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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-di fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Microstructure Characterization of a Complex Branched Low-density Polyethylene

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Chinese Journal of Polymer Science 2015年第3期33卷 508-522页

作者： Yan-hu Xue Yan-di fan Shu-qin Bo 姬相玲 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences

A low-density polyethylene （LDPE） resin with excellent processing and film-forming properties is fractionated through temperature rising elution fractionation （TREF） technique. The chain structures of both the original resin and its fractions are further analyzed using high-temperature gel permeation chromatography （GPC） coupled with triple detectors （refractive index （RI）-light scattering （LS）-viscometer （VIS））, ^13C-nuclear magnetic resonance spectroscopy （^13C-NMR）, Fourier transform infrared spectroscopy （FTIR）, differential scanning calorimetry （DSC） and successive self- nucleation/annealing （SSA） thermal fractionation. The ^13C-NMR results show that the original resin has both short chain branch （SCB）（2.82 mol%） and long chain branch （LCB）（0.52 mol%） structures. The FTIR results indicate that the methyl numbers （per 1000 C） of the fractions gradually decrease from 81 to 46 with increasing elution temperature from 25 ℃ to 75 ℃. The TREF-GPC cross-fractionation results show that the main component is collected at around 68 ℃. The molecular weight of the components in the high elution temperatures of 60 ℃ to 75 ℃ is from 2.0× 10^3 g/mol to 2.0 × 10^6 g/mol, and the relative amount is more than 80%. In the low elution temperature region below 50 ℃, the molecular weights of the components range from 1.0 × 10^3 g/mol to 1.6 × 10^4 g/mol, and the relative amount is less than 10%. In the DSC results, the melting peaks of the fractions gradually increase from 80.1℃ to 108.8 ℃ with elution temperature. In the SSA thermal fractionation, each resin fraction shows a broad range of endotherm with multiple melting peaks （more than eight peaks）. The melting peaks shift toward high temperatures with the elution temperature. The characteristic chain microstructure for the resin is also discussed in detail.

关键词： Polyethylene Cross-fractionation Microstructure Characterization TREF.

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Ring-opening Copolymerization of Cyclohexene Oxide and Maleic Anhydride Catalyzed by Mononuclear [Zn(L)(H_2O)] or Binuclear [Zn_2(L)(OAc)_2(H_2O)] Complex Based on the Salen-type Schiff-base Ligand

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Chinese Journal of Polymer Science 2014年第6期32卷 768-777页

作者： Li-ying Wu Dai-di fan 吕兴强卢荣 Shaanxi Key Laboratory of Degradable Medical Material Northwest University

From the self-assembly of the typical Salen-type Schiff-base ligand H2L and Zn（OAc）2.2H20 in the molar ratio of 1：1 or 1：2, the mononuclear [Zn（L）（H2O）] （1） or binuclear [Zn2（L）（OAc）2（H2O）] （2） are obtained, respectively. For both complexes 1 and 2, the unsaturated five-coordinate coordination environment to the catalytic active centers （Zn2＋ ions） permits the monomer insertion for the effective solution copolymerization of cyclohexene oxide and maleic anhydride. All the solution copolymerizations afford poly（ester-co-ether）s, while lower catalyst and co-catalyst concentrations are helpful for the formation of alternating polyester. Of the three co-catalysts, 4-（dimethylamino）pyridine is found to be the most efficient, while an excess thereof is detrimental for chain growth of the copolymers.

关键词： Mononuclear [Zn(L)(H2O)] (1) or binuclear [Znz(L)(OAc)z(H2O)] (2) based on Salen-type Schiffobase ligandHzL Ring-opening copolymerization from CHO and MA Poly(ester-co-ether) and polyester.

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Development of metal-organic deposition-derived second-generation high-temperature superconductor tapes and artificial flux pinning

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Advances in Manufacturing 2023年第3期11卷 523-540页

作者： Dong-Xu Wang Jing Chen di-fan Zhou Chuan-Bing Cai Shanghai Key Laboratory of High Temperature Superconductors Shanghai Frontiers Science Center of Quantum and Superconducting Matter StatesDepartment of PhysicsShanghai UniversityShanghai 200444People's Republic of China Shanghai Creative Superconductor Technologies Co.Ltd. Shanghai 201401People's Republic of China

The second-generation high-temperature superconductor tape(2G-HTS,also known as a coated conductor)based on REBaCuO(REBa_(2)Cu_(3)O_(7-δ))exhibits high current density and potential cost-effective price/performance,compared with conventional superconducting *** commercial 2G-HTS tapes,more than a dozen cable vendors had been manufacturing REBCO cables,such as the latest kilometer-class REBCO cable,which was incorporated into a civil grid on December 2021,as part of the recordbreaking 35-kV-voltage superconductor cable demonstration project in downtown *** paper describes the development of HTS-coated conductors,then outlines the various technological routes for their preparation,reviews the artificial flux pinning of coated conductors,and finally summarizes the technological breakthroughs,the latest research advances,and provides an outlook on their application prospects.

