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Communications in Theoretical Physics 2008年第6期49卷 1580-1582页

作者： ZHENG fang-lan YANG Chun-Bin Institute of Particle Physics Huazhong Normal University Wuhan 430079 China

With the experimental data from STAR program on the centrality dependence of the PT spectra of charged hadron produced in d＋Au collisions at √^8NN=200 GeV, we show that there also exists a scaling distribution in the backward rapidity regions. Using this scaling distribution, we get the theoretical psedorapidity asymmetry which is basically in agreement with STAR data in the regions of 0≤｜η｜≤0.5 and 0.5 ≤｜η｜≤1. No theoretical models are used in any part of this phenomenological analysis.

关键词： scaling distribution pseudorapidity asymmetry

Two new flavanone glycosides from Macrothelypteris torresiana (Gaud.) Ching

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Chinese Chemical Letters 2009年第5期20卷 579-581页

作者： Wei Fu Wei fang Jin lan Ruan College of Pharmacy Tongji Medical Center Huazhong University of Science and Technology Wuhan 430030 China

Two new flavanone glycosides 1 and 2 were isolated from the aerial parts of Macrothelypteris torresiana （Gaud.） Ching. The structures of two products were identified as （2S）-5,7,2＇,5＇-tetrahydroxyflavanone-2＇-O-β-D-6＂-O-acetylglucopyranoside and （2S）- 5,7,2＇,5＇-tetrahydroxyflavanone-2＇-O-β-D-glucopyranoside on the basis of their chemical and spectral analysis, respectively.

关键词： Macrothelypteris torresiana (Gaud.) Ching Flavanone glycosides Spectral analysis

The extended auxiliary the KdV equation with equation method for variable coefficients

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Chinese Physics B 2011年第10期20卷 166-170页

作者： Shi lan-fang Chen Cai-Sheng Zhou Xian-Chun College of Mathematics Hohai University Nanjing 210098 China College of Mathematics and Physics Nanjing University of Information Science and Technology Nanjing 210044 China College of Electronic and Information Engineering Nanjing University of Information Science and Technology Nanjing 210044 Chins

This paper applies an extended auxiliary equation method to obtain exact solutions of the KdV equation with variable coefficients. As a result, solitary wave solutions, trigonometric function solutions, rational function solutions, Jacobi elliptic doubly periodic wave solutions, and nonsymmetrical kink solution are obtained. It is shown that the extended auxiliary equation method, with the help of a computer symbolic computation system, is reliable and effective in finding exact solutions of variable coefficient nonlinear evolution equations in mathematical physics.

关键词： extended auxiliary equation method KdV equation with variable coefficients exactsolutions

A magnetic hydroxyapatite composite scaffoldbased magnetic therapy for bone repair:an experimental study in canis lupus familiaris

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Regenerative Biomaterials 2017年第2期4卷 97-103页

作者： Jing He Hao Hu Xiaobo Zeng fang lan fang Wu Yao Wu National Engineering Research Centre for Biomaterials Sichuan UniversityChengdu 610064PR China

While the beneficial effect of magnetic nanoparticle on the biological functions of calcium phosphate scaffolds has been well documented,little is known about the effect of magnetic nanoparticle on the in vivo performance of hydroxyapatite(HA)*** this study,to further investigate the influence of magnetic hydroxyapatite(MHA)scaffolds on bone repair and the interactions between the magnetic scaffolds and the exterior magnetic field in vivo,we implanted the scaffolds into a beagle dog experimental model of femur transverse *** with traditional HA scaffolds,the MHA scaffolds could accelerate bone tissue regeneration in situ,especially in the first ***,it had a synergic effect between external magnetic fields and MHA scaffolds on bone repair in *** 1 month,the bone density on MHA exposed to an external magnetic field was roughly 30%greater than that of HA,and only slightly less than the bone density observed on HA after 3 ***,the results suggest the improvement of bone ingrowth is critical for HA scaffold with magnetic fields,which is significant for the early bone fixation and repair.

关键词： magnetic nanoparticles static magnetic fields magnetic hydroxyapatite bone regeneration

LINK BETWEEN OXIDATIVE STRESS AND INSULIN RESISTANCE

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Chinese Medical Sciences Journal 2007年第4期22卷 254-259页

作者： lan-fang Li Jian Li Key Laboratory of Geriatrics of Ministry of Health Beijing Institute of Geriatrics Beijing Hospital Ministry of Health Beijing 100730

Many studies on oxidative stress,insulin resistance,and antioxidant treatment have shown that increased oxidative stress may accelerate the development of diabetic complications through the excessive glucose and free fatty acids metabolism in diabetic and insulin-resistant *** pathogenic mechanisms such as insulin receptor substrate phosphorylation are involved in insulin resistance induced by oxidative *** antioxidant treatments can show benefits in animal models of diabetes mellitus and insulin ***,negative evidence from large clinical trials suggests that new and more powerful antioxidants need to be studied to demonstrate whether antioxidants can be effective in treating diabetic ***,it appears that oxidative stress is only one of the factors contributing to diabetic ***,antioxidant treatment would most likely be more effective if it were coupled with other treatments for diabetic complications.

关键词： insulin resistance oxidative stress diabetes mellitus

Adenovirus-associated hemophagocytic syndrome in a young child

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World Journal of Pediatrics 2020年第2期16卷 215-216页

作者： Fei-Zhou Zhang Yu-Qing Cai lan-fang Tang Department of Pulmonology Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadHangzhou 310051China

A 2-year-old boy was admitted to our hospital because of recurrent fever,cough and wheezing for half a *** examination revealed obvious inspiratory three-concave sign,moist rales,wheezing,rash on the face and hepatosplenomegaly.A chest computer tomography revealed bilateral lung consolidation(Fig.1).Direct immunofluorescence of nasopharyngeal swab was positive for *** data showed reduced white blood cell of 3.63×10^9 cells/L(ref:4-10×10^9),hemoglobin of 98 g/L(ref:110-155 g/L)and platelets of 64×10^9/L(ref:100-400×10^9).Serum ferritin continued to be above 1500μg/L.

