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Dust pollution during shotcrete process in high-altitude tunnel based on numerical simulation

Particuology 2023年第4期75卷 82-95页

作者： Cong Li Zhongan Jiang Guoliang Zhang Xue Feng fabin Zeng College of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China NHC Key Laboratory for Engineering Control of Dust Hazard University of Science and Technology BeijingBeijing100083China

The surrounding rock needs shotcrete support after drilling and blasting excavation in the tunnel;the high concentration of dust generated in the process will endanger workers'occupational ***,to ensure the cleanness and safety of the tunnel construction process,a full-scale model of the tunnel was established based on field data of a high-altitude tunnel of the Sichuan-Tibet *** dust production mechanism is summarized by combing the whole process of *** Computa-tional Fluid Dynamics(CFD)method was used to study the diffusion and transport of dust under different *** grey relational analysis was applied to investigate the correlation values of the influ-encing factors on dust diffusion in the shotcrete operation *** results show that the dust gener-ation mechanism of shotcrete includes the sudden change of particle velocity in the jet area leading to escape and particle impact dust generation,where fine dust is easily dispersed in the *** continuous dust production,the dust concentration is higher near the wet spraying machine and on the backflow side of the working *** the air supply volume and shortening the distance between the air duct and the working face is conducive to diluting the dust concentration in the *** the high-altitude environment,the dust concentration in the tunnel decreases,the diffusion distance be-comes smaller,the settlement proportion of dust particles increases,and the risk of secondary pollution *** simulation results and the field measurement data are consistent,which can provide theoretical support for the construction site dust control.

关键词： High-altitude tunnel Shotcrete Dust diffusion Numerical simulation Ventilation system

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Effect of inlet area on the performance of a two-stage cyclone separator

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Chinese Journal of Chemical Engineering 2022年第4期35卷 8-19页

作者： Jihe Chen Zhongan Jiang Bin Yang Yapeng Wang fabin Zeng School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China China Academy of Safety Science and Technology Beijing 100029China

The cyclone separator is an important separation *** paper presents a new type of embedded two-stage cyclone,which includes a 2 nd-stage cyclone(internal traditional cyclone)with multiple inlets and a 1 st-stage cyclone(outer cylinder)that unifies the 2 nd-stage cyclone inlets into one *** Taguchi experimental method was used to study the two-stage cyclone separator’s inlet area on its *** have shown that the increase of the 1 st-stage cyclone inlet area and the increase in the number of 2 nd-stage cyclone inlets(N)positively affect reducing the pressure drop and a negative effect on *** is recommended to use 2 S(the original 1 st-stage cyclone inlet area)of the 1 st-stage cyclone inlet area and 2 N of the 2 nd-stage cyclone inlets when separating fine *** with a traditional cyclone,the pressure drop is reduced by 1303 Pa,the mass separation efficiency(Eq)is increased by 0.56%,and the number separation efficiency(En)is increased by 2.05%.When separating larger particles,it is recommended to use 2 S of the 1 st-stage cyclone inlet area and 4 N of the 2 nd-stage cyclone *** with a traditional cyclone,although Endecreases slightly,the pressure drop is reduced by 3055 Pa,and the Eqis increased by 0.56%.The research results provide new insight into the design of the cyclone.

关键词： Two-stage cyclone Mass separation efficiency Pressure drop Taguchi method Particle concentration

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Time-dependent reliability analysis of aerospace electromagnetic relay considering hybrid uncertainties quantification of probabilistic and interval variables

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Chinese Journal of Aeronautics 2024年第12期37卷 99-115页

作者： fabin MEI Hao CHEN Wenying YANG Xuerong YE Guofu ZHAI School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001China

Reliability is a crucial metric in aerospace *** results of reliability assessments for components like aerospace electromagnetic relays directly impact the development and operational reliability of aerospace engineering *** methods for analyzing the reliability of aerospace electromagnetic relays have limitations,such as neglecting the combined effects of multiple uncertain factors,degradation of key component properties,and the influence of fluctuations in aerospace ***,these methods often assume a single-type uncertainty in the manufacturing process,leading to significant deviations between the analysis results and actual measurement *** address these issues,this study proposes an efficient timedependent reliability analysis method based on the HL-RF algorithm,considering a hybrid of probabilistic and interval uncertainty that accounts for degradation and environmental *** proposed method is applied to the reliability analysis of actual aerospace electromagnetic relay products and compared with traditional methods,demonstrating significant *** proposed method has been applied to the time-dependent reliability analysis of actual aerospace electromagnetic relay products under different environmental *** analysis results exhibit an error margin within 5.12% compared to actual measurement *** to analysis methods solely based on probabilistic uncertainty quantification or interval uncertainty quantification,this method reduces the analysis error by 52% and 67% *** compared to two other state-of-the-art methods that integrate probabilistic and interval uncertainty quantification,the error reduction is 23%.These demonstrate the superiority of the proposed method and validates its *** presented approach has the potential to be extended for reliability analysis in other aerospace electromechanical systems.