关键词： High-temperature superconductors RE123 superconductor tapes Chemical solution deposition Flux pinning

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Design of a low-sidelobe-level and wideband dielectric resonator antenna array for 60 GHz millimeter wave communication

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High Technology Letters 2018年第4期24卷 402-407页

作者： Lin Jiahong Shen Wenhui Ren fang fan di School of Communication and Information Engineering Shanghai University

A low-sidelobe-level( SLL) and wideband linear dielectric resonator antenna( DRA) array is proposed for 60 GHz millimeter wave communication. The array consists of 10 wideband DRAs which work at 60 GHz and it is fed by a Chebyshev feeding network to get a low SLL. To avoid the influence from the feeding network,a U-shaped substrate and a conformal ground are used,which can separate the DRA array and the feeding network. The parameter analysis and simulated results are presented.

关键词： dielectric resonator antenna array low-sidelobe-level(SLL) wideband 60 GHz millimeter wave communication

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A Study on Ezra Pound's Cathay from the Perspective of Deconstructionist Translation Theory

A Study on Ezra Pound's Cathay from the Perspective of Decon...

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作者： fan di 西安外国语大学

学位级别：硕士

埃兹拉·庞德作为美国20世纪最有影响力的诗人之一，他对美国文坛的贡献不仅在于诗歌，他的译作也对美国文坛影响颇深。《华夏集》便是其中最具代表性的一部作品。自《华夏集》1915年出版发行后，学界及译界众说纷纭，褒贬不一。一些评... 详细信息

埃兹拉·庞德作为美国20世纪最有影响力的诗人之一，他对美国文坛的贡献不仅在于诗歌，他的译作也对美国文坛影响颇深。《华夏集》便是其中最具代表性的一部作品。自《华夏集》1915年出版发行后，学界及译界众说纷纭，褒贬不一。一些评论家十分推崇称赞庞德的创造性翻译和《华夏集》浓郁的异域特色，而另一些评论家指责其文字语法上的错误，认为其在翻译的过程中过多的加入自己的理解，翻译的忠实性不高。事实上，庞德强调诗歌的意义与诗学效果在目的语中的保留的重要性。同时解构主义则提倡打破传统译学研究中的一元中心论，强调译者的主体性。而翻译的目的是向目的语读者传递诗歌的实质，并为诗歌在目的语中的再生做出贡献。因此，解构主义与庞德的翻译观在某种程度有异曲同工之妙。因此本文将从解构主义理论视角，来重新探讨庞德《华夏集》的英译。本文将会从解构主义角度对华夏集的原文与译文进行对比分析。首先介绍解构主义的起源于发展，并对解构主义理论对翻译理论及翻译实践的影响进行阐述。论文接着从解构主义视角出发，对庞德《华夏集》中的语言与非语言因素进行解构剖析。综上所述，从解构主义视角解读庞德《华夏集》的英译，本文认为译者在其翻译策略的选择上是有道理的，并非胡译、乱译。虽然《华夏集》的英译有其局限性，但其总体上是成功的，因为他的译作使中国古典诗歌在全新的文化环境中获得了再生，并对西方诗歌运动产生了巨大的影响。并证明了该理论对文学翻译具有很强的解释力和指导作用。通过对庞德《华夏集》英译中创造性翻译的研究，证明了该理论对文学翻译具有很强的解释力和指导作用。因此在文学翻译过程中译者应当打破传统原文意义的一元论与中心论，强调译者的主体性，对译入语文化因素多加考量。这也为我国庞德翻译研究者及文学翻译爱好者的研究提供了一个新的视角。

关键词：埃兹拉·庞德《华夏集》解构主义语言文化

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Numerical simulation of hydrodynamic environment effects of the reclamation project of Nanhui tidal flat in Yangtze Estuary

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Journal of Hydrodynamics 2019年第3期31卷 603-613页

作者： di-fan Cao Yong-ming Shen Mei-rong Su Chun-xue Yu Institute of Environmental and Ecological Engineering Guangdong University of Technology Guangzhou 510006 China Ocean & Hydraulic Engineering Institute Power China Huadong Engineering Corporation Limited Hangzhou 311122 China State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China Research Center far Eco-Environmental Engineering Dongguan University of Technology Dongguan 523808 China

The reclamation is the main method in the coast exploitation, and the assessment of the hydrodynamic environment effect of the reclamation project is important for project's site selection and environmental protection. With consideration of the baroclinic water, a 3?D numerical model MIKE3 is applied to simulate Yangtze Estuary's hydrodynamic environment to predict the impacts of the reclamation project of the Nanhui tidal flat. The simulated results of the model agree well with the field data of the tide level, the current speed, the current direction, the temperature, the salinity and the water quality, and it is indicated that after the reclamation project, the high tide level will be lower, while the low tide level will be higher in the South Branch in general. During the spring tide in the dry season, the peak velocity during the ebb tide in the North Channel will be reduced by 13%, while it will be increased by 21% in the South Channel in average. The salinity will be increased in the North Channel, while reduced in the South Passage, besides, the reclamation project will aggravate the saltwater intrusion of the North Branch. The value of N/P will be increased by about 4% in the whole South Branch except for the North Channel, leading to a slight aggravation of the phosphorus restriction effect in the Yangtze Estuary.

