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Risk factors for running-related injuries:An umbrella systematic review

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Journal of Sport and Health Science 2024年第6期13卷 793-804页

作者： Clara Knierim Correia Jean Marlon Machado fabio Hech Dominski Marcelo Peduzzi de castro Heiliane de Brito Fontana Caroline Ruschel College of Health and Sport Science State University of the Santa CatarinaFlorianopolis 88080-350Brazil Fisiolab Institut Florianopolis 88015-310Brazil Biological Sciences Centre Federal University of Santa CatarinaFlorianopolis 88040-900Brazil

Purpose:This umbrella systematic review(SR)of SRs and meta-analysis seeks to comprehensively synthesize existing literature to identify and consolidate the diverse range of risk factors contributing to running-related injuries(RRIs).Methods:Systematic searches were conducted on June 28,2023,across Web of Science,SPORTDiscus,Scopus,PubMed,and Cochrane *** included SRs,whether accompanied by meta-analyses or not,that focused on investigating risk factors for RRIs within observational *** methodological quality of the SRs was evaluated using the Assessing the Methodological Quality of Systematic Reviews *** assess the extent of overlap across reviews,the corrected covered area metric was ***:From 1509 records retrieved,13 SRs were *** degree of overlap between SRs was low(4%),and quality varied from critically low(n=8)to low(n=5).Two hundred seven outcomes assessed in 148 primary studies were identified as being associated with the occurrence of *** effect sizes of the associations for which risk measures were reported(n=131)were classified as large(n=30,23%),medium(n=38,29%),small(n=48,37%)or no effect(n=15,11%).Running/training characteristics,health and lifestyle factors,along with morphological and biomechanical aspects,exhibit large effect sizes in increasing the risk for ***:Drawing from the outcomes of the low-quality SRs and associations with large effect sizes,our findings indicate that running/training characteristics and health and lifestyle factors,as well as morphological and biomechanical aspects,are all implicated in elevating the risk of RRIs,emphasizing the multifactorial basis of injury incidence in *** the low quality and heterogeneity of SR,individual findings warrant cautious interpretation.

关键词： Umbrella review Runners Injury Risk factor

Insights into the oxidation resistance mechanism and tribological behaviors of multilayered TiSiN/CrVxN hard coatings

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International Journal of Minerals,Metallurgy and Materials 2023年第12期30卷 2459-2468页

作者： Hongbo Ju Moussa Athmani Jing Luan Abbas AL-Rjoub Albano Cavaleiro Talha Bin Yaqub Abdelouahad Chala fabio Ferreira Filipe fernandes School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Laboratory of Physics of Thin Films and Applications University of Mohamed KhiderBP 145 RPBiskra 07000Algeria CEMMPRE ARISEDepartment of Mechanical EngineeringUniversity of CoimbraCoimbra 3030-788Portugal IPN-LED&MAT-Instituto Pedro Nunes Laboratory of TestsWear and MaterialsCoimbra 3030-199Portugal ISEP Polytechnic of PortoRua Dr.António Bernardino de AlmeidaPorto 4249-015Portugal

In the last decades,vanadium alloyed coatings have been introduced as potential candidates for self-lubrication due to their perfect tribological *** this work,the influence of V incorporation on the wear performance and oxidation resistance of TiSiN/CrN film coatings deposited by direct current(DC)reactive magnetron sputtering is *** results show that vanadium incorporation significantly decreases the oxidation resistance of the *** general,two layers are formed during the oxidation process:i)Ti(V)O_(2) on top,followed by a protective layer,which is subdivided into two layers,Cr_(2)O_(3) and ***)The diffusion of V controls the oxidation of V-containing *** addition of vanadium improves the wear resistance of coatings,and the wear rate decreases with increasing V content in the coatings;however,the friction coefficient is independent of the chemical composition of the *** wear of the V-containing coatings is driven by polishing wear.

