *** correlation coefficients(R 2 ) between the peak areas and the corresponding concentrations of analytes were greater than *** limits of detection(LODs) (S/N=3) of the analytes were 0.97-4.00μg/*** results indicate the superiority of CCD in optimizing the separation conditions of complex samples such as TCM prescriptions.

关键词： Micellar electrokinetic capillary chromatography Traditional Chinese medicine Central composite design Yangwei granule

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Skill enhancement learning with knowledge distillation

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Science China(Information Sciences) 2024年第8期67卷 206-220页

作者： Naijun LIU Fuchun SUN bin fang Huaping LIU Department of Computer Science and Technology Tsinghua University

Skill learning through reinforcement learning has significantly progressed in recent years. However, it often struggles to efficiently find optimal or near-optimal policies due to the inherent trial-and-error exploration in reinforcement learning. Although algorithms have been proposed to enhance skill learning efficacy, there is still much room for improvement in terms of skill learning performance and training stability. In this paper, we propose an algorithm called skill enhancement learning with knowledge distillation(SELKD), which integrates multiple actors and multiple critics for skill learning. SELKD employs knowledge distillation to establish a mutual learning mechanism among actors. To mitigate critic overestimation bias,we introduce a novel target value calculation method. We also perform theoretical analysis to ensure the convergence of SELKD. Finally, experiments are conducted on several continuous control tasks, illustrating the effectiveness of the proposed algorithm.

关键词： skill learning enhancement learning reinforcement learning knowledge distillation

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Global Stability for a Heroin Model with Age-Dependent Susceptibility

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Journal of Systems Science & Complexity 2015年第6期28卷 1243-1257页

作者： fang bin LI Xuezhi MARTCHEVA Maia CAI Liming Department of Mathematics Xinyang Normal University Beijing Institute of Information and Control Department of Mathematics University of Florida

This paper considers global asymptotic properties for an age-structured model of heroin use based on the principles of mathematical epidemiology where the incidence rate depends on the age of susceptible individuals. The basic reproduction number of the heroin spread is obtained. It completely determines the stability of equilibria. By using the direct Lyapunov method with Volterra type Lyapunov function, the authors show that the drug-free equilibrium is globally asymptotically stable if the basic reproduction number is less than one, and the unique drug spread equilibrium is globally asymptotically stable if the basic reproduction number is greater than one.

关键词： Age-structured basic reproduction number equilibrium global stability heroin model

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Synthesis and Characterization of a Novel Functional Biodegradable Copolymer-Poly(lactic acid-4-hydroxyproline-polyethylene glycol)

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Chinese Chemical Letters 2006年第8期17卷 1125-1128页

作者： Jiu fang DUAN Yu bin ZHENG Department of Polymer Science Dalian University of Technology Dalian 116012

A series of poly（lactic acid-4-hydroxyproline-polyethylene glycol）（PLA-Hpr-PEG） copolymers were synthesized by direct melt copolymerization of D,L-lactic acid and 4-hydroxyproline with different feed amount of polyethylene glycol （PEG） 0.1%, 0.5%, 1% and 5%, respectively. The properties of these copolymers were characterized by using IR spectroscopy, proton nuclear magnetic resonance （1H-NMR） spectroscopy, gel permeation chromatography （GPC）, X-ray diffraction and differential scaning calorimetry （DSC）. PLA-Hpr-PEG are amorphous copolymers. Copolymers showed increasing water uptake capacity with increasing PEG percentage in the feed, which result in an increasing degradable rate in phosphate buffer solution （pH 7.4） at 37℃.

关键词： Lactic acid 4-hydroxyproline polyethylene glycol.

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Analysis of the Management Policy and Comprehensive Benefit of Agriculture in the Rural Area:A Case Study on Pujiang County,China

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Agricultural Sciences in China 2008年第11期7卷 1403-1412页

作者： fang bin MENG Ying College of Land Management School of Geography Science Nanjing Normal University Nanjing 210046 P.R.China

To solve the problems of the poverty in rural areas and raise the output efficiency of agriculture, policy is the primary factor. Guiding by good policies, the design of agricultural structure and management technology are the two main technical supports for agricultural development. The authors apply the model to determine the consequences of four so-called poverty alleviation strategies：（i） intensification of production, （ii） diversification of livestock production, （iii） land expansion, and （iv） an exit from agriculture, with a set of regional poverty and biodiversity indicators. Diversification seems to be the most promising poverty reduction strategy, but requires an efficient use of animal manure in cropping systems to avoid environmental problems. Improved nutrient management in cropping systems is effective in reducing the regional nitrogen surplus, but less effective in increasing per capita income. The exit strategy is beneficial for reducing poverty and achieving biodiversity goals, but may have important social consequences, which are not addressed in this study. Further reduction of rural poverty is hampered by labor constraints during the harvesting period of high value crops, such as vegetables and fruits, which calls for research and development in the field of agricultural mechanization.

关键词： diversification intensification LP sustainability ecosystem approach

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Formation mechanism of solid product produced from co-pyrolysis of Pingdingshan lean coal with organic matter in Huadian oil shale

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 363-372页

作者： Xiangchun Liu Jun Hu Ruilun Xie bin fang Ping Cui Anhui Key Laboratory of Coal Clean Conversion&Utilization Anhui Province Key Laboratory of Coal Clean Conversion and High Valued UtilizationSchool of Chemistry and Chemical EngineeringAnhui University of TechnologyMa’anshan 243032China

A mixture of Pingdingshan lean coal and acid-treated Huadian oil shale was co-pyrolyzed in a drop-tube fixed-bed reactor in the temperature range of 300℃–450℃.To reveal the formation mechanism of the solid co-pyrolysis product,changes in some physicochemical properties were investigated,using analysis by X-ray diffraction,X-ray photoelectron spectroscopy,scanning electron microscopy,pore analysis,thermogravimetry,and electron spin resonance.X-ray diffraction showed that the lattice plane spacing for the co-pyrolyzed mixture decreased from 0.357 nm to 0.346 nm and the average stacking height increased from 1.509 nm to 1.980 nm in the temperature range of 300°C–450°C,suggesting that pyrolysis treatment increased its degree of *** amount of oxygen-containing functional groups and pore volume decreased with increasing *** and electron spin resonance results showed that synergistic effects occurred during the co-pyrolysis process.A formation mechanism for the solid product was ***-rich radicals generated from the pyrolysis of the oil shale were trapped by hydrogen-poor macromolecular radicals of the intermediate metaplast produced from coal pyrolysis,thereby increasing the yield of solid product.

关键词： co-pyrolysis coal oil shale electron spin resonance mechanism

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