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Adsorption,in vitro digestion and human gut microbiota regulation characteristics of three Poria cocos polysaccharides

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Food Science and Human Wellness 2024年第3期13卷 1685-1697页

作者： fangming Zhang Hui Zheng Tao Zheng Pan Xu Yao Xu Yuxin Cao fan jia Yiqiong Zeng Yubing fan Kai He Xinwen Dai Fengfei Hou Yong Yang College of Pharmacy Hunan University of Chinese MedicineChangsha 410208China School of Pharmaceutical Science Hunan University of MedicineHuaihua 418000China Hunan Fuling Engineering Technology Research Center Huaihua 418100China

Poria cocos(PC)is a famous traditional Chinese medicine(TCM)and a widely used healthcare ingredient,which has antiobesity,enhancing immunity and improving sleep ***,only water-soluble poria polysaccharide(WSP)is extracted and applied for clinical application,while insoluble polysaccharide(alkali-soluble poria polysaccharide,ASP)is discarded as herb ***,the whole PC has also been historically utilized as functional herbal *** the beneficial role of dietary fiber and the traditional use of PC,ASP may also contribute substantially to the therapy function of *** to WSP,little attention has been paid to ASP and ASP modified product carboxymethyl poria polysaccharide(CMP)which has been used as an antitumor adjuvant *** this study,the oil,cholesterol,metal ions and polyphenols adsorption ability,in vitro simulated digestive and the gut microbiota fermentation characteristics of WSP,ASP and CMP were studied to evaluate the functional values of three *** polysaccharides(PCPs).The results showed that all three PCPs had good adsorption capacity on cholesterol,polyphenols and metal ions(Cd^(2+)/Zn^(2+)/Mg^(2+)),among which ASP showed the highest capacity than WSP and *** adsorption capacity of all three PCPs on heavy metal ions(Cd^(2+)/Zn^(2+))was stronger than that of non-heavy metal ions(Mg^(2+));The in vitro digestibility of all three PCPs was very low,but WSP was slightly higher than ASP and CMP;Moreover,the indigestible residue of all three PCPs could improve the richness and diversity of gut microbiota,among which ASP had the greatest *** general,ASP and CMP could significantly promote the proliferation of some probiotics and inhibit the growth of some harmful *** gut microbiota diversity of CMP was reduced,but the richness of probiotics,especially Parabacteroides distasonis was significantly enhanced compared with the ASP group,and the growth of harmful bacteria Klebsiella pneumoniae was inh

关键词： Poria cocos polysaccharides Alkali-soluble poria polysaccharide Carboxymethyl poria polysaccharide Adsorption characteristics In vitro simulated digestion In vitro simulated gut microbiota fermentation

Enhanced homing of mesenchymal stem cells for in situ niche remodeling and bone regeneration

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Nano Research 2024年第8期17卷 7449-7460页

作者： Yin Yuan Lijun Chen Jing Yang Sining Zhou Yangxin fang Qi Zhang Ning Zhang Yifei Li Li Yuan fan jia Shuo Ni Charlie Xiang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Biology The David H.Koch Institute for Integrative Cancer Research at MITMassachusetts Institute of TechnologyCambridgeMA 02139USA Research Units of Infectious disease and Microecology Chinese Academy of Medical SciencesHangzhou 310003China Innovative Precision Medicine(IPM)Group Hangzhou 311215China MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Cancer Immunology and Virology Dana-Farber Cancer InstituteBostonMA 02215USADepartment of ImmunologyHarvard Medical SchoolBoston MA 02115USA Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200233China

Mesenchymal stem cells(MSCs)transplantation is a promising strategy for osteoporosis ***,limited sources and poor tissue-homing efficiency limit their clinical *** this study,we isolated a kind of MSCs from women’s menstrual blood(MenSCs)noninvasively and established a novel MSCs bone marrow-targeted delivery system by utilizing waterin-oil-in-water droplet *** were encapsulated withinβ-cyclodextrin-functionalized alginate microcapsules loaded with zoledronates,which has a high affinity for *** this delivery system,MenSCs could be preferentially delivered to the bone marrow tissues via intravenous infusion,and restored bone mass by remodeling the bone marrow niche in situ in ovariectomized mouse ***,scRNA-seq analysis demonstrated that those MenSCs homed to the bone marrow recruited CD4^(+)FOXP3^(+)natural regulatory T(nT_(reg))cells by secreting *** recruited nTreg promoted CD8^(+)T cells to secret Wnt family member 10B(WNT10B),activating the Wnt signaling in osteoblasts and thus promoting bone formation in situ in the bone *** study reveals a promising application of MenSCs in postmenopausal osteoporosis treatment and highlights the clinical value of MenSCs by encouraging women to reserve autologous MenSCs before menopause to prevent and alleviate postmenopausal osteoporosis.

