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Left-sided gallbladder:A rare biliary tree anomaly

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 655-657页

作者： fabio Rondelli Walter Bugiantella Christian Ivan Zapana Chillitupa Claudio Marcacci Michele De Rosa Department of Surgical and Biomedical Sciences School of MedicineUniversity of PerugiaVia G.Dottori06100PerugiaItaly General and Specialized Surgery Unit “Santa Maria”HospitalVia T.Di Joannuccio105100TerniItaly Department of General Surgery “Nuovo San Giovanni Battista”HospitalUsl Umbria 2Via M.Arcamone106034FolignoPGItaly

To the Editor:Hepatobiliary anatomical variations may increase the complexity of surgery with a relevant risk of iatrogenic lesions.Left-sided gallbladder(LSG)is a rare and little known condition whereby the viscus is located on the visceral surface of the left lobe of the liver and is often discovered unexpectedly during surgery.The position of the gallbladder over the liver pedicle and the simultaneous presence of variations in the liver vascularization are potentially associated to a challenging surgical dissection and consequently to an increased risk of morbidity.Despite open approach remains an option in more complex procedures,cholecystectomy is usually performed with a minimally invasive technique,which is generally safe even in the rare case of an LSG,as long as a high level of awereness of anatomical variations and a careful surgical dissection are pursued.

关键词： gallbladder surgery sided

Current guidelines for diagnosis and management of hepatic involvement in hereditary hemorrhagic teleangiectasia

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World Journal of Hepatology 2023年第5期15卷 675-687页

作者： Luca Ielasi Matteo Tonnini fabio Piscaglia Ilaria Serio Department of Medical and Surgical Sciences University of BolognaBologna 40138Italy Department of Internal Medicine Ospedale per gli Infermi di FaenzaFaenza 48018Italy Division of Internal Medicine Hepatobiliary and Immunoallergic DiseasesIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy

Hereditary hemorrhagic teleangiectasia(HHT),also known as Rendu-Osler-Weber syndrome,is the most common cause of hepatic vascular malformations in adults.Different vascular shunts(arteriovenous,arterioportal or portovenous)lead to different clinical manifestations.Even though no hepatic-related symptoms are reported in the majority of cases,the severity of liver disease could lead to refractory medical conditions,in some cases requiring liver transplantation.The aim of this manuscript is to provide an updated overview of the current evidence regarding the diagnosis and treatment of HHT liver involvement and liver-related complications.

关键词： involvement diagnosis hemorrhagic

Physical properties of sandstone reservoirs: Implication for fluid mobility

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Energy Geoscience

Energy Geoscience 2022年第4期3卷 349-359页

作者： Richardson M.Abraham-A fabio Taioli Anthony I.Nzekwu Institute of Energy and Environment University of Sao Paulo(IEE-USP)Sao PaloBrazil Department of Applied Geophysics Federal University of TechnologyAkure(FUTA)Ondo StateNigeria

Core samples representing depths of hydrocarbon-bearing zones are not readily accessible for reservoir evaluations.On the other hand,wireline logs with incorporated seismic data,which can be archived over a more extended period while retaining their original forms,are typically more available for research purposes.Therefore,the study relies on wireline logs with seismic data to predict the reservoirs'fluid mobility by evaluating the hydraulic(flow)units,reservoir depths,fluid saturations,and geothermal gradients.It also indicates the associated water cut(C_(w))within Ritchie oil and gas field,Niger Delta considering a three-phase(oil-gas-water-bearing)reservoir(R_(A))and an oil-saturated reservoir(R_(B))delineated across three wells(R_(W1),R_(W2) and R_(W3)).Research activities combining the presented factors to achieve the stated objectives are not quite common within the study location.It shows lower,average and upper limits of the flow unit factors and irreducible water saturation(S_(wirr))within the reservoirs.The study shows the relationship between hydraulic units/fluid saturations and fluid mobility/associated C_(w) within the sandstone reservoirs.It maximises porosity(Ф)for the theoretical flow units'prediction during qualitative and quantitative estimation based on the adopted expressions.Therefore,the study reveals that water saturation(S_(w))and hydrocarbon/water ratios substantially control C_(w),and other contributing factors include thermal gradients and S_(wirr).The flow unit factors are also significant and will encourage fluid mobility.The evaluated reservoirs(R_(A) and R_(B))are below 10400 ft(3170 m)across wells R_(W1),R_(W2) and R_(W3) within the Agbada Formation of a geothermal gradient up to 2.7℃/100 m;therefore,they have good thermal conditions to enhance hydrocarbon mobility and increase S wirr.Hence,the reservoir should feature significant hydrocarbon extraction via primary recovery.The average water cut(C_(w-avg).)(12.3%)estimated for reservoir R_(A) is within the acceptable range;theref

