检索结果-南通市图书馆

Histopathological assessment of the microscopic activity in inflammatory bowel diseases:What are we looking for?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第36期28卷 5300-5312页

作者： Ondrej fabian Lukas Bajer Clinical and Transplant Pathology Centre Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Department of Pathology and Molecular Medicine 3rd Faculty of MedicineCharles University and Thomayer HospitalPrague 14059Czech Republic Hepatogastroenterology Department Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Institute of Microbiology Czech Academy of SciencesPrague 14220Czech Republic

Advances in diagnostics of inflammatory bowel diseases(IBD)and improved treatment strategies allowed the establishment of new therapeutic ***,it is desirable not only to cease clinical symptoms,but mainly to achieve endoscopic remission,a macroscopic normalization of the bowel ***,up to one-third of IBD patients in remission exhibit persisting microscopic activity of the *** evidence suggests a better predictive value of histology for the development of clinical complications such as clinical relapse,surgical intervention,need for therapy escalation,or development of colorectal *** proper assessment of microscopic inflammatory activity thus became an important part of the overall histopathological evaluation of colonic biopsies and many histopathological scoring indices have been ***,a majority of them have not been validated and no scoring index became a part of the routine bioptic *** review summarizes a predictive value of microscopic disease activity assessment for the subsequent clinical course of IBD,describes the most commonly used scoring indices for Crohn's disease and ulcerative colitis,and comments on current limitations and unresolved issues.

关键词： Crohn’s disease Microscopy Predictor Score Ulcerative colitis

Interactive map reports summarizing bivariate geographic data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Visual Informatics 2019年第1期3卷 27-37页

作者： Shahid Latif fabian Beck University of Duisburg–Essen paluno–The Ruhr Institute of Software TechnologyGermany

Bivariate map visualizations use different encodings to visualize two variables but comparison across multiple encodings is *** to a univariate visualization,it is significantly harder to read regional differences and spot geographical *** targeting inexperienced users of visualizations,we advocate the use of natural language text for augmenting map visualizations and understanding the relationship between two geo-statistical *** propose an approach that selects interesting findings from data analysis,generates a respective text and visualization,and integrates both into a single *** generated reports interactively link the visualization with the textual *** can get additional explanations and have the ability to compare different *** text generation process is flexible and adapts to various geographical and contextual settings based on small sets of *** showcase this flexibility through a number of application examples.

关键词： Geographic visualization Natural language generation Interactive documents

District heating system operation in power systems with high share of wind power

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2017年第6期5卷 850-862页

作者： Ilias DIMOULKAS Mikael AMELIN fabian LEVIHN School of Electrical Engineering Electric Power and Energy SystemsKTH Royal Institute of TechnologyStockholmSweden Fortum Va¨rme StockholmSweden School of Industrial Engineering and Management Industrial Economics and ManagementKTH Royal Institute of TechnologyStockholmSweden

The integration of continuously varying and not easily predictable wind power generation is affecting the stability of the power system and leads to increasing demand for balancing *** this study,a short-term operation model of a district heating system is proposed to optimally schedule the production of both heat and power in a system with high wind power *** application of the model in a case study system shows the increased flexibility offered by the coordination of power generation,consumption and heat storage units which are available in district heating systems.

关键词： District heating systems Combined heat and power(CHP) Flexible power system operation Heat storage

Retinal pigment epithelium–Bruch’s membrane volume in grading of age-related macular degeneration

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2023年第11期16卷 1827-1831页

作者： fabian Kananen Ilkka Immonen Department of Ophthalmology Örebro University HospitalÖrebro 70185Sweden Department of Ophthalmology and Otorhinolaryngology Helsinki UniversityHelsinki 00014Finland Department of Ophthalmology Helsinki University Central HospitalHelsinki 00014Finland

AIM:To assess the agreement of optical coherence tomography(OCT)algorithm-based retinal pigment epithelium–Bruch’s membrane complex volume(RBV)with fundus photograph-based age-related macular degeneration(AMD)***:Digital color fundus photographs(CFPs)and spectral domain OCT images were acquired from 96 elderly *** were graded according to Age-Related Eye Disease Study(AREDS)*** image segmentation and RBV data calculation were done with OrionTM *** and multivariate analyses were performed to find out whether AMD lesion features associated with higher ***:RBV correlated with AMD grading(rs=0.338,P=0.001),the correlation was slightly stronger in early AMD(n=52;rs=0.432,P=0.001).RBV was higher in subjects with early AMD compared with those with no AMD lesions evident in fundus photographs(1.05±0.20 vs 0.96±0.13 mm3,P=0.023).In multivariate analysis higher RBVs were associated significantly with higher total drusen(β=0.388,P=0.027)and pigmentation areas(β=0.319,P=0.020)in fundus photographs,whereas depigmentation area(β=-0.295,P=0.015)associated with lower ***:RBV correlate with AMD grading status,with a stronger association in patients with moderate,non-late AMD *** effect is driven mostly by lesions with drusen or *** with depigmentation tend to have lower *** is more comprehensive measurement of the key area of AMD pathogenesis,compared to sole drusen volume *** measurements are independent on grader variations and offer a possibility to quantify early and middle grade AMD lesions in a research setting,but may not substitute fundus photograph-based grading in the whole range of AMD spectrum.

