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Three-dimensional imaging of the uterus:The value of the coronal plane

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World Journal of Radiology 2015年第12期7卷 484-493页

作者： Lufee Wong Nikki White Jayshree Ramkrishna Edward Araujo Júnior Simon Meagher fabricio da silva costa Monash Ultrasound for Women Department of Obstetrics and Gynaecology Monash Medical CentreSouthern Health Department of Obstetrics Paulista School of Medicine-Federal University of Sao Paulo(EPM-UNIFESP)

Advent in three-dimensional(3D) imaging technology has seen 3D ultrasound establish itself as a useful adjunct complementary to traditional two-dimensional imaging of the female pelvis. This advantage largely arises from its ability to reconstruct the coronal plane of the uterus, which allows further delineation of many gynecological disorders. 3D imaging of the uterus is now the preferred imaging modality for assessing congenital uterine anomalies and intrauterine device localization. Newer indications include the diagnosis of adenomyosis. It can also add invaluable information to delineate other endometrial and myometrial pathology such as fibroids and endometrial polyps.

关键词： Three-dimensional ultrasound Coronal view Pelvis Uterus Uterine anomalies

Enhancement of the Antigenotoxic and Antioxidant Actions of Eugenol from Spice Clove and the Stabilizer Gum Arabic on Colorectal Carcinogenesis

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Food and Nutrition Sciences 2024年第1期15卷 71-100页

作者： Nayanna de Oliveira Ramos Melo Lucas Gabriel da costa Marques Humberto Maia costa Neto Matheus De Sousa silva Francisco Vagnaldo Fechine Jamacaru Bruno Coêlho Cavalcanti Antônio Adailson De Sousa silva Conceição Aparecida Dornelas Postgraduate Program in Medical-Surgical Sciences School of Medicine Federal University of Ceará Fortaleza Brazil School of Medicine Federal University of Ceará Fortaleza Brazil Nucleus of Research and Development of Medicines (NPDM) Laboratory of Pharmacology and Preclinical Research School of Medicine Federal University of Ceará Fortaleza Brazil Nucleus for Research and Development of Medicines (NPDM) National Laboratory of Experimental Oncology Federal University of Ceará Fortaleza Brazil Postgraduate Program in Pathology and Medical-Surgical Sciences School of Medicine Federal University of Ceará Fortaleza Brazil

Spices are defined as any aromatic condiment of plant origin used to alter the flavor and aroma of foods. Besides flavor and aroma, many spices have antioxidant activity, mainly related to the presence in cloves of phenolic compounds, such as flavonoids, terpenoids and eugenol. In turn, the most common uses of gum arabic are in the form of powder for addition to soft drink syrups, cuisine and baked goods, specifically to stabilize the texture of products, increase the viscosity of liquids and promote the leavening of baked products (e.g., cakes). Both eugenol, extracted from cloves, and gum arabic, extracted from the hardened sap of two species of the Acacia tree, are dietary constituents routinely consumed virtually throughout the world. Both of them are also widely used medicinally to inhibit oxidative stress and genotoxicity. The prevention arm of the study included groups: Ia, IIa, IIIa, Iva, V, VI, VII, VIII. Once a week for 20 weeks, the controls received saline s.c. while the experimental groups received DMH at 20 mg/kg s.c. During the same period and for an additional 9 weeks, the animals received either water, 10% GA, EUG, or 10% GA + EUG by gavage. The treatment arm of the study included groups Ib, IIb, IIIb e IVb, IX, X, XI, XII). Once a week for 20 weeks, the controls received saline s.c. while the experimental groups received DMH at 20 mg/kg s.c. During the subsequent 9 weeks, the animals received either water, 10% GA, EUG or 10% GA + EUG by gavage. The novelty of this study is the investigation of their use alone and together for the prevention and treatment of experimental colorectal carcinogenesis induced by dimethylhydrazine. Our results show that the combined use of 10% gum arabic and eugenol was effective, with antioxidant action in the colon, as well as reducing oxidative stress in all colon segments and preventing and treating genotoxicity in all colon segments. Furthermore, their joint administration reduced the number of aberrant crypts and th