关键词： mesenchymal stem cells microfluidics bone marrow homing stem cell niche postmenopausal osteoporosis

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基于功耗计数器的处理器功耗实时估算方法

高技术通讯 2024年第1期34卷 25-32页

作者：贾凡章隆兵计算机体系结构国家重点实验室(中国科学院计算技术研究所) 北京100190 中国科学院计算技术研究所北京100190 中国科学院大学北京100049

针对现有的2类处理器功耗实时估算方法的不足,本文开发了一种基于功耗计数器的处理器功耗实时估算方法。该方法结合了基于性能事件计数器和基于电路信号方法的优点,利用功耗计数器记录与处理器功耗密切相关的电路信号的变化次数,能够以... 详细信息

针对现有的2类处理器功耗实时估算方法的不足,本文开发了一种基于功耗计数器的处理器功耗实时估算方法。该方法结合了基于性能事件计数器和基于电路信号方法的优点,利用功耗计数器记录与处理器功耗密切相关的电路信号的变化次数,能够以较小的观测粒度实时估算处理器的功耗,并且具有较低的硬件开销。本文在龙芯GS364处理器上实现并评估了该方法。结果表明,使用16个功耗计数器可以在512个时钟周期的粒度内实现0.83%的估算误差,与此同时,它的硬件开销只占处理器总面积的0.063%。

关键词：功耗估算功耗计数器功耗管理性能事件计数 LASSO回归

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肝癌诊疗新进展:指南引领规范创新赋能精准

中华消化外科杂志 2024年第2期23卷 197-203页

作者：樊嘉高强复旦大学附属中山医院复旦大学肝癌研究所上海200032

原发性肝癌是严重威胁我国人民生命健康的重大疾病。免疫治疗联合靶向药物(以下简称靶免联合治疗)在肝癌中的突破性进展开创了肝癌治疗新时代。当前,以免疫治疗为基础的联合治疗已经贯穿于肝癌全线治疗,特别是近期在新辅助治疗、转化治... 详细信息

原发性肝癌是严重威胁我国人民生命健康的重大疾病。免疫治疗联合靶向药物(以下简称靶免联合治疗)在肝癌中的突破性进展开创了肝癌治疗新时代。当前,以免疫治疗为基础的联合治疗已经贯穿于肝癌全线治疗,特别是近期在新辅助治疗、转化治疗、术后辅助治疗、联合局部治疗等方面的探索取得诸多成效,进一步提高了患者预后。尽管如此,无论是靶免联合治疗还是双免疫治疗,总体应答率仍有待进一步提高,精准选择有效人群仍未实现。尤其是原发性耐药以及获得性耐药问题更是目前迫切需要解决的重大临床和科学问题,肿瘤基础理论的突破、治疗新靶点的鉴定、制药工业的创新研发、敏感耐药机制的解析等各方面齐头并进显得尤为关键。笔者深入阐述肝癌临床和转化治疗研究创新进展,以期为学界开展相关研究提供参考。

关键词：肝肿瘤靶向治疗免疫治疗耐药预后

Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells

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The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten Komila Rasuleva Md Saimon Mia Aaron Bauer Santhalingam Elamurugan Nega Ejjigu Sudipa Maity Amara Arshad Min Wu Wenjie Xia jia fan Ang Guo Sijo Mathew Dali Sun Department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Department of Pharmaceutical Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular Diagnostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Institute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PDAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease *** and selective treatments are urgently needed,since current therapies have limited efficacy and significant side *** proteomics analysis of extracellular vesicles,we discovered an imbalanced distribution of amino acids secreted by PDAC tumor *** findings revealed that PDAC cells preferentially excrete proteins with certain preferential amino acids,including isoleucine and histidine,via extracellular *** amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PDAC tumor *** in vitro and in vivo experiments demonstrated that supplementation with these specific amino acids effectively eradicated PDAC ***,we also identified XRN1 as a potential target for these amino *** high selectivity of this treatment method allows for specific targeting of tumor metabolism with very low toxicity to normal ***,we found this treatment approach is easy-to-administer and with sustained tumor-killing ***,our findings reveal that exocytosed amino acids may serve as therapeutic targets for designing treatments of intractable PDAC and potentially offer alternative treatments for other types of cancers.

关键词： finding identif selectivity

电动车跨临界CO_(2)热系统充注定量需求规律及非适充系统失稳特性

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制冷学报 2024年第4期45卷 59-67页

作者：王从飞贾凡殷翔曹锋中国制冷学会北京100142 西安交通大学能源与动力工程学院西安710049 西安交通大学国家储能技术产教融合创新平台(中心) 西安710049

跨临界CO_(2)热系统是解决电动车“低温续航衰减”和“热系统工质温室效应强”主要问题的最佳技术之一,而电动车多变场景耦合跨临界循环复杂性,系统性能及运行稳定性强依赖于充注量。通过仿真研究了跨临界CO_(2)热系统在不同工况下的CO_... 详细信息

