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美沙拉嗪联合益生菌对溃疡性结肠炎患者肠黏膜屏障功能及环氧合酶-2水平的影响

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山西医药杂志 2024年第7期53卷 514-518页

作者：范益博胥明上海市浦东新区人民医院消化内科 201299

目的分析美沙拉嗪联合益生菌对溃疡性结肠炎患者肠黏膜屏障功能及环氧合酶-2(COX-2)水平的影响。方法选择2020年3月至2021年10月我院收治的100例溃疡性结肠炎患者为研究对象,随机将其分为对照组(50例,给予美沙拉嗪治疗)和治疗组(50例... 详细信息

目的分析美沙拉嗪联合益生菌对溃疡性结肠炎患者肠黏膜屏障功能及环氧合酶-2(COX-2)水平的影响。方法选择2020年3月至2021年10月我院收治的100例溃疡性结肠炎患者为研究对象,随机将其分为对照组(50例,给予美沙拉嗪治疗)和治疗组(50例,在对照组的基础上给予益生菌治疗),对比2组患者肠黏膜屏障功能指标、细胞因子水平、临床疗效以及不良反应发生情况。结果治疗后,治疗组患者总治疗效率明显高于对照组(P0.05)。结论美沙拉嗪联合益生菌可有效改善溃疡性结肠炎患者临床症状,恢复肠粘膜屏障功能,减少炎症因子分泌,提高治疗效果。

关键词：氨水杨酸鼠李糖乳杆菌结肠炎溃疡性前列腺素内过氧化物合酶类

A Review of Deep Learning-Based Vulnerability Detection Tools for Ethernet Smart Contracts

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 77-108页

作者： Huaiguang Wu yibo Peng Yaqiong He Jinlin fan School of Computer Science and Technology Zhengzhou University of Light IndustryZhengzhou450001China

In recent years,the number of smart contracts deployed on blockchain has ***,the issue of vulnerability has caused incalculable *** to the irreversible and immutability of smart contracts,vulnerability detection has become particularly *** the popular use of neural network model,there has been a growing utilization of deep learning-based methods and tools for the identification of vulnerabilities within smart *** paper commences by providing a succinct overview of prevalent categories of vulnerabilities found in smart ***,it categorizes and presents an overview of contemporary deep learning-based tools developed for smart contract *** tools are categorized based on their open-source status,the data format and the type of feature extraction they *** we conduct a comprehensive comparative analysis of these tools,selecting representative tools for experimental validation and comparing them with traditional tools in terms of detection coverage and ***,Based on the insights gained from the experimental results and the current state of research in the field of smart contract vulnerability detection tools,we suppose to provide a reference standard for developers of contract vulnerability detection ***,forward-looking research directions are also proposed for deep learning-based smart contract vulnerability detection.

关键词： Smart contract vulnerability detection deep learning

Outcome of the efficacy of Chinese herbal medicine for functional constipation:A systematic review and meta-analysis

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World Journal of Clinical Cases 2022年第15期10卷 4856-4877页

作者： Zipan Lyu yibo fan Yang Bai Tao Liu Linda LD Zhong Hui-Feng Liang Teaching and Research Division School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 99977China Department of Cardiology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Digestive Endoscope Center Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China The Institute for Science Technology and HumanitiesShanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Functional constipation(FC)is a common and chronic gastrointestinal disease and its treatment remains *** To evaluate the efficacy and safety of Chinese herbal medicine(CHM)on efficacy rate,global symptoms,bowel movements and the Bristol Stool Scale score in patients with FC by summarizing current available randomized controlled trials(RCTs).METHODS RCTs with CHM to treat FC were identified by a systematic search of six databases from inception to October 20,*** independent reviewers assessed the quality of the included articles and extracted ***-analyses were performed to odds ratio(OR),mean differences(MD)and 95%confidence interval(CI)using random-effects *** analyses and sensitivity analyses were used to explore and interpret the sources of *** funnel plot,Begg’s test and Egger’s test were used to detect publication *** Ninety-seven studies involving 8693 patients were included in this *** was significantly associated with a higher efficacy rate(OR:3.62,95%CI:3.19-4.11,P<0.00001)less severe global symptoms(OR:4.03,95%CI:3.49-4.65,P<0.00001)compared with control treatment,with the low heterogeneity between studies(I2=0%,P=0.76).CHM was also associated with more frequent bowel movements(MD 0.83,95%CI:0.67-0.98,P<0.00001),a lower score on the Bristol Stool Scale(OR:1.63,95%CI:1.15-2.32,P<0.006),and a not significant recurrence rate(OR:0.47,95%CI:0.22-0.99,P=0.05).No serious adverse effects of CHM were *** In this meta-analysis,we found that CHM may have potential benefits in increasing the number of bowel movements,improving stool characteristics and alleviating global symptoms in FC ***,a firm conclusion could not be reached because of the poor quality of the included *** trials with higher quality are required.

