检索结果-南通市图书馆

Enhancing crystal integrity and structural rigidity of CsPbBr_(3) nanoplatelets to achieve a narrow colorsaturated blue emission

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第5期13卷 985-997页

作者： Qianqian Huang Wenxu Yin bo Gao Qingsen zeng Dong Yao Hao Zhang Yinghe Zhao Weijia Zheng Jiaqi Zhang Xuyong Yang Xiaoyu Zhang Andrey L.Rogach Key Laboratory of Automobile Materials MOE School of Materials Science&Engineeringand Jilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsJilin UniversityChangchunChina. State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchunChina. State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhanHubeiChina. Department of Chemistry University of VictoriaVictoriaBCCanada. Key Laboratory of Advanced Display and System Applications of Ministry of Education Shanghai UniversityShanghaiChina. Department of Materials Science and Engineering and Centre for Functional Photonics(CFP)City University of Hong KongHong Kong S.A.RChina

Quantum-confined CsPbBr_(3) perovskites are promising blue emitters for ultra-high-definition displays,but their soft lattice caused by highly ionic nature has a limited ***,we endow CsPbBr_(3) nanoplatelets(NPLs)with atomic crystal-like structural rigidity through proper surface engineering,by using strongly bound N-dodecylbenzene sulfonic acid(DBSA).A stable,rigid crystal structure,as well as uniform,orderly-arranged surface of these NPLs is achieved by optimizing intermediate reaction stage,by switching from molecular clusters to mono-octahedra,while interaction with DBSA resulted in formation of a Cs_(x)O monolayer shell capping the NPL *** a result,both structural and optical stability of the CsPbBr3 NPLs is enhanced by strong covalent bonding of DBSA,which inhibits undesired phase transitions and decomposition of the perovskite phase potentially caused by ligand ***,rather small amount of DBSA ligands at the NPL surface results in a short inter-NPL spacing in their closely-packed films,which facilitates efficient charge injection and *** photoluminescence of the produced CsPbBr_(3) NPLs is bright(nearly unity emission quantum yield)and peaks at 457 nm with an extremely narrow bandwidth of 3.7 nm at 80 K,while the bandwidth of the electroluminescence(peaked at 460 nm)also reaches a record-narrow value of 15 nm at room *** value corresponds to the CIE coordinates of(0.141,0.062),which meets Rec.2020 standards for ultra-high-definition displays.

关键词： temperature stability narrow

(+)/(-)-Mycosphatide A,a pair of highly oxidized polyketides with lipid-lowering activity from the mangrove endophytic fungus Mycosphaerella ***-DZG01

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第9期35卷 210-213页

作者： Qi Tan Run-Zhu fan Wencong Yang Ge Zou Tao Chen Jianying Wu bo Wang Sheng Yin Zhigang She School of Chemistry Sun Yat-sen UniversityGuangzhou 510006China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

(±)-Mycosphatide A(1a/1b),a pair of highly oxidized enantiomeric polyketides featuring a unique5/5/6/5-fused tetracyclic ring system,were isolated from the mangrove endophytic fungus Mycosphaerella *** structures were established by extensive spectroscopic analyses,single crystal Xray diffraction,and experimental electronic circular dichroism(ECD)spectra *** plausible biosynthetic pathway of 1 was proposed,which involved the generation of a key spiro[4.5]decane ***(+)-1a and(-)-1b exhibited significant lipid-lowering activity in 3T3-L1 adipocytes model,with EC50values of 7.85±1.56 and 8.87±0.80μmol/L,respectively.