关键词： Eugenol Gum Arabic Carcinogenesis Oxidative Stress Genotoxicity

Personalized medicine:Clinical oncology on molecular view of treatment

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World Journal of Clinical Oncology 2024年第8期15卷 992-1001页

作者： Rafick costa Dos Santos da silva Nathalia de Andrade Simon AndréAlves Dos Santos Gabriel De Melo Olegário Jayne Ferreira da silva Naide Oliveira Sousa Manuel Alvarez Troncoso Corbacho Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória Da Conquista 45029-094BahiaBrazil

Cancer,the second leading global cause of death,impacts both physically and *** treatments such as surgeries,chemotherapy,and radiotherapy have adverse effects,driving the need for more precise *** medicine enables more targeted *** mapping,alongside other molecular biology approaches,identifies specific genes,contributing to accurate *** review addresses,in clinical use,a molecular perspective on *** like alpha-fetoprotein,beta-human chorionic gonadotropin,5-hydroxyindoleacetic acid,programmed death-1,and cytotoxic T lymphocyte-associated protein 4 are explored,providing valuable ***,with an emphasis on artificial intelligence,revolutionizes the analysis of biological data,offering more accurate *** like liquid biopsy are emphasized for early *** medicine guides therapeutic strategies based on the molecular characteristics of the tumor,as evidenced in the molecular subtypes of breast *** allow personalized treatments,highlighting the role of trastuzumab and endocrine *** the benefits,challenges persist,including high costs,tumor heterogeneity,and ethical *** obstacles requires collaboration,ensuring that advances in molecular biology translate into accessible benefits for all.

关键词： Oncology Neoplasia Molecular biology Personalized medicine Molecular Markers Cancer

A single session of strength training changed plasma levels of resistin,but not leptin in overweight and obese men

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Sports Medicine and Health Science 2024年第4期6卷 324-330页

作者： Yago Martins Fortes Antonio Felipe Souza-Gomes Alessandro Roberto Silveira Moreira Leo Nogueira Campos Samara silva de Moura Lucelia Scarabeli silva Barroso Marcelo Henrique Salviano de Faria Heliana de Barros Fernandes Aline silva de Miranda Hugo Cesar Martins-costa Ana Cristina Simoes e silva Janaina Matos Moreira Albena Nunes-silva Laboratory of Inflammation and Exercise Immunology Department of Physical EducationSchool of Physical EducationFederal University of Ouro PretoOuro PretoMGBrazil Postgraduate Program in Health and Nutrition Nutrition SchoolFederal University of Ouro PretoOuro PretoMGBrazil Interdisciplinary Medical Research Laboratory Faculty of MedicineFederal University of Minas GeraisBelo HorizonteMGBrazil Neurobiology Laboratory Institute of Biological SciencesFederal University of Minas GeraisBelo HorizonteMGBrazil Department of Physical Education Pontifical Catholic University of Minas GeraisBrazil Department of Pediatrics Faculty of MedicineFederal University of Minas Gerais(UFMG)Belo HorizonteMGBrazil