关键词： Hybrid Uncertainty analysis Time series Reliability analysis Degradation Electromagnetic Relay

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Fabrication and Characterization of NASICON-Based CO_2 Gas Sensor

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稀有金属材料与工程 2006年第A3期35卷 132-135页

作者： Yuehua He Baofu Quan Biao Wang Fengmin Liu Kuixue Liu fabin Qiu College of Electronic Science and Engineering Jilin University Changchun 130012 China

Tube-type CO_2 gas sensors based on NASICON (Na Super Ion Conductor) material were *** material was synthesized by conventional sol-gel method,and the resulted powders were characterized by *** tube-type CO_2 sensor was prepared with the sensing electrode Li_2CO_3-BaCO_3 binary carbonates in molar ratio 1:*** concentration of CO_2 range from 300μg/g to 3000μg/g,the sensitivity of the sensor was 62.3 mV/*** response and recovery time (90%)corresponding to the switching change between 300μg/g and 1000μg/g CO_2 were 20 s and 2 min,*** the sensing electrode was modified with binary oxides,the steady time of the sensor could be greatly reduced from 30 min to 5 min and the stability and humid-resistance of the sensor were improved.

关键词： NASICON CO2 gas sensor binary oxides Li2CO3-BaCO3

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PCAF and SIRT1 modulateβTrCP1 protein stability in an acetylation-dependent manner

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Journal of Genetics and Genomics 2021年第7期48卷 652-655页

作者： fabin Dang Cong Jiang Tao Zhang Hiroyuki Inuzuka Wenyi Wei Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215USA

Ubiquitination plays critical roles in regulating various physiological events,such as protein degradation,activation,secretion,sorting and trafficking(Dang et al.,2021).The ubiquitination process involves three major steps,catalyzed by ubiquitin-activating enzymes(E1s),ubiquitin-conjugating enzymes(E2s),and ubiquitin ligases(E3s),respectively(Scheffner et al.,1995).

关键词： stability steps catalyzed

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No seamount subduction,no magmatic arc?

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Earth and Planetary Physics 2022年第4期6卷 424-429页

作者： XiaoBo He JunTao Tao Yi Cao fabin Pan EnYuan He LingMin Cao YiXian Zheng Department of Ocean Exploration&Technology Zhejiang Ocean UniversityZhoushan Zhejiang 316022China School of Earth Sciences China University of GeosciencesWuhan 430074China Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Department of Marine Sciences Zhejiang UniversityZhoushan Zhejiang 316021China

Water is essential for the formation of a magmatic arc by lowering the melting temperature of materials in the mantle *** such,it is logical to attribute the absence of a magmatic arc to insufficient water released from the subducting plate,although a number of other factors may cause volcanic arc quiescence as well,such as a slab window or flat slab *** this contribution,we present a possible but testable correlation between the occurrence of a magmatic arc and seamount subduction in light of bathymetric data obtained near *** correlation,if it holds true,in turn means that a magmatic arc is unlikely to occur when the subducting slabs have not been severely fractured and that one of the main reasons for excluding effects such as the slab window or flat slab subduction may be that the plate is not accompanied by ***,the role that seamount subduction plays in recycling water back into the mantle deserves more attention from the earth sciences community.

关键词： seamount subduction arc volcano slab dehydration slab faulting bathymetric anomaly

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Application of ANSYS 3D FEM in Studies of Surface Deformation Caused by Pipe Jacking

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Wuhan University Journal of Natural Sciences 2007年第4期12卷 633-637页

作者： LI fabin FANG Kun LI Hechao Sichuan Research Institute of Territorial Surveying and Planning Chengdu 610031 Sichuan China

By using site observation data and establishing 3D model using ANSYS software, this paper has discussed the strain change of stratum stress during process of jacking-in and the impact of machine head on ground surface under different frontal resistances. Analysis of the two cases shows that soil pressure reaches its maximum point when the soil is right above machine head, and soil stress will gradually decline when machine head passes over it. It also shows that impact brought by pipe-jacking construction on stress change of the surrounding soil is limited. The thesis suggest that road surface should be consolidated and soil condition be improved before construction to prevent loss and disaster caused by road surface deformation, jacking force can be increased so that jacking efficiency can be enhanced when ground stratum is well filled with soil, but the frontal resistance facing machine head should be equal to surrounding soil pressure in order to avoid rise of ground surface.