关键词： Mangrove endophytic fungus Mycosphaerella sp. Polyketide Highly oxidized Lipid-lowering activity

Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2024年第2期39卷 347-350页

作者： Yi Yin Yi Zhang Lelin Sun Shuqiang Wang Yong zeng bo Gong Lulin Huang Yongquan He Zhenglin Yang Center for Natural Products Research Chengdu Institute of BiologyChinese Academy of SciencesChengdu610213China Sichuan Provincial Key Laboratory for Human Disease Gene Study Center for Medical GeneticsDepartment of Laboratory MedicineSichuan Academy of Medical Sciences&Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences&Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China University of Chinese Academy of Sciences Beijing100049China Infectious Disease Department Sichuan Academy of Medical Sciences&Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China Department of Ophthalmology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China

Dear Editor,Genome-wide association studies(GWASs)have reported a genetic association between certain populations and the severity of *** severe patients,changes in the locus 3p21.31(including SLC6A20,LZTFL1,CCR9,FYCO1,CXCR6,and XCR1)are associated with COVID-19 hospitalization(Ellinghaus et al.,2020).Moreover,variations in 9p34.2 region(including genes related to the Abo blood grouping)can affect both susceptibility and severity of COVID-19;in particular,individuals with blood group A may have an increased risk of COVID-19 infection,while those with blood group O may have a protective effect(Ellinghaus et al.,2020;Shelton et al.,2021).

关键词： patients protective

Achieving strength–ductility synergy in novel paramagnetic Fe-based medium-entropy alloys through deep cryogenic deformation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4493-4507页

作者： Hu-Wen Ma Yan-Chun Zhao Li Feng Tian-zeng Liu Zhi-Qi Yu bo Jin Wang-Chun Duan Peter K.Liaw Dong Ma State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of Technology Wenzhou Pump and Valve Engineering Research Institute Lanzhou University of Technology Iron and Steel Research Institute Jiuquan Iron and Steel Corporation Lanzhou Resources and Environment Voc-Tech University Department of Materials Science and Engineering The University of Tennessee Neutron Science Center Songshan Lake Materials Laboratory

Cryogenic pre-deformation treatment has been widely used to effectively improve the comprehensive mechanical properties of steels and novel metals. However,the dislocation evolution and phase transformation induced by different degrees of deep cryogenic deformation are not yet fully elucidated. In this study, the effects of multiple cryogenic pre-treatments on the mechanical properties and deformation mechanisms of a paramagnetic Fe63.3Mn14-Si9.1Cr9.8C3.8medium-entropy alloy（MEA） were investigated, leading to the discovery of a pretreated MEA that exhibits exceptional mechanical properties, including a fracture strength of 3.0 GPa, plastic strain of 26.1% and work-hardening index of 0.57. In addition, X-ray diffraction（XRD） and transmission electron microscopy（TEM）analyses revealed that multiple cryogenic pre-deformation treatments significantly increased the dislocation density of the MEA(from 9 × 1015to 4 × 1016m-2after three pretreatments), along with a transition in the dislocation type from predominantly edge dislocations to mixed dislocations（including screw-and edge-type dislocations）. Notably, this pretreated MEA retained its paramagnetic properties（μr< 1.0200） even after fracture. Thermodynamic calculations showed that cryogenic pretreatment can significantly reduce the stacking fault energy of the MEA by a factor of approximately four(i.e., from 9.7 to2.6 m J·m-2), thereby activating the synergistic effects of transformation-induced plasticity, twinning-induced plasticity and dislocation strengthening mechanisms. These synergistic effects lead to simultaneous strength and ductility enhancement of the MEA.

关键词： Deep cryogenic transformation Dislocation evolution Iron-based medium-entropy alloys Phase transformation Stacking fault energy

The Optical Variability Properties of TeV Blazars

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第9期24卷 66-75页

作者： Zi-An Su Wen-Xin Yang Xiang-Tao zeng Le-Jian Ou Ze-Lin Li Jiang-He Yang Jun-Hui fan Department of Physics School of Physics and ElectronicsHunan Normal UniversityChangsha 410081China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Greater Bay Brand Center of the National Astronomical Data Center Guangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China College of Microelectronics Feicuihu Campus of Hefei University of TechnologyHefei 230601China College of Mathematics and Physics Science Hunan University of Arts and ScienceChangde 415000China

