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World Journal of Gastrointestinal Oncology 2010年第1期2卷 44-50页

作者： Katharine E Bevan faheez mohamed Brendan J Moran Pseudomyxoma Peritonei Centre Basingstoke and North Hampshire Hospital Foundation Trust

Pseudomyxoma peritonei (PMP) is an uncommon "bor-derline malignancy" generally arising from a perforated appendiceal epithelial tumour. Optimal treatment involves a combination of cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC). Controversy persists regarding the pathological classification and its prognostic value. Computed tomography scanning is the optimal preoperative staging technique. Tumour marker elevations correlate with worse prognosis and increased recurrence rates. Following CRS with HIPEC, 5-year survival ranges from 62.5% to 100% for low grade, and 0%-65% for high grade disease. Treat-ment related morbidity and mortality ranges from 12 to 67.6%, and 0 to 9%, respectively. Surgery and HIPEC are the optimal treatment for PMP which is at best a "borderline" peritoneal malignancy.

关键词： Pseudomyxoma peritonei Cytoreductive surgery Heated intraperitoneal chemotherapy Jelly belly Appendiceal mucinous tumour Peritoneal malignancy Borderline malignancy

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Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal metastases

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World Journal of Gastroenterology 2014年第38期20卷 14018-14032页

作者： Reza Mirnezami Brendan J Moran Kate Harvey Tom Cecil Kandiah Chandrakumaran Norman Carr faheez mohamed Alexander H Mirnezami Section of Biosurgery and Surgical Technology Department of Surgery and CancerImperial College London10th Floor QEQM BuildingSt Mary’s Hospital National Pseudomyxoma Peritonei Centre Hampshire Hospitals Foundation Trust Somers Cancer Research Building University of Southampton Cancer Sciences DivisionSouthampton University Hospital NHS Trust

AIM: To systematically review the available evidence regarding cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) for colorectal peritoneal metastases (CPM).

关键词： Colorectal cancer Peritoneal metastasis Cytoreductive surgery Intraperitoneal chemotherapy Hyperthermic intraperitoneal chemotherapy

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Laparoscopic total colectomy: Does the indication influence the outcome?

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World Journal of Gastrointestinal Surgery 2011年第11期3卷 177-182页

作者： Eddy Cotte faheez mohamed Stéphane Nancey Yves Franois Olivier Glehen Bernard Flourié Jean-Christophe Saurin Gilles Poncet Department of Digestive Surgery Centre Hospitalo-Universitaire Lyon Sud Hospices Civils de Lyon EA 3738 Université Claude Bernard Lyon1 Faculté de Médecine Lyon Sud Colorectal Research Unit Basingstoke and North Hampshire Foundation Trust Department of Gastro-enterology Centre Hospitalo-Universitaire Lyon-Sud Hospices Civils de Lyon Digestive Federation Centre Hospitalo-Universitaire Edouard Herriot Hospices Civils de Lyon

AIM: To assess and compare outcomes of laparoscopic total colectomy performed for a variety of indications. METHODS: Sixty six patients underwent laparoscopic total colectomy for inflammatory bowel disease (IBD) (13) and other diseases (53). Data on demographics, pre and post-operative outcomes were collected ***: Mean operative time was 4.5 h. Conversion rate was 13.6%. Total colectomy performed for IBD was associated with a signifi cantly higher anastomotic leak rate (23.1% vs 1.9%, P < 0.05). On univariate analysis, hand sewn anastomosis and treatment with more than 20 mg of prednisolone for at least 3 mo was associated with a higher anastomotic leak rate (P < 0.05). No signifi cant difference was found in return of gut function and overall morbidity between disease groups. CONCLUSION: Laparoscopic total colectomy is feasible and outcomes are equivalent whatever the indica- tion, except for anastomotic leak rate which is higher for patients with IBD.

关键词： Colectomy Inflammatory bowel disease Laparoscopy Familial adenomatous polyposis Constipation Colonic neoplasms Hereditary nonpolyposis Diverticulosis Treatment outcomes

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