关键词： DC magnetron sputtering TiSiN/CrVxN multilayer coatings oxidation resistance tribology wear rate

Acromyrmex ameliae sp. n. （Hymenoptera： Formicidae）： A new social parasite of leaf-cutting ants in Brazil

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Insect Science 2007年第3期14卷 251-257页

作者： DANIVAL JOSE DE SOUZA ILKA MARIA fernandes SOARES TEREZINHA MARIA castro DELLA LUCIA Institut de Recherche sur la Biologie de 1'Insecte Université Francois Rabelais Tours France Departamento de Biologia Animal Laboratório de Ecologia de Comunidades Departamento de Biologia Geral Universidade Federal de Vicosa MG 36570-000 Brazil

The fungus-growing ants （Tribe Attini） are a New World group of〉 200 species, all obligate symbionts with a fungus they use for food. Four attine taxa are known to be social parasites of other attines. Acromyrmex （ Pseudoatta） argentina argentina and Acromyrmex （Pseudoatta） argentina platensis （parasites of Acromyrmex lundi）, and Acromyrmex sp. （a parasite of Acromyrmex rugosus） produce no worker caste. In contrast, the recently discovered Acromyrmex insinuator （a parasite of Acromyrmex echinatior） does produce workers. Here, we describe a new species, Acromyrmex ameliae, a social parasite of Acromyrmex subterraneus subterraneus and Acromyrmex subterraneus brunneus in Minas Gerais, Brasil. Like A. insinuator, it produces workers and appears to be closely related to its hosts. Similar social parasites may be fairly common in the fungus-growing ants, but overlooked due to the close resemblance between parasite and host workers.

关键词： Acromyrmex leaf-cutting ants social evolution social parasitism

New translational and experimental insights into the role of proresolving lipid mediators in inflammatory bowel disease

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World Journal of Experimental Medicine 2022年第1期12卷 1-15页

作者： Lívia Bitencourt Pascoal Bruna Biazon Palma fabio Henrique Mendonça Chaim Marina Moreira de castro Tiago Andrade Damázio Ana Paula Menezes de Freitas Franceschini Marciane Milanski Lício AugustoVelloso Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory Colorectal Surgery UnitDepartment of SurgerySchool of Medical SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Metabolic Disorders School of Applied SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Cell Signaling School of Medical SciencesUniversity of CampinasCampinas 13083-864São PauloBrazil

The resolution of inflammation is an active process,guided by specialized proresolution lipid mediators(SPMs).These mediators originate from polyunsaturated fatty acids,such as *** evidence suggests that the beneficial effects attributed to omega-3 are,at least in part,the result of the immunomodulatory action of the SPMs,which act systemically by overcoming inflammation and repairing tissue damage,without suppressing the immune *** studies suggest that an imbalance in the synthesis and/or activity of these compounds may be associated with the pathogenesis of several inflammatory conditions,such as inflammatory bowel disease(IBD).Thus,this review highlights the advances made in recent years with regard to the endogenous synthesis and the biological role of lipoxins,resolvins,protectins,and maresins,as well as their precursors,in the regulation of inflammation;and provides an update on the participation of these mediators in the development and evolution of IBD and the therapeutic approaches that these immunomodulating substances are involved in this context.

关键词： Pro-resolving lipid mediators Anti-inflammatory cytokines Omega-3 Chronic inflammation Pro-inflammatory cytokines Inflammatory bowel disease

Total segmental aplasia of uterus body in bitch

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Asian pacific Journal of Reproduction 2019年第1期8卷 43-44页

作者： Leonardo Martins Leal Fábio Rodrigo castro Bastos Tais Harumi de castro Sasahara Paola castro Moraes Márcia Rita fernandes Machado Centro Universitário Ingá-UNINGá MaringáPRBrazil Universidade de Sao Paulo-USP Sao PauloSPBrazil Universidade Estadual Paulista-Unesp JaboticabalSPBrazil

Congenital anomalies of the female tubular genital tract are rare and known as segmental aplasia, resulting from incomplete development of paramesonephric ducts during embryonic stage, which originate from the cranial portion of vagina, cervix, uterus and oviducts. In the literature consulted, several reports of uterine horn aplasia are described in bitches, however there is only one report described in the world literature on total aplasia of the body of the uterus. This study aimed to describe the case of a two years old bitch, no breed defined, with 12 kg of weight, with segmental aplasia of uterus body diagnosed during ovariohysterectomy. During surgery it was noted that the bitch had the ovaries and uterine horns in their anatomical position, however an aplasia was noted in the body of the uterus. It was also found that the uterine horns had liquid inside, suggesting hydrometra. It was concluded in this case that although segmental aplasia of the body of the uterus is rare and difficult to diagnose by maintaining normal cyclicity of the female, it should be considered in dogs that do not have bloody vaginal discharge in proestrus and can not become pregnant after natural coverage or artificial insemination.