Obesity has a complex multifactorial etiology and is characterized by excessive accumulation of adipose *** adipose tissue has deleterious effects on health because it secretes large amounts of inflammatory *** calorie restriction associated with strength training may be useful in managing chronic systemic *** study aimed to evaluate the acute effect of a single strength-training session on plasma adipokine levels in sedentary,overweight,and obese young *** study included twelve men(Age:[34.95±9.77]years;Height:[174.16±3.66]centimeter[cm];Weight:[97.83±12.87]kilogram(kg);body mass index[BMI]:[32.30±4.51]kg/m2),who performed a single strength training *** strength training protocol consisted of 4 sets of 12 repetitions in the following six exercises,45°leg press,bench press,leg extension,machine row,leg curl,and shoulder *** samples were collected before,immediately after,and 1-h subsequent after strength *** plasma levels of resistin and leptin were measured.A significant decrease in resistin levels were found 1 h after the strength training session if compared to levels before the training session(pre-[before][2390±1199]picograms per milliliter[pg/mL]vs post-1 h[1-h subsequent][1523±798],6 pg/mL,p=0.0028).The plasma leptin levels did not differ at any time *** conclusion,a very well controlled single session of strength training significantly decreased the plasma levels of resistin without altering the concentration of leptin in overweight and obese *** effect,at least in part,supports the benefits of exercise by reducing the low grade inflammation and insulin resistance in obesity.

关键词： Strength training Adipose tissue Obesity Chronicinflammation Resistin Leptin

Feasibility of performing the 3-minute step test with remote supervision in children and adolescents with cystic fibrosis: A comparative study

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Pediatric Investigation 2024年第2期8卷 83-90页

作者： Fernanda Maria Vendrusculo Gisele Apolinario da costa Maria Amelia Bagatini Brenda Maria Henrique Maia Lemes Carolina Aguiar Faria Larissa Carvalhaes de Oliveira Evanirso da silva Aquino Marcio Vinicius Fagundes Donadio Laboratory of Pediatric Physical Activity Infant CenterPontificia Universidade Catolica do Rio Grande do Sul(PUCRS)Porto AlegreBrazil Hospital Infantil Joao Paulo II-Fundacao Hospitalar do Estado de Minas Gerais(FHEMIG) Belo HorizonteBrazil Departament of Physiotherapy Pontificia Universidade Catolica de Minas Gerais(PUCMG)-Campus BetimBetimBrazil Department of Physiotherapy Faculty of Medicine and Health SciencesUniversitat Internacional de Catalunya(UIC)BarcelonaSpain

Importance:The 3-min step test is a simple option to monitor submaximal exercise capacity,although its use via remote video monitoring has not been investigated in children with cystic fibrosis(CF).Objective:This study aimed to assess the feasibility and reproducibility of performing the 3-min step test with remote ***:A cross-sectional study including CF patients(6-18 years)from two CF services were ***,anthropometric,clinical,and lung function data were collected and two 3-min step tests were performed:(i)in-person supervision,and(ii)remotely supervised by video *** and after the tests,heart rate(HR),oxygen saturation(SpO_(2)),and the Borg score for dyspnea and lower limb fatigue were ***:Twenty-three patients(10.7±3.7 years)with a mean FEV1 of 89.5%±23.2%were *** were no significant differences between tests,with mean differences(95%confidence intervals)in final HR of-3.3(-8.9,2.4),change in HR of-1.9(-6.1,2.1),final SpO_(2) of 0.3(-0.4,1.0),and final dyspnea of 0.1(-0.8,0.9).The intraclass correlation coefficient was 0.852(final HR),0.762(final SpO_(2)),and 0.775(final lower limb fatigue).Significant and moderate correlations were found between tests for final HR(r=0.75),change in HR(r=0.61),and final SpO_(2)(r=0.61).The Bland-Altman analysis showed a mean difference in final SpO_(2) between tests of 0.3%(limit of agreement-3.0%,3.5%).Interpretation:Physiological responses between tests were similar,indicating it was feasible to perform the 3-min step test with remote supervision in CF children.