关键词： trenchless technology pipe jacking finite element ground settlement

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Mesenchymal stem cell-derived extracellular vesicles therapy in traumatic central nervous system diseases:a systematic review and meta-analysis

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Neural Regeneration Research 2023年第11期18卷 2406-2412页

作者： Zhelun Yang Zeyan Liang Jian Rao fabin Lin Yike Lin Xiongjie Xu Chunhua Wang Chunmei Chen Department of Neurosurgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Although there are challenges in treating traumatic central nervous system diseases,mesenchymal stem cell-de rived extracellular vesicles(MSC-EVs) have recently proven to be a promising non-cellular the *** comprehensively evaluated the efficacy of mesenchymal stem cell-de rived extracellular vesicles in traumatic central nervous system diseases in this meta-analysis based on preclinical *** meta-analysis was registered at PROSPERO(CRD42022327904,May 24,2022).To fully retrieve the most relevant articles,the following databases were thoro ughly searched:PubMed,Web of Science,The Cochrane Library,and Ovid-Embase(up to April 1,2022).The included studies were preclinical studies of mesenchymal stem cell-derived extracellular vesicles for traumatic central nervous system *** Systematic Review Centre for Laboratory Animal Experimentation(SYRCLE)’s risk of bias tool was used to examine the risk of publication bias in animal *** screening 2347studies,60 studies were included in this study.A meta-analysis was conducted for spinal co rd injury(n=52) and traumatic brain injury(n=8).The results indicated that mesenchymal stem cell-derived extracellular vesicles treatment prominently promoted motor function recovery in spinal co rd injury animals,including rat Basso,Beattie and Bresnahan locomotor rating scale scores(standardized mean difference [SMD]:2.36,95% confidence interval [CI]:1.96-2.76,P <0.01,I2=71%) and mouse Basso Mouse Scale scores(SMD=2.31,95% CI:1.57-3.04,P=0.01,I2=60%) compared with ***,mesenchymal stem cell-de rived extracellular vesicles treatment significantly promoted neurological recovery in traumatic brain injury animals,including the modified N eurological Severity Score(SMD=-4.48,95% CI:-6.12 to-2.84,P <0.01,I2=79%) and Foot Fault Test(SMD=-3.26,95% CI:-4.09 to-2.42,P=0.28,I2=21%) compared with *** analyses showed that characteristics may be related to the therapeutic effect of mesenchymal stem cel

关键词： animals central nervous system diseases extracellular vesicles mesenchymal stromal cell meta-analysis spinal cord injury traumatic brain injury

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Development of stem cell-based therapy for Parkinson’s disease

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Translational Neurodegeneration 2015年第1期4卷 120-132页

作者： fabin Han Deborah Baremberg Junyu Gao Jing Duan Xianjie Lu Nan Zhang Qingfa Chen Centre for Stem Cells and Regenerative Medicine The Liaocheng People’s Hospital/Affiliated Liaocheng HospitalTaishan Medical UniversityShandong 252000China

Parkinson’s disease(PD)is one of the most common neurodegenerative disorders of aging,characterized by the degeneration of dopamine neurons(DA neurons)in the substantial nigra,leading to the advent of both motor symptoms and non-motor *** treatments include electrical stimulation of the affected brain areas and dopamine replacement *** though both categories are effective in treating PD patients,the disease progression cannot be *** research advance into cell therapies provides exciting potential for the treatment of *** cell sources include neural stem cells(NSCs)from fetal brain tissues,human embryonic stem cells(hESCs),induced pluripotent stem cells(iPSCs)and directly induced dopamine neurons(iDA neurons).Here,we evaluate the research progress in different cell sources with a focus on using iPSCs as a valuable source and propose key challenges for developing cells suitable for large-scale clinical applications in the treatment of PD.

关键词： Parkinson’s disease Dopamine neuron Neural stem cell Human embryonic stem cells Induced pluripotent stem cell Induced dopamine neuron

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Protective Effects of Ciliary Neurotrophic Factor on Denervated Skeletal Muscle

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第2期22卷 148-151页

作者： HUANG Shilong(黄仕龙) WANG fabin(王发斌) HONG Guangxiang(洪光祥) WAN Shengxiang(万圣祥) KANG Hao(康皓) Department of Hand Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Department of Hand Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Department of Hand Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Department of Hand Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Department of Hand Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022

Summary: To study the effects of ciliary neurotrophic factor (CNTF) on denervated skeletal muscle atrophy and to find a new approach to ameliorate atrophy of denervated muscle, a model was established by cutting the right sciatic nerve in 36 Wistar mice, with the left side serving as control. Then they were divided into two groups randomly. CNTF (1 U/ml) 0.1 ml was injected into the right tibial muscle every day in experimental group, and saline was used into another group for comparison. The muscle wet weight, muscle total protein, Ca 2+, physiological response and morphology were analyzed on the 7th, 14th and 28th day after operation. Our results showed that compared to control group, there was a significant increase in muscle wet weight, total protein, Ca 2+, muscle fiber cross-section area in CNTF group (P0.05), but significantly larger 28 days after the denervation (P<0.05). Our results suggest that CNTF exerts myotrophic effects by attenuating the morphological and functional changes associated with denervation of rat muscles and has protective effects on denervated muscle and motor end plate.

关键词： peripheral nerve skeletal muscle atrophy

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