关键词： Segmental aplasia Surgery Ovariohysterectomy Reproduction

Efficient fully laser-patterned flexible perovskite modules and solar cells based on low-temperature solution-processed SnO2/mesoporous-TiO2 electron transport layers

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Nano Research 2018年第5期11卷 2669-2681页

作者： Janardan Dagar Sergio castro-Hermosa Matteo Gasbarri Alessandro L. Palma Lucio Cina fabio Matteocci Emanuele Calabro Aldo Di Carlo Thomas M. Brown CHOSE (Centre for Hybrid and Organic Solar Energy) Department of Electronic Engineering University of Rome Tor Vergato Via del Politecnico 1 00133 Rome Italy Cicci Research srl via Giordania 227 Grosseta 58100 Italy Department of semiconductor electronics and device physics National University of Science and Technology "MISiS" Leninskii pr.4 Moscow 119049 Russia

Efficient flexible perovskite solar cells and modules were developed using a combination of SnO2 and mesoporous-TiO2 as a fully solution-processed electron transport layer （ETL）. Cells using such ETLs delivered a maximum power conversion efficiency （PCE） of 14.8%, which was 30% higher than the PCE of cells with only SnO2 as the ETL. The presence of a mesoporous TiO2 scaffold layer over SnO2 led to higher rectification ratios, lower series resistances, and higher shunt resistances. The cells were also evaluated under 200 and 400 lx artificial indoor illumination and found to deliver maximum power densities of 9.77 μW/cm^2 （estimated PCE of 12.8%） and 19.2 μW/cm^2 （estimated PCE of 13.3%）, respectively, representing the highest values among flexible photovoltaic technologies reported so far. Furthermore, for the first time, a fully laser-patterned flexible perovskite module was fabricated using a complete three-step laser scribing procedure （P1, P2, P3） with a PCE of 8.8% over an active area of 12 cm^2 under an illumination of 1 sun.

关键词： SnO2/mesoporous-TiO2(meso-TiO2) electron transport layer,flexible perovskite solar cell,flexible perovskite module,laser patterning indoor light harvesting

In vitro induced pluripotency from urine-derived cells in porcine

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World Journal of Stem Cells 2022年第3期14卷 231-244页

作者： Kaiana Recchia Lucas Simões Machado Ramon Cesar Botigelli Naira Caroline Godoy Pieri Gabriela Barbosa Raquel Vasconcelos Guimarães de castro Mariana Groke Marques Laís Vicari de Figueiredo Pessôa Paulo Fantinato Neto Flávio Vieira Meirelles Aline Fernanda de Souza Simone Maria Massami Kitamura Martins Fabiana fernandes Bressan Department of Surgery Faculty of Veterinary Medicine and Animal SciencesUniversity of São PauloPirassununga 13635-000São PauloBrazil Department of Pharmacology and Biotechnology Institute of BioscienceSão Paulo State UniversityBotucatu 18618-689São PauloBrazil Department of Veterinary Medicine Faculty of Animal Sciences and Food EngineeringUniversity of São PauloPirassununga 13635-000São PauloBrazil Embrapa Suínos e Aves Empresa Brasileira de Pesquisa AgropecuáriaConcordia 89715-899Santa CatarinaBrazil Department of Animal Sciences Faculty of Animal Sciences and Food EngineeringUniversity of São PauloPirassununga 13635-000São PauloBrazil

BACKGROUND The generation of induced pluripotent stem cells(iPSC)has been a game-changer in translational and regenerative medicine;however,their large-scale applicability is still hampered by the scarcity of accessible,safe,and reproducible *** porcine model is a large biomedical model that enables translational applications,including gene editing,long term in vivo and offspring analysis;therefore,suitable for both medicine and animal *** To reprogramme in vitro into pluripotency,and herein urine-derived cells(UDCs)were isolated from porcine *** The UDCs were reprogrammed in vitro using human or murine octamer-binding transcription factor 4(OCT4),SRY-box2(SOX2),Kruppel-like factor 4(KLF4),and C-MYC,and cultured with basic fibroblast growth factor(bFGF)*** characterize the putative porcine iPSCs three clonal lineages were submitted to immunocytochemistry for alkaline phosphatase(AP),OCT4,SOX2,NANOG,TRA181 and SSEA 1 *** transcripts related to the pluripotency(OCT4,SOX2 and NANOG)were analyzed via reverse transcription quantitative realtime polymerase chain reaction in different time points during the culture,and all three lineages formed embryoid bodies(EBs)when cultured in suspension without bFGF *** The UDCs were isolated from swine urine samples and when at passage 2 submitted to in vitro *** of putative iPSCs were obtained only from UDCs transduced with the murine factors(mOSKM),but not from human factors(hOSKM).Three clonal lineages were isolated and further cultured for at least 28 passages,all the lineages were positive for AP detection,the OCT4,SOX2,NANOG markers,albeit the immunocytochemical analysis also revealed heterogeneous phenotypic profiles among lineages and passages for NANOG and SSEA1,similar results were observed in the abundance of the endogenous transcripts related to pluripotent *** the clonal lineages when cultured in suspension without

