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Real-time mechanical characterization of DNA degradation under therapeutic X-rays and its theoretical modeling

Microsystems & Nanoengineering 2016年第1期2卷 9-17页

作者： Grégoire Perret Thomas Lacornerie Fabio Manca Stefano Giordano Momoko Kumemura Nicolas Lafitte Laurent Jalabert Mehmet C.Tarhan Eric F.Lartigau fabrizio cleri Hiroyuki Fujita Dominique Collard LIMMS/CNRS-IIS UMI 2820 Institute of Industrial ScienceThe University of Tokyo4-6-1 Komaba Meguro KuTokyo 153-8505Japan IEMN UMR8520CNRSAvenue PoincaréCitéScientifiqueBP 60069Villeneuve d’AscqCedex 59652France CNRS/IIS/COL/Lille 1 SMMiL-E project CNRS Délégation Nord-Pas de Calais et Picardie2 rue de CanonniersLilleCedex 59046France Centre Oscar Lambret Universitéde LilleDépartement Universitaire de RadiothérapieCentre Oscar LambretLille 59000France Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan

The killing of tumor cells by ionizing radiation beams in cancer radiotherapy is currently based on a rather empirical understanding of the basic mechanisms and effectiveness of DNA damage by *** contrast,the mechanical behaviour of DNA encompassing sequence sensitivity and elastic transitions to plastic responses is much better understood.A novel approach is proposed here based on a micromechanical Silicon Nanotweezers *** instrument allows the detailed biomechanical characterization of a DNA bundle exposed to an ionizing radiation beam delivered here by a therapeutic linear particle accelerator(LINAC).The micromechanical device endures the harsh environment of radiation beams and still retains molecular-level detection *** this study,the first real-time observation of DNA damage by ionizing radiation is *** DNA bundle degradation is detected by the micromechanical device as a reduction of the bundle stiffness,and a theoretical model provides an interpretation of the *** first real-time observations pave the way for both fundamental and clinical studies of DNA degradation mechanisms under ionizing radiation for improved tumor treatment.

关键词： biomechanical measurements DNA damage microfluidic radiotherapy real-time Silicon Nanotweezers

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Optimized design and integration of energy storage in Solar-Assisted Ground-Source Heat Pump systems

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Building Simulation 2023年第10期16卷 1933-1948页

作者： Maria Ferrara Enrico fabrizio Department of Energy Politecnico di TorinoTurin10121Italy

The integrated use of multiple renewable energy sources to increase the efficiency of heat pump systems,such as in Solar Assisted Geothermal Heat Pumps(SAGHP),may lead to significant benefits in terms of increased efficiency and overall system performance especially in extreme climate contexts,but requires careful integrated optimization of the different system *** particular,thermal storages take a fundamental role in optimizing the integration of renewable energy sources and the system *** work investigates the potential design optimization of a SAGHP system in a mountain site by exploring many different alternatives to optimize the mutual relationship between the solar field,the geothermal field and the water thermal *** is done through an original simulation-based multi-objective optimization framework considering energy efficiency and economic feasibility,which allows appraising the impact of the different design alternatives on the overall system performance and on the dynamics of the different system *** identify a set of optimized system configurations that optimize the integrated exploitation of the different thermal sources showing a potential increase of the overall system performance leading to 34%lower global cost compared to the initial *** robustness of the optimal design solutions is reported with respect to the current context of high economic uncertainty.

关键词： thermal storage geothermal energy heat pumps building simulation artificial intelligence cost optimization energy flexibility

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Biodegradability of soil water soluble organic carbon extracted from seven different soils

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Journal of Environmental Sciences 2009年第5期21卷 641-646页

作者： SCAGLIA Barbara ADANI fabrizio Department of Crop Science Section of Soil Chemistry University of Milano

Water soluble organic carbon （WSOC） is considered the most mobile and reactive soil carbon source and its characterization is an important issue for soil ecology study. A biodegradability test was set up to study WSOC extracted from 7 soils differently managed. WSOC was extracted from soil with water （soil/water ratio of 1：2, W/V） for 30 min, and then tested for biodegradability by a liquid state respirometric test. Result obtained confirmed the finding that WSOC biodegradability depended on the both land use and management practice. These results suggested the biodegradability test as suitable method to characterize WSOC, and provided useful information to soil fertility.

