Protective Effects of Ciliary Neurotrophic Factor on Denervated Skeletal Muscle

作     者：HUANG Shilong(黄仕龙) WANG Fabin(王发斌) HONG Guangxiang(洪光祥) WAN Shengxiang(万圣祥) KANG Hao(康皓) HUANG Shilong , WANG Fabin , HONG Guangxiang , WAN Shengxiang , KANG Hao Department of Hand Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022

作者机构：Department of Hand Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Department of Hand Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Department of Hand Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Department of Hand Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Department of Hand Surgery Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2002年第22卷第2期

页      面：148-151页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：peripheral nerve skeletal muscle atrophy 

摘      要：Summary: To study the effects of ciliary neurotrophic factor (CNTF) on denervated skeletal muscle atrophy and to find a new approach to ameliorate atrophy of denervated muscle, a model was established by cutting the right sciatic nerve in 36 Wistar mice, with the left side serving as control. Then they were divided into two groups randomly. CNTF (1 U/ml) 0.1 ml was injected into the right tibial muscle every day in experimental group, and saline was used into another group for comparison. The muscle wet weight, muscle total protein, Ca 2+, physiological response and morphology were analyzed on the 7th, 14th and 28th day after operation. Our results showed that compared to control group, there was a significant increase in muscle wet weight, total protein, Ca 2+, muscle fiber cross-section area in CNTF group (P0.05), but significantly larger 28 days after the denervation (P0.05). Our results suggest that CNTF exerts myotrophic effects by attenuating the morphological and functional changes associated with denervation of rat muscles and has protective effects on denervated muscle and motor end plate.