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Clinical features,course and outcome in patients with late-onset SLE

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Clinical features,course and outcome in patients with late-o...

Anthropogenic pressures increase extinction risk of an isolated Asian elephant(Elephas maximus)population in southwestern China,as revealed by a combination of molecular-and landscape-scale approaches

The 8th International Congress on SLE

作者： fabiola atzeni Luca Iaccarino Piercarlo Sarzi-Puttini Anna Ghirardello Alberto Batticciotto Sandra Zampieri Rheumatology Unit L Sacco University HospitalMilan-Italy Chair of Rheumatology University of PaduaItaly Chair of Rheumatology University of PaduaItaly Rheumatology Unit L Sacco University HospitalMilan-Italy Chair of Rheumatology University of PaduaItaly

＜正＞Purpose:Systemic lupus erythematosus（SLE）is uncommon after the age of 50 years.Age at onset has been recognized as having a modifying effect on the clinical manifestations of SLE;thus,the elderly may constitute a specific SLE patient subgroup.Aim of this study was to examine the type and extent of clinical involvement and outcome in late-onset（LO-SLE）versus early-onset （EO-SLE）SLE.

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Integrative Zoology 2022年第6期17卷 1078-1094页

作者： Ying CHEN Yakuan SUN Luciano atzeni Luke GIBSON Mei HUA Keyu LI Kun SHI David DUDGEON School of Ecology and Nature Conservation Beijing Forestry UniversityBeijingChina School of Biological Sciences The University of Hong KongHong KongChina Eco-Bridge Continental BeijingChina School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhenChina Institute of Special Animal and Plant Sciences of Chinese Academy of Agricultural Sciences ChangchunChina School of Earth Sciences Yunnan UniversityKunmingChina

Identiﬁcation of the effect of anthropogenic threats on ecosystem is crucial.We used molecular tools and remote sensing to evaluate the population status of an isolated Asian elephant population in southwestern China in response to changes in habitat suitability between 1989 and 2019.A total of 22 unique genotypes were identiﬁed from 117 dung samples collected between March and June 2018 using microsatellite DNA analysis,including 13 males and 9 females.Based on the size of fecal boli,1 animal was a juvenile,9 were subadults,and 12 were adults,indicating that recruitment was limited.The effective population size was small(15.3)but there was no signature of a recent population bottleneck.We observed a low genetic diversity(He=0.46±0.05)and a high level of inbreeding(Fis of 0.43±0.11),suggesting low population viability and high risk of extinction.In total,these elephants lost nearly two thirds(62%)of their habitat in 3 decades.The expansion of agriculture and rubber plantations followed by an increase in human settlements after 1989 increased the isolation of this population.We recommend that resettlement of 800 inhabitants of 2 villages and the abandonment of associated farmland and rubber plantations would make an additional 20 km2 of suitable habitat available.This could allow a population increase of 14 elephants,possibly by translocating individuals from elsewhere in China.Ourﬁndings can be applied to the management and conservation of other fragmented populations in China or in other range countries of Asian elephants.

关键词： fragmentation inbreeding isolation land-use change population viability

Spatiotemporal behavior of predators and prey in an arid environment of Central Asia

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Current Zoology 2023年第6期69卷 670-681页

作者： Marcello Franchini Luciano atzeni Sandro Lovari Battogtokh Nasanbat Samiya Ravchig Francisco Ceacero Herrador Giovanni Bombieri Claudio Augugliaro Department of Research and Conservation Wildlife Initiative ItaliaVia Rovigo1231040 Pederobba(TV)Italy Department of Agri-Food Environmental and Animal SciencesUniversity of UdineVia Sondrio 2/A33100UdineItaly Wildlife Institute School of Ecology and Nature ConservationBeijing Forestry UniversityBeijingChina Maremma Natural History Museum Grossetoand Department of Life SciencesUniversity of SienaSienaItaly Faculty of Tropical AgriSciences Czech University of Life Sciences PraguePragueCzech Republic Institute of Biology Mongolian Academy of SciencesUlaanbaatarMongolia School of Arts and Sciences National University of MongoliaUlaanbaatarMongolia World Biodiversity Association—C/o Museo Civico di Storia Naturale Lungadige Porta Vittoria 937129 VeronaItalia Wildlife Initiative Bayangol6th KhorooMicro District 10Ulaanbaatar 210349Mongolia Department of Ecology and Evolution University of LausanneBiophoreQuartier SorgeLausanneCH-1015Switzerland