关键词： Water cut Thermal gradient Fluid saturations Hydrocarbon mobility Sandstone reservoir Reservoir quality Agbada Formation Niger Delta

Branching patterns of the left portal vein and consequent implications in liver surgery:The left anterior sector

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 399-402页

作者： Mattia Garancini Mauro Alessandro Scotti Luca Gianotti Antonio Rovere fabio Uggeri Marco Braga Fabrizio Romano Unit of Hepatobiliary Pancreatic Surgery Department of General Surgery 1ASST-MonzaSan Gerardo HospitalMilano-Bicocca Universityvia Pergolesi 3320900 MonzaMBItaly Unit of Interventional Radiology Department of RadiologyASST-MonzaSan Gerardo HospitalMilano-Bicocca Universityvia Pergolesi 3320900 MonzaMBItaly

To the Editor: There are still some open issues about the systematization of the knowledge of the branching of the left portal vein(LPV) and the division in anatomo-functional units within the left liver. The first controversial topic concerns the division of S4 in subsegments. The Brisbane 20 0 0 system of Nomenclature of Hepatic Anatomy and Resections(B20 0 0) [1] does not mention such subdivision, but in literature this is still a matter of discussion.

关键词： branching portal discussion

Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

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Frontiers of Chemical Science and Engineering 2022年第1期16卷 128-135页

作者： fabio de Moliner Ina Biazruchka Karolina Konsewicz Sam Benson Suraj Singh Jun-Seok Lee Marc Vendrell Centre for Inflammation Research Queen’s Medical Research InstituteThe University of EdinburghEdinburgh EH164TJUK Molecular Recognition Research Centre Korea Institute of Science and Technology(KIST)&Bio-Med ProgramKIST-School USTSeoul 02792Korea Department of Pharmacology Korea University College of MedicineSeoul 02841Korea

The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging.In this work,we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors.C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most nearinfrared dyes.We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+and Fe^(3+)ions in aqueous media.

关键词： fluorescence probes iron screening library

利用强子探针研究奇特原子核的点质子分布半径及强子探针效应

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Science Bulletin 2024年第11期69卷 1647-1652页

作者：张寂潮孙保华 Isao Tanihata Rituparna Kanungo Christoph Scheidenberger Satoru Terashima 王枫 Frederic Ameil Joel Atkinson Yassid Ayyad Soumya Bagchi Dolores Cortina-Gil Iris Dillmann Alfredo Estradé Alexey Evdokimov fabio Farinon Hans Geissel Giulia Guastalla Rudolf Janik Satbir Kaur Ronja Knöbel Jan Kurcewicz Yury Litvinov Michele Marta Magdalena Mostazo Ivan Mukha Chiara Nociforo Hooi Jin Ong Stephane Pietri Andrej Prochazka Branislav Sitar Peter Strmen Maya Takechi Junki Tanaka Jossitt Vargas Helmut Weick John Stuart Winfield School of Physics Beihang UniversityBeijing 100191China Research Center for Nuclear Physics(RCNP) Osaka UniversityOsaka 567-0047Japan Astronomy and Physics Department Saint Mary’s UniversityHalifax B3H 3C3Canada TRIUMF Vancouver V6T 4A3Canada GSI Helmholtzzentrum für Schwerionenforschung Darmstadt D-64291Germany Justus-Liebig University Gießn 35392Germany Helmholtz Research Academy Hesse for FAIR(HFHF) GSI Helmholtz Center for Heavy Ion ResearchGießn 35392Germany Universidad de Santiago de Compostela Santiago de Compostella E-15706Spain Department of Physics Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India Faculty of Mathematics and Physics Comenius UniversityBratislava 84215Slovakia Department of Physics and Atmospheric Science Dalhousie UniversityHalifax B3H 4R2Canada

We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on carbon are for the first time.Benefiting from the data set,we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both targets.This allows us to deduce proton radii(R_p)for the first time from the cross sections on hydrogen.Nearly identical R_p values are deduced from both target data for the neutron-rich carbon isotopes;however,the R_p from the hydrogen target is systematically smaller in the neutron-rich nitrogen isotopes.This calls for further experimental and theoretical investigations.