关键词： Induced pluripotent stem cells Noninvasive Pluripotency Reprogramming Urine Porcine

Pseudomelanosis duodeni associated with chronic renal failure

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World Journal of Gastroenterology 2012年第12期18卷 1414-1416页

作者： Marcia Henriques de Magalhes Costa Maria da Gloria fernandes Pegado Cleber Vargas Maria Elizabeth C castro Kalil Madi Tiago Nunes Cyrla Zaltman Gastroenterology Section Department of Internal MedicineClementino Fraga Filho University HospitalUniversidade Federal do Rio de JaneiroRio de Janeiro 21941-913Brazil Department of Pathology Clementino Fraga Filho University HospitalUniversidade Federal do Rio de JaneiroRio de Janeiro 21941-913Brazil Hospital Clínic i Provincial/IDIBAPS Barcelona 08036Spain

Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different *** report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain,nausea,melena and progressive reduction of hemoglobin *** endoscopy revealed erosions in the esophagus and stomach,with no active bleeding at the *** addition,the duodenal mucosa presented marked signs of melanosis;later confirmed by histopathological *** though PD is usually regarded as a benign condition,its pathogenesis and clinical significance is yet to be defined.

关键词：慢性肾功能衰竭病理组织学十二指肠血红蛋白临床意义发病机制胃肠 PD

Melatonin restores zinc levels,activates the Keap1/Nrf2 pathway,and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2022年第2期13卷 11-22页

作者： Silvia Bona Sabrina Alves fernandes Andrea C Janz Moreira Graziella Rodrigues Elizângela G Schemitt fabio Cangeri Di Naso Cláudio A Marroni Norma P Marroni Medical Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90035-903Rio Grande do SulBrazil Posgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90040-001Rio Grande do SulBrazil Biological Sciences Program Universidade Federal do Rio Grande do SulPorto Alegre 90050-170Rio Grande do SulBrazil Postgraduate Program in Pneumological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90000-000Rio Grande do SulBrazil

BACKGROUND Melatonin(MLT)is a potent antioxidant molecule that is shown to have a beneficial effect in various pathological situations,due to its action against free *** To evaluate the effect of MLT on carbon tetrachloride(CCl_(4))induced liver injury in rats in terms of oxidative stress,reticular stress,and cell *** Twenty male Wistar rats(230-250 g)were divided into four groups:Control rats,rats treated with MLT alone,rats treated with CCl_(4)alone,and rats treated with CCl_(4)plus ***_(4)was administered as follows:Ten doses every 5 d,ten every 4 d,and seven every 3 *** was administered intraperitoneally at a dose of 20 mg/kg from the 10th wk to the end of the experiment(16th wk).RESULTS MLT was able to reduce the release of liver enzymes in the bloodstream and to decrease oxidative stress in CCl_(4)treated rats by decreasing the level of thiobarbituric acid reactive substances and increasing superoxide dismutase activity,with a lower reduction in serum zinc levels,guaranteeing a reduction in liver damage;additionally,it increased the expression of nuclear factor(erythroid-derived 2)-like 2 and decreased the expression of Kelch-like ECH-associated protein *** also decreased the expression of the proteins associated with endoplasmic reticulum stress,i.e.,glucose-regulated protein 78 and activating transcription factor 6,as well as of heat shock factor 1 and heat shock protein *** MLT has a hepatoprotective effect in an experimental model of CCl_(4)-induced liver injury,since it reduces oxidative stress,restores zinc levels,and modulates endoplasmic reticulum stress.

关键词： Liver injury Cell damage Antioxidant Melatonin Carbon tetrachloride