关键词： Children Cystic fibrosis Exercise test Telehealth

Complexed amino acid minerals vs. bis-glycinate chelated minerals:Impact on the performance of old laying hens

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Animal Nutrition 2024年第1期16卷 395-408页

作者： Marcos J.B.Santos Maria C.M.M.Ludke Leandro M.silva Carlos B.V.Rabello Mércia R.Barros Fabiano S.costa Clariana S.Santos Jamille S.S.Wanderley Department of Animal Science Rural Federal University of Pernambuco Department of Veterinary Science Rural Federal University of Pernambuco

The present study was to evaluate the effect of trace minerals(Zn, Mn, and Cu) from complexed amino acid minerals(ZMCAA) and bis-glycinate chelated minerals(ZMCGly) in laying hen diets on performance,internal and external egg quality, yolk mineral deposition, intestinal morphometry, and bone characteristics. From 78 to 98 weeks of age, 400 White LSL-Lite strain laying hens were distributed in a randomized design with 4 treatments with 10 replicates per treatment. Treatments were distributed in a 2 ×2 factorial arrangement using either Zn, Mn, and Cu of ZMCAA or ZMCGly source at 2 levels: low(20, 20,and 3.5 mg/kg of Zn, Mn, and Cu, respectively) or high(40, 40, and 7 mg/kg of Zn, Mn, and Cu,respectively). The analysis of variance was performed, and in cases where differences were observed, the means were compared using Tukey?s test(P < 0.05). The source and level of trace mineral supplementation had a significant impact on the performance of laying hens. Hens fed ZMCAA had higher egg production(P = 0.01), egg weight(P = 0.02), egg mass(P = 0.01), and lower feed conversion ratio(P =0.05) compared to those fed ZMCGly. The ZMCAA supplementation showed higher albumen height(P =0.01), albumen weight(P = 0.01), and eggshell thickness(P < 0.01). The deposition of Zn(P < 0.01), Mn(P< 0.01), and Cu(P < 0.01) in the egg yolk was greater for hens received ZMCAA. Tibia weight(P = 0.04)and bone densitometry(P < 0.01) in the tibia were higher with ZMCAA supplementation. In the small intestine, ZMCAA resulted in longer villi(P = 0.02) and shorter crypt depth(P = 0.01) in the *** and ileum measurements were influenced by the level and source of trace minerals(P < 0.05).Laying hens fed ZMCAA exhibited superior performance, egg quality, deposition of trace minerals in the egg yolk, and bone density compared to hens fed ZMCGly. In this study, older laying hens supplemented with ZMCAA at lower levels demonstrated adequate levels of supplementation.

关键词： Bis-glycinates Metal-amino acids Radiodensity Trace minerals

香椿的树木年轮宽度与超年生殖行为的相互关系:对树轮学研究的警示

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Journal of Plant Ecology 2024年第1期17卷 165-171页

作者： Monique silva costa Thaís Jorge de Vasconcellos Claudio Sergio Lisi Arno Fritz Neves Brandes Mario Tomazello-Filho Cátia Henriques Callado Instituto de Aplicação Fernando Rodrigues da Silveira Universidade do Estado do Rio de JaneiroRua Barão de Itapagipe96.Rio Comprido 20261-005Rio de JaneiroBrazil Laboratório de Anatomia Vegetal Universidade do Estado do Rio de JaneiroRua São Francisco Xavier524Maracanã20550-013Rio de JaneiroBrazil Departamento de Biologia Universidade Federal de SergipeAv.Marechal Rondon s/n-Rosa Elze.São Cristóvão 49100-000SergipeBrazil Departamento de Biologia Geral Universidade Federal FluminenseRua Prof.Marcos Waldemar de Freitas ReisS/N.Gragoatá24210-201Rio de JaneiroBrazil Escola Superior de Agricultura Luiz de Queiroz Universidade de São PauloAv.Pádua Dias11.Piracicaba 13418-900São PauloBrazil

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的... 详细信息

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的树木年轮宽度与超年生殖行为相关联。总体而言,生殖结构的发育发生在湿润的年份,在生长季初期没有出现水分亏缺。然而,在这些年份,树木年轮宽度较小。这些结果可能与树木年轮宽度与当地气候之间缺乏相关性有关。因此,我们强调在径向生长研究中纳入生殖数据的重要性,以扩大对热带森林生长变异性的理解。