The mechanisms of interactions between apex and smaller carnivores may range from competition to facilitation.Conversely,interactions between predators and prey are mainly driven by the prey reducing the likelihood of encounters with predators.In this study,we investigated(1)the spatiotemporal interactions between an apex(the snow leopard)and a meso-predator(the red fox),and(2)the temporal interactions between the snow leopard and its potential prey(Siberian ibex,argali,Asian wild ass,Tolai hare)through camera trapping in the Mongolian Great Gobi-A.The probability of occurrence for the red fox was higher in the presence of the snow leopard than in its absence.Moreover,the red fox activity pattern matched that of the snow leopard,with both species mostly active at sunset.This positive spatiotemporal interaction suggests that the presence of the snow leopard may be beneficial for the red fox in terms of scavenging opportunities.However,other explanations may also be possible.Amongst prey,the Siberian ibex and the argali were mainly active during the day,whereas the Asian wild ass and the Tolai hare were more nocturnal.These findings suggest that potential prey(especially the Siberian ibex and the argali)may shape their behavior to decrease the opportunity for encounters with the snow leopard.Our results have revealed complex interactions between apex and smaller predators andbetween apexpredatorand its potential prey.

关键词： avoidance facilitation Mongolia Panthera uncia ungulates Vulpes vulpes

Assessment of habitat suitability of the snow leopard (Panthera uncia) in Qomolangma National Nature Reserve based on MaxEnt modeling

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Zoological Research 2018年第6期39卷 373-386页

作者： De-Feng Bai Peng-Ju Chen Luciano atzeni Lhaba Cering Qian Li Kun Shi Wildfife Institute School of Nature Conservation Beiiing Forestry University Beijing 100083 China Everest Snow Leopard Conservation Center Rikaze Xizang 857000 China Qomolangma National Nature Reserve Administration Rikaze Xizang 857000 China Eco-Bridge Continental Beijing 100085 China

Habitat evaluation constitutes an important and fundamental step in the management of wildlife populations and conservation policy planning. Geographic information system （GIS） and species presence data provide the means by which such evaluation can be done. Maximum Entropy （MaxEnt） is widely used in habitat suitability modeling due to its power of accuracy and additional descriptive properties To survey snow leopard populations in Qomolangma （Mt. Everest） National Nature Reserve （QNNR）, Xizang （Tibet）, China, we pooled 127 pugmarks, 415 scrape marks, and 127 non-invasive identifications of the animal along line transects and recorded 87 occurrences through camera traps from 2014-2017. We adopted the MaxEnt model to generate a map highlighting the extent of suitable snow leopard habitat in QNNR. Results showed that the accuracy of the MaxEnt model was excellent （mean AUC=0.921）. Precipitation in the driest quarter, ruggedness, elevation, maximum temperature of the warmest month, and annual mean temperature were the main environmental factors influencing habitat suitability for snow leopards, with contribution rates of 20.0%, 14.4%, 13.3%, 8.7%, and 8.2% respectively The suitable habitat area extended for 7 001.93 km^2, representing 22.72% of the whole reserve. The regions bordering Nepal were the main suitable snow leopard habitats and consisted of three separate habitat patches Our findings revealed that precipitation, temperature conditions, ruggedness, and elevations of around 4 000 m a.s.I, influenced snow leopard preferences at the landscape level in QNNR. We advocate further research and cooperation with Nepal to evaluate habitat connectivity and to explore possible proxies of population isolation among these patches. Furthermore, evaluation of subdivisions within the protection zones of QNNR is necessary to improve conservation strategies and enhance protection.