关键词： Functional constipation Chinese herbal medicine Efficacy Systematic review Meta-analysis

Geographical patterns and determinants of insect biodiversity in China

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Science China(Life Sciences) 2024年第6期67卷 1255-1265页

作者： Huizhong fan Tongyi Liu Youhua Chen Ziyan Liao Jun Chen yibo Hu Gexia Qiao Fuwen Wei CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&China-Croatia“Belt and Road”Joint Laboratory on Biodiversity and Ecosystem Services Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China Jiangxi Provincial Key Laboratory of Conservation Biology College of ForestryJiangxi Agricultural UniversityNanchang 330045China University of Chinese Academy of Sciences Beijing 100049China

Insects play important roles in the maintenance of ecosystem functioning and the provision of livelihoods for millions of ***,compared with terrestrial vertebrates and angiosperms,such as the giant panda,crested ibis,and the metasequoia,insect conservation has not attracted enough attention,and a basic understanding of the geographical biodiversity patterns for major components of insects in China is ***,we investigated the geographical distribution of insect biodiversity across multiple dimensions(taxonomic,genetic,and phylogenetic diversity)based on the spatial distribution and molecular DNA sequencing data of *** analysis included 18 orders,360 families,5,275 genera,and 14,115 species of *** results revealed that Southwestern and Southeastern China harbored higher insect biodiversity and numerous older lineages,representing a museum,whereas regions located in Northwestern China harbored lower insect biodiversity and younger lineages,serving as an evolutionary *** also observed that mean annual temperature and precipitation had significantly positive effects,whereas altitude had significantly negative effects on insect biodiversity in most ***,cultivated vegetation harbored the highest insect taxonomic and phylogenetic diversity,and needleleaf and broadleaf mixed forests harbored the highest insect genetic *** results indicated that human activities may positively contribute to insect spatial diversity on a regional *** study fills a knowledge gap in insect spatial diversity in *** findings could help guide national-level conservation plans and the post-2020 biodiversity conservation framework.

关键词： insect spatial patterns multiple dimensions driving factors vegetation types

Stereoselective recognition of morphine enantiomers by μ-opioid receptor

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National Science Review 2024年第3期11卷 183-191页

作者： yibo Wang Van A.Ngo Xiaohui Wang Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of Sciences Advanced Computing for Life Sciences and Engineering Group Science Engagement Section National Center for Computational Sciences Oak Ridge National Lab School of Applied Chemistry and Engineering University of Science and Technology of China Beijing National Laboratory for Molecular Sciences

Stereospecific recognition of chiral molecules plays a crucial role in biological systems. The μ-opioid receptor（MOR） exhibits binding affinity towards（-）-morphine, a well-established gold standard in pain management, while it shows minimal binding affinity for the（+）-morphine enantiomer, resulting in a lack of analgesic activity. Understanding how MOR stereoselectively recognizes morphine enantiomers has remained a puzzle in neuroscience and pharmacology for over half-a-century due to the lack of direct observation techniques. To unravel this mystery, we constructed the binding and unbinding processes of morphine enantiomers with MOR via molecular dynamics simulations to investigate the thermodynamics and kinetics governing MOR's stereoselective recognition of morphine enantiomers. Our findings reveal that the binding of（-）-morphine stabilizes MOR in its activated state, exhibiting a deep energy well and a prolonged residence time. In contrast,（+）-morphine fails to sustain the activation state of ***, the results suggest that specific residues, namely D1142.50and D1473.32, are deprotonated in the active state of MOR bound to（-）-morphine. This work highlights that the selectivity in molecular recognition goes beyond binding affinities, extending into the realm of residence time.