关键词： Yangtze Estuary 3-D numerical model hydrodynamics nutrients reclamation project

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Crystallization mechanism of glass-ceramics prepared from stainless steel slag

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Rare Metals 2018年第5期37卷 413-420页

作者： Wen-di fan Qiang-Wei Yang Bin Guo Bo Liu Shen-Gen Zhang Institute for Advanced Materials and Technology University of Science and Technology Beijing

Glass-ceramics have been prepared by using stainless steel slag, fly ash and coal fly ash that were figobtained from industrial solid waste. The crystallization behavior and mechanical characterization of the glass-ce-ramics with different （CaO ＋ MgO）/（SiO2 ＋ Al2O3） content ratios were studied. While the basicity decreases from 1.2 to 0.9 cm^-3, the bridge oxygen content increases from 1.18 ~ 10^21 to 1.34 ~ 10^21 cm^-3. According to the deconvolution of Raman spectra, the relative abundance of the stretching of Si-Onb bond （Q^n units） can be obtained. The increase in the Q^3 units dominates the polymerization in the process of decreasing basicity. This change in bonding is demonstrated to lead to polymerization of the glass network and the increase in crystallization activation energy from 336.0 to 360.7 kJ·mol^-l. The results demonstrate that the production of the glass-ceramics from industrial steel slag, fly ash and coal fly ash is cost-effective and offers advantages over other production methods.

关键词： Glass-ceramics Stainless steel slag Augite

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Elemental Compositions of Clinopyroxenes from Southern Okinawa Trough Basalt:Implications for Magmatism and Structural Environment in an Initial Back-Arc Basin

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Journal of Ocean University of China 2024年第3期23卷 643-653页

作者： GUO Kun ZHAI Shikui fan di ZHANG Xia ZHANG Yu ZHU Zhimin Laoshan Laboratory Qingdao 266237China Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of EducationCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Submarine Geosciences&Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China

The major and trace elemental compositions of clinopyroxene from basalt were used to characterize the nature of the primitive magma and structural environment beneath the southern Okinawa Trough(SOT),which is an initial back-arc basin at a continental *** clinopyroxenes in the basalt were augite with variable Mg^(#)contents(73.37-78.22).The regular variations in major oxide contents(i.e.,CaO,FeO,TiO_(2),and Cr)with decreasing Mg#implied that the clinopyroxenes evolved from being enriched in Mg,Ca,and Cr to being enriched in Fe and *** clinopyroxenes had relatively low rare earth element concentrations(7.51×10^(-6) to 12.68×10^(-6))and negative Eu anomalies(δEu=0.67-0.95).The Kd_(cpx) values of clinopyroxenes(0.2-0.26),which were used to examine whether the clinopyroxene was equilibrated with its host basalt,demonstrate that these clinopyroxene phenocrysts were not captured crystals but were instead produced by crystallization differentiation of the *** calculated clinopyroxene crystallization temperatures showed a narrow range of 990-1061℃,and their crystallization pressures ranged from 2.0 to 3.2 *** geochemistry features of these clinopyroxenes indicated that the parent magma belonged to the subalkaline tholeiitic magma series and suggested that the magma experienced crystallization differentiation of olivine,plagioclase,and clinopyroxene,where the crystallization of plagioclase occurred earlier than that of *** with geophysical data,this research on primitive magma and its crystallization differentiation from clinopyroxene indicates that the SOT is in the stage of‘seafloor spreading’and that basaltic rocks produced from tholeiitic magma represent the generation of oceanic crust.

关键词： trace elements clinopyroxenes southern Okinawa Trough seafloor spreading back-arc basin

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MiR-24-3p Attenuates Doxorubicin-induced Cardiotoxicity via the Nrf2 Pathway in Mice

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Current Medical Science 2022年第1期42卷 48-55页

作者： di fan Hong-bin CHEN Yan LENG Shi-jun YANG Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430060China Department of Pulmonary and Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhan 430060China.

Objective:The nuclear factor erythroid 2(NFE2)-related factor 2(Nrf2)is associated with doxorubicin(DOX)-induced cardiac *** has been reported that microRNA-24-3p(miR-24-3p)may regulate the Keapl by mRNA degradation,whereas Keapl can suppress the activation of ***,the role of miR-24-3p in DOX-related cardiotoxicity remains unclear.

关键词： miR-24-3p Ros doxorubicin nuclear factor erythroid 2-related factor 2 apoptosis

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