Variability is one of the typical observational properties of blazars and the spectral changes are usually associated with variability,although this kind of association is unclear *** this work,we used data from the Steward Observatory blazar monitoring program to investigate the optical variability properties including the short-term timescale,the brightness-dependent spectral property,the correlation between the the brightness variation and the polarization,and then estimate the Doppler factors based on the obtained short timescale to study the polarization property for a sample of 20 TeV *** analyses arrive at the following results:(1)The largest variation amplitude in R-band,ΔR_(M),covers a range from ΔR_(M)=0.29 mag(1ES 2344+514)to ΔR_(M)=4.66 mag(3C 279).(2)Intra-day variability was found from five sources with timescales from 0.14 day for S50716+714 to 0.98 day for PKS *** sources show spectra that are bluer when they become brighter,suggesting a common bluer-when-brighter property.(3)The plot of the polarization versus estimated Doppler factor is consistent with the Doppler factor dependent formula of polarization.(4)The largest polarization is correlated with the largest optical variation,suggesting that the high polarization and high amplitude variation are both the indicator of beaming effect.

关键词： galaxies:active galaxies:jets radiation mechanisms:non-thermal

FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1479-1499页

作者： Xuan-zeng Pei Min Cai Da-Wei Jiang Song-Hai Chen Qing-Qing Wang Hui-Min Lu Yi-fan Lu Department of Hepatological Surgery The First Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Our study investigated the role of FAM53B in regulating macrophage M2 polarization and its potential mechanisms in promoting pancreatic ductal adenocarcinoma(PDAC)*** To further investigate the role of FAM53B in regulating macrophage M2 polarization and its potential mechanism in promoting PDAC *** goal is to determine how FAM53B affects macrophage M2 polarization and to define its underlying mechanism in PDAC *** Cell culture and various experiments,including protein analysis,immunohisto-chemistry,and animal model experiments,were *** compared FAM53B expression between PDAC tissues and healthy tissues and assessed the correlation of FAM53B expression with clinical *** study analyzed the role of FAM53B in macrophage M2 polarization in vitro by examining the expression of relevant ***,we used a murine model to study the role of FAM53B in PDAC metastasis and analyzed the potential underlying *** Our research showed that there was a significant increase in FAM53B levels in PDAC tissues,which was linked to adverse tumor *** findings indicated that FAM53B can enhance macrophage M2 polarization,leading to increased anti-inflammatory factor *** results from the mouse model further supported the role of FAM53B in PDAC metastasis,as blocking FAM53B prevented tumor cell invasion and *** FAM53B promotes PDAC metastasis by regulating macrophage M2 *** discovery could lead to the development of new strategies for treating *** example,interfering with the FAM53B signaling pathway may prevent cancer *** research findings also provide important information for expanding our understanding of PDAC pathogenesis.

关键词： FAM53B Pancreatic ductal adenocarcinoma Tumor metastasis Macrophage polarization

Rapidly growing primordial black holes as seeds of the massive high-redshift JWST Galaxies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 139-146页

作者： Guan-Wen Yuan Lei Lei Yuan-Zhu Wang bo Wang Yi-Ying Wang Chao Chen Zhao-Qiang Shen Yi-Fu Cai Yi-Zhong fan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Deep Space Exploration Laboratory/Department of Astronomy School of Physical SciencesUniversity of Science and Technology of ChinaHefei 230026China Jockey Club Institute for Advanced Study The Hong Kong University of Science and TechnologyHong KongChina

A group of massive galaxies at redshifts of z■7 have been recently detected by the James Webb Space Telescope(JWST),which were unexpected to form at such an early time within the standard Big Bang *** this work,we propose that this puzzle can be explained by the presence of some primordial black holes(PBHs)with a mass of~1000M_(⊙).These PBHs act as seeds for early galaxy formation with masses of~10^(8)-10^(10)M_(⊙)at high redshift,hence accounting for the JWST *** use a hierarchical Bayesian inference framework to constrain the PBH mass distribution models,and find that the Lognormal model with the M_(c)~750M_(⊙)is preferred over other *** rapidly growing BHs are expected to have strong radiation and may appear as high-redshift compact objects,similar to those recently discovered by *** we focused on PBHs in this work,the bound on the initial mass of the seed black holes remains robust even if they were formed through astrophysical channels.