关键词： Qomolangma National Nature Reserve Snow leopard MaxEnt Habitat suitability assessment Tibet

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High-speed integrated QKD system

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Photonics Research 2023年第6期11卷 1007-1014页

作者： REBECKA SAX ALBERTO BOARON GIANLUCA BOSO SIMONE atzeni ANDREA CRESPI FADRI GRÜNENFELDER DAVIDE RUSCA AWS AL-SAADI DANILO BRONZI SEBASTIAN KUPIJAI HANJO RHEE ROBERTO OSELLAME HUGO ZBINDEN Group of Applied Physics University of Geneva1205 GenèveSwitzerland ID Quantique SA 1227 GenèveSwitzerland Institute for Photonics and Nanotechnologies and NO-IFN CNR-IFN20133 MilanoItaly Dipartimento di Fisica Politecnico di Milano20133 MilanoItaly Sicoya GmbH 12489 BerlinGermany

Quantum key distribution(QKD)is nowadays a well-established method for generating secret keys at a distance in an information-theoretically secure way,as the secrecy of QKD relies on the laws of quantum physics and not on computational complexity.In order to industrialize QKD,low-cost,mass-manufactured,and practical QKD setups are required.Hence,photonic and electronic integration of the sender's and receiver's respective components is currently in the spotlight.Here we present a high-speed(2.5 GHz)integrated QKD setup featuring a transmitter chip in silicon photonics allowing for high-speed modulation and accurate state preparation,as well as a polarization-independent low-loss receiver chip in aluminum borosilicate glass fabricated by the femtosecond laser micromachining technique.Our system achieves raw bit error rates,quantum bit error rates,and secret key rates equivalent to a much more complex state-of-the-art setup based on discrete components[A.Boaron et al.,Phys.Rev.Lett.121,190502(2018)].

关键词： technique QKD polarization

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Fuel-ion diffusion in shock-driven inertial confinement fusion implosions

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Matter and Radiation at Extremes 2019年第5期4卷 50-54页

作者： Hong Sio Chikang Li Cody E.Parker Brandon Lahmann Ari Le Stefano atzeni Richard D.Petrasso Plasma Science and Fusion Center Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Los Alamos National Laboratory Los AlamosNew Mexico 87545USA Dipartimento SBAI Universita degli Studi di Roma“La Sapienza”Via Antonio Scarpa 1400161RomaItaly

The impact of fuel-ion diffusion in inertial confinement fusion implosions is assessed using nuclear reaction yield ratios and reaction histories.In T3He-gas-filled(with trace D)shock-driven implosions,the observed TT/T3He yield ratio is∼23lower than expected from temperature scaling.InD3He-gas-filled(with trace T)shock-driven implosions,the timing of theD3He reaction history is∼50 ps earlier than those of the DT reaction histories,and average-ion hydrodynamic simulations cannot reconcile this timing difference.Both experimental observations are consistent with reduced T ions in the burn region as predicted by multi-ion diffusion theory and particle-in-cell simulations.

关键词： diffusion shock filled

Multibeam laser±plasma interaction at the Gekko Ⅻ laser facility in conditions relevant for direct-drive inertial confinement fusion

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High Power Laser Science and Engineering 2023年第2期 75-85页

作者： G.Cristoforetti P.Koester S.atzeni D.Batani S.Fujioka Y.Hironaka S.Hüller T.Idesaka K.Katagiri K.Kawasaki R.Kodama D.Mancelli Ph.Nicolai N.Ozaki A.Schiavi K.Shigemori R.Takizawa T.Tamagawa D.Tanaka A.Tentori Y.Umeda A.Yogo L.A.Gizzi Intense Laser Irradiation Laboratory 2. Dipartimento SBAI Università di Roma ‘La Sapienza' 3. Université BordeauxCNRS CEA CELIA Institute of Laser Engineering Osaka University Centre de Physique Théorique CPHT CNRS IP ParisEcole Polytechnique Graduate School of Engineering Osaka University Institute of Plasma Physics and Lasers Hellenic Mediterranean University Research Centre Institute for Integrated Radiation and Nuclear Science Kyoto University

Laser±plasma interaction and hot electrons have been characterized in detail in laser irradiation conditions relevant for direct-drive inertial confinement fusion. The experiment was carried out at the Gekko XII laser facility in multibeam planar target geometry at an intensity of approximately 3 × 1015W/cm2. Experimental data suggest that high-energy electrons, with temperatures of 20-50 ke V and conversion efficiencies of η < 1%, were mainly produced by the damping of electron plasma waves driven by two-plasmon decay(TPD). Stimulated Raman scattering(SRS) is observed in a near-threshold growth regime, producing a reflectivity of approximately 0.01%, and is well described by an analytical model accounting for the convective growth in independent speckles. The experiment reveals that both TPD and SRS are collectively driven by multiple beams, resulting in a more vigorous growth than that driven by single-beam laser intensity.