关键词： biodegradability test cumulated oxygen uptake water extractable organic carbon water soluble organic carbon

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Mechanosensitivity of N-methyl-D-aspartate receptors(NMDAR)is the key through which amyloid beta oligomers activate them

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Neural Regeneration Research 2022年第6期17卷 1263-1264页

作者： Giulia Fani fabrizio Chiti Department of Experimental and Clinical Biomedical Sciences Section of BiochemistryUniversity of FlorenceFlorenceItaly

Alzheimer’s disease(AD)is one of the major forms of dementia,accounting for 60 to 80%of the cases of dementia,affecting approximately 50 million people worldwide,which is why it has become an object of great interest in both the medical and social fields(Source:Alzheimer’s Association).One of the main histopathological hallmarks of AD is the formation and accumulation of senile plaques in the brain parenchyma,mainly composed by fibrillar aggregates of the amyloidβ(Aβ)*** peptide is generated by the cleavage of the membrane protein named amyloidβprecursor protein,and its secretion in the extracellular space leads to its aggregation into amyloid *** intermediates of this process of aggregation have been identified,and it was found that prefibrillar,soluble oligomeric forms of Aβare more likely to be the pathological species(Benilova et al.,2012).

关键词： amyloid Alzheimer Aβ

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Smart inverter operation in distribution networks with high penetration of photovoltaic systems

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Journal of Modern Power Systems and Clean Energy 2015年第4期3卷 504-511页

作者： Emilio GHIANI fabrizio PILO Department of Electrical and Electronic Engineering University of CagliariCagliariItaly

With the growing number and capacity of photovoltaic(PV)installations connected to distribution networks,power quality issues related to voltage regulation are becoming relevant problems for power distribution companies and for PV *** many countries,like Italy,this has required the revision of the standards concerning the connection to the public distribution network of distributed renewable *** new standards require a flexible operation of generation plants that have to be capable to change the active and reactive power dynamically in function of the network parameters(*** and network local voltage)in local control or following external ***,this paper investigates the use of smart inverter in a critical PV installation,where relevant voltage fluctuations exist.A case study,with real network parameters monitoring data and measurements,is discussed in the paper with the aim of showing how‘smart’features of new inverters can be implemented to increase PV plant integration in low voltage distribution networks.

关键词： Distributed generation Photovoltaic installations Voltage profile Radial distribution networks Measurements on power systems

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Cr(Ⅵ) reduction capability of humic acid extracted from the organic component of municipal solid waste

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Journal of Environmental Sciences 2013年第3期25卷 487-494页

作者： Barbara Scaglia Fulvia Tambone fabrizio Adani Gruppo Ricicla Dipartimento di Science Agrarie e Ambientali:ProduzioneTerritorioAgroenergiaUniversità degli Studi di Milano

The capacity of humic acid extracted from organic waste （HAw） to reduce Cr（Ⅵ） was tested at pH 2.5,4 and 6 and compared with coal-derived humic acid （HAc）.HAw was more effective than HAc in reducing Cr（Ⅵ）.The kinetics of Cr（Ⅵ） reductions depended strongly on *** calculation of the apparent rate coefficients indicated that HAw was more efficient at reducing Cr（Ⅵ） than HAc,but was also more efficient than HAs from soil and *** reduction capability of HAs depends on the type of functional groups （i.e.,thiols and phenols） present,rather than the free *** was more efficient at reducing Cr（Ⅵ） than HAc because more reactive phenols were present,i.e.,methoxy-and methyl-phenols.

关键词： hexavalent chromium humic acid reduction kinetic organic fraction municipal solid waste phenol molecules

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Set-point Filter Design for a Two-degree-of-freedom Fractional Control System

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IEEE/CAA Journal of Automatica Sinica 2016年第4期3卷 451-462页

作者： fabrizio Padula Antonio Visioli Department of Mathematics and Statistics Curtin University IEEE Department of Mechanical and Industrial Engineering University of Brescia

This paper focuses on a new approach to design(possibly fractional) set-point filters for fractional control *** designing a smooth and monotonic desired output signal,the necessary command signal is obtained via fractional input-output ***,a set-point filter is determined based on the synthesized command *** filter is computed by minimizing the 2-norm of the difference between the command signal and the filter step *** proposed methodology allows the designer to synthesize both integer and fractional setpoint *** pros and cons of both solutions are discussed in *** approach is suitable for the design of two degreeof-freedom controllers capable to make the set-point tracking performance almost independent from the feedback part of the *** results show the effectiveness of the proposed methodology.