关键词： age-related macular degeneration drusen optical coherence tomography Bruch’s membrane

Four-wheel-drive immune protection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第10期7卷 3637-3638页

作者： fabian Heinrich Susanne Krasemann Institute of Legal Medicine University Medical Center Hamburg Eppendorf20251 HamburgGermany Institute of Neuropathology University Medical Center Hamburg Eppendorf20251 HamburgGermany

In a recent study published in Cell,Zhang and colleagues provide the first longitudinal study comparing four different COVID-19 vaccines head-to-head for binding and neutralizing antibodies,spike-specific CD4+or CD8+T... 详细信息

关键词： antibodies immune vaccines

The AiiDA-KKR plugin and its application to highthroughput impurity embedding into a topological insulator

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2021年第1期7卷 108-116页

作者： Philipp Rüßmann fabian Bertoldoand Stefan Blügel Peter Grünberg Institut and Institute for Advanced Simulation Forschungszentrum Jülich and JARAD-52425 JülichGermany

The ever increasing availability of supercomputing resources led computer-based materials science into a new era of highthroughput ***,Pizzi et *** the AiiDA framework that provides a way to automate calculations while allowing to store the full provenance of complex workflows in a *** present the development of the AiiDA-KKR plugin that allows to perform a large number of ab initio impurity embedding calculations based on the relativistic full-potential Korringa-Kohn-Rostoker Green function *** capabilities of the AiiDA-KKR plugin are demonstrated with the calculation of several thousand impurities embedded into the prototypical topological insulator *** results are collected in the JuDiT database which we use to investigate chemical trends as well as Fermi level and layer dependence of physical properties of *** includes the study of spin moments,the impurity’s tendency to form in-gap states or its effect on the charge doping of the *** properties depend on the detailed electronic structure of the impurity embedded into the host crystal which highlights the need for ab initio calculations in order to get accurate predictions.

关键词： method topological embedding

Bioelemental patterns in the cerebrospinal fluid as potential biomarkers for neurodegenerative disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第8期13卷 1356-1357页

作者： fabian Maass Paul Lingor Department of Neurology University Medical Center GoettingenGermany cluster of excellence nanoscale microscopy and molecular Physiology of the Brain(CNMPB) GoettingenGermany

Neurodegenerative disorders like Parkinson＇s disease （PD） or atypi- cal Parkinsonian syndromes including the different synucleinopa- thies and tauopathies are an important burden for patients, rela- tives, care pro... 详细信息

关键词： PD Bioelemental patterns in the cerebrospinal fluid as potential biomarkers for neurodegenerative disorders

Determination of a Safe Distance for Atomic Hydrogen Depositions in Hot-Wire Chemical Vapour Deposition by Means of CFD Heat Transfer Simulations

在线全文

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2020年第2期16卷 225-235页

作者： Lionel fabian Fourie Lynndle Square Department of Physics and Astronomy University of the Western CapeBellville7535South Africa Department of Physics North-West UniversityPotchefstroom2520South Africa

A heat transfer study was conducted,in the framework of Computational Fluid Dynamics(CFD),on a Hot-Wire Chemical Vapour Deposition(HWCVD)reactor chamber to determine a safe deposition distance for atomic hydrogen produced by *** objective of this study was to show the feasibility of using heat transfer simulations in determining a safe deposition distance for deposition of this *** CFD simulations were set-up and solved within the framework of the CFD packages of OpenFOAM namely;snappyHexMesh for mesh generation,buoyantSimpleFoam and rhoSimpleFoam as the solvers and paraView as the post-processing *** a standard set of deposition parameters for the production of atomic hydrogen by HWCVD,plots of the gas temperature in the deposition region were *** these plots,we were able to determine a safe deposition distance in the HWCVD reactor to be in the range between 3 and 4 cm from the filament.

关键词： Heat transfer HWCVD OpenFOAM atomic hydrogen

On Unsupervised Training of Multi-Class Regularized Least-Squares Classifiers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2014年第1期29卷 90-104页

作者： Tapio Pahikkala Antti Airola fabian Gieseke Oliver Kramer ACM IEEE Department of Information Technology University of Turku Department of Computer Science University of Copenhagen Computer Science Department Carl von Ossietzky University of Oldenburg

In this work we present the first efficient algorithm for unsupervised training of multi-class regularized least- squares classifiers. The approach is closely related to the unsupervised extension of the support vector machine classifier known as maximum margin clustering, which recently has received considerable attention, though mostly considering the binary classification case. We present a combinatorial search scheme that combines steepest descent strategies with powerful meta-heuristics for avoiding bad local optima. The regularized least-squares based formulation of the problem allows us to use matrix algebraic optimization enabling constant time checks for the intermediate candidate solutions during the search. Our experimental evaluation indicates the potential of the novel method and demonstrates its superior clustering performance over a variety of competing methods on real world datasets. Both time complexity analysis and experimental comparisons show that the method can scale well to practical sized problems.

关键词： unsupervised learning multi-class regularized least-squares classification maximum margin clustering combinatorial optimization