关键词： stereoselective recognition thermodynamics and kinetics residence time morphine enantiomers μ-opioid receptor

Comparative Analysis of Noise Margin between Pure SET-SET and Hybrid SET-PMOS Inverters

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Chinese Journal of Electronics 2024年

作者： fan ZHANG Yi LIU yibo WANG Minghu WU Sheng HU Youli DONG Hubei Key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of Technology School of Electrical and Electronic Engineering Hubei University of Technology

Single-electron transistor（SET） is considered as one of the promising candidates for future electronic devices due to its advantages of low power consumption and high integration. The comparative analysis of SETbased inverters, especially the noise margin, is carried out. Pure SET-SET and hybrid SET with p type metal oxide semiconductor（SET-PMOS） inverters are designed for investigation. The effects of SET supply voltage, junction resistance and junction capacitance on noise tolerance and power consumption of inverters are studied. For hybrid SET-PMOS inverters, the noise margin for a logic high（NMH） is less than 60 mV under various conditions, which may become the bottleneck of its application. For pure SET-SET inverters, both NMH and the noise margin for a logic low（NML） could reach 300 mV at a supply voltage of 0.8 V. The minimum power consumption of pure SETSET and hybrid SET-PMOS inverters is 2.85 nW and 58 nW, respectively. The pure SET-SET inverters have greater noise tolerance and lower power consumption, which is more conducive to large-scale integration. When junction capacitance CJ= 0.0273 aF and junction resistance V, the NMH and NML are not significantly affected by the junction resistance and the noise margin fluctuates at 300mV.

关键词：

Aggregation-regulated bioreduction process of graphene oxide by Shewanella bacteria

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Chinese Journal of Chemical Engineering 2024年第5期69卷 56-62页

作者： Kaixin Han yibo Zeng Yinghua Lu Ping Zeng Liang Shen Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Chinese Research Academy of Environmental Sciences Beijing 100012China

The bioreduction of graphene oxide(GO)using environmentally functional bacteria such as Shewanella represents a green approach to produce reduced graphene oxide(rGO).This process differs from the chemical reduction that involves instantaneous molecular *** bioreduction,the contact of bacterial cells and GO is considered the rate-limiting *** reveal how the bacteria-GO integration regulates rGO production,the comparative experiments of GO and three Shewanella strains were carried ***-transform infrared spectroscopy,X-ray photoelectron spectroscopy,Raman spectroscopy,and atomic force microscopy were used to characterize the reduction degree and the aggregation *** results showed that a spontaneous aggregation of GO and Shewanella into the condensed entity occurred within 36 h.A positive linear correlation was established,linking three indexes of the aggregation potential,the bacterial reduction ability,and the reduction degree(ID/IG)comprehensively.

关键词： Graphene oxide Reduced graphene oxide Bioreduction Aggregation Shewanella

高速、可配置RSA密码协处理器的VLSI设计

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计算机研究与发展 2006年第6期43卷 1076-1082页

作者：范益波曾晓洋于宇复旦大学专用集成电路与系统国家重点实验室上海200433

通过算法级分析和对比RSA原始算法以及改进型模幂模乘算法,提出了一种双重流水线结构的RSA密码协处理器体系结构,该结构具备高速、可配置性能·基于该体系结构,可以根据不同的用户需求,方便地设计出支持各种速度和密钥长度的RSA密码处... 详细信息

通过算法级分析和对比RSA原始算法以及改进型模幂模乘算法,提出了一种双重流水线结构的RSA密码协处理器体系结构,该结构具备高速、可配置性能·基于该体系结构,可以根据不同的用户需求,方便地设计出支持各种速度和密钥长度的RSA密码处理器·该体系结构尤其适用于设计高速、高位宽RSA密码芯片;同时其可配置性能也可以满足低速、高位数、高安全性RSA系统的市场需求·另外,基于该体系结构设计的RSA加密IP,非常适合SoC的芯片设计·最后,基于该体系结构设计了一款高速1024b RSA密码加密芯片,采用0·18μm标准单元库设计,实现结果显示,芯片在150MHz时钟频率下能完成每秒5000次1024b RSA加密运算,是国内同类产品中速度最快的·

关键词： RSA 高速可配置加密芯片 VLSI

Safety-Critical Trajectory Tracking for Mobile Robots With Guaranteed Performance

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 2033-2035页

作者： Wentao Wu Di Wu yibo Zhang Shukang Chen Weidong Zhang Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China Department of Information and Communication Engineering Hainan UniversityHaikou 570288China

Dear Editor,This letter considers a collision-free trajectory tracking problem for performance-guaranteed mobile robots(MRs)subject to *** propose a safety-critical performance-guaranteed trajectory tracking method based on control barrier functions(CBFs).First,an auxiliary system is established to generate the non-negative signals for inflexible bounds such that the performance constraints are not violated when avoiding obstacles.

关键词： constraints bounds collision