关键词：植物生长策略树木年轮学树木生态学生殖权衡

Carpal Tunnel Syndrome: A Marker for Amyloidosis

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World Journal of Neuroscience 2024年第3期14卷 92-101页

作者： Luciana León Cejas Miguel Saucedo Mayra Aldecoa Gustavo Teruya fabricio silva Alvaro Muratore Gonzalo Viollaz Cintia Marchesoni Ana Pardal Pablo Dezanzo Alejandro Iotti Ricardo Reisin Neurology Department Hospital Britnico de Buenos Aires Buenos Aires Argentina Orthopedics Department Hospital Britnico de Buenos Aires Buenos Aires Argentina Pathology Department Hospital Britnico de Buenos Aires Buenos Aires Argentina

Introduction: Amyloidosis are systemic conditions and carpal tunnel syndrome (CTS) precedes the principal systemic complications and can be used as an early marker. Our objective was to determine the frequency of amyloid deposition in idiopathic CTS and its systemic impact. Methods: We retrospectively evaluated patients with CTS between September 2019 to January 2020. Samples from the anterior carpal ligament were pathologically evaluated and amyloid deposition was confirmed by apple-green birefringence on polarized light using Congo red stain. When amyloid was detected we performed genetic testing for transthyretin variants (ATTRv), immunofixation electrophoresis in serum and urine for light chains and multidisciplinary evaluation. Results: Thirty consecutive patients were included, 19 women, 11 men, mean age 70 years old (range 42 - 89 years). We identified 3 patients (10%) with amyloid deposits (mean age: 78.6 years, 2 men, 1 woman). Genetic testing for ATTRv and light chains studies were negative. During follow-up: The first patient required aortic valve replacement. The second patient developed progressive cardiac failure with syncopal episodes, atrioventricular block and atrial fibrillation and required a pacemaker and anticoagulation. The third patient had unexplained chronic edemas. The cardiac evaluation in all 3 patients revealed left ventricular hypertrophy and myocardial uptake (Perugini Score > 2) in their nuclear bone scintigraphies with technetium pyrophosphate. Two patients were treated with tafamidis and one patient died due to refractory cardiac insufficiency. Discussion: Our findings underline the importance of investigating amyloidosis in idiopathic CTS. The identification of deposits allows early diagnosis of cardiac amyloidosis leading to timely intervention and treatment.

关键词： Carpal Tunnel Amyloid Transthyretin Amyloid Cardiac Transthyretin Variants Light Chains

Yet Another Intelligent Code-Generating System： A Flexible and Low-Cost Solution

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Journal of Computer Science & Technology 2018年第5期33卷 940-965页

作者： Joao fabricio Filho Luis Gustavo Araujo Rodriguez Anderson Faustino da silva Department of Informatics State University of Maringd Maringd-PR 87020-900 Brazil Federal University of Technology -- Parand Campo Mourao-PR 87301-899 Brazil

Modern compilers apply various code transformation algorithms to improve the quality of the target code. However, a complex problem is to determine which transformation algorithms must be utilized. This is difficult because of three reasons： a number of transformation algorithms, various combination possibilities, and several configuration possibil- ities. Over the last few years, various intelligent systems were presented in the literature. The goal of these systems is to search for transformation algorithms and thus apply them to a certain program. This paper proposes a flexible, low-cost and intelligent system capable of identifying transformation algorithms for an input program, considering the program＇s specific features. This system is flexible for parameterization selection and has a low-computational cost. In addition, it has the capability to maximize the exploration of available computational resources. The system was implemented under the Low Level Virtual Machine infrastructure and the results indicate that it is capable of exceeding, up to 21.36%, performance reached by other systems. In addition, it achieved an average improvement of up to 17.72% over the most aggressive compiler optimization level of the Low Level Virtual Machine infrastructure.

关键词： compiler code transformation iterative compilation knowledge representation machine learning