关键词： Exotic nuclei Nuclear size Reaction cross section Glauber model Radioactive ion beam

Guidance on opioids prescribing for the management of persistent non-cancer pain in older adults

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World Journal of Clinical Cases 2017年第3期5卷 73-81页

作者： fabio Guerriero Department of Internal Medicine and Thera-peutics Section of GeriatricsUniversity of Pavia

Many older adults suffer from persistent pain but prevalence studies consistently showed high levels of untreated or under-treated pain in old population.Both persistent pain and pain under-treatment adversely affect independence and quality of life in geriatric patients.Pain management is challenging in this age-group because of the declining organ function,the presence of concurrent diseases and polypharmacy.For all the above reasons,persistent pain in the elderly should be considered a geriatric syndrome per se and effective approaches are warranted.Current guidelines and consensus statements recommend opioid therapy for older adults with moderateto-severe persistent pain or functional impairment and diminished quality of life due to pain.However clinicians and patients themselves have some concerns about opioids use.Age-related decline in organs functions and warnings about risk of addiction and drug misuse/abuse also in geriatric patients need particular attention for safe prescribing.On the basis of clinical evidence,these practical recommendations will help to improve the competence on opioid role in persistent pain management and the likelihood of a successful analgesic trial in older patients.

关键词： Chronic pain Opioids Pain management Elderly

Evidence of advancing spring xylem phenology in Chinese forests under global warming

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Science China Earth Sciences 2023年第10期66卷 2187-2199页

作者： Huihong XUE Feng SHI fabio GENNARETTI Yongshuo H.FU Bin HE Xiuchen WU Zhengtang GUO Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing100049China CAS Center for Excellence in Life and Paleoenvironment Beijing100044China Institut de Recherche sur les Forêts Groupe de Recherche enÉcologie de la MRC-AbitibiUniversitédu Québec en Abitibi-TémiscamingueAmosJ9T 2L8Canada College of Water Sciences Beijing Normal UniversityBeijing100875China Faculty of Geographical Science Beijing Normal UniversityBeijing100875China

Phenological responses of vegetation to the ongoing warming trend impact current and future primary productivity.However,few studies focus on wood phenology because its observed data are much scarcer,which hinders the estimation and prediction of forest carbon budgets over large regions.Here,we use a physiological process-based tree-ring growth model(Vaganov-Shashkin model)to investigate the spatial and temporal variations of spring xylem phenology(start of the growing season of xylem,SOS_(x))in tree-ring sites of China during 1962-2016 CE.The model is calibrated on measured tree-ring width chronologies(70 tree-ring chronologies)and successfully validated with field observations of xylogenesis.We found that spring xylem phenology significantly advances during 1962-2016 CE period under global warming,with the rate of advance quickly increasing after the 1990s to an average of 0.25 days per year.The preseason daily mean temperature is the main climatic driver for spring xylem phenology as indicated by its significant correlations with SOS_(x)at most sites(71%).Warmer preseason allows heat requirements for tree growth to be reached more quickly,with increase of 1℃in temperature of preseason anticipates SOS_(x)by 6 to 7 days,which will benefit the radial growth of trees in the relatively cold-humid environments.In addition,the significant positive correlation between the simulated spring xylem phenology and remote sensing derived phenology highlights the primary and secondary growth may be governed by the same variable(temperature)and change in the same direction with global warming.This study provides the long-term perspective on the spring xylem phenology variations covering most of China.

关键词： Tree-ring Xylem Phenology Vaganov-Shashkin model China

SPL transcription factors prevent inflorescence reversion in rice

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Molecular Plant 2021年第7期14卷 1041-1043页

作者： Francesca Giaume fabio Fornara Department of Biosciences University of MilanVia Celoria 2620133 MilanItaly

Plants show an incredible diversity of forms,dimensions,archi-tectures,structures,and reproductive behaviors.Yet,they can be geometrically described as composed of simple building units called phytomers,which are produced by the shoot apical meri-stem(SAM).A phytomer is made up of a node bearing a leaf and an axillary meristem,and of an internode connecting the node to the following phytomer.Piling of phytomers creates the plant body,similarly to a LEGO construction made of simple bricks.Modifications of the phytomeric unit creates diversity.The leaf can change in size and shape;the axillary meristem can be dormant or active,determinate or indeterminate;the internode can elongate considerably,or be compressed to the extent it might look invisible.

关键词： connecting dimensions visible