跨临界CO_(2)热系统是解决电动车“低温续航衰减”和“热系统工质温室效应强”主要问题的最佳技术之一,而电动车多变场景耦合跨临界循环复杂性,系统性能及运行稳定性强依赖于充注量。通过仿真研究了跨临界CO_(2)热系统在不同工况下的CO_(2)充注量定量需求变化规律。重点研究了环境温度、室内风量和室外风速这3个关键因素对不同模式下的系统制冷剂需求量的影响机理和定量表征;并探讨了在非适充场景下的系统动态特性。结果表明:热泵模式下,制冷剂需求下限随环境温度的升高、室内风量的降低和室外风速的增加而增大,其定量影响幅度为18.6%、6.16%和18.9%。制冷模式下,制冷剂需求下限则随环境温度的降低、室内风量的降低和室外风速的增加而增大,其定量影响幅度为7.03%、7.85%和2.27%。在非适充工况下,因非适充下的系统控制量与目标量作用关系发生潜在变化,导致系统出现失控,需要通过制冷剂分布调控缓解特殊工况的系统不稳定性。研究结果对于优化电动汽车空调系统储液器设计、提高其能效和舒适性具有重要参考价值。

关键词：电动汽车 CO_(2)热管理系统充注量需求系统失稳

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基于混合法的英语专业教材语法内容编写研究

外语教学 2024年第2期45卷 65-70页

作者：贾蕃冯钰涵卢珊西南交通大学外国语学院西安外国语大学研究生院西安外国语大学商学院

语法是英语专业教材的重要组成部分。本研究基于内容分析和半结构化访谈,从研究者和教材使用者的双重视角考察国内四套英语专业教材语法板块的内容讲解和练习编写。结果显示:1)四套教材的语法讲解均侧重形式,对意义的关注度较少;2)四套... 详细信息

语法是英语专业教材的重要组成部分。本研究基于内容分析和半结构化访谈,从研究者和教材使用者的双重视角考察国内四套英语专业教材语法板块的内容讲解和练习编写。结果显示:1)四套教材的语法讲解均侧重形式,对意义的关注度较少;2)四套教材的语法练习类型均为机械型练习最多,意义型练习其次,交际型练习最少;3)研究者对教材量化分析结果与教材使用者的访谈结果一致。本研究对提升教材语法编写质量,推动新时代英语专业教学改革有一定启示。

关键词：教材语法教学教材编写英语专业

全国化学奥林匹克竞赛中的配合物试题解析与反思

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化学教育（中英文） 2024年第13期45卷 123-129页

作者：范家悦陈凯江苏师范大学化学与材料科学学院江苏徐州221116 南京晓庄学院环境科学学院江苏南京211171

从配合物相关理论出发,详细解析了第35届、第36届和第37届全国化学奥林匹克竞赛(初赛)中有关配位化学的3道题目,对试题的学科背景、知识点分布、化学思想等进行了分析,延伸拓展了化学考题相应的科学背景和理论知识。从中收获配合物知识... 详细信息

从配合物相关理论出发,详细解析了第35届、第36届和第37届全国化学奥林匹克竞赛(初赛)中有关配位化学的3道题目,对试题的学科背景、知识点分布、化学思想等进行了分析,延伸拓展了化学考题相应的科学背景和理论知识。从中收获配合物知识学习与学科视野拓展的启发。

关键词：化学奥林匹克竞赛配合物试题解析学科视野拔尖创新人才

马克思主义基本原理同中华优秀传统文化相结合的前提性省思——从五四时期“大同”观念的再出场说起

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新疆师范大学学报(哲学社会科学版) 2024年第2期45卷 7-17+2页

作者：杨增岽范嘉祥北京师范大学马克思主义学院

马克思主义基本原理之所以能够同中华优秀传统文化相结合，马克思主义行是前提性方面之一。五四时期，部分西方学说传入中国并与中国本土传统文化发生作用，以“大同”观念为代表，表达自身的革命精神和价值追求。广大知识分子面对接纳... 详细信息

马克思主义基本原理之所以能够同中华优秀传统文化相结合，马克思主义行是前提性方面之一。五四时期，部分西方学说传入中国并与中国本土传统文化发生作用，以“大同”观念为代表，表达自身的革命精神和价值追求。广大知识分子面对接纳现代性与省思西方现代性的现实议题，受社会心理转变和推介核心价值观念的隐喻思维影响，纷纷试图采用“大同”观念解决时代问题。但因择取非科学的思想学说，不具备有效解决这些问题的理论空间，不仅未能带动传统观念发挥时代价值，而且使其落入倒退或空想的窠臼。马克思主义是科学真理，中国化时代化的马克思主义在中国根深叶茂，在于其升华了中华优秀传统文化的内容与形式，让传统文化发挥鼓舞群众实践的效力,使人民群众通过先进阶级语境中的传统观念理解、认同和运用指导思想，与时俱进地应对现实课题及社会心理转变，科学利用隐喻思维推动理论大众化。因此，坚持马克思主义在意识形态领域指导地位是“第二个结合”实现又一次思想解放、打开创新空间的根本要求。新时代新征程，“第二个结合”继承发展了科学的方法论，进行更多原创性理论探索和创新，回答了重大时代课题，进一步确证了民族标识和政党形象，承担世界责任、凝聚更为主动的精神力量。

关键词：马克思主义中国化时代化第二个结合马克思主义观中华优秀传统文化隐喻思维