关键词： admitted lung nasopharyngeal

Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

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Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： Jiawen Zhang Sihui Yu Qiao Peng Ping Wang lan fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

Vertically aligned W(Mo)S_(2)/N-W(Mo)C-based light-assisted electrocatalysis for hydrogen evolution in acidic solutions

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Rare Metals 2023年第5期42卷 1535-1544页

作者： lan-fang Wang Rui-Xia Yang Jin-Zhi Fu Yue-Yue Cao Rui-fang Ding Xiao-Hong Xu Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education&School of Chemistry and Materials Science of Shanxi Normal University Taiyuan030032China Kunshan Superior Silk Screen Printing Material Co. Ltd.Suzhou215300China

The development of non-noble-metal hydrogen evolution electrocatalysts holds great promises for a sustainable energy ***,a hybrid W(Mo)S_(2)/NW(Mo)C nanosheet with array structures was reported for an efficient light-as sis ted hydrogen evolution electrocatalysts in acidic *** resulting vertically aligned W(Mo)S_(2)/N-W(Mo)C was supported on a conductive carbon fiber paper,which can be produced through annealing W(Mo)S_(2)nanosheets by simultaneous carbonization and N-doping in Ar/H_(2)*** optimized WS_(2)/NWC and MoS_(2)/N-MoC electrode exhibits remarkable lightassisted electrocatalysis activity with overpotentials of0.120 and 0.122 V at 10 mA·cm^(-1)in acidic solutions,*** high hydrogen evolution activities should be attributed to the electrocatalytic synergistic effects of the abundant active sites existing in different phase boundaries and the absorption for ultraviolet-visible *** study shows that synthesis of low-cost and highly active W(Mo)S_(2)-based hydrogen evolution electrocatalyst opens up a route toward the development of scalable production of hydrogen fuels.

关键词： W(Mo)S_(2)/N-W(Mo)C heterostructures Vertically aligned nanosheets Hydrogen evolution Lightassisted electrocatalysis

Treatment of Pneumocystis jirovecii pneumonia in non-human immunodeficiency virus-infected patients using a combination of trimethoprim-sulfamethoxazole and caspofungin

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World Journal of Clinical Cases 2022年第9期10卷 2743-2750页

作者： Huan-Huan Wu Shuang-Yan fang Yan-Xiao Chen lan-fang Feng Department of Respiratory Medicine Dongyang Hospital Affiliated to Wenzhou Medical UniversityDongyang 322100Zhejiang ProvinceChina

BACKGROUND Pneumocystis jirovecii pneumonia(PJP)is an infectious disease common in immunocompromised ***,the currently,the clinical characteristics of non-HIV patients with PJP infection have not been fully *** To explore efficacy of trimethoprim–sulfamethoxazole(TMP-SMX)and caspofungin for treatment of non-human immunodeficiency virus(HIV)-infected PJP *** A retrospective study enrolled 22 patients with non-HIV-infected PJP treated with TMP-SMX and caspofungin from 2019 to *** manifestations,treatment and prognosis of the patients were *** Five patients presented with comorbidity of autoimmune diseases,seven with lung cancer,four with lymphoma,two with organ transplantation and four with membranous nephropathy associated with use of immunosuppressive *** main clinical manifestations of patients were fever,dry cough,and progressive *** patients presented with acute onset and respiratory *** most common imaging manifestation was ground glass opacity around the hilar,mainly in the upper *** patients were diagnosed using next-generation sequencing,and were treated with a combination of TMP-SMX and *** them,17 patients received short-term adjuvant glucocorticoid *** patients recovered well and were discharged from *** Non-HIV-infected PJP have rapid disease progression,high risk of respiratory failure,and high *** of TMP-SMX and caspofungin can effectively treat severe non-HIVinfected PJP patients with respiratory failure.

关键词： Acquired immunodeficiency syndrome Non-human immunodeficiency virus-infected patients Immunosuppression caspofungin Mortality Pneumocystis jirovecii pneumonia

A new strategy to design isostructural salts: The case of the antitumor drug dimethylaminomicheliolide

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Chinese Chemical Letters 2023年第2期34卷 150-153页

作者： Zhonghua Li Haibin Qu lan fang Songgu Wu Junbo Gong State Key Laboratory of Chemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515031China

Isostructural multicomponent crystals provide a promising way for fine-tuning physicochemical properties, whereas their design remains quite challenging. The purpose of this work was to provide a new strategy for obtaining isostructural multicomponent crystals by introducing coformers with functional group positional isomerism. Five isostructural salts of an antitumor drug dimethylaminomicheliolide(DMAMCL) were reported and designed with a series of dihydroxybenzoic acid regioisomers for the first time, which were identified by power and single-crystal X-ray diffractions. Similar lattice parameters suggested these obtained salts may have the same crystal packing mode. The quantitative similarity parameters via XPac, Crystal CMP and Mercury program further proved these crystal structures are3D isostructural. Hirshfeld surface maps and 2D fingerprint plots show that the isostructural salts have similar intermolecular interactions. Compared with DMAMCL, obvious improvement was observed in the thermal stability, hygroscopicity, and solubility of these isostructural salts. Meanwhile, isostructural crystals may have different physicochemical properties, even though the shape and molecular size are similar and the packing of crystal structures is equally matched.

关键词： Dimethylaminomicheliolide Crystal engineering Isostructural salt Intermolecular interactions Thermal analysis Hygroscopicity Solubility