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An evaluation of sustainability and societal impact of high-power laser and fusion technologies:a case for a new European research infrastructure

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High Power Laser Science and Engineering 2021年第4期9卷 66-69页

作者： S.atzeni D.Batani C.N.Danson L.A.Gizzi M.Perlado M.Tatarakis V.Tikhonchuk L.Volpe Dipartimento SBAI Universitàdi Roma"La Sapienza"Roma 00161Italy CELIA Universitéde Bordeaux-CNRS-CEAUMR 510733405 TalenceFrance AWE AldermastonReading RG74PRUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondon SW72AZUK Istituto Nazionale di Ottica Consiglio Nazionale delle Ricerche56125 PisaItaly Instituto Fusión Nuclear"Guillermo Velarde"Universidad Politecnica 28006 MadridSpain Institute of Plasma Physics and Lasers Hellenic Mediterranean University Research Centre74100 RethymnoGreece Department of Electronic Engineering Hellenic Mediterranean University73133 ChcmiaGreece ELI-Beamlines Center Institute of PhysicsCzech Academy of Sciences25241 Dolni BrezanyCzech Republic Centro de Laseres Pulsados(CLPU) Parque CientificoE-37185 VillamayorSalamancaSpain Laser-Plasma Chair at the University of Salamanca E-37185 VillamayorSalamancaSpain

Fusion energy research is delivering impressive new results emerging from different infrastructures and industrial devices evolving rapidly from ideas to proof-of-principle demonstration and aiming at the conceptual design of reactors for the production of electricity.A major milestone has recently been announced in laser fusion by the Lawrence Livermore National Laboratory and is giving new thrust to laser-fusion energy research worldwide.Here we discuss how these circumstances strongly suggest the need for a European intermediate-energy facility dedicated to the physics and technology of laser-fusion ignition,the physics of fusion materials and advanced technologies for high-repetitionrate,high-average-power broadband lasers.We believe that the participation of the broader scientific community and the increased engagement of industry,in partnership with research and academic institutions,make most timely the construction of this infrastructure of extreme scientific attractiveness.

关键词： fusion energy high power lasers plasmas inertial fusion high energy density

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Multibeam laser-plasma interaction at the Gekko XII laser facility in conditions relevant for direct-drive inertial confinement fusion

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High Power Laser Science and Engineering 2023年第2期11卷 70-80页

作者： G.Cristoforetti P.Koester S.atzeni D.Batani S.Fujioka Y.Hironaka S.Hüller T.Idesaka K.Katagiri K.Kawasaki R.Kodama D.Mancelli Ph.Nicolai N.Ozaki A.Schiavi K.Shigemori R.Takizawa T.Tamagawa D.Tanaka A.Tentori Y.Umeda A.Yogo L.A.Gizzi Intense Laser Irradiation Laboratory INO-CNRPisaItaly Dipartimento SBAI Universitàdi Roma‘La Sapienza’RomaItaly UniversitéBordeaux CNRSCEACELIATalenceFrance Institute of Laser Engineering Osaka UniversityOsakaJapan Centre de Physique Théorique CPHT CNRSIP ParisEcole PolytechniquePalaiseauFrance Graduate School of Engineering Osaka UniversityOsakaJapan Institute of Plasma Physics and Lasers Hellenic Mediterranean University Research CentreRethymnonGreece Institute for Integrated Radiation and Nuclear Science Kyoto UniversitySennanOsakaJapan

Laser–plasma interaction and hot electrons have been characterized in detail in laser irradiation conditions relevant for direct-drive inertial confinement fusion.The experiment was carried out at the Gekko XII laser facility in multibeam planar target geometry at an intensity of approximately 3×10^(15)W/cm^(2).Experimental data suggest that high-energy electrons,with temperatures of 20–50 keV and conversion efficiencies ofη<1%,were mainly produced by the damping of electron plasma waves driven by two-plasmon decay(TPD).Stimulated Raman scattering(SRS)is observed in a near-threshold growth regime,producing a reflectivity of approximately 0.01%,and is well described by an analytical model accounting for the convective growth in independent speckles.The experiment reveals that both TPD and SRS are collectively driven by multiple beams,resulting in a more vigorous growth than that driven by single-beam laser intensity.

关键词： inertial confinement fusion laser plasma interaction parametric instabilities