关键词： Fractional control systems two-degree-of-freedom control set-point following system inversion

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Relationships between biological aging and male reproductive monitors

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Asian Journal of Andrology 2020年第3期22卷 330-332页

作者： Giorgio Cavallini fabrizio Scroppo Private Outpatient Clinic Via Mascheraio 46Ferrara 44121Italy Department of Urology and Andrology Ospedale di Circolo and Macchi FoundationViale L.Borri 57Varese 21100Italy

Dear Editor,Advanced paternal age affects testicular function,reproductive hormones,and sperm parameters,but it is unclear whether chronological age or biological age exercises a greater sway on reproductive ***,the authors carried out this prospective,multicenter,observational study,in which sperm concentration;motility and morphology;ejaculated volume;testicular volume;and the blood concentrations of follicle-stimulating hormone(FSH),luteinizing hormone(LH),and total testosterone(T)were related to chronological and biological age.

关键词： function. stimulating aging

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A Modified Iterative Learning Control Approach for the Active Suppression of Rotor Vibration Induced by Coupled Unbalance and Misalignment

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 242-253页

作者： Yifan Bao Jianfei Yao fabrizio Scarpa Yan Li College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of High-end Compressor and System Technology Beijing 100029China Beijing Key Laboratory of High-end Mechanical Equipment Health Monitoring and Self-Recovery Beijing University of Chemical TechnologyBeijing 100029China Key Lab of Engine Health Monitoring-Control and Networking of Ministry of Education Beijing University of Chemical TechnologyBeijing 100029China Bristol Composites Institute(ACCIS) University of BristolBristol BS81TRUK Dynamics and Control Research Group(DCRG) University of BristolBristol BS81TRUK

This paper proposes a modified iterative learning control(MILC)periodical feedback-feedforward algorithm to reduce the vibration of a rotor caused by coupled unbalance and parallel *** control of the vibration of the rotor is provided by an active magnetic actuator(AMA).The iterative gain of the MILC algorithm here presented has a self-adjustment based on the magnitude of the *** filters are adopted to extract the synchronous(1×Ω)and twice rotational frequency(2×Ω)components of the rotor *** the notch frequency of the filter and the size of feedforward storage used during the experiment have a real-time adaptation to the rotational *** method proposed in this work can provide effective suppression of the vibration of the rotor in case of sudden changes or fluctuations of the rotor *** and experiments using the MILC algorithm proposed here are carried out and give evidence to the feasibility and robustness of the technique proposed.

关键词： Rotor vibration suppression Modified iterative learning control Unbalance Parallel misalignment Active magnetic actuator

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MicroRNA-206 as a promising epigenetic approach to modulate tumor-associated macrophages in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第41期30卷 4503-4508页

作者： Davide Ramoni fabrizio Montecucco Department of Internal Medicine University of GenoaGenoa 16132Italy First Clinic of Internal Medicine Department of Internal MedicineIRCCS Ospedale Policlinico San Martino Genoa-Italian Cardiovascular NetworkGenoa 16132Italy

This letter comments on the recently published manuscript by Huang et al in the World Journal of Gastroenterology,which focused on the immunomodulatory effect of Calculus bovis on hepatocellular carcinoma(HCC)tumor microenvironments(TME)by inhibiting M2-tumor-associated macrophage(M2-TAM)polarization via Wnt/β-catenin pathway *** research highlights the crucial role of TAMs and their polarization towards the M2 phenotype in promoting HCC *** regulation,particularly through microRNAs(miR),has emerged as a key factor in modulating immune responses and TAM polarization in the TME,influencing treatment responses and tumor *** editorial focuses on miR-206,which has been found to inhibit HCC cell proliferation and migration and promote ***,miR-206 enhances anti-tumor immune responses by promoting M1-polarization of Kupffer cells,facilitating CD8+T cell recruitment and suppressing liver cancer stem cell ***,challenges remain in understanding the precise mechanisms regulating miR-206 and its potential as a therapeutic *** epigenetic mechanisms and improving strategies,whether through pharmacological or genetic approaches,offer promising avenues to sensitize tumor cells to *** the intricate interactions between cancer and non-coding RNA regulation opens new avenues for developing targeted therapies,potentially improving HCC prognosis.

关键词： Epigenetic regulation Hepatocellular carcinoma Non-coding RNAs MicroRNA-206 Tumor-associated macrophages Tumor microenvironment

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