关键词： primordial black hole dark matter halo black hole accretion primordial galaxies

同方期刊数据库

Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration

在线全文

学校读者我要写书评

暂无评论

bone Research 2024年第2期12卷 390-406页

作者： Xinshu Zhang Yao Xiao bo Hu Yanhao Li Shaoyang Zhang Jian Tian Shuo Wang Zaijin Tao Xinqi zeng Ning-Ning Liu Baojie Li Shen Liu Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine600 Yishan RdShanghai 200233PR China Section of Spine Surgery Department of OrthopaedicsChangzheng HospitalNaval Medical UniversityShanghai 200003PR China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200241PR China Department of Orthopaedics Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityWuxi 214062PR China State Key Laboratory of Systems Medicine for Cancer Center for Single-Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China

Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without effective anti-fibrotic therapies,resulting in severe *** are widely recognized as a fibrotic trigger during peritendinous adhesion ***,different clusters of macrophages have various functions and receive multiple regulation,which are both still *** our current study,multi-omics analysis including single-cell RNA sequencing and proteomics was performed on both human and mouse tendon adhesion tissue at different stages after tendon *** transcriptomes of over 74000 human single cells were *** results,we found that SPP1^(+)macrophages,RGCC^(+)endothelial cells,ACKR1^(+)endothelial cells and ADAM12^(+)fibroblasts participated in tendon adhesion ***,despite specific fibrotic clusters in tendon adhesion,FOLR2^(+)macrophages were identified as an antifibrotic cluster by in vitro experiments using human ***,ACKR1 was verified to regulate FOLR2^(+)macrophages migration at the injured peritendinous site by transplantation of bone marrow from Lysm-Cre;R26R^(tdTomato) mice to lethally irradiated Ackr1^(-/-)mice(Ackr1^(-/-)chimeras;deficient in ACKR1)and control mice(WT chimeras).Compared with WT chimeras,the decline of FOLR2^(+)macrophages was also observed,indicating that ACKR1 was specifically involved in FOLR2^(+)macrophages *** together,our study not only characterized the fibrosis microenvironment landscape of tendon adhesion by multi-omics analysis,but also uncovered a novel antifibrotic cluster of macrophages and their *** results provide potential therapeutic targets against human tendon adhesion.

关键词： tendon analysis landscape

Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3585-3599页

作者： De-Gang Li Jia-Peng Jiang fan-Ye Chen Wei Wu Jun Fu Gong-He Wang Yu-bo Li Department of Gastrointestinal and Anorectal Surgery The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are typical gastrointestinal tract *** is the first-line therapy for GIST *** resistance limits the long-term effectiveness of *** regulatory effect of insulin-like growth factor 2(IGF2)has been confirmed in various cancers and is related to resistance to chemotherapy and a worse *** To further investigate the mechanism of IGF2 specific to *** IGF2 was screened and analyzed using Gene Expression Omnibus(GEO:GSE225819)*** IGF2 knockdown or overexpression by transfection,the phenotypes(proliferation,migration,invasion,apoptosis)of GIST cells were characterized by cell counting kit 8,Transwell,and flow cytometry *** used western blotting to evaluate pathway-associated and epithelial-mesenchymal transition(EMT)-associated *** injected transfected cells into nude mice to establish a tumor xenograft model and observed the occurrence and metastasis of *** Data from the GEO indicated that IGF2 expression is high in GISTs,associated with liver metastasis,and closely related to drug *** cells with high expression of IGF2 had increased proliferation and migration,invasiveness and *** of IGF2 significantly inhibited those *** addition,OEIGF2 promoted GIST metastasis in vivo in nude ***2 activated IGF1R signaling in GIST cells,and IGF2/IGF1R-mediated glycolysis was required for GIST with liver *** cells with IGF2 knockdown were sensitive to imatinib treatment when IGF2 overexpression significantly raised imatinib ***,2-deoxy-D-glucose(a glycolysis inhibitor)treatment reversed IGF2 overexpressionmediated imatinib resistance in *** IGF2 targeting of IGF1R signaling inhibited metastasis and decreased imatinib resistance by driving glycolysis in GISTs.

关键词： Insulin-like growth factor 2 Gastrointestinal stromal tumors IGF1R Glycolysis Imatinib resistance